Leptin signaling pathways in the central nervous system: Interactions between neuropeptide Y and melanocortins

BioEssays

Volumn 23, Issue 12, 2001, Pages 1095-1099

  Rahmouni, Kamal ^a   Haynes, William G ^a  

^a UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERMEDIN; CORTICOTROPIN RELEASING FACTOR; LEPTIN; NEUROPEPTIDE Y; PROOPIOMELANOCORTIN;

ANIMAL; CENTRAL NERVOUS SYSTEM; HYPOTHALAMUS; METABOLISM; NERVE CELL; PHYSIOLOGY; REVIEW; SIGNAL TRANSDUCTION;

ALPHA-MSH; ANIMAL; CENTRAL NERVOUS SYSTEM; CORTICOTROPIN-RELEASING HORMONE; HYPOTHALAMUS; LEPTIN; NEURONS; NEUROPEPTIDE Y; PRO-OPIOMELANOCORTIN; SIGNAL TRANSDUCTION;

EID: 0035542973     PISSN: 02659247     EISSN: None     Source Type: Journal    
DOI: 10.1002/bies.10018     Document Type: Article

References (36)

1. Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus
2. Human leptin: From an adipocyte hormone to an endocrine mediator
3. A neuro (endo)crine regulation of bone remodeling
4. State-of-the-art-lecture: Obesity-induced hypertension: New concepts from the emerging biology of obesity
5. Central nervous system control of food intake
6. The arcuate nucleus as a primary site of satiety effect of leptin in rats
7. Attenuation of leptin-mediated effects by monosodium glutamate-induced arcuate nucleus damage
8. Serum immunoreactive-leptin concentrations in normal-weight and obese humans
9. Physiological response to long-term peripheral and central leptin infusion in lean and obese mice
10. Diet-induced obese mice develop peripheral, but not central, resistance to leptin
11. A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction
12. Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity
13. Transgenic approach to the study of body weight regulation
14. Neuropeptide Y chronically injected into the hypothalamus: A powerful neurochemical inducer of hyperphagia and obesity
15. Increased neuropeptide-Y messenger ribonucleic acid (mRNA) and decreased neurotensin mRNA in the hypothalamus of the obese (ob/ob) mouse
16. Food deprivation and hypothalamic neuropeptide gene expression: Effects of strain background and the diabetes mutation
17. Attenuation of the obesity syndrome of ob/ob mice by the loss of neuropeptide Y
18. Central cardiovascular action of neuropeptide Y in conscious rabbits
19. Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y
20. Leptin increases hypothalamic pro-opiomelanocortin mRNA expression in the rostral arcuate nucleus
21. Regulation of hypothalamic proopiomelanocortin mRNA by leptin in ob/ob mice
22. Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain
23. Role of melanocortinergic neurons in feeding and the agouti obesity syndrome
24. Targeted disruption of the melanocortin-4 receptor results in obesity in mice
25. Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass
26. The melanocortin receptors: Agonists, antagonists, and the hormonal control of pigmentation
27. Cloning of the mouse agouti gene predicts a secreted protein ubiquitously expressed in mice carrying the lethal yellow mutation
28. Overexpression of Agrt leads to obesity in transgenic mice
29. Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein
30. Contrasting blood pressure effects of obesity in leptin-deficient ob/ob mice and agouti yellow obese mice
31. Pathophysiological role of leptin in obesity-related hypertension
32. A new concept of selective leptin resistance: Evidence from agouti yellow obese mice
33. Hypothalamic response to starvation: Implications for the study of wasting disorders
34. Effect of corticotrophin releasing hormone and neuropeptide Y on electrophysiological activity of sympathetic nerves to interscapular brown adipose tissue
35. Sympatho-adrenal medullary functions in response to intracerebroventricularly injected corticotrophin-releasing factor in anesthetized rats
36. Role of corticotrophin-releasing factor in effects of leptin on sympathetic nerve activity and arterial pressure