The myocardial β-adrenergic system in spontaneously hypertensive heart failure (SHHF) rats

Hypertension

Volumn 33, Issue 1 II, 1999, Pages 402-407

  Anderson, Karen M ^a   Eckhart, Andrea D ^b   Willette, Robert N ^a   Koch, Walter J ^b  

^a GLAXOSMITHKLINE   (United Kingdom)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Adenylyl cyclase; Heart failure; Hypertension, experimental; Hypertrophy, cardiac; Kinase; Rats, inbred SHR; Receptors, adrenergic, beta

Indexed keywords

ADENYLATE CYCLASE; BETA ADRENERGIC RECEPTOR; ISOPRENALINE;

ADRENERGIC SYSTEM; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CATECHOLAMINE RELEASE; CONTROLLED STUDY; DRUG RECEPTOR BINDING; ENZYME ACTIVITY; GENETIC MODEL; HEART FAILURE; HEART FUNCTION; HEART HYPERTROPHY; HEART LEFT VENTRICLE ENDDIASTOLIC PRESSURE; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR DENSITY; REPRODUCIBILITY; SPONTANEOUSLY HYPERTENSIVE RAT;

EID: 0032897297     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.hyp.33.1.402     Document Type: Article

References (34)

1. Castellano M, Böhm M. The cardiac β-adrenoceptor-mediated signaling pathway and its alterations in hypertensive heart disease. Hypertension. 1997;29:715-722.
2. Ginsburg R, Bristow MR, Billingham ME, Stinson EB, Schroeder JS, Harrison DC. Study of the normal and failing isolated human heart: decreased response of failing heart to isoproterenol. Am Heart J 1983; 106:535-540.
3. 2-adrenoceptor-mediatcd positive inotropic effects in human end-stage heart failure. Br J Pharmacol. 1992;105:463-469.
4. Colucci W, Denniss AR, Leatherman GF, Quigg RJ, Ludmer PL, Marsh JD, Gauthier DF. Intracoronary infusion of dobutamine to patients with and without severe congestive heart failure: dose-response relationships, correlation with circulating catecholamines, and effect of phosphodiesterase inhibition. J Clin Invest. 1988;81:1103-1110.
5. Colucci WS, Ribeiro JP, Rocco MB, Quigg RJ, Creager MA, Marsh JD, Gauthier DF, Hartley LH. Impaired chronotropic response to exercise in patients with congestive heart failure: role of postsynaptic beta-adrenergic desensitization. Circulation. 1989;80:314-323.
6. Bristow MR, Ginsburg R, Minobe W, Cubicciotti RS, Sageman WS, Lurie K, Billingham ME, Harrison DC, Stinson EB. Decreased catecholamine sensitivity and β-adrenergic-receptor density in failing human hearts. N Engl J Med. 1982;307:205-211.
7. Gopalakrishnan M, Triggle DJ. The regulation of receptors, ion channels, and G proteins in congestive heart failure. Cardiovasc Drug Rev. 1990; 8:255-302.
8. Ungerer M, Bohm M, Elce JS, Erdmann E, Lohse MJ. Altered expression of β-adrenergic receptor kinase and β1-adrenergic receptors in the failing human heart. Circulation. 1993;87:454-463.
9. Brodde O-E. β-Adrenergic receptors in failing human myocardium. Basic Res Cardiol. 1993;91:35-40.
10. Ungerer M, Parruti G, Bohm M, Puzicha M, DeBlasi A, Erdmann E, Lohse MJ. Expression of β-arrestins and β-adrenergic receptor kinases in the failing human heart. Circ Res. 1994;74:206-213.
11. Lohse MJ. G-protein-coupled receptor kinases and the heart. Trends Cardiovasc Med. 1995;5:63-68.
12. Inglese J, Freedman NJ, Koch WJ, Lefkowitz RJ. Structure and mechanism of the G protein-coupled receptor kinases. J Biol Chem. 1993;268:23735-23738.
13. 1-adrenergic receptor: involvement of G protein-coupled receptor kinases and cAMP-dependent protein kinase. J Biol Chem. 1995;270:17953-17961.
14. Böhm M, Eschenhagen T, Gierschik P, Larisch K, Lensche H, Mende U, Schmitz W, Schnabel P, Scholz H, Steinfath M, Erdmann E. Radioimmunochemical quantification of Giα in right and left ventricles from patients with ischemic and dilated cardiomyopathy and predominant left ventricular failure. J Mol Cell Cardiol. 1994;26:133-149.
15. Brown LA, Harding SE. The effect of pertussis toxin on β-adrenoceplor responses in isolated cardiac myocytes from noradrenaline-treated guinea-pigs and patients with cardiac failure. Br J Pharmacol. 1992;106: 115-122.
16. Feldman AM, Cates AE, Veazy WB, Hershberger RE, Bristow MR, Baughman KL, Baumgartner WA, Van Dop C. Increase of the 40,000-mol wt pertussis toxin substrate (G protein) in the failing human heart. J Clin Invest. 1988;82:189-197.
17. i proteins in heart failure. Lancet. 1988;2: 936-937.
18. Bristow MR, Hershberger RE, Port JD, Minobe W, Rasmussen R. Beta 1- and beta 2-adrenergic receptor-mediated adenylate cyclase stimulation in nonfailing and failing human ventricular myocardium. Mol Pharmacol. 1989;35:295-303.
19. Feldman MD, Copelas L, Gwathmey JK, Phillips P, Warren SE, Schoen FJ, Grossman W, Morgan JP. Deficient production of cAMP: pharmacologic evidence of an important cause of contractile dysfunction in patients with end-stage heart failure. Circulation. 1987;75:331-339.
20. Denniss AR, Marsh JD, Quigg RJ, Gordon JB, Colucci WS. Beta-adrenergic receptor number and adenylate cyclase function in denervated transplanted and cardiomyopathic human hearts. Circulation. 1989;79: 1028-1034.
21. cp: a genetic model of congestive heart failure. In: PK Singal, IMC Dixon, RE Beamish, NS Dhalla, eds. Mechanisms of Heart Failure. Boston, MA: Kluwer Academic Publishers; 1995:91-106.
22. cp rats. Am J Physiol. 1997; 273(Heart Circ Physiol. 42):H228-H233.
23. Haas GJ, McCune SA, Brown DM, Cody RJ, Echocardiographic characterization of left ventricular adaptation in a genetically determined heart failure rat model. Am Heart J. 1995;130:806-811.
24. Gomez AM, Valdiva HH, Cheng H, Lederer MR, Santana LF, Cannell MB, McCune SA, Altschuld RA, Lederer WJ. Defective excitation-contraction coupling in experimental cardiac hypertrophy and heart failure. Science. 1997;276:800-806.
25. Hohl CM, Hu B, Fertel RH, Russell JC, McCune SA, Altshuld RA. Effects of obesity and hypertension on ventricular myocytes: comparison of cells from adults SHHF/Mcc-cp and JCR:LA-cp rats. Cardiovasc Res. 1993;27:238-242.
26. Gerdes AM, Onodera T, Wang A, McCune SA. Myocyte remodeling during the progression to failure in rats with hypertension. Hypertension. 1996;28:609-614.
27. Sack MN, Rader TA, Park S, Bastin J, McCune SA, Kelly DP. Fatty acid oxidation enzyme gene expression is downregulated in the failing heart. Circulation. 1996;94:2837-2842.
28. Koch WJ, Rockman HA, Samama P, Hamilton RA, Bond RA, Milano CA, Lefkowitz RJ. Cardiac function in mice overexpressing the β-adrenergic receptor kinase or an βARK inhibitor. Science. 1995;268: 1350-1353.
29. Choi D-J, Koch WJ, Hunter JJ, Rockman HA. Mechanism of β-adrenergic receptor desensitization in cardiac hypertrophy is increased β-adrenergic receptor kinase. J Biol Chem. 1997;272:17223-17229.
30. Rockman HA, Choi DJ, Rahman NU, Akhter SA, Lefkowitz RJ, Koch WJ. Receptor-specific in vivo desensitization by the G protein-coupled receptor kinase-5 in transgenic mice. Proc Natl Acad Sci U S A. 1996; 93:9954-9959.
31. 2-adrenergic responses without changes in inhibitory G proteins or receptor kinases. J Clin Invest. 1998;101:1273-1282.
32. cp rat model: effects of gender and genotype on age of expression of metabolic complications and congestive heart failure and on response to drug therapy. In: EE Shafrir, ed. Lessons from Animal Diabetes. London, UK: Smith-Gordon; 1995:255-270.
33. Lefkowitz RJ. G-protein-coupled receptors and receptor kinases: from molecular biology to potential therapeutic applications. Nat Biotechnol. 1996;14:283-286.
34. Eckhart AD, Anderson KM, Griswold MC, Rockman HA, Koch WJ. Adenoviral-mediated gene transfer of a β-adrenergic receptor kinase inhibitor reverses functional uncoupling in failing cardiomyocytes isolated from SHHF rats. Circulation. 1998;98(suppl I):I-806. Abstract.