Arsenic-Induced Changes to the Epigenome

Toxicology and Epigenetics

Volumn , Issue , 2012, Pages 149-190

  Bailey, Kathryn A ^a   Fry, Rebecca C ^a  

^a The University of North Carolina at Chapel Hill   (United States)

Author keywords

Alterations in DNA methylation with As exposure in utero; Arsenic exposure effects, and metabolism on cofactor availability; Arsenic induced changes to the epigenome; Chronic As poisoning, significant worldwide health concern; DNA methylation patterns and active DNA methylation demethylation; Epigenetic alterations, role in human disease development; Epigenetic modifications, determining phenotypic variation; Gene silencing by CpG methylation, and mechanisms; Histone modifications, and arsenic exposure; Precise mechanisms of As mediated disease, elusive

Indexed keywords

EID: 84874018318     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9781118349045.ch8     Document Type: Chapter

References (196)

1. Ahlborn, G.J., Nelson, G.M., Ward, W.O. et al. (2008) Dose response evaluation of gene expression profiles in the skin of K6/ODC mice exposed to sodium arsenite. Toxicol. Appl. Pharmacol., 227, 400-416.
2. Anetor, J.I., Wanibuchi, H., and Fukushima, S. (2007) Arsenic exposure and its health effects and risk of cancer in developing countries: micronutrients as host defence. Asian Pac. J. Cancer Prev., 8, 13-23.
3. Antequera, F. and Bird, A. (1993) CpG islands. EXS , 64, 169-185.
4. Arita, A. and Costa, M. (2009) Epigenetics in metal carcinogenesis: nickel, arsenic, chromium and cadmium. Metallomics, 1, 222-228.
5. Arrigo, A.P. (1983) Acetylation and methylation patterns of core histones are modified after heat or arsenite treatment of Drosophila tissue culture cells. Nucleic Acids Res., 11, 1389-1404.
6. Baccarelli, A. and Bollati, V. (2009) Epigenetics and environmental chemicals. Curr. Opin. Pediatr., 21, 243-251.
7. Bagnyukova, T.V., Luzhna, L.I., Pogribny, I.P., and Lushchak, V.I. (2007) Oxidative stress and antioxidant defenses in goldfish liver in response to short-term exposure to arsenite. Environ. Mol. Mutagen., 48, 658-665.
8. Bailey, K.A., Hester, S.D., Knapp, G.W. et al. (2010) Gene expression of normal human epidermal keratinocytes modulated by trivalent arsenicals. Mol. Carcinog., 49, 981-998.
9. Bailey, K., Xia, Y., Ward, W.O. et al. (2009) Global gene expression profiling of hyperkeratotic skin lesions from inner mongolians chronically exposed to arsenic. Toxicol. Pathol., 37, 849-859.
10. Bannister, A.J. and Kouzarides, T. (2011) Regulation of chromatin by histone modifications. Cell Res., 21, 381-395.
11. Bannister, A.J., Schneider, R., and Kouzarides, T. (2002) Histone methylation: dynamic or static? Cell, 109, 801-806.
12. Baskerville, S. and Bartel, D.P. (2005) Microarray profiling of microRNAs reveals frequent coexpression with neighboring miRNAs and host genes. RNA, 11, 241-247.
13. Bedford, M.T. and Clarke, S.G. (2009) Protein arginine methylation in mammals: who, what, and why. Mol. Cell, 33, 1-13.
14. Benbrahim-Tallaa, L., Waterland, R.A., Styblo, M. et al. (2005) Molecular events associated with arsenic-induced malignant transformation of human prostatic epithelial cells: aberrant genomic DNA methylation and K-ras oncogene activation. Toxicol. Appl. Pharmacol., 206, 288-298.
15. Bestor, T.H. and Verdine, G.L. (1994) DNA methyltransferases. Curr. Opin. Cell Biol., 6, 380-389.
16. Boellmann, F., Zhang, L., Clewell, H.J. et al. (2010) Genome-wide analysis of DNA methylation and gene expression changes in the mouse lung following subchronic arsenate exposure. Toxicol. Sci., 117, 404-417.
17. Brambila, E.M., Achanzar, W.E., Qu, W. et al. (2002) Chronic arsenic-exposed human prostate epithelial cells exhibit stable arsenic tolerance: mechanistic implications of altered cellular glutathione and glutathione S-transferase. Toxicol. Appl. Pharmacol., 183, 99-107.
18. Camato, R. and Tanguay, R.M. (1982) Changes in the methylation pattern of core histones during heat-shock in Drosophila cells. EMBO J., 1, 1529-1532.
19. Cantone, L., Nordio, F., Hou, L. et al. (2011) Inhalable metal-rich air particles and histone H3K4 dimethylation and H3K9 acetylation in a cross-sectional study of steel workers. Environ. Health Perspect., 119, 964-969.
20. Cao, Y., Yu, S.L., Wang, Y. et al. (2011) MicroRNA-dependent regulation of PTEN after arsenic trioxide treatment in bladder cancer cell line T24. Tumour Biol., 32, 179-188.
21. Ceman, S. and Saugstad, J. (2011) MicroRNAs: meta-controllers of gene expression in synaptic activity emerge as genetic and diagnostic markers of human disease. Pharmacol. Ther., 130, 26-37.
22. Centeno, J.A., Mullick, F.G., Martinez, L. et al. (2002) Pathology related to chronic arsenic exposure. Environ. Health Perspect., 110 (Suppl. 5), 883-886.
23. Centeno, J.A., Tseng, C.H., Van der Voet, G.B., and Finkelman, R.B. (2007) Global impacts of geogenic arsenic: a medical geology research case. AMBIO, 36, 78-81.
24. Chai, C.Y., Huang, Y.C., Hung, W.C. et al. (2007) Arsenic salts induced autophagic cell death and hypermethylation of DAPK promoter in SV-40 immortalized human uroepithelial cells. Toxicol. Lett., 173, 48-56.
25. Chanda, S., Dasgupta, U.B., Guhamazumder, D. et al. (2006) DNA hypermethylation of promoter of gene p53 and p16 in arsenic-exposed people with and without malignancy. Toxicol. Sci., 89, 431-437.
26. Chen, W.T., Hung, W.C., Kang, W.Y. et al. (2007) Urothelial carcinomas arising in arsenic-contaminated areas are associated with hypermethylation of the gene promoter of the death-associated protein kinase. Histopathology, 51, 785-792.
27. Chen, H., Li, S., Liu, J. et al. (2004) Chronic inorganic arsenic exposure induces hepatic global and individual gene hypomethylation: implications for arsenic hepatocarcinogenesis. Carcinogenesis, 25, 1779-1786.
28. Cheung, H.H., Lee, T.L., Rennert, O.M., and Chan, W.Y. (2009) DNA methylation of cancer genome. Birth Defects Res.C Embryo Today, 87, 335-350.
29. Chi, P., Allis, C.D., and Wang, G.G. (2010) Covalent histone modifications-miswritten, misinterpreted and mis-erased in human cancers. Nat. Rev. Cancer, 10, 457-469.
30. Chu, F., Ren, X., Chasse, A. et al. (2011) Quantitative mass spectrometry reveals the epigenome as a target of arsenic. Chem. Biol. Interact., 192, 113-117.
31. Cohen, S.M., Arnold, L.L., Eldan, M. et al. (2006) Methylated arsenicals: the implications of metabolism and carcinogenicity studies in rodents to human risk assessment. Crit. Rev. Toxicol., 36, 99-133.
32. Coppin, J.F., Qu, W., and Waalkes, M.P. (2008) Interplay between cellular methyl metabolism and adaptive efflux during oncogenic transformation from chronic arsenic exposure in human cells. J. Biol. Chem., 283, 19342-19350.
33. Cravo, M., Fidalgo, P., Pereira, A.D. et al. (1994) DNA methylation as an intermediate biomarker in colorectal cancer: modulation by folic acid supplementation. Eur. J. Cancer Prev., 3, 473-479.
34. Cui, X., Wakai, T., Shirai, Y. et al. (2006a) Chronic oral exposure to inorganic arsenate interferes with methylation status of p16INK4a and RASSF1A and induces lung cancer in A/J mice. Toxicol. Sci., 91, 372-381.
35. Cui, X., Wakai, T., Shirai, Y. et al. (2006b) Arsenic trioxide inhibits DNA methyltransferase and restores methylationsilenced genes in human liver cancer cells. Hum. Pathol., 37, 298-311.
36. Das, N.K. and Sengupta, S.R. (2008) Arsenicosis: diagnosis and treatment. Indian J. Dermatol. Venereol. Leprol., 74, 571-581.
37. Das, P.M. and Singal, R. (2004) DNA methylation and cancer. J. Clin. Oncol., 22, 4632-4642.
38. Davis, C.D., Uthus, E.O., and Finley, J.W. (2000) Dietary selenium and arsenic affect DNA methylation in vitro in Caco-2 cells and in vivo in rat liver and colon. J. Nutr., 130, 2903-2909.
39. Deroo, B.J. and Korach, K.S. (2006) Estrogen receptors and human disease. J. Clin. Invest., 116, 561-570.
40. Desrosiers, R. and Tanguay, R.M. (1986) Further characterization of the posttranslational modifications of core histones in response to heat and arsenite stress in Drosophila. Biochem. Cell Biol., 64, 750-757.
41. Dobosy, J.R. and Selker, E.U. (2001) Emerging connections between DNA methylation and histone acetylation. Cell. Mol. Life Sci., 58, 721-727.
42. Doi, A., Park, I.H., Wen, B. et al. (2009) Differential methylation of tissue and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts. Nat. Genet., 41, 1350-1353.
43. Dolinoy, D.C. and Jirtle, R.L. (2008) Environmental epigenomics in human health and disease. Environ. Mol. Mutagen., 49, 4-8.
44. Drobna, Z., Styblo, M., and Thomas, D.J. (2009) An overview of arsenic metabolism and toxicity, Current Protocols in Toxicology, Supplement 42: Techniques for Analysis of Chemical Biotransformation, John Wiley & Sons, Inc., New York, pp. 4.31.1-4.31.6.
45. Eberharter, A. and Becker, P.B. (2002) Histone acetylation: a switch between repressive and permissive chromatin. Second in review series on chromatin dynamics. EMBO Rep., 3, 224-229.
46. Eden, A., Gaudet, F., Waghmare, A., and Jaenisch, R. (2003) Chromosomal instability and tumors promoted by DNA hypomethylation. Science, 300, 455.
47. Ehrlich, M. (2002) DNA methylation in cancer: too much, but also too little. Oncogene, 21, 5400-5413.
48. Esquela-Kerscher, A. and Slack, F.J. (2006) Oncomirs-microRNAs with a role in cancer. Nat. Rev. Cancer, 6, 259-269.
49. Esteller, M. (2007) Cancer epigenomics: DNA methylomes and histone-modification maps. Nat. Rev. Genet., 8, 286-298.
50. Fabbri, M. and Calin, G.A. (2010) Epigenetics and miRNAs in human cancer. Adv. Genet., 70, 87-99.
51. Felsenfeld, G., Clark, D., and Studitsky, V. (2000) Transcription through nucleosomes. Biophys. Chem., 86, 231-237.
52. Fewtrell, L., Fuge, R., and Kay, D. (2005) An estimation of the global burden of disease due to skin lesions caused by arsenic in drinking water. J. Water Health, 3, 101-107.
53. Finkelstein, J.D. (2007) Metabolic regulatory properties of S-adenosylmethionine and S-adenosylhomocysteine. Clin. Chem. Lab. Med., 45, 1694-1699.
54. Finkelstein, J.D., and Martin, J.J. (2000) Homocysteine. Int. J. Biochem. Cell Biol., 32, 385-389.
55. Fraga, M.F., Ballestar, E., Paz, M.F. et al. (2005a) Epigenetic differences arise during the lifetime of monozygotic twins. Proc. Natl. Acad. Sci. U.S.A., 102, 10604-10609.
56. Fraga, M.F., Ballestar, E., Villar-Garea, A. et al. (2005b) Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer. Nat. Genet., 37, 391-400.
57. Fu, H.Y., Shen, J.Z., Wu, Y. et al. (2010) Arsenic trioxide inhibits DNA methyltransferase and restores expression of methylation-silenced CDKN2B/CDKN2A genes in human hematologic malignant cells. Oncol. Rep., 24, 335-343.
58. Gardiner-Garden, M. and Frommer, M. (1987) CpG islands in vertebrate genomes. J. Mol. Biol., 196, 261-282.
59. Gebel, T.W. (2001) Genotoxicity of arsenical compounds. Int. J. Hyg. Environ. Health, 203, 249-262.
60. Gehring, M., Reik, W., and Henikoff, S. (2009) DNA demethylation by DNA repair. Trends Genet., 25, 82-90.
61. Geiman, T.M., and Robertson, K.D. (2002) Chromatin remodeling, histone modifications, and DNA methylation-how does it all fit together? J. Cell. Biochem., 87, 117-125.
62. Gelato, K.A. and Fischle, W. (2008) Role of histone modifications in defining chromatin structure and function. Biol. Chem., 389, 353-363.
63. Germolec, D.R., Spalding, J., Boorman, G.A. et al. (1997) Arsenic can mediate skin neoplasia by chronic stimulation of keratinocyte-derived growth factors. Mutat. Res., 386, 209-218.
64. Germolec, D.R., Yoshida, T., Gaido, K. et al. (1996) Arsenic induces overexpression of growth factors in human keratinocytes. Toxicol. Appl. Pharmacol., 141, 308-318.
65. Ghosh, P., Banerjee, M., Giri, A.K., and Ray, K. (2008) Toxicogenomics of arsenic: classical ideas and recent advances. Mutat. Res., 659, 293-301.
66. Girault, I., Tozlu, S., Lidereau, R., and Bieche, I. (2003) Expression analysis of DNA methyltransferases 1, 3A, and 3B in sporadic breast carcinomas. Clin. Cancer Res., 9, 4415-4422.
67. Gregus, Z., Roos, G., Geerlings, P., and Nemeti, B. (2009) Mechanism of thiol-supported arsenate reduction mediated by phosphorolytic-arsenolytic enzymes: II. Enzymatic formation of arsenylated products susceptible for reduction to arsenite by thiols. Toxicol. Sci., 110, 282-292.
68. Haluskova, J. (2010) Epigenetic studies in human diseases. Folia Biol., 56, 83-96.
69. Hamadeh, H.K., Trouba, K.J., Amin, R.P. et al. (2002) Coordination of altered DNA repair and damage pathways in arsenite-exposed keratinocytes. Toxicol. Sci., 69, 306-316.
70. Hammond, S.M. (2007) MicroRNAs as tumor suppressors. Nat. Genet., 39, 582-583.
71. He, L. and Hannon, G.J. (2004) MicroRNAs: small RNAs with a big role in gene regulation. Nat. Rev. Genet., 5, 522-531.
72. Hobert, O. (2008) Gene regulation by transcription factors and microRNAs. Science, 319, 1785-1786.
73. Huang, Y.C., Hung, W.C., Chen, W.T. et al. (2011) Effects of DNMT and MEK inhibitors on the expression of RECK, MMP-9, -2, uPA and VEGF in response to arsenite stimulation in human uroepithelial cells. Toxicol. Lett., 201, 62-71.
74. Hughes, M.F. (2002) Arsenic toxicity and potential mechanisms of action. Toxicol. Lett., 133, 1-16.
75. IARC (1987) International Agency for Research on Cancer Monographs on the Evaluation of Carcinogenic Risks to Humans: Overall Evaluations-Carcinogenicity: An Updating of IARC Monographs, vol. 1-42, Supplement 7, IARC Scientific, Lyon, pp. 100-106.
76. IARC (2004) Some Drinking-water disinfectants and contaminants, including arsenic, Monographs on the Evaluation of Carcinogenic Risks to Humans, IARC Scientific Publications, Lyon, 84, pp.
77. Irizarry, R.A., Ladd-Acosta, C., Wen, B. et al. (2009) The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores. Nat. Genet., 41, 178-186.
78. Jacinto, F.V. and Esteller, M. (2007) Mutator pathways unleashed by epigenetic silencing in human cancer. Mutagenesis, 22, 247-253.
79. Jafari, S., Hosseini, M.S., Hajian, M. et al. (2011) Improved in vitro development of cloned bovine embryos using S-adenosylhomocysteine, a non-toxic epigenetic modifying reagent. Mol. Reprod. Dev., 78, 576-584.
80. Jensen, T.J., Novak, P., Eblin, K.E. et al. (2008) Epigenetic remodeling during arsenical-induced malignant transformation. Carcinogenesis, 29, 1500-1508.
81. Jensen, T.J., Novak, P., Wnek, S.M. et al. (2009a) Arsenicals produce stable progressive changes in DNA methylation patterns that are linked to malignant transformation of immortalized urothelial cells. Toxicol. Appl. Pharmacol., 241, 221-229.
82. Jensen, T.J., Wozniak, R.J., Eblin, K.E. et al. (2009b) Epigenetic mediated transcriptional activation of WNT5A participates in arsenical-associated malignant transformation. Toxicol. Appl. Pharmacol., 235, 39-46.
83. Jenuwein, T. and Allis, C.D. (2001) Translating the histone code. Science, 293, 1074-1080.
84. Ji, H., Ehrlich, L.I., Seita, J. et al. (2010) Comprehensive methylome map of lineage commitment from haematopoietic progenitors. Nature, 467, 338-342.
85. Jo, W.J., Ren, X., Chu, F. et al. (2009) Acetylated H4K16 by MYST1 protects UROtsa cells from arsenic toxicity and is decreased following chronic arsenic exposure. Toxicol. Appl. Pharmacol., 241, 294-302.
86. Jones, P.A. and Baylin, S.B. (2002) The fundamental role of epigenetic events in cancer. Nat. Rev. Genet., 3, 415-428.
87. Jurkowska, R.Z., Jurkowski, T.P., and Jeltsch, A. (2011) Structure and function of mammalian DNA methyltransferases. Chembiochem., 12, 206-222.
88. Kim, K.C., Friso, S., and Choi, S.W. (2009) DNA methylation, an epigenetic mechanism connecting folate to healthy embryonic development and aging. J. Nutr. Biochem., 20, 917-926.
89. Kisseljova, N.P. and Kisseljov, F.L. (2005) DNA demethylation and carcinogenesis. Biochemistry Mosc., 70, 743-752.
90. Kitchin, K.T. (2001) Recent advances in arsenic carcinogenesis: modes of action, animal model systems, and methylated arsenic metabolites. Toxicol. Appl. Pharmacol., 172, 249-261.
91. Kitchin, K.T. and Ahmad, S. (2003) Oxidative stress as a possible mode of action for arsenic carcinogenesis. Toxicol. Lett., 137, 3-13.
92. Kitchin, K.T. and Conolly, R. (2010) Arsenic-induced carcinogenesis-oxidative stress as a possible mode of action and future research needs for more biologically based risk assessment. Chem. Res. Toxicol., 23, 327-335.
93. Kitchin, K.T. and Wallace, K. (2008) The role of protein binding of trivalent arsenicals in arsenic carcinogenesis and toxicity. J. Inorg. Biochem., 102, 532-539.
94. Klein, C.B., Leszczynska, J., Hickey, C., and Rossman, T.G. (2007) Further evidence against a direct genotoxic mode of action for arsenic-induced cancer. Toxicol. Appl. Pharmacol., 222, 289-297.
95. Kligerman, A.D. and Tennant, A.H. (2007) Insights into the carcinogenic mode of action of arsenic. Toxicol. Appl. Pharmacol., 222, 281-288.
96. Kozomara, A. and Griffiths-Jones, S. (2011) miRBase: integrating microRNA annotation and deep-sequencing data. Nucleic Acids Res., 39, D152-D157.
97. Kumar, M.S., Lu, J., Mercer, K.L. et al. (2007) Impaired microRNA processing enhances cellular transformation and tumorigenesis. Nat. Genet., 39, 673-677.
98. Laird, P.W. and Jaenisch, R. (1994) DNA methylation and cancer. Hum. Mol. Genet., 3 (Spec No), 1487-1495.
99. Lee, Y., Jeon, K., Lee, J.T. et al. (2002) MicroRNA maturation: stepwise processing and subcellular localization. EMBO J., 21, 4663-4670.
100. Leuba, S.H., Yang, G., Robert, C. et al. (1994) Three-dimensional structure of extended chromatin fibers as revealed by tapping-mode scanning force microscopy. Proc. Natl. Acad. Sci. U.S.A., 91, 11621-11625.
101. Lewis, B.P., Burge, C.B., and Bartel, D.P. (2005) Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell, 120, 15-20.
102. Li, B., Carey, M., and Workman, J.L. (2007) The role of chromatin during transcription. Cell, 128, 707-719.
103. Li, J., Chen, P., Sinogeeva, N. et al. (2002) Arsenic trioxide promotes histone H3 phosphoacetylation at the chromatin of CASPASE-10 in acute promyelocytic leukemia cells. J. Biol. Chem., 277, 49504-49510.
104. Li, J., Gorospe, M., Barnes, J., and Liu, Y. (2003) Tumor promoter arsenite stimulates histone H3 phosphoacetylation of proto-oncogenes c-fos and c-jun chromatin in human diploid fibroblasts. J. Biol. Chem., 278, 13183-13191.
105. Lokuge, K.M., Smith, W., Caldwell, B. et al. (2004) The effect of arsenic mitigation interventions on disease burden in Bangladesh. Environ. Health Perspect., 112, 1172-1177.
106. Lu, J., Getz, G., Miska, E.A. et al. (2005) MicroRNA expression profiles classify human cancers. Nature, 435, 834-838.
107. Luger, K., Mader, A.W., Richmond, R.K. et al. (1997) Crystal structure of the nucleosome core particle at 2.8 A resolution. Nature, 389, 251-260.
108. Luger, K. and Richmond, T.J. (1998) The histone tails of the nucleosome. Curr. Opin. Genet. Dev., 8, 140-146.
109. Lund, E., Guttinger, S., Calado, A. et al. (2004) Nuclear export of microRNA precursors. Science, 303, 95-98.
110. Mai, A., Massa, S., Rotili, D. et al. (2005) Histone deacetylation in epigenetics: an attractive target for anticancer therapy. Med. Res. Rev., 25, 261-309.
111. Majumdar, S., Chanda, S., Ganguli, B. et al. (2010) Arsenic exposure induces genomic hypermethylation. Environ. Toxicol., 25, 315-318.
112. Mandal, B.K., Ogra, Y., Anzai, K., and Suzuki, K.T. (2004) Speciation of arsenic in biological samples. Toxicol. Appl. Pharmacol., 198, 307-318.
113. de Maria, N., Manno, M., and Villa, E. (2002) Sex hormones and liver cancer. Mol. Cell. Endocrinol., 193, 59-63.
114. Marsit, C.J., Eddy, K., and Kelsey, K.T. (2006a) MicroRNA responses to cellular stress. Cancer Res., 66, 10843-10848.
115. Marsit, C.J., Karagas, M.R., Danaee, H. et al. (2006b) Carcinogen exposure and gene promoter hypermethylation in bladder cancer. Carcinogenesis, 27, 112-116.
116. Martin, C. and Zhang, Y. (2005) The diverse functions of histone lysine methylation. Nat. Rev. Mol. Cell Biol., 6, 838-849.
117. Martinez, L., Jimenez, V., Garcia-Sepulveda, C. et al. (2011) Impact of early developmental arsenic exposure on promotor CpG-island methylation of genes involved in neuronal plasticity. Neurochem. Int., 58, 574-581.
118. Mass, M.J. and Wang, L. (1997) Arsenic alters cytosine methylation patterns of the promoter of the tumor suppressor gene p53 in human lung cells: a model for a mechanism of carcinogenesis. Mutat. Res., 386, 263-277.
119. Meng, X.Z., Zheng, T.S., Chen, X. et al. (2011) microRNA expression alteration after arsenic trioxide treatment in HepG-2 cells. J. Gastroenterol. Hepatol., 26, 186-193.
120. Morse, R.H. (1989) Nucleosomes inhibit both transcriptional initiation and elongation by RNA polymerase III in vitro. EMBO J., 8, 2343-2351.
121. Mosharov, E., Cranford, M.R., and Banerjee, R. (2000) The quantitatively important relationship between homocysteine metabolism and glutathione synthesis by the transsulfuration pathway and its regulation by redox changes. Biochemistry, 39, 13005-13011.
122. Mukherjee, A., Sengupta, M.K., Hossain, M.A. et al. (2006) Arsenic contamination in groundwater: a global perspective with emphasis on the Asian scenario. J. Health Popul. Nutr., 24, 142-163.
123. Niu, C., Yan, H., Yu, T. et al. (1999) Studies on treatment of acute promyelocytic leukemia with arsenic trioxide: remission induction, follow-up, and molecular monitoring in 11 newly diagnosed and 47 relapsed acute promyelocytic leukemia patients. Blood, 94, 3315-3324.
124. Nohara, K., Baba, T., Murai, H. et al. (2011) Global DNA methylation in the mouse liver is affected by methyl deficiency and arsenic in a sex-dependent manner. Arch. Toxicol., 85, 653-661.
125. Nordstrom, D.K. (2002) Public health. Worldwide occurrences of arsenic in ground water. Science, 296, 2143-2145.
126. Okano, M., Bell, D.W., Haber, D.A., and Li, E. (1999) DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell, 99, 247-257.
127. Okoji, R.S., Yu, R.C., Maronpot, R.R., and Froines, J.R. (2002) Sodium arsenite administration via drinking water increases genome-wide and Ha-ras DNA hypomethylation in methyl-deficient C57BL/6J mice. Carcinogenesis, 23, 777-785.
128. Paluszczak, J. and Baer-Dubowska, W. (2006) Epigenetic diagnostics of cancer-the application of DNA methylation markers. J. Appl. Genet., 47, 365-375.
129. Patra, S.K., Patra, A., Zhao, H., and Dahiya, R. (2002) DNA methyltransferase and demethylase in human prostate cancer. Mol. Carcinog., 33, 163-171.
130. Perez-Cadahia, B., Drobic, B., Khan, P. et al. (2010) Current understanding and importance of histone phosphorylation in regulating chromatin biology. Curr. Opin. Drug Discov. Devel., 13, 613-622.
131. Peterson, C.L. and Laniel, M.A. (2004) Histones and histone modifications. Curr. Biol., 14, R546-R551.
132. Pilsner, J.R., Liu, X., Ahsan, H. et al. (2007) Genomic methylation of peripheral blood leukocyte DNA: influences of arsenic and folate in Bangladeshi adults. Am. J. Clin. Nutr., 86, 1179-1186.
133. Pilsner, J.R., Liu, X., Ahsan, H. et al. (2009) Folate deficiency, hyperhomocysteinemia, low urinary creatinine, and hypomethylation of leukocyte DNA are risk factors for arsenic-induced skin lesions. Environ. Health Perspect., 117, 254-260.
134. Portela, A. and Esteller, M. (2010) Epigenetic modifications and human disease. Nat. Biotechnol., 28, 1057-1068.
135. Pozharny, Y., Lambertini, L., Clunie, G. et al. (2010) Epigenetics in women's health care. Mt. Sinai J. Med., 77, 225-235.
136. Pradhan, S., Bacolla, A., Wells, R.D., and Roberts, R.J. (1999) Recombinant human DNA (cytosine-5) methyltransferase. I. Expression, purification, and comparison of de novo and maintenance methylation. J. Biol. Chem., 274, 33002-33010.
137. Pruss-Ustun, A., Vickers, C., Haefliger, P., and Bertollini, R. (2011) Knowns and unknowns on burden of disease due to chemicals: a systematic review. Environ. Health, 10, 9.
138. Rahman, M.M., Naidu, R., and Bhattacharya, P. (2009a) Arsenic contamination in groundwater in the Southeast Asia region. Environ. Geochem. Health, 31 (Suppl 1), 9-21.
139. Rahman, M.M., Ng, J.C., and Naidu, R. (2009b) Chronic exposure of arsenic via drinking water and its adverse health impacts on humans. Environ. Geochem. Health, 31 (Suppl 1), 189-200.
140. Ramirez, T., Brocher, J., Stopper, H., and Hock, R. (2008) Sodium arsenite modulates histone acetylation, histone deacetylase activity and HMGN protein dynamics in human cells. Chromosoma, 117, 147-157.
141. Reichard, J.F., Schnekenburger, M., and Puga, A. (2007) Long term low-dose arsenic exposure induces loss of DNA methylation. Biochem. Biophys. Res. Commun., 352, 188-192.
142. Ren, X., McHale, C.M., Skibola, C.F. et al. (2011) An emerging role for epigenetic dysregulation in arsenic toxicity and carcinogenesis. Environ. Health Perspect., 119, 11-19.
143. Rossman, T.G. (2003) Mechanism of arsenic carcinogenesis: an integrated approach. Mutat. Res., 533, 37-65.
144. Saavedra, O.M., Isakovic, L., Llewellyn, D.B. et al. (2009) SAR around (l)-S-adenosyl-l-homocysteine, an inhibitor of human DNA methyltransferase (DNMT) enzymes. Bioorg. Med. Chem. Lett., 19, 2747-2751.
145. Saito, Y., Kanai, Y., Nakagawa, T. et al. (2003) Increased protein expression of DNA methyltransferase (DNMT) 1 is significantly correlated with the malignant potential and poor prognosis of human hepatocellular carcinomas. Int. J. Cancer, 105, 527-532.
146. Sassen, S., Miska, E.A., and Caldas, C. (2008) MicroRNA: implications for cancer. Virchows Arch., 452, 1-10.
147. Sciandrello, G., Caradonna, F., Mauro, M., and Barbata, G. (2004) Arsenic-induced DNA hypomethylation affects chromosomal instability in mammalian cells. Carcinogenesis, 25, 413-417.
148. Scott, N., Hatlelid, K.M., MacKenzie, N.E., and Carter, D.E. (1993) Reactions of arsenic(III) and arsenic(V) species with glutathione. Chem. Res. Toxicol., 6, 102-106.
149. Selhub, J. (1999) Homocysteine metabolism. Annu. Rev. Nutr., 19, 217-246.
150. Sengupta, S.R., Das, N.K., and Datta, P.K. (2008) Pathogenesis, clinical features and pathology of chronic arsenicosis. Indian J. Dermatol. Venereol. Leprol., 74, 559-570.
151. Sharma, S., Kelly, T.K., and Jones, P.A. (2010) Epigenetics in cancer. Carcinogenesis, 31, 27-36.
152. Shen, L., Kondo, Y., Guo, Y. et al. (2007) Genome-wide profiling of DNA methylation reveals a class of normally methylated CpG island promoters. PLoS Gene., 3, 2023-2036.
153. Shi, Y., Lan, F., Matson, C. et al. (2004) Histone demethylation mediated by the nuclear amine oxidase homolog LSD1. Cell, 119, 941-953.
154. Shimizu, M., Hochadel, J.F., Fulmer, B.A., and Waalkes, M.P. (1998) Effect of glutathione depletion and metallothionein gene expression on arsenic-induced cytotoxicity and c-myc expression in vitro. Toxicol. Sci., 45, 204-211.
155. Singh, K.P. and DuMond, J.W. Jr. (2007) Genetic and epigenetic changes induced by chronic low dose exposure to arsenic of mouse testicular Leydig cells. Int. J. Oncol., 30, 253-260.
156. Smeester, L., Rager, J.E., Bailey, K.A. et al. (2011) Epigenetic changes in individuals with arsenicosis. Chem. Res. Toxicol., 24, 165-167.
157. Smith, A.H., Lingas, E.O., and Rahman, M. (2000) Contamination of drinking-water by arsenic in Bangladesh: a public health emergency. Bull. World Health Organ., 78, 1093-1103.
158. Soignet, S.L., Frankel, S.R., Douer, D. et al. (2001) United States multicenter study of arsenic trioxide in relapsed acute promyelocytic leukemia. J. Clin. Oncol., 19, 3852-3860.
159. States, J.C., Srivastava, S., Chen, Y., and Barchowsky, A. (2009) Arsenic and cardiovascular disease. Toxicol. Sci., 107, 312-323.
160. Straif, K., Benbrahim-Tallaa, L., Baan, R. et al. (2009) A review of human carcinogens-part C: metals, arsenic, dusts, and fibres. Lancet Oncol., 10, 453-454.
161. Takahashi, M., Barrett, J.C., and Tsutsui, T. (2002) Transformation by inorganic arsenic compounds of normal Syrian hamster embryo cells into a neoplastic state in which they become anchorage-independent and cause tumors in newborn hamsters. Int. J. Cancer, 99, 629-634.
162. Tapio, S. and Grosche, B. (2006) Arsenic in the aetiology of cancer. Mutat. Res., 612, 215-246.
163. Terry, M.B., Delgado-Cruzata, L., Vin-Raviv, N. et al. (2011) DNA methylation in white blood cells: Association with risk factors in epidemiologic studies. Epigenetics, 6, 828-837.
164. Thomas, D.J., Li, J., Waters, S.B. et al. (2007) Arsenic (+3 oxidation state) methyltransferase and the methylation of arsenicals. Exp. Biol. Med., 232, 3-13.
165. Thomas, D.J., Styblo, M., and Lin, S. (2001) The cellular metabolism and systemic toxicity of arsenic. Toxicol. Appl. Pharmacol., 176, 127-144.
166. Thomas, D.J., Waters, S.B., and Styblo, M. (2004) Elucidating the pathway for arsenic methylation. Toxicol. Appl. Pharmacol., 198, 319-326.
167. Tsukada, Y., Fang, J., Erdjument-Bromage, H. et al. (2006) Histone demethylation by a family of JmjC domaincontaining proteins. Nature, 439, 811-816.
168. Uthus, E.O. and Davis, C. (2005) Dietary arsenic affects dimethylhydrazine-induced aberrant crypt formation and hepatic global DNA methylation and DNA methyltransferase activity in rats. Biol. Trace Elem. Res., 103, 133-145.
169. Vahter, M. (1999) Methylation of inorganic arsenic in different mammalian species and population groups. Sci. Prog., 82 (Pt 1), 69-88.
170. Vahter, M. (2008) Health effects of early life exposure to arsenic. Basic Clin. Pharmacol. Toxicol., 102, 204-211.
171. Valeri, N., Vannini, I., Fanini, F. et al. (2009) Epigenetics, miRNAs, and human cancer: a new chapter in human gene regulation. Mamm. Genome, 20, 573-580.
172. Waalkes,M.P., Liu, J., Chen, H. et al. (2004a) Estrogen signaling in livers of male mice with hepatocellular carcinoma induced by exposure to arsenic in utero. J. Natl. Cancer Inst., 96, 466-474.
173. Waalkes, M.P., Liu, J., Ward, J.M., and Diwan, B.A. (2004b) Animal models for arsenic carcinogenesis: inorganic arsenic is a transplacental carcinogen in mice. Toxicol. Appl. Pharmacol., 198, 377-384.
174. Waalkes, M.P., Ward, J.M., Liu, J., and Diwan, B.A. (2003) Transplacental carcinogenicity of inorganic arsenic in the drinking water: induction of hepatic, ovarian, pulmonary, and adrenal tumors in mice. Toxicol. Appl. Pharmacol., 186, 7-17.
175. Wade, P.A. (2001) Methyl CpG binding proteins: coupling chromatin architecture to gene regulation. Oncogene, 20, 3166-3173.
176. Wang, Z., Zhao, Y., Smith, E. et al. (2011) Reversal and prevention of arsenic-induced human bronchial epithelial cell malignant transformation by microRNA-200b. Toxicol. Sci., 121, 110-122.
177. World Health Organization (WHO) (2006) Guidelines for drinking water quality, First Addendum to 3rd edn, Vol. 1, WHO Press, Geneva.
178. Wild, L. and Flanagan, J.M. (2010) Genome-wide hypomethylation in cancer may be a passive consequence of transformation. Biochim. Biophys. Acta, 1806, 50-57.
179. Wilson, A.S., Power, B.E., and Molloy, P.L. (2007) DNA hypomethylation and human diseases. Biochim. Biophys. Acta, 1775, 138-162.
180. Wu, G., Bazer, F.W., Cudd, T.A. et al. (2004) Maternal nutrition and fetal development. J. Nutr., 134, 2169-2172.
181. Wu, S.C. and Zhang, Y. (2010) Active DNA demethylation: many roads lead to Rome. Nat. Rev. Mol. Cell Biol., 11, 607-620.
182. Wysocka, J., Allis, C.D., and Coonrod, S. (2006) Histone arginine methylation and its dynamic regulation. Front. Biosci., 11, 344-355.
183. Xie, Y., Liu, J., Benbrahim-Tallaa, L. et al. (2007) Aberrant DNA methylation and gene expression in livers of newborn mice transplacentally exposed to a hepatocarcinogenic dose of inorganic arsenic. Toxicology, 236, 7-15.
184. Xie, Y., Trouba, K.J., Liu, J. et al. (2004) Biokinetics and subchronic toxic effects of oral arsenite, arsenate, monomethylarsonic acid, and dimethylarsinic acid in v-Ha-ras transgenic (Tg.AC) mice. Environ. Health Perspect., 112, 1255-1263.
185. Yager, J.D. and Liehr, J.G. (1996) Molecular mechanisms of estrogen carcinogenesis. Annu. Rev. Pharmacol. Toxicol., 36, 203-232.
186. Yang, X.J. and Seto, E. (2007) HATs and HDACs: from structure, function and regulation to novel strategies for therapy and prevention. Oncogene, 26, 5310-5318.
187. Yih, L.H., Hsueh, S.W., Luu, W.S. et al. (2005) Arsenite induces prominent mitotic arrest via inhibition of G2 checkpoint activation in CGL-2 cells. Carcinogenesis, 26, 53-63.
188. Yoshida, T., Yamauchi, H., and Fan Sun, G. (2004) Chronic health effects in people exposed to arsenic via the drinking water: dose-response relationships in review. Toxicol. Appl. Pharmacol., 198, 243-252.
189. Zeisel, S.H. (2009) Epigenetic mechanisms for nutrition determinants of later health outcomes. Am. J. Clin. Nutr., 89, 1488S-1493S.
190. Zhang, A.H., Bin, H.H., Pan, X.L., and Xi, X.G. (2007) Analysis of p16 gene mutation, deletion and methylation in patients with arseniasis produced by indoor unventilated-stove coal usage in Guizhou, China. J. Toxicol. Environ. Health A, 70, 970-975.
191. Zhao, C.Q., Young, M.R., Diwan, B.A. et al. (1997) Association of arsenic-induced malignant transformation with DNA hypomethylation and aberrant gene expression. Proc. Natl. Acad. Sci. U.S.A., 94, 10907-10912.
192. Zhong, C.X. and Mass, M.J. (2001) Both hypomethylation and hypermethylation of DNA associated with arsenite exposure in cultures of human cells identified by methylation-sensitive arbitrarily-primed PCR. Toxicol. Lett., 122, 223-234.
193. Zhou, X., Li, Q., Arita, A. et al. (2009) Effects of nickel, chromate, and arsenite on histone 3 lysine methylation. Toxicol. Appl. Pharmacol., 236, 78-84.
194. Zhou, X., Sun, H., Ellen, T.P. et al. (2008) Arsenite alters global histone H3 methylation. Carcinogenesis, 29, 1831-1836.
195. Zhu, J. and Yao, X. (2007) Use of DNA methylation for cancer detection and molecular classification. J. Biochem. Mol. Biol., 40, 135-141.
196. Zykova, T.A., Zhu, F., Lu, C. et al. (2006) Lymphokine-activated killer T-cell-originated protein kinase phosphorylation of histone H2AX prevents arsenite-induced apoptosis in RPMI7951 melanoma cells. Clin. Cancer Res., 12, 6884-6893.