The cellular metabolism and systemic toxicity of arsenic

Toxicology and Applied Pharmacology

Volumn 176, Issue 2, 2001, Pages 127-144

  Thomas, David J ^a   Styblo, Miroslav ^b   Lin, Shan ^c  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

Arsenic; Dimethylated arsenicals; Human; Inorganic arsenic; Metabolism; Methylated arsenicals; Mouse; Rat

Indexed keywords

ARSENIC;

CELL METABOLISM; DETOXIFICATION; DOSE RESPONSE; GENOTOXICITY; HUMAN; HUMAN CELL; METHYLATION; REVIEW; RISK ASSESSMENT;

EID: 0034759637     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.2001.9258     Document Type: Review

References (181)

1. Arsenic species that cause release of iron from ferritin and generation of activated oxygen
2. Associations of drinking water and urinary arsenic levels and skin lesions in Bangladesh
3. Enzymatic methylation of arsenic compounds: II - An overview
4. Enzymatic methylation of arsenic species and other new approaches to arsenic toxicity
5. DMPS-arsenic challenge test. I. Increased urinary excretion of monomethylarsonic acid in humans given dimercaptopropane sulfonate
6. DMPS-arsenic challenge test. II. Modulation of arsenic species, including monomethylarsonous acid (MMA(III)), excreted in urine
7. Occurrence of monomethylarsonous acid in urine of humans exposed to inorganic arsenic
8. Arsenic induces oxidant stress and NF-κB activation in cultured aortic endothelial cells
9. Stimulation of reactive oxygen, but not reactive nitrogen species, in vascular endothelial cells exposed to low levels of arsenite
10. Low levels of arsenic trioxide stimulate proliferative signals in primary vascular cells without activating stress effector pathways
11. The transcription factor NF-κB and human disease
12. Arsenic ingestion and internal cancers: A review
13. Case-control study of bladder cancer and arsenic in drinking water
14. Health aspects of burning coal with a high arsenic content. II. Heating changes in exposed children
15. Arsenic speciation in human organs following fatal arsenic trioxide poisoning: A case report
16. 74As labeled arsenite
17. Prevention of cytotoxic effects of arsenic by short-term dietary supplementation with selenium in mice in vivo
18. Arsenic binding proteins of mammalian systems: I. Isolation of three arsenitebinding proteins of rabbit liver
19. Epidemiological studies on human subjects exposed to arsenic in drinking water in Southeast Hungary
20. The influence of liver disease on the methylation of arsenite in humans
21. Study of inorganic arsenic methylation by rat in vitro: Relevance for the interpretation of observations in man
22. Role of thiols in the in vitro methylation of inorganic arsenic by rat liver cytosol
23. Possible roles of nitric oxide and redox cell signaling in metal-induced toxicity and carcinogenesis: A review
24. Carcinogenic risks of inorganic arsenic in perspective
25. Chronic arsenic poisoning in the north of Mexico
26. Higher prevalence of goiter in endemic area of blackfoot disease of Taiwan
27. Malignant neoplasms among residents of a blackfoot disease-endemic area in Taiwan: High arsenic artesian well water and cancers
28. Cancer potential in liver, lung, bladder and kidney due to ingested inorganic arsenic in drinking water
29. Increased prevalence of hypertension and long-term arsenic exposure
30. Dose-response relationship between ischemic heart disease mortality and long-term arsenic exposure
31. Comparative study of the high prevalence of bladder cancer in the Blackfoot disease endemic area of Taiwan
32. Incidence of internal cancers and ingested inorganic arsenic: A seven-year follow-up study
33. Dose-response relationship between prevalence of cerebrovascular disease and ingested inorganic arsenic
34. Arsenic methylation capacity, body retention, and null genotypes of glutathione S-transferase M1 and M2 among current arsenic-exposed residents of Taiwan
35. Developmental toxicity of metals - Implications for public health
36. In vitro effect of arsenical compounds on glutathione-related enzymes
37. Groundwater arsenic contamination in Bangladesh and West Bengal
38. Urothelial cytotoxicity and regeneration induced by dimethylarsinic acid in rats
39. Metabolism of inorganic arsenic in children with chronic high arsenic exposure in Northern Argentina
40. Exposure to inorganic arsenic metabolites during early human development
41. Changes in the chemical speciation of arsenic following ingestion by man
42. The reduction of trimethylarsine oxide to trimethylarsine by thiols: A mechanistic model for the biological reduction of arsenicals
43. The reaction of methylarsenicals with thiols: Some biological implications
44. Ingested arsenic, keratoses, and bladder cancer
45. Urinary excretion of arsenic species in a human population chronically exposed to arsenic via drinking water: A pilot study
46. Altered profile of urinary arsenic metabolites in adults with chronic arsenism. A pilot study
47. Determination of trivalent methylated arsenicals in biological matrices
48. Transfer of arsenite from glutathione to dithiol: A model of interaction
49. Reduction and binding of arsenate and dimethylarsenate by glutathione: A multinuclear magnetic resonance study
50. Complexation of arsenic species in rabbit erythrocytes
51. Time dependence of accumulation and binding of inorganic and organic arsenic species in rabbit erythrocytes
52. An assessment of the developmental toxicity of inorganic arsenic
53. Vascular effects of chronic arsenic exposure: A review
54. Cancer related to exposure to arsenic at a copper smelter
55. Lung cancer and arsenic concentrations in drinking water in Chile
56. Arsenic-induced oxidative stress and its reversibility following combined administration of N-acetylcysteine and meso 2,3-dimercaptosuccinic acid in rats
57. Abnormal methylation capacity in human liver cirrhosis
58. Selenocysteine, identified as the penultimate C-terminal residue in human T-cell thioredoxin reductase, corresponds to TGA in the human placental gene
59. The enigma of arsenic carcinogenesis: Role of metabolism
60. Biliary and urinary excretion of inorganic arsenic: Monomethylarsonous acid as a major biliary metabolite in rats
61. Arsenic in drinking water and incidence of urinary cancers
62. Enzymatic methylation of arsenic compounds: IV. In vitro and in vivo deficiency of the methylation of arsenite and monomethylarsenic in the guinea pig
63. Enzymatic methylation of arsenic compounds. V. Arsenite methyltransferase activity in tissues of mice
64. Synergism between occupational arsenic exposure and smoking in the induction of lung cancer
65. Conversion of arsenite and arsenate to methylarsenic and dimethylarsenic compounds by homogenates prepared from livers and kidneys of rats and mice
66. Thioredoxin
67. Developmental effects of methylated arsenical metabolites in mice
68. Human studies do not support the methylation threshold hypothesis for the toxicity of inorganic arsenic
69. Bladder cancer mortality associated with arsenic in the drinking water in Argentina
70. Methylation study of a population environmentally exposed to arsenic in drinking water
71. Lung and kidney cancer mortality associated with arsenic in drinking water in Cordoba, Argentina
72. Chronic arsenic exposure and risk of infant mortality in two areas of Chile
73. Multiple risk factors associated with arsenic-induced skin cancer: Effects of chronic liver disease and malnutrition
74. Serum β carotene level, arsenic methylation capability, and increase in skin cancer
75. Low serum carotene level and increased risk of ischemic heart disease related to long-term arsenic exposure
76. Strain-dependent disposition of inorganic arsenic in the mouse
77. Dose-dependent effects on tissue distribution and metabolism of dimethylarsinic acid in the mouse after intravenous administration
78. A hospital-based case-control study of stillbirths and environmental exposure to arsenic using an atmospheric dispersion model linked to a geographical information system
79. Aneuploidy induced by dimethylarsinic acid in mouse bone marrow cells
80. Dimethylarsenics reveal DNA damage induced by superoxide anion radicals
81. Influence of dietary selenium on the disposition of arsenate in the female B6C3F1 mouse
82. Influence of dietary selenium on the disposition of arsenite and arsenate in the female B6C3F1 mouse
83. Recent advances in arsenic carcinogenesis: Modes of action, animal model systems and methylated arsenic metabolites
84. Ingested inorganic arsenic and prevalence of diabetes mellitus
85. Speciation of key arsenic metabolic intermediates in human urine
86. Determination of monmethylarsonous acid, a key arsenic methylation intermediate, in human urine
87. Modulation of cellular antioxidant defense activities by sodium arsenite in human fibroblasts
88. Drinking water arsenic in Utah: A cohort mortality study
89. Methylarsenicals and arsinothiols are potent inhibitors of mouse liver thioredoxin reductase
90. Arsenicals inhibit thioredoxin reductase in cultured rat hepatocytes
91. Arsenic speciation in urine from humans intoxicated by inorganic arsenic compounds
92. Human exposure to arsenic and health effects in Bayingnormen, Inner Mongolia
93. Identification of dimethylarsinous and monomethylarsinous acids in human urine of the arsenic-affected areas in West Bengal, India
94. Intracellular interaction and biotransformation of arsenite in rats and rabbits
95. 74As] arsenite in mice and rabbits
96. NAT2 slow acetylation and bladder cancer risk: A meta-analysis of 22 case-control studies conducted in the general population
97. Threshold carcinogenicity using arsenic as an example
98. Epidemiological studies on the Morinaga powdered milk poisoning incident
99. Methylated trivalent arsenic species are genotoxic
100. Arsenic in drinking water and the prevalence of respiratory effects in West Bengal, India
101. Risk of internal cancers from arsenic in drinking water
102. Relative genotoxic potency of arsenic and its methylated metaholites
103. Renal lesions induced in F344/DuCrj rats by 4 weeks oral administration of dimethylarsenic acid
104. Preferential increase of heterochromatin in venular endothelium of lung in mice after administration of dimethylarsinic acid, a major metabolite of inorganic arsenics
105. Developmental toxicity assessment of arsenic acid in mice and rabbits
106. Glutathione plays different roles in the induction of the cytotoxic effects of inorganic and organic arsenic compounds in cultured BALB/c 3t3 cells
107. Dimethylarsinic acid causes apoptosis in HL-60 cells via interaction with glutathione
108. Arsenate reduction mediated by the plasmid-encoded ArsC protein is coupled to glutathione
109. Induction of chromosomal aberrations in cultured human fibroblasts by inorganic and organic arsenic compounds and the different roles of glutathione in such induction
110. Evaluation of evidence of nonlinearities in the dose-response curve for arsenic carcinogenesis
111. Monomethylarsonous acid (MMA(III)) is more toxic than arsenite in Chang human hepatocytes
112. 50 in hamsters and in vitro inhibition of pyruvate dehydrogenase
113. Enzymatic reduction of arsenic compounds in mammalian systems: Reduction of arsenate to arsenite by human liver arsenate reductase
114. Diabetes mellitus associated with arsenic exposure in Bangladesh
115. DNA-strand breaks induced by dimethylarsinic acid, a metabolite of inorganic arsenics, are strongly enhanced by superoxide anion radicals
116. The teratogenic potential of cacodylic acid in the rat and mouse
117. Inorganic and methylated arsenic compounds induce cell death in murine macrophages via different mechanisms
118. Monomethylarsonic acid reductase and monomethylarsonous acid in hamster tissue
119. Hepatic manifestations in chronic arsenic toxicity
120. Oxidative stress in liver of mice exposed to arsenic-contaminated water
121. Effect of arsenic (V) on the antioxidant defense system: In vitro oxidation of rat plasma lipoprotein
122. Reaction of arsenic(III) and arsenic(V) species with glutathione
123. Mechanisms of arsenic carcinogenicity: Genetic or epigenetic mechanisms?
124. Airborne arsenic exposure and excretion of methylated arsenic compounds
125. Cancer risks from arsenic in drinking water
126. The biomethylation of sodium arsenate by rat liver cytosol determined by mass spectroscopy
127. Marked increase in bladder and lung cancer in a region of northern Chile due to arsenic in drinking water
128. Arsenic-induced skin lesions among Atacameño people in Northern Chile despite good nutrition and centuries of exposure
129. Comparative in vitro methylation of trivalent and pentavalent arsenic species
130. Biological mechanisms and toxicological consequences of the methylation of arsenic
131. In vitro inhibition of glutathione reductase by arsenotriglutathione
132. Mono- and dimethylation of arsenic in rat liver cytosol in vitro
133. Liberation and analysis of protein-bound arsenicals
134. Binding of arsenicals to proteins in an in vitro methylation system
135. Comparative inhibition of yeast glutathione reductase by arsenicals and arsenothiols
136. Metabolism of arsenic in primary cultures of human and rat hepatocytes
137. Metabolism and toxicity of arsenicals in cultured cells
138. Comparative toxicity of trivalent and pentavalent inorganic and methylated arsenicals in human cells
139. The NAT2* slow acetylator genotype is associated with bladder cancer in Taiwanese, but not in the Black Foot Disease-endemic area population
140. The present situation of chronic arsenism in China
141. The effect of S-adenosylmethionine on methylation of inorganic arsenic
142. A new selenoprotein from human lung adenocarcinoma cells: Purification, properties, and thioredoxin reductase activity
143. Gene damage induced in human alveolar type II (L-132) cells by exposure to dimethylarsinic acid
144. Effects of arsenic, lead and cadmium on the cardiovascular system
145. Effect of hepatic methyl donor status on urinary excretion and DNA damage in B6C3F1 mice treated with sodium arsenite
146. Prevalence of skin cancer in an endemic area of chronic arsenicism in Taiwan
147. Blackfoot disease in Taiwan: A 30-year follow-up study
148. Abnormal peripheral microcirculation in seemingly normal subjects living in blackfoot-disease-hyperendemic villages in Taiwan
149. Lipid profile and peripheral vascular disease in arseniasis-hyperendemic villages in Taiwan
150. Long-term arsenic exposure and incidence of non-insulin-dependent diabetes mellitus: A cohort study in arseniasis-hyperendemic villages in Taiwan
151. Ingested arsenic and internal cancer: A historical cohort study followed for 33 years
152. The inhibitory effect of selenium on induction of tetraploidy by dimethylarsinic acid in Chinese hamster cells
153. National primary drinking water regulations; arsenic and clarifications to compliance and new source contaminants monitoring; final rule (40 CFR Parts 9, 141 and 142)
154. National primary drinking water regulations; arsenic and clarifications to compliance and new source contaminants monitoring: Delay of effective date; final rule (40 CFR Parts 9, 141, and 142)
155. Proposed guidelines for carcinogen risk assessment
156. Species differences in the metabolism of arsenic compounds
157. Methylation of inorganic arsenic in different mammalian species and population groups
158. Genetic polymorphism in the biotransformation of inorganic arsenic and its role in toxicity
159. Intracellular interaction and metabolic fate of arsenite and arsenate in mice and rats
160. 74As-dimethylarsinic acid in mice and rat
161. Reduction and binding of arsenate in marmoset monkeys
162. Effects of low dietary intake of methionine, choline or proteins on the biotransformation of arsenite in the rabbit
163. Lack of methylation of inorganic arsenic in the chimpanzee
164. A unique metabolism of arsenic in native Andean women
165. Arsenic in the ground water supplies of the United States
166. Chronic endemic hydroarsenicism
167. Dose-response relation between arsenic concentration in well water and mortality from cancer and cardiovascular disease
168. Dimethylated arsenics induce DNA strand breaks in lung via the production of active oxygen in mice
169. Induction of DNA damage by dimethylarsine, a metabolite of inorganic arsenics, is for the major part likely due to its peroxyl radical
170. Induction of lung-specific DNA damage by metabolically methylated arsenics via production of free radicals
171. DNA single-strand breaks in L-132 cells resulting from inhibition of repair polymerization shortly after exposure to dimethylarsinic acid
172. Dynamic changes of inorganic and methylarsenic compounds in human urine after oral intake of arsenic trioxide
173. Toxicity and metabolism of inorganic and methylated arsenicals
174. Enzymatic methylation of arsenic compounds: Assay, partial purification, and properties of arsenite methyltransferase and monomethylarsonic acid methyltransferase from rabbit liver
175. Enzymatic methylation of arsenic compounds III. The marmoset and tamarin, but not the rhesus, monkeys are deficient in methyltransferases that methylate inorganic arsenic
176. Enzymatic reduction of arsenic compounds in mammalian systems: The rate-limiting enzyme of rabbit liver arsenic biotransformation is MMA(V) reductase
177. Arsenite methylation by methylcobalamin B12 and glutathione does not require an enzyme
178. Enzymatic methylation of arsenic compounds. VII. Monomethylarsonous acid (MMAIII) is the substrate for MMA methyltransferase of rabbit liver and human hepatocytes
179. Apoptosis and growth inhibition in malignant lymphocytes after treatment with arsenic trioxide at clinically achievable concentrations