Coordination of altered DNA repair and damage pathways in arsenite-exposed keratinocytes

Toxicological Sciences

Volumn 69, Issue 2, 2002, Pages 306-316

  Hamadeh, Hisham K ^a,b   Trouba, Kevin J ^a   Amin, Rupesh P ^a   Afshari, Cynthia A ^a,b   Germolec, Dori ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b AMGEN INC   (United States)

Author keywords

Arsenic; Keratinocytes; Microarray; Toxicity

Indexed keywords

ARSENIC; ARSENIC TRIOXIDE; COMPLEMENTARY DNA; CYCLINE; DNA; DNA BINDING PROTEIN; ONCOPROTEIN; PROTEIN KINASE C DELTA; PROTEIN P53; PROTEIN SERINE THREONINE KINASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); SUPEROXIDE DISMUTASE;

ARTICLE; CELL PROLIFERATION; CELL TRANSFORMATION; CONTROLLED STUDY; CORRELATION FUNCTION; DATA ANALYSIS; DNA DAMAGE; DNA DETERMINATION; DNA MICROARRAY; DNA REPAIR; DOSE RESPONSE; EPIDERMIS CELL; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; KERATINOCYTE; MITOSIS; ONCOGENE; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; SKIN CARCINOGENESIS;

ACETYLCYSTEINE; ARSENITES; BLOTTING, NORTHERN; CELL LINE; CELL SURVIVAL; DNA DAMAGE; DNA REPAIR; DNA, COMPLEMENTARY; FREE RADICAL SCAVENGERS; GENE EXPRESSION; HUMANS; KERATINOCYTES; MITOTIC INDEX; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; SKIN; THYMIDINE; TRANSCRIPTION, GENETIC;

EID: 0036772333     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/69.2.306     Document Type: Article

References (47)

1. Afshari, C. A., and Barrett, J. C. (1994). Disruption of G0-G1 arrest in quiescent and senescent cells treated with phosphatase inhibitors. Cancer Res. 54, 2317-2321.
2. Amundson, S. A., Bittner, M., Chen, Y., Trent, J., Meltzer, P., and Fornace, A. J., Jr. (1999). Fluorescent cDNA microarray hybridization reveals complexity and heterogeneity of cellular genotoxic stress responses. Oncogene 18, 3666-3672.
3. ATSDR (2000). Toxicological profile for arsenic. Agency for Toxic Substances and Disease Registry, U.S. Department of Health and Human Services, Public Health Service.
4. Bayol-Denizot, C., Daval, J. L., Netter, P., and Minn, A. (2000). Xenobiotic-mediated production of superoxide by primary cultures of rat cerebral endothelial cells, astrocytes, and neurones. Biochim. Biophys. Acta 1497, 115-126.
5. Boonchai, W., Walsh, M., Cummings, M., and Chenevix-Trench, G. (2000). Expression of p53 in arsenic-related and sporadic basal cell carcinoma. Arch. Dermatol. 136, 195-198.
6. Brown, J. L., and Kitchin, K. T. (1996). Arsenite, but not cadmium, induces ornithine decarboxylase and heme oxygenase activity in rat liver: Relevance to arsenic carcinogenesis. Cancer Lett. 98, 227-231.
7. Bushel, P. R., Hamadeh, H., Bennett, L., Sieber, S., Martin, K., Nuwaysir, E. F., Johnson, K., Reynolds, K., Paules, R. S., and Afshari, C. A. (2001). MAPS: A microarray project system for gene expression experiment information and data validation. Bioinformatics 17, 564-565.
8. Byron, W. R., Bierbower, G. W., Brouwer, J. B., and Hansen, W. H. (1967). Pathologic changes in rats and dogs from two-year feeding of sodium arsenite or sodium arsenate. Toxicol. Appl. Pharmacol. 10, 132-147.
9. Chen, Y., Dougherty, E. R., and Bittner, M. L. (1997). Ratio-based decisions and the quantitative analysis of cDNA microarray images. J. Biomed. Optics 2, 364-374.
10. Cresteil, T., and Jaiswal, A. K. (1991). High levels of expression of the NAD(P)H:quinone oxidoreductase (NQO1) gene in tumor cells compared to normal cells of the same origin. Biochem. Pharmacol. 42, 1021-1027.
11. De Flora, S., Izzotti, A., D'Agustini, F., and Balansky, R. M. (2001). Mechanisms of N-acetylcysteine in the prevention of DNA damage and cancer, with special reference to smoking-related end-points. Carcinogenesis 22, 999-1013.
12. Detmar, M., and Orfanos, C. E. (1990). Tumor necrosis factor-α inhibits cell proliferation and induces class II antigens and cell adhesion molecules in cultured normal human keratinocytes in vitro. Arch. Dermatol. Res. 282, 238-245.
13. Dong, G., Loukinova, E., Chen, Z., Gangi, L., Chanturita, T. I., Liu, E. T., and Van Waes, C. (2001). Molecular profiling of transformed and metastatic murine squamous carcinoma cells by differential display and cDNA microarray reveals altered expression of multiple genes related to growth, apoptosis, angiogenesis, and the NF-κB signal pathway. Cancer Res. 61, 4797-4808.
14. Duggan, D. J., Bittner, M., Chen, Y., Meltzer, P., and Trent, J. M. (1999). Expression profiling using cDNA microarrays. Nat. Genet. 21, 10-14.
15. Edelmann, W., Cohen, P. E., Kneitz, B., Winand, N., Lia, M., Heyer, J., Kolodner, R., Pollard, J. W., and Kucherlapati, R. (1999). Mammalian MutS homologue 5 is required for chromosome pairing in meiosis. Nat. Genet. 21, 123-127.
16. Germolec, D. R., Yoshida, T., Gaido, K., Wilmer, J. L., Simeonova, P. P., Kayama, F., Burleson, F., Dong, W., Lange, R. W., and Luster, M. I. (1996). Arsenic induces overexpression of growth factors in human keratinocytes. Toxicol. Appl. Pharmacol. 141, 308-318.
17. Gniadecki, R. (1998). Regulation of keratinocyte proliferation. Gen. Pharmacol. 30, 619-622.
18. Gonsebatt, M. E., Vega, L., Salazar, A. M., Montero, R., Guzman, P., Blas, J., Del Razo, L. M., Garcia-Vargas, G., Albores, A., Cebrian, M. E., Kelsh, M., and Ostrosky-Wegman, P. (1997). Cytogenetic effects in human exposure to arsenic. Mutat. Res. 386, 219-228.
19. Hamadeh, H. K., Vargas, M., Lee, E., and Menzel, D. B. (1999). Arsenic disrupts cellular levels of p53 and mdm2: A potential mechanism of carcinogenesis. Biochem. Biophys. Res. Commun. 263, 446-449.
20. Hartwig, A., Groblinghoff, U, D., Beyersmann, D., Natarajan, A. T., Filon, R., and Mullenders, L. H. (1997). Interaction of arsenic(III) with nucleotide excision repair in UV-irradiated human fibroblasts. Carcinogenesis 18, 399-405.
21. Huang, C., Bode, A. M., Chen, N. Y., Ma, W. Y., Li, J., Nomura, M., and Dong, Z. (2001). Transactivation of AP-1 in AP-1-luciferase reporter transgenic mice by arsenite and arsenate. Anticancer Res. 21, 261-267.
22. Jaiswal, A. K. (1994). Human NAD(P)H:quinone oxidoreductase2: Gene structure, activity, and tissue-specific expression. J. Biol. Chem. 269, 14502-14508.
23. Kitchin, K. T. (2001). Recent advances in arsenic carcinogenesis: Modes of action, animal model systems, and methylated arsenic metabolites. Toxicol. Appl. Pharmacol. 172, 249-261.
24. Kreppel, H., Bauman, J. W., Liu, J., McKim, J. M., Jr., and Klaassen, C. D. (1993). Induction of metallothionein by arsenicals in mice. Fundam. Appl. Toxicol. 20, 184-189.
25. Kroes, R., van Logten, M. J., Berkvens, J. M., de Vries, T., and van Esch, G. J. (1974). Study on the carcinogenicity of lead arsenate and sodium arsenate and on the possible synergistic effect of diethylnitrosamine. Food Cosmet. Toxicol. 12, 671-679.
26. Leonard, A., and Lauwerys, R. R. (1980). Carcinogenicity, teratogenicity, and mutagenicity of arsenic. Mutat. Res. 75, 49-62.
27. Li, R., and Murray, A. W. (1991). Feedback control of mitosis in budding yeast. Cell 66, 519-531.
28. Maier, A., Dalton, T. P., and Puga, A. (2000). Disruption of dioxin-inducible phase I and phase II gene expression patterns by cadmium, chromium, and arsenic. Mol. Carcinog. 28, 225-235.
29. Mass, M. J., and Wang, L. (1997). Arsenic alters cytosine methylation patterns of the promoter of the tumor suppressor gene p53 in human lung cells: A model for a mechanism of carcinogenesis. Mutat. Res. 386, 263-277.
30. Matsui, M., Nishigori, C., Toyokuni, S., Takada, J., Akaboshi, M., Ishikawa, M., Imamura, S., and Miyachi, Y. (1999). The role of oxidative DNA damage in human arsenic carcinogenesis: Detection of 8-hydroxy-2′-deoxyguanosine in arsenic-related Bowen's disease. J. Invest. Dermatol. 113, 26-31.
31. Mazumder, D. N., Das Gupta, J., Santra, A., Pal, A., Ghose, A., and Sarkar, S. (1998). Chronic arsenic toxicity in west Bengal-the worst calamity in the world. J. Indian Med. Assoc. 96, 4-7, 18.
32. Nuwaysir, E. F., Bittner, M., Trent, J., Barrett, J. C., and Afshari, C. A. (1999). Microarrays and toxicology: The advent of toxicogenomics. Mol. Carcinog. 24, 153-159.
33. Ota, T., Maeda, M., Tanino, M., and Tatsuka, M. (2001). Functional suppression of integrin β 4-mediated adhesion caused by in vivo sequential selection for cancer cell intravasation. Anticancer Res. 21, 205-211.
34. Pombo, C. M., Tsujita, T., Kyriakis, J. M., Bonventre, J. V., and Force, T. (1997). Activation of the Ste20-like oxidant stress response kinase-1 during the initial stages of chemical anoxia-induced necrotic cell death. Requirement for dual inputs of oxidant stress and increased cytosolic [Ca2+]. J. Biol. Chem. 272, 29372-29379.
35. Prieto-Alamo, M. J., Jurado, J., Gallardo-Madueno, R., Monje-Casas, F., Holmgren, A., and Pueyo, C. (2000). Transcriptional regulation of glutaredoxin and thioredoxin pathways and related enzymes in response to oxidative stress. J. Biol. Chem. 275, 13398-13405.
36. Rossman, T. G., Uddin, A. N., Burns, F. J., and Bosland, M. C. (2001). Arsenite is a cocarcinogen with solar ultraviolet radiation for mouse skin: An animal model for arsenic carcinogenesis. Toxicol. Appl. Pharmacol. 176, 64-71.
37. Seewaldt, V. L., Caldwell, L. E., Johnson, B. S., Swisshelm, K., Collins, S. J., and Tsai, S. (1997). Inhibition of retinoic acid receptor function in normal human mammary epithelial cells results in increased cellular proliferation and inhibits the formation of a polarized epithelium in vitro. Exp. Cell. Res. 236, 16-28.
38. Smith, M. L., Ford, J. M., Hollander, M. C., Bortnick, R. A., Amundson, S. A., Seo, Y. R., Deng, C. X., Hanawalt, P. C., and Fornace, A. J., Jr. (2000). p53-mediated DNA repair responses to UV radiation: Studies of mouse cells lacking p53, p21, and/or gadd45 genes. Mol. Cell. Biol. 20, 3705-3714.
39. Thorgeirsson, U. P., Dalgard, D. W., Reeves, J., and Adamson, R. H. (1994). Tumor incidence in a chemical carcinogenesis study of nonhuman primates. Regul. Toxicol. Pharmacol. 19, 130-151.
40. Trouba, K. J., Glanzer, J. G., and Vorce, R. L. (1999). Wild-type and Ras-transformed fibroblasts display differential mitogenic responses to transient sodium arsenite exposure. Toxicol. Sci. 50, 72-81.
41. Trouba, K. J., Wauson, E. M., and Vorce, R. L. (2000). Sodium arsenite-induced dysregulation of proteins involved in proliferative signaling. Toxicol. Appl. Pharmacol. 164, 161-170.
42. Vega, L., Styblo, M., Patterson, R., Cullen, W., Wang, C., and Germolec, D. (2001). Differential effects of trivalent and pentavalent arsenicals on cell proliferation and cytokine secretion in normal human epidermal keratinocytes. Toxicol. Appl. Pharmacol. 172, 225-232.
43. Vogt, B. L., and Rossman, T. G. (2001). Effects of arsenite on p53, p21, and cyclin D expression in normal human fibroblasts-a possible mechanism for arsenite's comutagenicity. Mutat. Res. 478, 159-168.
44. Wang, C., Lin, J. M., and Lazarides, E. (1992). Methylations of 70,000-Da heat shock proteins in 3T3 cells: Alterations by arsenite treatment, by different stages of growth, and by virus transformation. Arch. Biochem. Biophys. 297, 169-175.
45. Yamanaka, K., and Okada, S. (1994). Induction of lung-specific DNA damage by metabolically methylated arsenics via the production of free radicals. Environ. Health Perspect. 102(Suppl. 3), 37-40.
46. Zhu, N. L., Wu, L., Liu, P. X., Gordon, E. M., Anderson, W. F., Starnes, V. A., and Hall, F. L. (1997). Downregulation of cyclin G1 expression by retrovirus-mediated antisense gene transfer inhibits vascular smooth muscle cell proliferation and neointima formation. Circulation 96, 628-635.
47. Zhu, Q., Wani, M. A., El-Mahdy, M., and Wani, A. A. (2000). Decreased DNA repair efficiency by loss or disruption of p53 function preferentially affects removal of cyclobutane pyrimidine dimers from nontranscribed strand and slow repair sites in transcribed strand. J. Biol. Chem. 275, 11492-11497.