Epigenetics in women's health care

Mount Sinai Journal of Medicine

Volumn 77, Issue 2, 2010, Pages 225-235

  Pozharny, Yevgeniya ^a   Lambertini, Luca ^a   Clunie, Garfield ^a   Ferrara, Lauren ^a   Lee, Men Jean ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Epigenetics; Imprinted genes; Placenta

Indexed keywords

ENDOCRINE DISRUPTOR; FOLIC ACID; HEAVY METAL;

ADULT; CHILD; DIETARY INTAKE; DNA MODIFICATION; EMBRYO; EMBRYO DEVELOPMENT; ENVIRONMENTAL EXPOSURE; EPIGENETICS; FERTILIZATION; GAMETOGENESIS; GENE CONTROL; GENOME IMPRINTING; GLUCOSE INTAKE; HUMAN; INTRAUTERINE GROWTH RETARDATION; LIPID DIET; NONHUMAN; PATHOGENESIS; PREECLAMPSIA; REVIEW; WOMEN'S HEALTH;

DNA METHYLATION; ENDOCRINE DISRUPTORS; EPIGENESIS, GENETIC; EPIGENOMICS; FEMALE; FETAL GROWTH RETARDATION; GAMETOGENESIS; HUMANS; METALS, HEAVY; NUTRITIONAL STATUS; PRE-ECLAMPSIA; PREGNANCY; PREGNANCY COMPLICATIONS; WOMEN'S HEALTH; WOMEN'S HEALTH SERVICES;

EID: 77949857385     PISSN: 00272507     EISSN: 19317581     Source Type: Journal    
DOI: 10.1002/msj.20176     Document Type: Review

References (100)

1. Nafee TM, Farrell WE, Carroll WD, et al. Epigenetic control of fetal gene expression. BJOG 2008; 115: 158-168.
2. Reik W, Dean W, Walter J. Epigenetic reprogramming in mammalian development. Science 2001; 293: 1089-1093.
3. Surani MA. Reprogramming of genome function through epigenetic inheritance. Nature 2001; 414: 122-128.
4. Godfrey KM, Lillycrop KA, Burdge GC, et al. Epigenetic mechanisms and the mismatch concept of the developmental origins of health and disease. Pediatr Res 2007; 61: 5R-10R.
5. Robertson KD. DNA methylation and human disease. Nat Rev Genet 2005; 6: 597-610.
6. Trasler JM. Gamete imprinting: setting epigenetic patterns for the next generation. Reprod Fertil Dev 2006; 18: 63-69.
7. Bird A. DNA methylation patterns and epigenetic memory. Genes Dev 2002; 16: 6-21.
8. Quina AS, Buschbeck M, Di Croce L. Chromatin structure and epigenetics. Biochem Pharmacol 2006; 72: 1563-1569.
9. Klose RJ, Bird AP. Genomic DNA methylation: the mark and its mediators. Trends Biochem Sci 2006; 31: 89-97.
10. D'Amours D, Desnoyers S, D'Silva I, Poirier GG. Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions. Biochem J 1999; 342(pt 2): 249-268.
11. Fuks F, Hurd PJ, Deplus R, Kouzarides T. The DNA methyltransferases associate with HP1 and the SUV39H1 histone methyltransferase. Nucleic Acids Res 2003; 31: 2305-2312.
12. Geyer PK. The role of insulator elements in defining domains of gene expression. Curr Opin Genet Dev 1997; 7: 242-248.
13. Morgan HD, Santos F, Green K, et al. Epigenetic reprogramming in mammals. Hum Mol Genet 2005; 14: R47-R58.
14. Beaujean N, Taylor J, Gardner J, et al. Effect of limited DNA methylation reprogramming in the normal sheep embryo on somatic cell nuclear transfer. Biol Reprod 2004; 71: 185-193.
15. Beaujean N, Martin C, Debey P, Renard JP. Reprogramming and epigenesis [in French]. Med Sci (Paris) 2005; 21: 412-421.
16. Bestor TH. The DNA methyltransferases of mammals. Hum Mol Genet 2000; 9: 2395-2402.
17. Richardson B. Impact of aging on DNA methylation. Ageing Res Rev 2003; 2: 245-261.
18. Santos F, Hendrich B, Reik W, Dean W. Dynamic reprogramming of DNA methylation in the early mouse embryo. Dev Biol 2002; 241: 172-182.
19. Dean W, Ferguson-Smith A. Genomic imprinting: mother maintains methylation marks. Curr Biol 2001; 11: R527-R530.
20. Ginsburg M, Snow MH, McLaren A. Primordial germ cells in the mouse embryo during gastrulation. Development 1990; 110: 521-528.
21. Seki Y, Hayashi K, Itoh K, et al. Extensive and orderly reprogramming of genome-wide chromatin modifications associated with specification and early development of germ cells in mice. Dev Biol 2005; 278: 440-458.
22. Sato S, Yoshimizu T, Sato E, Matsui Y. Erasure of methylation imprinting of Igf2r during mouse primordial germ-cell development. Mol Reprod Dev 2003; 65: 41-50.
23. Hajkova P, Erhardt S, Lane N, et al. Epigenetic reprogramming in mouse primordial germ cells. Mech Dev 2002; 117: 15-23.
24. Singh SM, Murphy B, O'Reilly RL. Involvement of gene-diet/drug interaction in DNA methylation and its contribution to complex diseases: from cancer to schizophrenia. Clin Genet 2003; 64: 451-460.
25. Waterland RA, Jirtle RL. Early nutrition, epigenetic changes at transposons and imprinted genes, and enhanced susceptibility to adult chronic diseases. Nutrition 2004; 20: 63-68.
26. Issa JP, Ottaviano YL, Celano P, et al. Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon. Nat Genet 1994; 7: 536-540.
27. McKay JA, Williams EA, Mathers JC. Folate and DNA methylation during in utero development and aging. Biochem Soc Trans 2004; 32: 1006-1007.
28. Toyota M, Issa JP. The role of DNA hypermethylation in human neoplasia. Electrophoresis 2000; 21: 329-333.
29. Dolinoy DC, Weidman JR, Jirtle RL. Epigenetic gene regulation: linking early developmental environment to adult disease. Reprod Toxicol 2007; 23: 297-307.
30. Feil R. Environmental and nutritional effects on the epigenetic regulation of genes. Mutat Res 2006; 600: 46-57.
31. Kaati G, Bygren LO, Edvinsson S. Cardiovascular and diabetes mortality determined by nutrition during parents' and grandparents' slow growth period. Eur J Hum Genet 2002; 10: 682-688.
32. Lane N, Dean W, Erhardt S, et al. Resistance of IAPs to methylation reprogramming may provide a mechanism for epigenetic inheritance in the mouse. Genesis 2003; 35: 88-93.
33. Morgan HD, Sutherland HG, Martin DI, Whitelaw E. Epigenetic inheritance at the agouti locus in the mouse. Nat Genet 1999; 23: 314-318.
34. Reik W, Walter J. Imprinting mechanisms in mammals. Curr Opin Genet Dev 1998; 8: 154-164.
35. Tilghman SM. The sins of the fathers and mothers: genomic imprinting in mammalian development. Cell 1999; 96: 185-193.
36. Jirtle RL, Skinner MK. Environmental epigenomics and disease susceptibility. Nat Rev Genet 2007; 8: 253-262.
37. Badcock C, Crespi B. Imbalanced genomic imprinting in brain development: an evolutionary basis for the aetiology of autism. J Evol Biol 2006; 19: 1007-1032.
38. Barker DJ, Osmond C. Infant mortality, childhood nutrition, and ischaemic heart disease in England and Wales. Lancet 1986; 1: 1077-1081.
39. Kensara OA, Wootton SA, Phillips DI, et al. Fetal programming of body composition: relation between birth weight and body composition measured with dual-energy X-ray absorptiometry and anthropometric methods in older Englishmen. Am J Clin Nutr 2005; 82: 980-987.
40. Osmond C, Barker DJ, Winter PD, et al. Early growth and death from cardiovascular disease in women. BMJ 1993; 307: 1519-1524.
41. Hales CN, Barker DJ. Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis. Diabetologia 1992; 35: 595-601.
42. Cooper C, Fall C, Egger P, et al. Growth in infancy and bone mass in later life. Ann Rheum Dis 1997; 56: 17-21.
43. Gluckman PD, Hanson MA. The developmental origins of the metabolic syndrome. Trends Endocrinol Metab 2004; 15: 183-187.
44. Gluckman PD, Hanson MA. Living with the past: evolution, development, and patterns of disease. Science 2004; 305: 1733-1736.
45. Lillycrop KA, Phillips ES, Jackson AA, et al. Dietary protein restriction of pregnant rats induces and folic acid supplementation prevents epigenetic modification of hepatic gene expression in the offspring. J Nutr 2005; 135: 1382-1386.
46. Lillycrop KA, Slater-Jefferies JL, Hanson MA, et al. Induction of altered epigenetic regulation of the hepatic glucocorticoid receptor in the offspring of rats fed a protein-restricted diet during pregnancy suggests that reduced DNA methyltransferase-1 expression is involved in impaired DNA methylation and changes in histone modifications. Br J Nutr 2007; 97: 1064-1073.
47. Burdge GC, Lillycrop KA, Jackson AA, et al. The nature of the growth pattern and of the metabolic response to fasting in the rat are dependent upon the dietary protein and folic acid intakes of their pregnant dams and post-weaning fat consumption. Br J Nutr 2008; 99: 540-549.
48. Bogdarina I, Welham S, King PJ, et al. Epigenetic modification of the renin-angiotensin system in the fetal programming of hypertension. Circ Res 2007; 100: 520-526.
49. Sinclair KD, Allegrucci C, Singh R, et al. DNA methylation, insulin resistance, and blood pressure in offspring determined by maternal periconceptional B vitamin and methionine status. Proc Natl Acad Sci U S A 2007; 104: 19351-19356.
50. Weaver IC, Cervoni N, Champagne FA, et al. Epigenetic programming by maternal behavior. Nat Neurosci 2004; 7: 847-854.
51. Fraga MF, Ballestar E, Paz MF, et al. Epigenetic differences arise during the lifetime of monozygotic twins. Proc Natl Acad Sci U S A 2005; 102: 10604-10609.
52. Vickers MH, Gluckman PD, Coveny AH, et al. Neonatal leptin treatment reverses developmental programming. Endocrinology 2005; 146: 4211-4216.
53. Gluckman PD, Lillycrop KA, Vickers MH, et al. Metabolic plasticity during mammalian development is directionally dependent on early nutritional status. Proc Natl Acad Sci U S A 2007; 104: 12796-12800.
54. Wyrwoll CS, Mark PJ, Mori TA, et al. Prevention of programmed hyperleptinemia and hypertension by postnatal dietary omega-3 fatty acids. Endocrinology 2006; 147: 599-606.
55. Nylund L, Lunell NO, Lewander R, Sarby B. Uteroplacental blood flow index in intrauterine growth retardation of fetal or maternal origin. Br J Obstet Gynaecol 1983; 90: 16-20.
56. Laurin J, Lingman G, Marsal K, Persson PH. Fetal blood flow in pregnancies complicated by intrauterine growth retardation. Obstet Gynecol 1987; 69: 895-902.
57. Bell AW, Hay WW Jr, Ehrhardt RA. Placental transport of nutrients and its implications for fetal growth. J Reprod Fertil Suppl 1999; 54: 401-410.
58. Waterland RA, Garza C. Potential mechanisms of metabolic imprinting that lead to chronic disease. Am J Clin Nutr 1999; 69: 179-197.
59. Maloney CA, Rees WD. Gene-nutrient interactions during fetal development. Reproduction 2005; 130: 401-410.
60. Randhawa R, Cohen P. The role of the insulin-like growth factor system in prenatal growth. Mol Genet Metab 2005; 86: 84-90.
61. Fowden AL, Sibley C, Reik W, Constancia M. Imprinted genes, placental development and fetal growth. Horm Res 2006; 65(suppl 3): 50-58.
62. Constancia M, Hemberger M, Hughes J, et al. Placental-specific IGF-II is a major modulator of placental and fetal growth. Nature 2002; 417: 945-948.
63. Myatt L. Placental adaptive responses and fetal programming. J Physiol 2006; 572: 25-30.
64. Roberts JM, Gammill HS. Preeclampsia: recent insights. Hypertension 2005; 46: 1243-1249.
65. Granger JP, Alexander BT, Llinas MT, et al. Pathophysiology of preeclampsia: linking placental ischemia/hypoxia with microvascular dysfunction. Microcirculation 2002; 9: 147-160.
66. Gupta S, Agarwal A, Sharma RK. The role of placental oxidative stress and lipid peroxidation in preeclampsia. Obstet Gynecol Surv 2005; 60: 807-816.
67. Redman CW, Sargent IL. Placental debris, oxidative stress and pre-eclampsia. Placenta 2000; 21: 597-602.
68. Elsheikh A, Creatsas G, Mastorakos G, et al. The renin-aldosterone system during normal and hypertensive pregnancy. Arch Gynecol Obstet 2001; 264: 182-185.
69. Redman CW, Sargent IL. Preeclampsia and the systemic inflammatory response. Semin Nephrol 2004; 24: 565-570.
70. Wang JX, Knottnerus AM, Schuit G, et al. Surgically obtained sperm, and risk of gestational hypertension and pre-eclampsia. Lancet 2002; 359: 673-674.
71. Kanayama N, Takahashi K, Matsuura T, et al. Deficiency in p57Kip2 expression induces preeclampsia-like symptoms in mice. Mol Hum Reprod 2002; 8: 1129-1135.
72. Knox KS, Baker JC. Genome-wide expression profiling of placentas in the p57Kip2 model of preeclampsia. Mol Hum Reprod 2007; 13: 251-263.
73. Chelbi ST, Vaiman D. Genetic and epigenetic factors contribute to the onset of preeclampsia. Mol Cell Endocrinol 2008; 282: 120-129.
74. Miller JW, Nadeau MR, Smith J, et al. Folatedeficiency-induced homocysteinaemia in rats: disruption of S-adenosylmethionine's co-ordinate regulation of homocysteine metabolism. Biochem J 1994; 298(pt 2): 415-419.
75. Xu X, Chen J. One-carbon metabolism and breast cancer: an epidemiological perspective. J Genet Genomics 2009; 36: 203-214.
76. Scholl TO, Johnson WG. Folic acid: influence on the outcome of pregnancy. Am J Clin Nutr 2000; 71: 1295S-1303S.
77. Shaw GM, Carmichael SL, Nelson V, et al. Occurrence of low birthweight and preterm delivery among California infants before and after compulsory food fortification with folic acid. Public Health Rep 2004; 119: 170-173.
78. Knudtson EJ, Smith K, Mercer BM, et al. Serum homocysteine levels after preterm premature rupture of the membranes. Am J Obstet Gynecol 2004; 191: 537-541.
79. Wouters MG, Boers GH, Blom HJ, et al. Hyperhomocysteinemia: a risk factor in women with unexplained recurrent early pregnancy loss. Fertil Steril 1993; 60: 820-825.
80. Goddijn-Wessel TA, Wouters MG, van de Molen EF, et al. Hyperhomocysteinemia: a risk factor for placental abruption or infarction. Eur J Obstet Gynecol Reprod Biol 1996; 66: 23-29.
81. Menon MK, Sengupta M, Ramaswamy N. Accidental haemorrhage and folic acid deficiency. J Obstet Gynaecol Br Commonw 1966; 73: 49-52.
82. Dekker GA, de Vries JI, Doelitzsch PM, et al. Underlying disorders associated with severe earlyonset preeclampsia. Am J Obstet Gynecol 1995; 173: 1042-1048.
83. Laurence KM. Prenatal detection and prevention of neural tube defects in South Wales. J R Soc Health. 1986; Oct; 106(5): 153-60.
84. Smithells RW. 1982. Neural tube defects: prevention by vitamin supplements. Pediatrics 69: 498-499.
85. Zhang S, Hunter DJ, Hankinson SE, et al. A prospective study of folate intake and the risk of breast cancer. JAMA 1999; 281: 1632-1637.
86. Stolzenberg-Solomon RZ, Chang SC, Leitzmann MF, et al. Folate intake, alcohol use, and postmenopausal breast cancer risk in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. Am J Clin Nutr 2006; 83: 895-904.
87. Yenbutr P, Hilakivi-Clarke L, Passaniti A. Hypomethylation of an exon I estrogen receptor CpG island in spontaneous and carcinogen-induced mammary tumorigenesis in the rat. Mech Ageing Dev 1998; 106: 93-102.
88. Dabelea D, Hanson RL, Lindsay RS, et al. Intrauterine exposure to diabetes conveys risks for type 2 diabetes and obesity: a study of discordant sibships. Diabetes 2000; 49: 2208-2211.
89. Cheng RY, Hockman T, Crawford E, et al. Epigenetic and gene expression changes related to transgenerational carcinogenesis. Mol Carcinog 2004; 40: 1-11.
90. Shiao YH, Crawford EB, Anderson LM, et al. Allelespecific germ cell epimutation in the spacer promoter of the 45S ribosomal RNA gene after Cr(III) exposure. Toxicol Appl Pharmacol 2005; 205: 290-296.
91. Takiguchi M, Achanzar WE, Qu W, et al. Effects of cadmium on DNA-(cytosine-5) methyltransferase activity and DNA methylation status during cadmiuminduced cellular transformation. Exp Cell Res 2003; 286: 355-365.
92. Reichard JF, Schnekenburger M, Puga A. Long term low-dose arsenic exposure induces loss of DNA methylation. Biochem Biophys Res Commun 2007; 352: 188-192.
93. Salnikow K, Costa M. Epigenetic mechanisms of nickel carcinogenesis. J Environ Pathol Toxicol Oncol 2000; 19: 307-318.
94. Chen H, Ke Q, Kluz T, et al. Nickel ions increase histone H3 lysine 9 dimethylation and induce transgene silencing. Mol Cell Biol 2006; 26: 3728-3737.
95. Edwards TM, Myers JP. Environmental exposures and gene regulation in disease etiology. Environ Health Perspect 2007; 115: 1264-1270.
96. Couture LA, Abbott BD, Birnbaum LS. A critical review of the developmental toxicity and teratogenicity of 2,3,7,8-tetrachlorodibenzo- p-dioxin: recent advances toward understanding the mechanism. Teratology 1990; 42: 619-627.
97. Foster PM. Disruption of reproductive development in male rat offspring following in utero exposure to phthalate esters. Int J Androl 2006; 29: 140-147.
98. Tao L, Wang W, Li L, et al. DNA hypomethylation induced by drinking water disinfection by-products in mouse and rat kidney. Toxicol Sci 2005; 87: 344-352.
99. Desaulniers D, Xiao GH, Leingartner K, et al. Comparisons of brain, uterus, and liver mRNA expression for cytochrome p450s, DNA methyltransferase-1, and catechol-o-methyltransferase in prepubertal female Sprague-Dawley rats exposed to a mixture of aryl hydrocarbon receptor agonists. Toxicol Sci 2005; 86: 175-184.
100. McLachlan JA, Simpson E, Martin M. Endocrine disrupters and female reproductive health. Best Pract Res Clin Endocrinol Metab 2006; 20: 63-75.