Arsenic induces overexpression of growth factors in human keratinocytes

Toxicology and Applied Pharmacology

Volumn 141, Issue 1, 1996, Pages 308-318

  Germolec, Dori R ^a   Yoshida, Takahiko ^b   Gaido, Kevin ^d   Wilmer, James L ^a   Simeonova, Petia P ^a   Kayama, Fujio ^c   Burleson, Florence ^a   Dong, Wumin ^a   Lange, Robert W ^a   Luster, Michael I ^a,e  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b TOKAI UNIVERSITY   (Japan)

^c UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

^d CIIT CENTERS FOR HEALTH RESEARCH   (United States)

^e NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARSENIC; ARSENITE SODIUM; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; MESSENGER RNA; TRANSFORMING GROWTH FACTOR ALPHA;

ARTICLE; CELL CULTURE; CELL PROLIFERATION; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; KERATINOCYTE; ONCOGENE C MYB; TECHNIQUE;

ANIMALIA;

EID: 0030296602     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.1996.0288     Document Type: Article

References (59)

1. Ansel, J., Perry, P., Brown, J., Damm, D., Phan, T., Hart, C., Luger, T., and Hefeneider, S. (1990). Cytokine modulation of keratinocyte cytokines. J. Invest. Dermatol. 94, 101S-107S.
2. Beutler, B., Greenweld, B., Hulmes, J. D., Chang, M., Pan, Y. C., Maathison, J., Ulevitch, J., and Cerami, A. (1985). Identity of tumor necrosis factor and the macrophage secreted factor cachectin. Nature 316, 552-556.
3. Braunstein, S., Kaplan, G., Gottlieb, A. B., Schwartz, M., Walsh, G., Abalos, R. M., Fajardo, T. T., Guido, L. S., and Krueger, J. G. (1994). GM-CSF activates regenerative epidermal growth and stimulates keratinocyte proliferation in human skin in vivo. J. Invest. Dermatol. 103, 601-604.
4. Chen, C.-J., Chuang, Y.-C., Lin, T.-M., and Wu, H.-Y. (1985). Malignant neoplasms among residents of a Blackfoot disease-endemic area in Taiwan: High-arsenic artesian well water and cancers. Cancer Res. 45, 5895-5899.
5. Chen, C. J., and Lin, L. J. (1994). Human carcinogenicity and atherogenicity induced by chronic exposure to inorganic arsenic. In Arsenic in the Environment. Part II: Human Health and Ecosystem Effects (J. O. Nriagu, Ed.), pp. 109-131. Wiley, New York.
6. Cheng, C., Tennenbaum, T., Dempsey, P. J., Coffey, R. J., Yuspa, S. H., and Dlugosz, A. A. (1993). Epidermal growth factor receptor ligands regulate keratin 8 expression in keratinocytes, and transforming growth factor α mediates the induction of keratin 8 by the v-Ha-ras oncogene. Cell Growth Differ. 4, 317-327.
7. Chiou, H.-Y., Hsueh, Y.-M., Liaw, K.-F., Horng, S.-F., Chiang, M.-H., Pu, Y.-S., Lin, J. S.-N., Huang, C.-H., and Chen, C.-J. (1995). Incidence of internal cancers and ingested inorganic arsenic: A seven-year follow-up study in Taiwan. Cancer Res. 55, 1296-1300.
8. Choi, E. J., Toscano, D. G., Ryan, J. A., Riedel, N., and Toscano, W. A., Jr. (1991). Dioxin induces transforming growth factor-α in human keratinocytes. J. Biol. Chem. 266, 9591-9597.
9. Coffey, R. J., Derynck, R., Wilcox, J. N., Bringman, T. S., Goustin, A. S., Moses, H. L., and Pittelkow, M. R. (1987). Production and auto-induction of transforming growth factor-α in human keratinocytes. Nature 328, 817-820.
10. Ha-induced epidermal neoplasia: Potential involvement of alternate epidermal growth factor receptor ligands. Cancer Res. 55, 1883-1893.
11. Dominey, A. M., Wang, X. J., King, L. E., Nanney, L. B., Gagne, T. A., Sellheyer, K., Bundman, D. S., Longley, M. A., Rothnagel, J. A., Greenhalgh, D. A., and Roop, D. R. (1993). Targeted overexpression of transforming growth factor alpha in the epidermis of transgenic mice elicits hyperplasia, hyperkeratosis, and spontaneous, squamous papillomas. Cell Growth Differ. 4, 1071-1082.
12. Edwards, D. R., and Heath, J. K. (1991). Regulation of transcription by transforming growth factor-β. In The Hormonal Control of Gene Transcription (P. Cohen and J. G. Foulkes, Eds.), pp. 333-347. Elsevier, New York.
13. Edwards, M. J., Marks, R., Dykes, P. J., Merrett, V. R., Morgan, H. E., and O'Donovan, M. R. (1991). Heat shock proteins in cultured human keratinocytes and fibroblasts. J. Invest. Dermatol. 96, 392-396.
14. Elder, J. T., Fisher, G. J., Lindquist, P. B., Bennett, G. L., Pittelkow, M. R., Coffey, R. J., Jr., Ellingsworth, L., Derynck, R., and Voorhees, J. J. (1989). Overexpression of transforming growth factor-α in psoriatic epidermis. Science 243, 811-814.
15. EPA (1987). Special Report on Ingested Inorganic Arsenic: Skin Cancer and Nutritional Essentiality. Risk Assessment Forum. U.S. Environmental Protection Agency, Washington, DC.
16. Finzi, E., Kilkenny, A., Strickland, J. E., Balaschak, M., Bringman, T., Derynck, R., Aaronson, S., and Yuspa, S. H. (1988). TGF-alpha stimulates growth of skin papillomas by autocrine and paracrine mechanisms but does not cause neoplastic progression. Mol. Carcinog. 1, 7-12.
17. Furstenberger, G., Rogers, M., Schnapke, R., Bauer, G., Hofler, P., and Marks, F. (1989). Stimulatory role of transforming growth factors in multistage skin carcinogenesis: Possible explanation for the tumor-inducing effects of wounding in initiated NMRI mouse skin. Int. J. Cancer 43, 915-921.
18. Gaido, K. W., Maness, S. C., Leonard, L. S., and Greenlee, W. F. (1992). 2,3,7,8-Tetrachlorodibenzo-p-dioxin-dependent regulation of transforming growth factors-α and -β2 expression in a human keratinocyte cell line involves both transcriptional and post-transcriptional control. J. Biol. Chem. 267, 24591-24595.
19. Glick, A. B., Sporn, M. B., and Yuspa, S. H. (1991). Altered regulation of TGF-β1 and TGF-α in primary keratinocytes and papillomas expressing v-Ha-ras. Mol. Carcinog. 4, 210-219.
20. Gottlieb, A. B., Chang, C. K., Posnett, D. N., Fanelli, B., and Tam, J. P. (1988). Detection of transforming growth factor α in normal malignant and hyperproliferative human keratinocytes. J. Exp. Med. 167, 670-675.
21. Hancock, G. E., Kaplan, G., and Cohn, Z. A. (1988). Keratinocyte growth regulation by the products of immune cells. J. Exp. Med. 168, 1395-1402.
22. Imamoto, A., Beltran, L. M., and DiGiovanni, J. (1991). Evidence for autocrine/paracrine growth stimulation by transforming growth factor-α during the process of skin tumor promotion. Mol. Carcinog. 4, 52-60.
23. Jhappan, C., Stahle, C., Harkins, R. N., Fausto, N., Smith, G. H., and Merlino, G. T. (1990). TGF alpha overexpression in transgenic mice induces liver neoplasia and abnormal development of the mammary gland and pancreas. Cell 61, 1137-1146.
24. Kachinskas, D., Phillips, M. A., Qin, Q., Stokes, J. D., and Rice, R. H. (1994). Arsenate perturbation of human keratinocyte differentiation. Cell Growth Differ. 5, 1235-1241.
25. Kayama, F., Yoshida, T., Elwell, M. R., and Luster, M. I. (1995). Role of tumor necrosis factor-α in cadmium-induced hepatotoxicity. Toxicol. Appl. Pharmacol. 131, 224-234.
26. Kubo, Y., Yasunaga, M., Masuhara, M., Terai, S., Nakamura, T., and Okita, K. (1996). Hepatocyte proliferation induced in rats by lead nitrate is suppressed by several tumor necrosis factor α inhibitors. Hepatology 23, 104-114.
27. Lee, S. W., Morhenn, V. B., Ilnicka, M., Eugui, E. M., and Allison, A. C. (1991). Autocrine stimulation of interleukin-1α and transforming growth factor-α production in human keratinocytes and its antagonism by glucocorticoids. J. Invest. Dermatol. 97, 106-110.
28. Lee, T.-C., Tanaka, N., Lamb, P. W., Gilmer, T. M., and Barrett, J. C. (1988). Induction of gene amplification by arsenic. Science 241, 79-81.
29. Luger, T. A., and Schwarz, T. (1990). Epidermal cell-derived cytokines. In Skin Immune System (J. D. Bos, Ed.), pp. 257-291. CRC Press, Boca Raton, FL.
30. Malejczyk, J., Malejczyk, M., Kock, A., Urbanski, G., Majewski, S., Hunzelmann, N., Jablonska, S., Orth, G., and Luger, T. A. (1992). Autocrine growth limitation of human papillomavirus type 16-harboring keratinocytes by constitutively released tumor necrosis factor-a. J. Immunol. 149, 2702-2708.
31. Mass, M. J., and Wang, L. (1996). Alterations of methylation of the tumor suppressor gene p53: Insights into potential mechanisms of arsenic carcinogenesis. In Arsenic Exposure and Health Effects (W. R. Chappell, C. O. Abernathy, and R. Calderon, Eds.), in press. Chapman & Hall, London.
32. Matsue, H., Bergstresser, P. R., and Takashima, A. (1993). Reciprocal cytokine-mediated cellular interactions in mouse epidermis: Promotion of γδ T-cell growth by IL-7 and TNFα and inhibition of keratinocyte growth by γIFN. J. Invest. Dermatol. 101, 543-548.
33. Matsui, Y., Halter, S. A., Holt, J. T., Hogan, B. L. M., and Coffey, R. J. (1990). Development of mammary hyperplasia and neoplasia in MMTV-TGF alpha transgenic mice. Cell 61, 1147-1155.
34. Molin, L., and Wester, P. O. (1976). The estimated daily losses of trace elements from normal skin by desquamation. Scand. J. Clin. Lab Invest. 36, 679-688.
35. Nevins, J. R. (1987). Isolation and analysis of nuclear RNA. Methods Enzymol. 152, 234-241.
36. Nickoloff, B. J., Karabin, G. D., Barker, J. N., Griffith, C. E., Sarma, V., Mitra, R. S., Elder, J. T., Kunkel, S. L., and Dixit, V. M. (1991). Cellular localization of interleukin-8 and its inducer, tumor necrosis factor-alpha in psoriasis. Am. J. Pathol. 138, 129-140.
37. Nriagu, J. O. (1994). Arsenic in the Environment, Part II. Human Health and Ecosystem Effects. Wiley, New York.
38. Olaniran, A. K., Baker, B. S., Garioch, J. J., Powles, A. V., and Fry, L. (1995). A comparison of the stimulatory effects of cytokines on normal and psoriatic keratinocytes in vitro. Arch. Dermatol. Res. 287, 231-236.
39. Owsianowski, F. W., Busch, F. W., Bonnekoh, B., and Orfanos, C. E. (1991). Long-term cultured adult human keratinocytes secrete granulocyte-macrophage colony-stimulating factor but not interleukin-3 after cytokine exposure in vitro. Skin Pharmacol. 4, 158-164.
40. Partridge, M., Chantry, D., Turner, M., and Feldman, M. (1991). Production of interleukin-1 and interleukin-6 by human keratinocytes and squamous cell carcinoma cell lines. J. Invest. Dermatol. 96, 771-776.
41. Pietenpol, J. A., Holt, J. T., Stein, R. W., and Moses, H. L. (1990). Transforming growth factor β1 suppression of c-myc gene transcription: Role in inhibition of keratinocyte proliferation. Proc. Natl. Acad. Sci. USA 87, 3758-3762.
42. Pittelkow, M. R., Lindquist, P. B., Abraham, R. T., Graves-Deal, R., Derynck, R., and Coffey, R. J., Jr. (1991). Induction of transforming growth factor-α expression in human keratinocytes by phorbol esters. J. Biol. Chem. 264, 5164-5171.
43. Ranges, G. E., Alotnik, A., Espevik, T., Dinarello, C. A., Cerami, A., and Palladino, M. A., Jr. (1988). Tumor necrosis factor α/cachectin is a growth factor for thymocytes. J. Exp. Med. 167, 1472-1478.
44. Robertson, F. M., Bijur, G. N., Oberyszyn, A. S., Pellegrini, A. E., Boros, L. G., Sabourin, L. K., and Oberyszyn, T. M. (1994). Granulocyte-macrophage colony stimulating factor gene expression and function during tumor formation. Carcinogenesis 15, 1012-1029.
45. Sandgren, E. P., Luetteke, N. C., Palmiter, R. D., Brinster, R. L., and Lee, D. C. (1990). Overexpression of TGF alpha in transgenic mice: Induction of epithelial hyperplasia, pancreatic metaplasia, and carcinoma of the breast. Cell 61, 1121-1135.
46. Satoh, M., and Yamazaki, M. (1993). In vitro DNA synthesis of mouse hepatocytes stimulated by tumor necrosis factor is inhibited by glucocorticoids and prostaglandin D2 but enhanced by retinoic acid. J. Cell. Physiol. 157, 134-139.
47. Shipley, G. D., Pittelkow, M. R., Wille, J. J., Scott, R. E., and Moses, H. L. (1986). Reversible inhibition of normal human prokeratinocyte proliferation by type-β transforming growth factor-growth inhibitor in serum free medium. Cancer Res. 46, 2068-2071.
48. Smith, A. H., Hopenhayn-Rich, C., Bates, M. N., Goeden, H. M., Hertz-Picciotto, P., Duggan, H. M., Wood, R., Kornett, M. J., and Smith, M. T. (1992). Cancer risks from arsenic in drinking water. Environ. Health Perspect. 97, 259-267.
49. Sommers, S. C., and McManus, R. G. (1953). Multiple arsenical cancers of skin and internal organs. Cancer 6, 347-359.
50. Stohrer, G. (1991). Arsenic: Opportunity for risk assessment. Arch. Toxicol. 65, 525-531.
51. Takagi, H., Sharp, R., Takayama, H., Anver, M. R., Ward, J. M., and Merlino, G. (1993). Collaboration between growth factors and diverse chemical carcinogens in hepatocarcinogenesis of transforming growth factor α transgenic mice. Cancer Res. 53, 4329-4336.
52. Tornaletti, S., and Pfeifer, G. P. (1995). Complete and tissue-independent methylation of CpG sites in the p53 gene: Implications for mutations in human cancers. Oncogene 10, 1493-1499.
53. Tsuda, T., Babazono, A., Yamamoto, E., Kurumatani, N., Mino, Y., Ogawa, T., Kishi, Y., and Aoyama, H. (1995). Ingested arsenic and internal cancer: A historical cohort study followed for 33 years. Am. J. Epidemiol. 141, 198-209.
54. Van Wijk, R., Welters, M., Souren, J. E. M., Ovelgonne, H., and Wiegant, F. A. C. (1993). Serum-stimulated cell cycle progression and stress protein synthesis in C3H10T1/2 fibroblasts treated with sodium arsenite. J. Cell Physiol. 155, 266-272.
55. Vassar, R., and Fuchs, E. (1991). Transgenic mice provide new insights into the role of TGF-α during epidermal development and differentiation. Genes Dev. 5, 714-727.
56. Vasunia, K. B., Miller, M. L., Puga, A., and Baxter, C. S. (1994). Granulocyte-macrophage colony-stimulating factor (GM-CSF) is expressed in mouse skin in response to tumor-promoting agents and modulates dermal inflammation and epidermal dark cell numbers. Carcinogenesis 15, 653-660.
57. Wijeweera, J. B., Thomas, C. M., Gandolfi, A. J., and Brendel, K. (1995). Sodium arsenite and heat shock induce stress proteins in precision-cut rat liver slices. Toxicology 104, 35-45.
58. Wilmer, J. L., Burleson, F. G., Kayama, F., Kannou, J., and Luster, M. I. (1994). Contact irritant-induced inflammation in mouse skin and its relation to patterns of cytokine production in human epidermal keratinocytes. J. Invest. Dermatol. 102, 915-922.
59. Yamauchi, H., and Fowler, B. A. (1994). Toxicity and metabolism of inorganic and methylated arsenicals. In Arsenic in the Environment. Part II: Human Health and Ecosystem Effects (J. O. Nriagu. Ed.), pp. 35-43. Wiley, New York.