Transcriptional and epigenetic regulation of human microRNAs

Cancer Letters

Volumn 331, Issue 1, 2013, Pages 1-10

  Wang, Zifeng ^a   Yao, Hong ^a   Lin, Sheng ^b   Zhu, Xiao ^c   Shen, Zan ^d   Lu, Gang ^a   Poon, Wai Sang ^a   Xie, Dan ^e   Lin, Marie Chia Mi ^a   Kung, Hsiang Fu ^a  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^b Shenzhen Research Institute of Population and Family Planning   (China)

^c GUANGDONG MEDICAL UNIVERSITY   (China)

^d SHANGHAI JIAO TONG UNIVERSITY   (China)

^e SUN YAT SEN UNIVERSITY   (China)

Author keywords

Cancer; Epigenetic regulation; MiRNA; Transcription machinery; Transcriptional regulation

Indexed keywords

DNA DIRECTED RNA POLYMERASE; DNA DIRECTED RNA POLYMERASE III; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LET 7A 1; LET 7D; LET 7F 1; MAX PROTEIN; MICRORNA; MICRORNA 100; MICRORNA 125B 1; MICRORNA 21; MICRORNA 22; MICRORNA 221; MICRORNA 222; MICRORNA 33; MYC PROTEIN; PROTEIN C FOS; PROTEIN C JUN; RNA POLYMERASE II; STAT1 PROTEIN; TRANSCRIPTION FACTOR E2F1; UNCLASSIFIED DRUG;

5' RACE; 5' UNCODING REGION; ACUTE LYMPHOBLASTIC LEUKEMIA; BINDING SITE; CHROMATIN IMMUNOPRECIPITATION; CHROMOSOME 19; DNA METHYLATION; EPIGENETIC REPRESSION; GENE CLUSTER; GENE EXPRESSION; GENE REGULATORY NETWORK; HISTONE MODIFICATION; HOUSEKEEPING GENE; HUMAN; HUMAN GENOME; NCRNA GENE; ONCOGENE C MYC; POLYADENYLATION; POSTTRANSCRIPTIONAL GENE SILENCING; PREDICTION; PRIORITY JOURNAL; PROMOTER REGION; RNA PROCESSING; RNA SEQUENCE; RNA STRUCTURE; SHORT SURVEY; TRANSCRIPTION INITIATION SITE; TRANSCRIPTION REGULATION;

EID: 84873523265     PISSN: 03043835     EISSN: 18727980     Source Type: Journal    
DOI: 10.1016/j.canlet.2012.12.006     Document Type: Review

References (200)

1. Lee Y.S., Dutta A. MicroRNAs in cancer. Annu. Rev. Pathol. 2009, 4:199-227.
2. Lee Y., Jeon K., Lee J.T., Kim S., Kim V.N. MicroRNA maturation: stepwise processing and subcellular localization. EMBO J. 2002, 21:4663-4670.
3. Cullen B.R. Transcription and processing of human microRNA precursors. Mol. Cell 2004, 16:861-865.
4. Lee Y., Kim M., Han J., Yeom K.H., Lee S., Baek S.H., Kim V.N. MicroRNA genes are transcribed by RNA polymerase II. EMBO J. 2004, 23:4051-4060.
5. Denli A.M., Tops B.B., Plasterk R.H., Ketting R.F., Hannon G.J. Processing of primary microRNAs by the microprocessor complex. Nature 2004, 432:231-235.
6. Gregory R.I., Yan K.P., Amuthan G., Chendrimada T., Doratotaj B., Cooch N., Shiekhattar R. The Microprocessor complex mediates the genesis of microRNAs. Nature 2004, 432:235-240.
7. Lee Y., Ahn C., Han J., Choi H., Kim J., Yim J., Lee J., Provost P., Radmark O., Kim S., Kim V.N. The nuclear RNase III Drosha initiates microRNA processing. Nature 2003, 425:415-419.
8. Ruby J.G., Jan C.H., Bartel D.P. Intronic microRNA precursors that bypass Drosha processing. Nature 2007, 448:83-86.
9. Chiang H.R., Schoenfeld L.W., Ruby J.G., Auyeung V.C., Spies N., Baek D., Johnston W.K., Russ C., Luo S.J., Babiarz J.E., Blelloch R., Schroth G.P., Nusbaum C., Bartel D.P. Mammalian microRNAs: experimental evaluation of novel and previously annotated genes. Genome Dev. 2010, 24:992-1009.
10. Berezikov E., Chung W.J., Willis J., Cuppen E., Lai E.C. Mammalian mirtron genes. Mol. Cell 2007, 28:328-336.
11. Havens M.A., Reich A.A., Duelli D.M., Hastings M.L. Biogenesis of mammalian microRNAs by a non-canonical processing pathway. Nucleic Acids Res. 2012, 40:4626-4640.
12. Lund E., Guttinger S., Calado A., Dahlberg J.E., Kutay U. Nuclear export of microRNA precursors. Science 2004, 303:95-98.
13. Yi R., Qin Y., Macara I.G., Cullen B.R. Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs. Genes Dev. 2003, 17:3011-3016.
14. Hutvagner G., McLachlan J., Pasquinelli A.E., Balint E., Tuschl T., Zamore P.D. A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA. Science 2001, 293:834-838.
15. Salzman D.W., Shubert-Coleman J., Furneaux H. P68 RNA helicase unwinds the human let-7 microRNA precursor duplex and is required for let-7-directed silencing of gene expression. J. Biol. Chem. 2007, 282:32773-32779.
16. Humphreys D.T., Westman B.J., Martin D.I., Preiss T. MicroRNAs control translation initiation by inhibiting eukaryotic initiation factor 4E/cap and poly(A) tail function. Proc. Natl. Acad. Sci. USA 2005, 102:16961-16966.
17. Pillai R.S., Bhattacharyya S.N., Artus C.G., Zoller T., Cougot N., Basyuk E., Bertrand E., Filipowicz W. Inhibition of translational initiation by Let-7 MicroRNA in human cells. Science 2005, 309:1573-1576.
18. Wu L., Fan J., Belasco J.G. MicroRNAs direct rapid deadenylation of mRNA. Proc. Natl. Acad. Sci. USA 2006, 103:4034-4039.
19. Guo H., Ingolia N.T., Weissman J.S., Bartel D.P. Mammalian microRNAs predominantly act to decrease target mRNA levels. Nature 2010, 466:835-840.
20. Kloosterman W.P., Plasterk R.H. The diverse functions of microRNAs in animal development and disease. Dev. Cell 2006, 11:441-450.
21. Bartel D.P. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 2004, 116:281-297.
22. He L., Hannon G.J. MicroRNAs: small RNAs with a big role in gene regulation. Nat. Rev. Genet. 2004, 5:522-531.
23. Miska E.A. How microRNAs control cell division, differentiation and death. Curr. Opin. Genet. Dev. 2005, 15:563-568.
24. Wu W., Sun M., Zou G.M., Chen J. MicroRNA and cancer: current status and prospective. Int. J. Cancer 2007, 120:953-960.
25. Wang Y., Lee C.G. MicroRNA and cancer-focus on apoptosis. J. Cell Mol. Med. 2009, 13:12-23.
26. Zhang B., Pan X., Cobb G.P., Anderson T.A. MicroRNAs as oncogenes and tumor suppressors. Dev. Biol. 2007, 302:1-12.
27. Zhang L., Huang J., Yang N., Greshock J., Megraw M.S., Giannakakis A., Liang S., Naylor T.L., Barchetti A., Ward M.R., Yao G., Medina A., O'Brien-Jenkins A., Katsaros D., Hatzigeorgiou A., Gimotty P.A., Weber B.L., Coukos G. MicroRNAs exhibit high frequency genomic alterations in human cancer. Proc. Natl. Acad. Sci. USA 2006, 103:9136-9141.
28. Saini H.K., Griffiths-Jones S., Enright A.J. Genomic analysis of human microRNA transcripts. Proc. Natl. Acad. Sci. USA 2007, 104:17719-17724.
29. Thomson J.M., Newman M., Parker J.S., Morin-Kensicki E.M., Wright T., Hammond S.M. Extensive post-transcriptional regulation of microRNAs and its implications for cancer. Genes Dev. 2006, 20:2202-2207.
30. Schramm L., Hernandez N. Recruitment of RNA polymerase III to its target promoters. Genes Dev. 2002, 16:2593-2620.
31. Zeng Y., Wagner E.J., Cullen B.R. Both natural and designed micro RNAs technique can inhibit the expression of cognate mRNAs when expressed in human cells. Mol. Cell 2002, 9:1327-1333.
32. Zeng Y., Cai X., Cullen B.R. Use of RNA polymerase II to transcribe artificial microRNAs. Methods Enzymol. 2005, 392:371-380.
33. Cai X., Hagedorn C.H., Cullen B.R. Human microRNAs are processed from capped, polyadenylated transcripts that can also function as mRNAs. RNA 2004, 10:1957-1966.
34. Borchert G.M., Lanier W., Davidson B.L. RNA polymerase III transcribes human microRNAs. Nat. Struct. Mol. Biol. 2006, 13:1097-1101.
35. Mahony S., Corcoran D.L., Feingold E., Benos P.V. Regulatory conservation of protein coding and microRNA genes in vertebrates: lessons from the opossum genome. Genome Biol. 2007, 8:R84.
36. Bortolin-Cavaille M.L., Dance M., Weber M., Cavaille J. C19MC microRNAs are processed from introns of large Pol-II, non-protein-coding transcripts. Nucleic Acids Res. 2009, 37:3464-3473.
37. Bracken C.P., Gregory P.A., Kolesnikoff N., Bert A.G., Wang J., Shannon M.F., Goodall G.J. A double-negative feedback loop between ZEB1-SIP1 and the microRNA-200 family regulates epithelial-mesenchymal transition. Cancer Res. 2008, 68:7846-7854.
38. Eis P.S., Tam W., Sun L.P., Chadburn A., Li Z.D., Gomez M.F., Lund E., Dahlberg J.E. Accumulation of miR-155 and BIC RNA in human B cell lymphomas. Proc. Natl. Acad. Sci. USA 2005, 102:3627-3632.
39. Di Leva G., Gasparini P., Piovan C., Ngankeu A., Garofalo M., Taccioli C., Iorio M.V., Li M., Volinia S., Alder H., Nakamura T., Nuovo G., Liu Y., Nephew K.P., Croce C.M. MicroRNA cluster 221-222 and estrogen receptor alpha interactions in breast cancer. J. Natl Cancer Inst. 2010, 102:706-721.
40. Hino K., Fukao T., Watanabe M. Regulatory interaction of HNF1-alpha to microRNA-194 gene during intestinal epithelial cell differentiation. Nucleic Acids Symp. Ser. (Oxf) 2007, 415-416.
41. Hino K., Tsuchiya K., Fukao T., Kiga K., Okamoto R., Kanai T., Watanabe M. Inducible expression of microRNA-194 is regulated by HNF-1alpha during intestinal epithelial cell differentiation. RNA 2008, 14:1433-1442.
42. Grady W.M., Parkin R.K., Mitchell P.S., Lee J.H., Kim Y.H., Tsuchiya K.D., Washington M.K., Paraskeva C., Willson J.K., Kaz A.M., Kroh E.M., Allen A., Fritz B.R., Markowitz S.D., Tewari M. Epigenetic silencing of the intronic microRNA hsa-miR-342 and its host gene EVL in colorectal cancer. Oncogene 2008, 27:3880-3888.
43. Corney D.C., Flesken-Nikitin A., Godwin A.K., Wang W., Nikitin A.Y. MicroRNA-34b and MicroRNA-34c are targets of p53 and cooperate in control of cell proliferation and adhesion-independent growth. Cancer Res. 2007, 67:8433-8438.
44. Toyota M., Suzuki H., Sasaki Y., Maruyama R., Imai K., Shinomura Y., Tokino T. Epigenetic silencing of microRNA-34b/c and B-cell translocation gene 4 is associated with CpG island methylation in colorectal cancer. Cancer Res. 2008, 68:4123-4132.
45. Tarasov V., Jung P., Verdoodt B., Lodygin D., Epanchintsev A., Menssen A., Meister G., Hermeking H. Differential regulation of microRNAs by p53 revealed by massively parallel sequencing: miR-34a is a p53 target that induces apoptosis and G1-arrest. Cell Cycle 2007, 6:1586-1593.
46. Bommer G.T., Gerin I., Feng Y., Kaczorowski A.J., Kuick R., Love R.E., Zhai Y., Giordano T.J., Qin Z.S., Moore B.B., MacDougald O.A., Cho K.R., Fearon E.R. P53-mediated activation of miRNA34 candidate tumor-suppressor genes. Curr. Biol. 2007, 17:1298-1307.
47. Pulikkan J.A., Dengler V., Peramangalam P.S., Peer Zada A.A., Muller-Tidow C., Bohlander S.K., Tenen D.G., Behre G. Cell-cycle regulator E2F1 and microRNA-223 comprise an autoregulatory negative feedback loop in acute myeloid leukemia. Blood 2010, 115:1768-1778.
48. Fazi F., Racanicchi S., Zardo G., Starnes L.M., Mancini M., Travaglini L., Diverio D., Ammatuna E., Cimino G., Lo-Coco F., Grignani F., Nervi C. Epigenetic silencing of the myelopoiesis regulator microRNA-223 by the AML1/ETO oncoprotein. Cancer Cell 2007, 12:457-466.
49. Marson A., Levine S.S., Cole M.F., Frampton G.M., Brambrink T., Johnstone S., Guenther M.G., Johnston W.K., Wernig M., Newman J., Calabrese J.M., Dennis L.M., Volkert T.L., Gupta S., Love J., Hannett N., Sharp P.A., Bartel D.P., Jaenisch R., Young R.A. Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells. Cell 2008, 134:521-533.
50. Wang X., Xuan Z., Zhao X., Li Y., Zhang M.Q. High-resolution human core-promoter prediction with CoreBoost_HM. Genome Res. 2009, 19:266-275.
51. Ozsolak F., Poling L.L., Wang Z., Liu H., Liu X.S., Roeder R.G., Zhang X., Song J.S., Fisher D.E. Chromatin structure analyses identify miRNA promoters. Genes Dev. 2008, 22:3172-3183.
52. Corcoran D.L., Pandit K.V., Gordon B., Bhattacharjee A., Kaminski N., Benos P.V. Features of mammalian microRNA promoters emerge from polymerase II chromatin immunoprecipitation data. PLoS ONE 2009, 4:e5279.
53. Zhou X., Ruan J., Wang G., Zhang W. Characterization and identification of microRNA core promoters in four model species. PLoS Comput. Biol. 2007, 3:e37.
54. Monteys A.M., Spengler R.M., Wan J., Tecedor L., Lennox K.A., Xing Y., Davidson B.L. Structure and activity of putative intronic miRNA promoters. Rna-a Publication of the Rna Society 2010, 16:495-505.
55. Dieci G., Fiorino G., Castelnuovo M., Teichmann M., Pagano A. The expanding RNA polymerase III transcriptome. Trends Genet. 2007, 23:614-622.
56. Fujita S., Ito T., Mizutani T., Minoguchi S., Yamamichi N., Sakurai K., Iba H. MiR-21 Gene expression triggered by AP-1 is sustained through a double-negative feedback mechanism. J. Mol. Biol. 2008, 378:492-504.
57. Rodriguez A., Griffiths-Jones S., Ashurst J.L., Bradley A. Identification of mammalian microRNA host genes and transcription units. Genome Res. 2004, 14:1902-1910.
58. Baskerville S., Bartel D.P. Microarray profiling of microRNAs reveals frequent coexpression with neighboring miRNAs and host genes. RNA 2005, 11:241-247.
59. Najafi-Shoushtari S.H., Kristo F., Li Y., Shioda T., Cohen D.E., Gerszten R.E., Naar A.M. MicroRNA-33 and the SREBP host genes cooperate to control cholesterol homeostasis. Science 2010, 328:1566-1569.
60. He L., Thomson J.M., Hemann M.T., Hernando-Monge E., Mu D., Goodson S., Powers S., Cordon-Cardo C., Lowe S.W., Hannon G.J., Hammond S.M. A microRNA polycistron as a potential human oncogene. Nature 2005, 435:828-833.
61. O'Donnell K.A., Wentzel E.A., Zeller K.I., Dang C.V., Mendell J.T. C-Myc-regulated microRNAs modulate E2F1 expression. Nature 2005, 435:839-843.
62. Wang Z., Lin S., Li J.J., Xu Z., Yao H., Zhu X., Xie D., Shen Z., Sze J., Li K., Lu G., Chan D.T., Poon W.S., Kung H.F., Lin M.C. MYC protein inhibits transcription of the microRNA cluster MC-let-7a-1-let-7d via noncanonical E-box. J. Biol. Chem. 2011, 286:39703-39714.
63. Song G., Wang L. Transcriptional mechanism for the paired miR-433 and miR-127 genes by nuclear receptors SHP and ERRgamma. Nucleic Acids Res. 2008, 36:5727-5735.
64. Cooper S.J., Trinklein N.D., Anton E.D., Nguyen L., Myers R.M. Comprehensive analysis of transcriptional promoter structure and function in 1% of the human genome. Genome Res. 2006, 16:1-10.
65. He L., He X., Lim L.P., de Stanchina E., Xuan Z., Liang Y., Xue W., Zender L., Magnus J., Ridzon D., Jackson A.L., Linsley P.S., Chen C., Lowe S.W., Cleary M.A., Hannon G.J. A microRNA component of the p53 tumour suppressor network. Nature 2007, 447:1130-1134.
66. Talotta F., Cimmino A., Matarazzo M.R., Casalino L., De Vita G., D'Esposito M., Di Lauro R., Verde P. An autoregulatory loop mediated by miR-21 and PDCD4 controls the AP-1 activity in RAS transformation. Oncogene 2009, 28:73-84.
67. Topisirovic I., Svitkin Y.V., Sonenberg N., Shatkin A.J. Cap and cap-binding proteins in the control of gene expression. Wiley Interdiscipl. Rev. RNA 2011, 2:277-298.
68. Gruber J.J., Zatechka D.S., Sabin L.R., Yong J., Lum J.J., Kong M., Zong W.X., Zhang Z., Lau C.K., Rawlings J., Cherry S., Ihle J.N., Dreyfuss G., Thompson C.B. Ars2 links the nuclear cap-binding complex to RNA interference and cell proliferation. Cell 2009, 138:328-339.
69. Abeel T., Saeys Y., Bonnet E., Rouze P., Van de Peer Y. Generic eukaryotic core promoter prediction using structural features of DNA. Genome Res. 2008, 18:310-323.
70. Kouzarides T. Chromatin modifications and their function. Cell 2007, 128:693-705.
71. Barski A., Cuddapah S., Cui K., Roh T.Y., Schones D.E., Wang Z., Wei G., Chepelev I., Zhao K. High-resolution profiling of histone methylations in the human genome. Cell 2007, 129:823-837.
72. Schones D.E., Cui K., Cuddapah S., Roh T.Y., Barski A., Wang Z., Wei G., Zhao K. Dynamic regulation of nucleosome positioning in the human genome. Cell 2008, 132:887-898.
73. Mikkelsen T.S., Ku M., Jaffe D.B., Issac B., Lieberman E., Giannoukos G., Alvarez P., Brockman W., Kim T.K., Koche R.P., Lee W., Mendenhall E., O'Donovan A., Presser A., Russ C., Xie X., Meissner A., Wernig M., Jaenisch R., Nusbaum C., Lander E.S., Bernstein B.E. Genome-wide maps of chromatin state in pluripotent and lineage-committed cells. Nature 2007, 448:553-560.
74. Bernstein B.E., Kamal M., Lindblad-Toh K., Bekiranov S., Bailey D.K., Huebert D.J., McMahon S., Karlsson E.K., Kulbokas E.J., Gingeras T.R., Schreiber S.L., Lander E.S. Genomic maps and comparative analysis of histone modifications in human and mouse. Cell 2005, 120:169-181.
75. Bernstein B.E., Mikkelsen T.S., Xie X., Kamal M., Huebert D.J., Cuff J., Fry B., Meissner A., Wernig M., Plath K., Jaenisch R., Wagschal A., Feil R., Schreiber S.L., Lander E.S. A bivalent chromatin structure marks key developmental genes in embryonic stem cells. Cell 2006, 125:315-326.
76. Gilchrist D.A., Fargo D.C., Adelman K. Using ChIP-chip and ChIP-seq to study the regulation of gene expression: genome-wide localization studies reveal widespread regulation of transcription elongation. Methods 2009, 48:398-408.
77. The ENCODE (ENCyclopedia of DNA Elements) Project. Science 2004, 306:636-640.
78. Kawaji H., Severin J., Lizio M., Waterhouse A., Katayama S., Irvine K.M., Hume D.A., Forrest A.R., Suzuki H., Carninci P., Hayashizaki Y., Daub C.O. The FANTOM web resource from mammalian transcriptional landscape to its dynamic regulation. Genome Biol. 2009, 10:R40.
79. Davuluri R.V., Grosse I., Zhang M.Q. Computational identification of promoters and first exons in the human genome. Nat. Genet. 2001, 29:412-417.
80. Shiraki T., Kondo S., Katayama S., Waki K., Kasukawa T., Kawaji H., Kodzius R., Watahiki A., Nakamura M., Arakawa T., Fukuda S., Sasaki D., Podhajska A., Harbers M., Kawai J., Carninci P., Hayashizaki Y. Cap analysis gene expression for high-throughput analysis of transcriptional starting point and identification of promoter usage. Proc. Natl. Acad. Sci. USA 2003, 100:15776-15781.
81. O'Hara S.P., Splinter P.L., Gajdos G.B., Trussoni C.E., Fernandez-Zapico M.E., Chen X.M., Larusso N.F. NF kappa B p50-CCAAT/Enhancer-binding Protein beta (C/EBP beta)-mediated Transcriptional Repression of MicroRNA let-7i following Microbial Infection. J. Biol. Chem. 2010, 285:216-225.
82. Fukao T., Fukuda Y., Kiga K., Sharif J., Hino K., Enomoto Y., Kawamura A., Nakamura K., Takeuchi T., Tanabe M. An evolutionarily conserved mechanism for microRNA-223 expression revealed by microRNA gene profiling. Cell 2007, 129:617-631.
83. Goll M.G., Bestor T.H. Eukaryotic cytosine methyltransferases. Annu. Rev. Biochem. 2005, 74:481-514.
84. Bernstein B.E., Meissner A., Lander E.S. The mammalian epigenome. Cell 2007, 128:669-681.
85. Lujambio A., Ropero S., Ballestar E., Fraga M.F., Cerrato C., Setien F., Casado S., Suarez-Gauthier A., Sanchez-Cespedes M., Git A., Spiteri I., Das P.P., Caldas C., Miska E., Esteller M. Genetic unmasking of an epigenetically silenced microRNA in human cancer cells. Cancer Res. 2007, 67:1424-1429.
86. Roman-Gomez J., Agirre X., Jimenez-Velasco A., Arqueros V., Vilas-Zornoza A., Rodriguez-Otero P., Martin-Subero I., Garate L., Cordeu L., San Jose-Eneriz E., Martin V., Castillejo J.A., Bandres E., Calasanz M.J., Siebert R., Heiniger A., Torres A., Prosper F. Epigenetic regulation of microRNAs in acute lymphoblastic leukemia. J. Clin. Oncol. 2009, 27:1316-1322.
87. Agirre X., Vilas-Zornoza A., Jimenez-Velasco A., Martin-Subero J.I., Cordeu L., Garate L., San Jose-Eneriz E., Abizanda G., Rodriguez-Otero P., Fortes P., Rifon J., Bandres E., Calasanz M.J., Martin V., Heiniger A., Torres A., Siebert R., Roman-Gomez J., Prosper F. Epigenetic silencing of the tumor suppressor microRNA Hsa-miR-124a regulates CDK6 expression and confers a poor prognosis in acute lymphoblastic leukemia. Cancer Res. 2009, 69:4443-4453.
88. Ando T., Yoshida T., Enomoto S., Asada K., Tatematsu M., Ichinose M., Sugiyama T., Ushijima T. DNA methylation of microRNA genes in gastric mucosae of gastric cancer patients: it is possible involvement in the formation of epigenetic field defect. Int. J. Cancer 2009, 124:2367-2374.
89. Augoff K., McCue B., Plow E.F., Sossey-Alaoui K. miR-31 and its host gene lncRNA LOC554202 are regulated by promoter hypermethylation in triple-negative breast cancer. Mol. Cancer 2012, 11.
90. Szulwach K.E., Li X.K., Smrt R.D., Li Y.J., Luo Y.P., Lin L., Santistevan N.J., Li W.D., Zhao X.Y., Jin P. Cross talk between microRNA and epigenetic regulation in adult neurogenesis. J. Cell Biol. 2010, 189:U127-U181.
91. Scott G.K., Mattie M.D., Berger C.E., Benz S.C., Benz C.C. Rapid alteration of microRNA levels by histone deacetylase inhibition. Cancer Res. 2006, 66:1277-1281.
92. Juan A.H., Kumar R.M., Marx J.G., Young R.A., Sartorelli V. Mir-214-dependent regulation of the polycomb protein Ezh2 in skeletal muscle and embryonic stem cells. Mol. Cell 2009, 36:61-74.
93. Saito Y., Liang G., Egger G., Friedman J.M., Chuang J.C., Coetzee G.A., Jones P.A. Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells. Cancer Cell 2006, 9:435-443.
94. Saito Y., Friedman J.M., Chihara Y., Egger G., Chuang J.C., Liang G. Epigenetic therapy upregulates the tumor suppressor microRNA-126 and its host gene EGFL7 in human cancer cells. Biochem. Biophys. Res. Commun. 2009, 379:726-731.
95. Datta J., Kutay H., Nasser M.W., Nuovo G.J., Wang B., Majumder S., Liu C.G., Volinia S., Croce C.M., Schmittgen T.D., Ghoshal K., Jacob S.T. Methylation mediated silencing of MicroRNA-1 gene and its role in hepatocellular carcinogenesis. Cancer Res. 2008, 68:5049-5058.
96. Noonan E.J., Place R.F., Pookot D., Basak S., Whitson J.M., Hirata H., Giardina C., Dahiya R. MiR-449a targets HDAC-1 and induces growth arrest in prostate cancer. Oncogene 2009, 28:1714-1724.
97. Varambally S., Cao Q., Mani R.S., Shankar S., Wang X., Ateeq B., Laxman B., Cao X., Jing X., Ramnarayanan K., Brenner J.C., Yu J., Kim J.H., Han B., Tan P., Kumar-Sinha C., Lonigro R.J., Palanisamy N., Maher C.A., Chinnaiyan A.M. Genomic loss of microRNA-101 leads to overexpression of histone methyltransferase EZH2 in cancer. Science 2008, 322:1695-1699.
98. Fabbri M., Garzon R., Cimmino A., Liu Z., Zanesi N., Callegari E., Liu S., Alder H., Costinean S., Fernandez-Cymering C., Volinia S., Guler G., Morrison C.D., Chan K.K., Marcucci G., Calin G.A., Huebner K., Croce C.M. MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B. Proc. Natl. Acad. Sci. USA 2007, 104:15805-15810.
99. Duursma A.M., Kedde M., Schrier M., le Sage C., Agami R. MiR-148 targets human DNMT3b protein coding region. RNA 2008, 14:872-877.
100. Johnson S.M., Grosshans H., Shingara J., Byrom M., Jarvis R., Cheng A., Labourier E., Reinert K.L., Brown D., Slack F.J. RAS is regulated by the let-7 microRNA family. Cell 2005, 120:635-647.
101. Sampson V.B., Rong N.H., Han J., Yang Q., Aris V., Soteropoulos P., Petrelli N.J., Dunn S.P., Krueger L.J. MicroRNA let-7a down-regulates MYC and reverts MYC-induced growth in Burkitt lymphoma cells. Cancer Res. 2007, 67:9762-9770.
102. Park S.M., Shell S., Radjabi A.R., Schickel R., Feig C., Boyerinas B., Dinulescu D.M., Lengyel E., Peter M.E. Let-7 prevents early cancer progression by suppressing expression of the embryonic gene HMGA2. Cell Cycle 2007, 6:2585-2590.
103. Garzon R., Pichiorri F., Palumbo T., Visentini M., Aqeilan R., Cimmino A., Wang H., Sun H., Volinia S., Alder H., Calin G.A., Liu C.G., Andreeff M., Croce C.M. MicroRNA gene expression during retinoic acid-induced differentiation of human acute promyelocytic leukemia. Oncogene 2007, 26:4148-4157.
104. Srivastava D., Zhao Y., Samal E. Serum response factor regulates a muscle-specific microRNA that targets Hand2 during cardiogenesis. Nature 2005, 436:214-220.
105. Lu L.N., Zhou L., Chen E.Z., Sun K., Jiang P.Y., Wang L.J., Su X.X., Sun H., Wang H.T. A Novel YY1-miR-1 Regulatory Circuit in Skeletal Myogenesis Revealed by Genome-Wide Prediction of YY1-miRNA Network. PLoS ONE 2012, 7.
106. Chen J.F., Tao Y.Z., Li J.A., Deng Z.L., Yan Z., Xiao X.A., Wang D.Z. MicroRNA-1 and microRNA-206 regulate skeletal muscle satellite cell proliferation and differentiation by repressing Pax7. J. Cell Biol. 2010, 190:867-879.
107. Reddy S.D., Ohshiro K., Rayala S.K., Kumar R. MicroRNA-7, a homeobox D10 target, inhibits p21-activated kinase 1 and regulates its functions. Cancer Res. 2008, 68:8195-8200.
108. Ma L., Young J., Prabhala H., Pan E., Mestdagh P., Muth D., Teruya-Feldstein J., Reinhardt F., Onder T.T., Valastyan S., Westermann F., Speleman F., Vandesompele J., Weinberg R.A. MiR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis. Nat. Cell Biol. 2010, 12:U247-U252.
109. Ma L., Teruya-Feldstein J., Weinberg R.A. Tumour invasion and metastasis initiated by microRNA-10b in breast cancer. Nature 2007, 449:682-688.
110. Zhao H., Kalota A., Jin S., Gewirtz A.M. The c-myb proto-oncogene and microRNA-15a comprise an active autoregulatory feedback loop in human hematopoietic cells. Blood 2009, 113:505-516.
111. Ofir M., Hacohen D., Ginsberg D. MiR-15 and miR-16 Are direct transcriptional targets of E2F1 that limit E2F-induced proliferation by targeting cyclin E. Mol. Cancer Res. 2011, 9:440-447.
112. Zhang X., Chen X., Lin J., Lwin T., Wright G., Moscinski L.C., Dalton W.S., Seto E., Wright K., Sotomayor E., Tao J. Myc represses miR-15a/miR-16-1 expression through recruitment of HDAC3 in mantle cell and other non-Hodgkin B-cell lymphomas. Oncogene 2012, 31:3002-3008.
113. Ji M., Rao E.Y., Ramachandrareddy H., Shen Y.L., Jiang C.S., Chen J.X., Hu Y.Q., Rizzino A., Chan W.C., Fu K., McKeithan T.W. The miR-17-92 MicroRNA cluster is regulated by multiple mechanisms in B-Cell malignancies. Am. J. Pathol. 2011, 179:1645-1656.
114. Zhou R., Hu G., Gong A.Y., Chen X.M. Binding of NF-kappaB p65 subunit to the promoter elements is involved in LPS-induced transactivation of miRNA genes in human biliary epithelial cells. Nucleic Acids Res. 2010, 38:3222-3232.
115. Du J., Yang S., An D., Hu F., Yuan W., Zhai C., Zhu T. BMP-6 inhibits microRNA-21 expression in breast cancer through repressing deltaEF1 and AP-1. Cell Res. 2009, 19:487-496.
116. Lan F., Yue X., Han L., Shi Z., Yang Y., Pu P., Yao Z., Kang C. Genome-wide identification of TCF7L2/TCF4 target miRNAs reveals a role for miR-21 in Wnt-driven epithelial cancer. Int. J. Oncol. 2012, 40:519-526.
117. Velu C.S., Baktula A.M., Grimes H.L. Gfi1 regulates miR-21 and miR-196b to control myelopoiesis. Blood 2009, 113:4720-4728.
118. Li P.F., Lin Z.Q., Murtaza I., Wang K., Jiao J.Q., Gao J. MiR-23a functions downstream of NFATc3 to regulate cardiac hypertrophy. Proc. Natl. Acad. Sci. USA 2009, 106:12103-12108.
119. Wang B., Hsu S.H., Frankel W., Ghoshal K., Jacob S.T. Stat3-mediated activation of microRNA-23a suppresses gluconeogenesis in hepatocellular carcinoma by down-regulating Glucose-6-phosphatase and peroxisome proliferator-activated receptor gamma, coactivator 1 alpha. Hepatology 2012, 56:186-197.
120. Dang C.V., Gao P., Tchernyshyov I., Chang T.C., Lee Y.S., Kita K., Ochi T., Zeller K.I., De Marzo A.M., Van Eyk J.E., Mendell J.T. C-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism. Nature 2009, 458:U100-U762.
121. Yang X., Sun Q., Zhang Y., Yang G., Chen X.P., Zhang Y.G., Cao G.J., Wang J., Sun Y.X., Zhang P., Fan M., Shao N.S. Transforming growth factor-beta-regulated miR-24 promotes skeletal muscle differentiation. Nucleic Acids Res. 2008, 36:2690-2699.
122. Fletcher C.E., Dart D.A., Sita-Lumsden A., Cheng H., Rennie P.S., Bevan C.L. Androgen-regulated processing of the oncomir MiR-27a, which targets Prohibitin in prostate cancer. Hum. Mol. Genet. 2012, 21:3112-3127.
123. Mohamed J.S., Lopez M.A., Boriek A.M. Mechanical stretch up-regulates microRNA-26a and induces human airway smooth muscle hypertrophy by suppressing glycogen synthase kinase-3beta. J. Biol. Chem. 2010, 285:29336-29347.
124. Salvatori B., Iosue I., Djodji Damas N., Mangiavacchi A., Chiaretti S., Messina M., Padula F., Guarini A., Bozzoni I., Fazi F., Fatica A. Critical role of c-myc in acute myeloid leukemia involving direct regulation of miR-26a and histone methyltransferase EZH2. Genes Cancer 2011, 2:585-592.
125. Pabst T., Eyholzer M., Schmid S., Wilkens L., Mueller B.U. The tumour-suppressive miR-29a/b1 cluster is regulated by CEBPA and blocked in human AML. Brit. J. Cancer 2010, 103:275-284.
126. Chen K.C., Liao Y.C., Hsieh I.C., Wang Y.S., Hu C.Y., Juo S.H.F. OxLDL causes both epigenetic modification and signaling regulation on the microRNA-29b gene: novel mechanisms for cardiovascular diseases. J. Mol. Cell. Cardiol. 2012, 52:587-595.
127. Winbanks C.E., Wang B., Beyer C., Koh P., White L., Kantharidis P., Gregorevic P. TGF-beta regulates miR-206 and miR-29 to control myogenic differentiation through regulation of HDAC4. J. Biol. Chem. 2011, 286:13805-13814.
128. Qin W., Chung A.C.K., Huang X.R., Meng X.M., Hui D.S.C., Yu C.M., Sung J.J.Y., Lan H.Y. TGF-beta/Smad3 signaling promotes renal fibrosis by inhibiting miR-29. J. Am. Soc. Nephrol. 2011, 22:1462-1474.
129. Wang H., Garzon R., Sun H., Ladner K.J., Singh R., Dahlman J., Cheng A., Hall B.M., Qualman S.J., Chandler D.S., Croce C.M., Guttridge D.C. NF-kappaB-YY1-miR-29 regulatory circuitry in skeletal myogenesis and rhabdomyosarcoma. Cancer Cell 2008, 14:369-381.
130. Jalava S.E., Urbanucci A., Latonen L., Waltering K.K., Sahu B., Janne O.A., Seppala J., Lahdesmaki H., Tammela T.L., Visakorpi T. Androgen-regulated miR-32 targets BTG2 and is overexpressed in castration-resistant prostate cancer. Oncogene 2012.
131. Pulikkan J.A., Peramangalam P.S., Dengler V., Ho P.A., Preudhomme C., Meshinchi S., Christopeit M., Nibourel O., Muller-Tidow C., Bohlander S.K., Tenen D.G., Behre G. C/EBPalpha regulated microRNA-34a targets E2F3 during granulopoiesis and is down-regulated in AML with CEBPA mutations. Blood 2010, 116:5638-5649.
132. Sui G.C., Cao P., Deng Z.Y., Wan M.M., Huang W.W., Cramer S.D., Xu J.F., Lei M. MicroRNA-101 negatively regulates Ezh2 and its expression is modulated by androgen receptor and HIF-1 alpha/HIF-1 beta. Mol. Cancer 2010, 9.
133. Petrocca F., Visone R., Onelli M.R., Shah M.H., Nicoloso M.S., de Martino I., Iliopoulos D., Pilozzi E., Liu C.G., Negrini M., Cavazzini L., Volinia S., Alder H., Ruco L.P., Baldassarre G., Croce C.M., Vecchione A. E2F1-regulated microRNAs impair TGFbeta-dependent cell-cycle arrest and apoptosis in gastric cancer. Cancer Cell 2008, 13:272-286.
134. Zeng C., Wang R., Li D., Lin X.J., Wei Q.K., Yuan Y., Wang Q., Chen W., Zhuang S.M. A novel GSK-3 beta-C/EBP alpha-miR-122-insulin-like growth factor 1 receptor regulatory circuitry in human hepatocellular carcinoma. Hepatology 2010, 52:1702-1712.
135. Li Z.Y., Xi Y., Zhu W.N., Zeng C., Zhang Z.Q., Guo Z.C., Hao D.L., Liu G., Feng L., Chen H.Z., Chen F., Lv X., Liu D.P., Liang C.C. Positive regulation of hepatic miR-122 expression by HNF4alpha. J. Hepatol. 2011, 55:602-611.
136. Hatziapostolou M., Polytarchou C., Aggelidou E., Drakaki A., Poultsides G.A., Jaeger S.A., Ogata H., Karin M., Struhl K., Hadzopoulou-Cladaras M., Iliopoulos D. An HNF4alpha-miRNA inflammatory feedback circuit regulates hepatocellular oncogenesis. Cell 2011, 147:1233-1247.
137. Conaco C., Otto S., Han J.J., Mandel G. Reciprocal actions of REST and a microRNA promote neuronal identity. Proc. Natl. Acad. Sci. USA 2006, 103:2422-2427.
138. Vo N., Klein M.E., Varlamova O., Keller D.M., Yamamoto T., Goodman R.H., Impey S. A cAMP-response element binding protein-induced microRNA regulates neuronal morphogenesis. Proc. Natl. Acad. Sci. USA 2005, 102:16426-16431.
139. Zhang S.Y., Hao J., Xie F., Hu X.G., Liu C., Tong J., Zhou J.D., Wu J.C., Shao C.H. Downregulation of miR-132 by promoter methylation contributes to pancreatic cancer development. Carcinogenesis 2011, 32:1183-1189.
140. Lodish H.F., Rao P.K., Kumar R.M., Farkhondeh M., Baskerville S. Myogenic factors that regulate expression of muscle-specific, microRNAs. Proc. Natl. Acad. Sci. USA 2006, 103:8721-8726.
141. Kim J., Inoue K., Ishii J., Vanti W.B., Voronov S.V., Murchison E., Hannon G., Abeliovich A. A MicroRNA feedback circuit in midbrain dopamine neurons. Science 2007, 317:1220-1224.
142. Yang J., Qin S.Y., Yi C.Q., Ma G., Zhu H., Zhou W.R., Xiong Y.Y., Zhu X.M., Wang Y.J., He L., Guo X.Z. MiR-140 is co-expressed with Wwp2-C transcript and activated by Sox9 to target Sp1 in maintaining the chondrocyte proliferation. FEBS Lett. 2011, 585:2992-2997.
143. Yamashita S., Miyaki S., Kato Y., Yokoyama S., Sato T., Barrionuevo F., Akiyama H., Scherer G., Takada S., Asahara H. L-Sox5 and Sox6 proteins enhance chondrogenic miR-140 MicroRNA expression by strengthening dimeric Sox9 activity. J. Biol. Chem. 2012, 287:22206-22215.
144. Cordes K.R., Sheehy N.T., White M.P., Berry E.C., Morton S.U., Muth A.N., Lee T.H., Miano J.M., Ivey K.N., Srivastava D. MiR-145 and miR-143 regulate smooth muscle cell fate and plasticity. Nature 2009, 460:705-710.
145. Boucher J.M., Peterson S.M., Urs S., Zhang C.X., Liaw L. The miR-143/145 cluster is a novel transcriptional target of Jagged-1/Notch signaling in vascular smooth muscle cells. (vol. 286, pp. 28312, 2011). J. Biol. Chem. 2012, 287:18585.
146. Dahiya R., Suh S.O., Chen Y., Zaman M.S., Hirata H., Yamamura S., Shahryari V., Liu J., Tabatabai Z.L., Kakar S., Deng G.R., Tanaka Y. MicroRNA-145 is regulated by DNA methylation and p53 gene mutation in prostate cancer. Carcinogenesis 2011, 32:772-778.
147. Zhang X., Liu S., Hu T., He Y., Sun S. Up-regulated microRNA-143 transcribed by nuclear factor kappa B enhances hepatocarcinoma metastasis by repressing fibronectin expression. Hepatology 2009, 50:490-499.
148. Sachdeva M., Liu Q., Cao J., Lu Z., Mo Y.Y. Negative regulation of miR-145 by C/EBP-beta through the Akt pathway in cancer cells. Nucleic Acids Res. 2012, 40:6683-6692.
149. Kent K.F.-T., Halushka MK RREB1 repressed miR-143/145 modulates KRAS signaling through downregulation of multiple targets. Oncogene 2012, 10.
150. Cameron J.E., Yin Q., Fewell C., Lacey M., McBride J., Wang X., Lin Z., Schaefer B.C., Flemington E.K. Epstein-Barr virus latent membrane protein 1 induces cellular MicroRNA miR-146a, a modulator of lymphocyte signaling pathways. J. Virol. 2008, 82:1946-1958.
151. Taganov K.D., Boldin M.P., Chang K.J., Baltimore D. NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses. Proc. Natl. Acad. Sci. USA 2006, 103:12481-12486.
152. Zou Q.M., Liu Z., Xiao B., Tang B., Li B.S., Li N., Zhu E.D., Guo G., Gu J.A., Zhuang Y.A., Liu X.F., Ding H.L., Zhao X.Y., Guo H., Mao X.H. Up-regulated microRNA-146a negatively modulate Helicobacter pylori-induced inflammatory response in human gastric epithelial cells. Microbes Infect. 2010, 12:854-863.
153. Lu L.F., Boldin M.P., Chaudhry A., Lin L.L., Taganov K.D., Hanada T., Yoshimura A., Baltimore D., Rudensky A.Y. Function of miR-146a in controlling treg cell-mediated regulation of Th1 responses. Cell 2010, 142:914-929.
154. Xiao B., Liu Z., Li B.S., Tang B., Li W., Guo G., Shi Y., Wang F., Wu Y., Tong W.D., Guo H., Mao X.H., Zou Q.M. Induction of microRNA-155 during Helicobacter pylori infection and its negative regulatory role in the inflammatory response. J. Infect. Dis. 2009, 200:916-925.
155. Thompson R.C., Herscovitch M., Zhao I., Ford T.J., Gilmore T.D. NF-kappaB down-regulates expression of the B-lymphoma marker CD10 through a miR-155/PU.1 pathway. J. Biol. Chem. 2011, 286:1675-1682.
156. Mallardo M., Gatto G., Rossi A., Rossi D., Kroening S., Bonatti S. Epstein-Barr virus latent membrane protein 1 trans-activates miR-155 transcription through the NF-kappa B pathway. Nucleic Acids Res. 2008, 36:6608-6619.
157. Liu S.H., Yang Y., Wu J.R. TNF alpha-induced up-regulation of miR-155 inhibits adipogenesis by down-regulating early adipogenic transcription factors. Biochem. Biophys. Res. Commun. 2011, 414:618-624.
158. Flemington E., Yin Q.Y., Wang X., McBride J., Fewell C. B-cell receptor activation induces BIC/miR-155 expression through a conserved AP-1 element. J. Biol. Chem. 2008, 283:2654-2662.
159. Vargova K., Curik N., Burda P., Basova P., Kulvait V., Pospisil V., Savvulidi F., Kokavec J., Necas E., Berkova A., Obrtlikova P., Karban J., Mraz M., Pospisilova S., Mayer J., Trneny M., Zavadil J., Stopka T. MYB transcriptionally regulates the miR-155 host gene in chronic lymphocytic leukemia. Blood 2011, 117:3816-3825.
160. Lu L.F., Thai T.H., Calado D.P., Chaudhry A., Kubo M., Tanaka K., Loeb G.B., Lee H., Yoshimura A., Rajewsky K., Rudensky A.Y. Foxp3-dependent microRNA155 confers competitive fitness to regulatory T cells by targeting SOCS1 protein. Immunity 2009, 30:80-91.
161. Lu L., Katsaros D., Shaverdashvili K., Qian B., Wu Y., de la Longrais I.A., Preti M., Menato G., Yu H. Pluripotent factor lin-28 and its homologue lin-28b in epithelial ovarian cancer and their associations with disease outcomes and expression of let-7a and IGF-II. Eur. J. Cancer 2009, 45:2212-2218.
162. Liu Q., Chen J., Liu L., Zhang J., Wang D., Ma L., He Y., Liu Y., Liu Z., Wu J. The X protein of hepatitis B virus inhibits apoptosis in hepatoma cells through enhancing the methionine adenosyltransferase 2A gene expression and reducing S-adenosylmethionine production. J. Biol. Chem. 2011, 286:17168-17180.
163. Ji J., Yamashita T., Wang X.W. Wnt/beta-catenin signaling activates microRNA-181 expression in hepatocellular carcinoma. Cell Biosci. 2011, 1:4.
164. Iliopoulos D., Rotem A., Struhl K. Inhibition of miR-193a expression by Max and RXRalpha activates K-Ras and PLAU to mediate distinct aspects of cellular transformation. Cancer Res. 2011, 71:5144-5153.
165. Kato M., Zhang J., Wang M., Lanting L., Yuan H., Rossi J.J., Natarajan R. MicroRNA-192 in diabetic kidney glomeruli and its function in TGF-beta-induced collagen expression via inhibition of E-box repressors. Proc. Natl. Acad. Sci. USA 2007, 104:3432-3437.
166. Liao Y.L., Hu L.Y., Tsai K.W., Wu C.W., Chan W.C., Li S.C., Lai C.H., Ho M.R., Fang W.L., Huang K.H., Lin W.C. Transcriptional regulation of miR-196b by ETS2 in gastric cancer cells. Carcinogenesis 2012, 33:760-769.
167. Lee Y.B., Bantounas I., Lee D.Y., Phylactou L., Caldwell M.A., Uney J.B. Twist-1 regulates the miR-199a/214 cluster during development. Nucleic Acids Res. 2009, 37:123-128.
168. Sakurai K., Furukawa C., Haraguchi T., Inada K., Shiogama K., Tagawa T., Fujita S., Ueno Y., Ogata A., Ito M., Tsutsumi Y., Iba H. MicroRNAs miR-199a-5p and-3p target the brm subunit of SWI/SNF to generate a double-negative feedback loop in a variety of human cancers. Cancer Res. 2011, 71:1680-1689.
169. Knouf E.C., Garg K., Arroyo J.D., Correa Y., Sarkar D., Parkin R.K., Wurz K., O'Briant K.C., Godwin A.K., Urban N.D., Ruzzo W.L., Gentleman R., Drescher C.W., Swisher E.M., Tewari M. An integrative genomic approach identifies p73 and p63 as activators of miR-200 microRNA family transcription. Nucleic Acids Res. 2012, 40:499-510.
170. Brabletz T., Burk U., Schubert J., Wellner U., Schmalhofer O., Vincan E., Spaderna S. A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells. EMBO Rep. 2008, 9:582-589.
171. Rokavec M., Wu W.L., Luo J.L. IL6-Mediated suppression of miR-200c directs constitutive activation of inflammatory signaling circuit driving transformation and tumorigenesis. Mol. Cell 2012, 45:777-789.
172. Piovan C., Palmieri D., Di Leva G., Braccioli L., Casalini P., Nuovo G., Tortoreto M., Sasso M., Plantamura I., Triulzi T., Taccioli C., Tagliabue E., Iorio M.V., Croce C.M. Oncosuppressive role of p53-induced miR-205 in triple negative breast cancer. Mol. Oncol. 2012, 6:458-472.
173. Song G., Wang L. Nuclear receptor SHP activates miR-206 expression via a cascade dual inhibitory mechanism. PLoS ONE 2009, 4:e6880.
174. Huang X., Ding L., Bennewith K.L., Tong R.T., Welford S.M., Ang K.K., Story M., Le Q.T., Giaccia A.J. Hypoxia-inducible mir-210 regulates normoxic gene expression involved in tumor initiation. Mol. Cell 2009, 35:856-867.
175. Wang H., Bian S.J., Yang C.S. Green tea polyphenol EGCG suppresses lung cancer cell growth through upregulating miR-210 expression caused by stabilizing HIF-1 alpha. Carcinogenesis 2011, 32:1881-1889.
176. Mazar J., DeYoung K., Khaitan D., Meister E., Almodovar A., Goydos J., Ray A., Perera R.J. The regulation of miRNA-211 expression and its role in melanoma cell invasiveness. PLoS ONE 2010, 5:e13779.
177. Dobbelstein M., Braun C.J., Zhang X., Savelyeva I., Wolff S., Moll U.M., Schepeler T., Orntoft T.F., Andersen C.L. P53-responsive micrornas 192 and 215 are capable of inducing cell cycle arrest. Cancer Res. 2008, 68:10094-10104.
178. Georges S.A., Biery M.C., Kim S.Y., Schelter J.M., Guo J., Chang A.N., Jackson A.L., Carleton M.O., Linsley P.S., Cleary M.A., Chau B.N. Coordinated regulation of cell cycle transcripts by p53-inducible microRNAs, miR-192 and miR-215. Cancer Res. 2008, 68:10105-10112.
179. Galardi S., Mercatelli N., Farace M.G., Ciafre S.A. NF-kB and c-Jun induce the expression of the oncogenic miR-221 and miR-222 in prostate carcinoma and glioblastoma cells. Nucleic Acids Res. 2011, 39:3892-3902.
180. Zhang Y.Z., Ma T., Yang S.P., Xia M.Y., Xu J., An H.J., Yang Y.J., Li S.L. High-mobility group A1 proteins enhance the expression of the oncogenic miR-222 in lung cancer cells. Mol. Cell. Biochem. 2011, 357:363-371.
181. Mattia G., Errico M.C., Felicetti F., Petrini M., Bottero L., Tomasello L., Romania P., Boe A., Segnalini P., Di Virgilio A., Colombo M.P., Care A. Constitutive activation of the ETS-1-miR-222 circuitry in metastatic melanoma. Pigment Cell Melanoma Res. 2011, 24:953-965.
182. Eyholzer M., Schmid S., Schardt J.A., Haefliger S., Mueller B.U., Pabst T. Complexity of miR-223 regulation by CEBPA in human AML. Leuk. Res. 2010, 34:672-676.
183. Johnnidis J.B., Harris M.H., Wheeler R.T., Stehling-Sun S., Lam M.H., Kirak O., Brummelkamp T.R., Fleming M.D., Camargo F.D. Regulation of progenitor cell proliferation and granulocyte function by microRNA-223. Nature 2008, 451:U1111-U1125.
184. Card D.A., Hebbar P.B., Li L., Trotter K.W., Komatsu Y., Mishina Y., Archer T.K. Oct4/Sox2-regulated miR-302 targets cyclin D1 in human embryonic stem cells. Mol. Cell. Biol. 2008, 28:6426-6438.
185. Liu H.Y., Deng S., Zhao Z.H., Zhang H.Y., Xiao J.X., Song W., Gao F., Guan Y.M. Oct4 regulates the miR-302 cluster in P19 mouse embryonic carcinoma cells. Mol. Biol. Rep. 2011, 38:2155-2160.
186. De Marchis M.L., Ballarino M., Salvatori B., Puzzolo M.C., Bozzoni I., Fatica A. New molecular network comprising PU.1, interferon regulatory factor proteins and miR-342 stimulates ATRA-mediated granulocytic differentiation of acute promyelocytic leukemia cells. Leukemia 2009, 23:856-862.
187. Xu Z., Xiao S.B., Xu P., Xie Q., Cao L., Wang D., Luo R., Zhong Y., Chen H.C., Fang L.R. MiR-365, a Novel negative regulator of interleukin-6 gene expression, is cooperatively regulated by Sp1 and NF-kappa B. J. Biol. Chem. 2011, 286:21401-21412.
188. Meng F., Wehbe-Janek H., Henson R., Smith H., Patel T. Epigenetic regulation of microRNA-370 by interleukin-6 in malignant human cholangiocytes. Oncogene 2008, 27:378-386.
189. Zhou A.D., Diao L.T., Xu H., Xiao Z.D., Li J.H., Zhou H., Qu L.H. Beta-catenin/LEF1 transactivates the microRNA-371-373 cluster that modulates the Wnt/beta-catenin-signaling pathway. Oncogene 2012, 31:2968-2978.
190. Hu H., Du L., Nagabayashi G., Seeger R.C., Gatti R.A. ATM is down-regulated by N-Myc-regulated microRNA-421. Proc. Natl. Acad. Sci. USA 2010, 107:1506-1511.
191. Nishikawa E., Osada H., Okazaki Y., Arima C., Tomida S., Tatematsu Y., Taguchi A., Shimada Y., Yanagisawa K., Yatabe Y., Toyokuni S., Sekido Y., Takahashi T. MiR-375 is activated by ASH1 and inhibits YAP1 in a lineage-dependent manner in lung cancer. Cancer Res. 2011, 71:6165-6173.
192. Rosa A., Ballarino M., Sorrentino A., Sthandier O., De Angelis F.G., Marchioni M., Masella B., Guarini A., Fatica A., Peschle C., Bozzoni I. The interplay between the master transcription factor PU.1 and miR-424 regulates human monocyte/macrophage differentiation. Proc. Natl. Acad. Sci. USA 2007, 104:19849-19854.
193. Song G., Wang L. MiR-433 and miR-127 arise from independent overlapping primary transcripts encoded by the miR-433-127 locus. PLoS ONE 2008, 3:e3574.
194. Simon D., Laloo B., Barillot M., Barnetche T., Blanchard C., Rooryck C., Marche M., Burgelin I., Coupry I., Chassaing N., Gilbert-Dussardier B., Lacombe D., Grosset C., Arveiler B. A mutation in the 3'-UTR of the HDAC6 gene abolishing the post-transcriptional regulation mediated by hsa-miR-433 is linked to a new form of dominant X-linked chondrodysplasia (vol 19, pp. 2015. Hum. Mol. Genet. 2010, 19(2010):3489-3490.
195. Hwang-Verslues W.W., Chang P.H., Wei P.C., Yang C.Y., Huang C.K., Kuo W.H., Shew J.Y., Chang K.J., Lee E.Y.H.P., Lee W.H. MiR-495 is upregulated by E12/E47 in breast cancer stem cells, and promotes oncogenesis and hypoxia resistance via downregulation of E-cadherin and REDD1. Oncogene 2011, 30:2463-2474.
196. Fan Yeung E.C., Guess Martin G., Bell Matthew L., Leinwand Leslie A. Myh7b/miR-499 gene expression is transcriptionally regulated by MRFs and Eos. Nucleic Acids Res. 2012, 40:15.
197. Xiao J.N., Lin H.X., Luo X.B., Luo X.Y., Wang Z.G. MiR-605 joins p53 network to form a p53:miR-605:mdm2 positive feedback loop in response to stress. EMBO J. 2011, 30:5021.
198. Reddy S.D., Pakala S.B., Ohshiro K., Rayala S.K., Kumar R. MicroRNA-661, a c/EBPalpha target, inhibits metastatic tumor antigen 1 and regulates its functions. Cancer Res. 2009, 69:5639-5642.
199. Song L., Dai T., Xie Y., Wang C., Lin C., Wu Z., Ying Z., Wu J., Li M., Li J. Up-regulation of miR-1245 by c-myc targets BRCA2 and impairs DNA repair. J. Mol. Cell. Biol. 2012, 4:108-117.
200. Zhang Y., Liao J.M., Zeng S.Y.X., Lu H. P53 downregulates down syndrome-associated DYRK1A through miR-1246. EMBO Rep. 2011, 12:811-817.