-
1
-
-
0027459198
-
Mdm2 expression is induced by wild type p53 activity
-
Barak Y, Juven T, Haffner R, Oren M (1993) mdm2 expression is induced by wild type p53 activity. EMBO J 12: 461-468
-
(1993)
EMBO J
, vol.12
, pp. 461-468
-
-
Barak, Y.1
Juven, T.2
Haffner, R.3
Oren, M.4
-
2
-
-
0032553485
-
Requirement for p53 and p21 to sustain G2 arrest after DNA damage
-
Bunz F, Dutriaux A, Lengauer C, Waldman T, Zhou S, Brown JP, Sedivy JM, Kinzler KW, Vogelstein B (1998) Requirement for p53 and p21 to sustain G2 arrest after DNA damage. Science 282: 1497-1501
-
(1998)
Science
, vol.282
, pp. 1497-1501
-
-
Bunz, F.1
Dutriaux, A.2
Lengauer, C.3
Waldman, T.4
Zhou, S.5
Brown, J.P.6
Sedivy, J.M.7
Kinzler, K.W.8
Vogelstein, B.9
-
3
-
-
34249817549
-
Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis
-
Chang TC, Wentzel EA, Kent OA, Ramachandran K, Mullendore M, Lee KH, Feldmann G, Yamakuchi M, Ferlito M, Lowenstein CJ, Arking DE, Beer MA, Maitra A, Mendell JT (2007) Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis. Mol Cell 26: 745-752
-
(2007)
Mol Cell
, vol.26
, pp. 745-752
-
-
Chang, T.C.1
Wentzel, E.A.2
Kent, O.A.3
Ramachandran, K.4
Mullendore, M.5
Lee, K.H.6
Feldmann, G.7
Yamakuchi, M.8
Ferlito, M.9
Lowenstein, C.J.10
Arking, D.E.11
Beer, M.A.12
Maitra, A.13
Mendell, J.T.14
-
4
-
-
77952550955
-
Small-molecule inhibitors of MDM2 as new anticancer therapeutics
-
Dickens MP, Fitzgerald R, Fischer PM (2010) Small-molecule inhibitors of MDM2 as new anticancer therapeutics. Semin Cancer Biol 20: 10-18
-
(2010)
Semin Cancer Biol
, vol.20
, pp. 10-18
-
-
Dickens, M.P.1
Fitzgerald, R.2
Fischer, P.M.3
-
5
-
-
60649090420
-
P53 and MDM2: Antagonists or partners in crime?
-
Eischen CM, Lozano G (2009) p53 and MDM2: antagonists or partners in crime? Cancer Cell 15: 161-162
-
(2009)
Cancer Cell
, vol.15
, pp. 161-162
-
-
Eischen, C.M.1
Lozano, G.2
-
6
-
-
77249179196
-
Genetic inactivation of AKT1, AKT2, and PDPK1 in human colorectal cancer cells clarifies their roles in tumor growth regulation
-
Ericson K, Gan C, Cheong I, Rago C, Samuels Y, Velculescu VE, Kinzler KW, Huso DL, Vogelstein B, Papadopoulos N (2010) Genetic inactivation of AKT1, AKT2, and PDPK1 in human colorectal cancer cells clarifies their roles in tumor growth regulation. Proc Natl Acad Sci USA 107: 2598-2603
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 2598-2603
-
-
Ericson, K.1
Gan, C.2
Cheong, I.3
Rago, C.4
Samuels, Y.5
Velculescu, V.E.6
Kinzler, K.W.7
Huso, D.L.8
Vogelstein, B.9
Papadopoulos, N.10
-
7
-
-
33751165954
-
A single decoy oligodeoxynucleotides targeting multiple oncoproteins produces strong anti-cancer effects
-
Gao H, Xiao J, Yang B, Sun Q, Lin H, Bai Y, Yang L, Wang H, Wang Z (2006) A single decoy oligodeoxynucleotides targeting multiple oncoproteins produces strong anti-cancer effects. Mol Pharmacol 70: 1621-1629
-
(2006)
Mol Pharmacol
, vol.70
, pp. 1621-1629
-
-
Gao, H.1
Xiao, J.2
Yang, B.3
Sun, Q.4
Lin, H.5
Bai, Y.6
Yang, L.7
Wang, H.8
Wang, Z.9
-
8
-
-
0035854746
-
Oxidative preconditioning and apoptosis in L-cells: Roles of protein kinase B and mitogen-activated protein kinases
-
Han H, Wang H, Long H, Nattel S, Wang Z (2001) Oxidative preconditioning and apoptosis in L-cells: roles of protein kinase B and mitogen-activated protein kinases. J Biol Chem 276: 26357-26364
-
(2001)
J Biol Chem
, vol.276
, pp. 26357-26364
-
-
Han, H.1
Wang, H.2
Long, H.3
Nattel, S.4
Wang, Z.5
-
9
-
-
18344377030
-
The p53 pathway: Positive and negative feedback loops
-
Harris SL, Levine AJ (2005) The p53 pathway: positive and negative feedback loops. Oncogene 24: 2899-2908
-
(2005)
Oncogene
, vol.24
, pp. 2899-2908
-
-
Harris, S.L.1
Levine, A.J.2
-
10
-
-
0030905284
-
Mdm2 promotes the rapid degradation of p53
-
Haupt Y, Maya R, Kazaz A, Oren M (1997) Mdm2 promotes the rapid degradation of p53. Nature 387: 296-299
-
(1997)
Nature
, vol.387
, pp. 296-299
-
-
Haupt, Y.1
Maya, R.2
Kazaz, A.3
Oren, M.4
-
11
-
-
34250851115
-
A microRNA component of the p53 tumour suppressor network
-
He L, He X, Lim LP, de Stanchina E, Xuan Z, Liang Y, Xue W, Zender L, Magnus J, Ridzon D, Jackson AL, Linsley PS, Chen C, Lowe SW, Cleary MA, Hannon GJ (2007) A microRNA component of the p53 tumour suppressor network. Nature 447: 1130-1134
-
(2007)
Nature
, vol.447
, pp. 1130-1134
-
-
He, L.1
He, X.2
Lim, L.P.3
De Stanchina, E.4
Xuan, Z.5
Liang, Y.6
Xue, W.7
Zender, L.8
Magnus, J.9
Ridzon, D.10
Jackson, A.L.11
Linsley, P.S.12
Chen, C.13
Lowe, S.W.14
Cleary, M.A.15
Hannon, G.J.16
-
12
-
-
74249123570
-
The miR-34 family in cancer and apoptosis
-
Hermeking H (2010) The miR-34 family in cancer and apoptosis. Cell Death Differ 17: 193-199
-
(2010)
Cell Death Differ
, vol.17
, pp. 193-199
-
-
Hermeking, H.1
-
13
-
-
0031583962
-
Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53
-
Honda R, Tanaka H, Yasuda H (1997) Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53. FEBS Lett 420: 25-27
-
(1997)
FEBS Lett
, vol.420
, pp. 25-27
-
-
Honda, R.1
Tanaka, H.2
Yasuda, H.3
-
14
-
-
67650150998
-
DNA double-strand break repair activities in mammary epithelial cells-influence of endogenous p53 variants
-
Keimling M, Wiesmüller L (2009) DNA double-strand break repair activities in mammary epithelial cells-influence of endogenous p53 variants. Carcinogenesis 30: 1260-1268
-
(2009)
Carcinogenesis
, vol.30
, pp. 1260-1268
-
-
Keimling, M.1
Wiesmüller, L.2
-
16
-
-
1342326910
-
Relevance of breast cancer cell lines as models for breast tumours: An update
-
Lacroix M, Leclercq G (2004) Relevance of breast cancer cell lines as models for breast tumours: an update. Breast Cancer Res Treat 83: 249-289
-
(2004)
Breast Cancer Res Treat
, vol.83
, pp. 249-289
-
-
Lacroix, M.1
Leclercq, G.2
-
17
-
-
67650087599
-
0-UTR interaction sites
-
0-UTR interaction sites. Genome Res 19: 1175-1183
-
(2009)
Genome Res
, vol.19
, pp. 1175-1183
-
-
Lee, I.1
Ajay, S.S.2
Yook, J.I.3
Kim, H.S.4
Hong, S.H.5
Kim, N.H.6
Dhanasekaran, S.M.7
Chinnaiyan, A.M.8
Athey, B.D.9
-
18
-
-
34249899965
-
+ channel gene mediates cell-growth signals on activation of oncoproteins Sp1 and NF-kB and inactivation of tumor suppressor Nkx3.1
-
+ channel gene mediates cell-growth signals on activation of oncoproteins Sp1 and NF-kB and inactivation of tumor suppressor Nkx3.1. J Cell Physiol 212: 137-147
-
(2007)
J Cell Physiol
, vol.212
, pp. 137-147
-
-
Lin, H.1
Xiao, J.2
Luo, X.3
Xu, C.4
Gao, H.5
Wang, H.6
Yang, B.7
Wang, Z.8
-
19
-
-
63349085394
-
Complex antisense inhibitors offer a superior approach for microRNA research and therapy
-
Lu Y, Xiao J, Lin H, Bai Y, Luo X, Wang Z, Yang B (2009) Complex antisense inhibitors offer a superior approach for microRNA research and therapy. Nucleic Acids Res 37: e24-e33
-
(2009)
Nucleic Acids Res
, vol.37
-
-
Lu, Y.1
Xiao, J.2
Lin, H.3
Bai, Y.4
Luo, X.5
Wang, Z.6
Yang, B.7
-
20
-
-
50649111705
-
Overexpression of Sp1 and downregulation of miR-1/miR-133 activates re-expression of pacemaker channel genes HCN2 and HCN4 in hypertrophic heart
-
Luo X, Lin H, Pan Z, Xiao J, Zhang Y, Lu Y, Yang B, Wang Z (2008) Overexpression of Sp1 and downregulation of miR-1/miR-133 activates re-expression of pacemaker channel genes HCN2 and HCN4 in hypertrophic heart. J Biol Chem 283: 20045-20052
-
(2008)
J Biol Chem
, vol.283
, pp. 20045-20052
-
-
Luo, X.1
Lin, H.2
Pan, Z.3
Xiao, J.4
Zhang, Y.5
Lu, Y.6
Yang, B.7
Wang, Z.8
-
21
-
-
0026649648
-
The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation
-
Momand J, Zambetti GP, Olson DC, George D, Levine AJ (1992) The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation. Cell 69: 1237-1245
-
(1992)
Cell
, vol.69
, pp. 1237-1245
-
-
Momand, J.1
Zambetti, G.P.2
Olson, D.C.3
George, D.4
Levine, A.J.5
-
22
-
-
0030855813
-
In vivo transfection of cis element 'decoy' against nuclear factor-kappaB binding site prevents myocardial infarction
-
Morishita R, Sugimoto T, Aoki M, Kida I, Tomita N, Moriguchi A, Maeda K, Sawa Y, Kaneda Y, Higaki J, Ogihara T (1997) In vivo transfection of cis element 'decoy' against nuclear factor-kappaB binding site prevents myocardial infarction. Nat Med 13: 894-899
-
(1997)
Nat Med
, vol.13
, pp. 894-899
-
-
Morishita, R.1
Sugimoto, T.2
Aoki, M.3
Kida, I.4
Tomita, N.5
Moriguchi, A.6
Maeda, K.7
Sawa, Y.8
Kaneda, Y.9
Higaki, J.10
Ogihara, T.11
-
23
-
-
34249822779
-
Transcriptional activation of miR-34a contributes to p53-mediated apoptosis
-
Raver-Shapira N, Marciano E, Meiri E, Spector Y, Rosenfeld N, Moskovits N, Bentwich Z, Oren M (2007) Transcriptional activation of miR-34a contributes to p53-mediated apoptosis. Mol Cell 26: 731-743
-
(2007)
Mol Cell
, vol.26
, pp. 731-743
-
-
Raver-Shapira, N.1
Marciano, E.2
Meiri, E.3
Spector, Y.4
Rosenfeld, N.5
Moskovits, N.6
Bentwich, Z.7
Oren, M.8
-
24
-
-
49749151009
-
MicroRNA-34 mediates AR-dependent p53-induced apoptosis in prostate cancer
-
Rokhlin OW, Scheinker VS, Taghiyev AF, Bumcrot D, Glover RA, Cohen MB (2008) MicroRNA-34 mediates AR-dependent p53-induced apoptosis in prostate cancer. Cancer Biol Ther 7: 1288-1296
-
(2008)
Cancer Biol Ther
, vol.7
, pp. 1288-1296
-
-
Rokhlin, O.W.1
Scheinker, V.S.2
Taghiyev, A.F.3
Bumcrot, D.4
Glover, R.A.5
Cohen, M.B.6
-
25
-
-
65249100143
-
Small-molecule inhibitors of the MDM2-p53 protein-protein interaction to reactivate p53 function: A novel approach for cancer therapy
-
Shangary S, Wang S (2009) Small-molecule inhibitors of the MDM2-p53 protein-protein interaction to reactivate p53 function: a novel approach for cancer therapy. Annu Rev Pharmacol Toxicol 49: 223-241
-
(2009)
Annu Rev Pharmacol Toxicol
, vol.49
, pp. 223-241
-
-
Shangary, S.1
Wang, S.2
-
26
-
-
34250868124
-
Differential regulation of microRNAs by p53 revealed by massively parallel sequencing: MiR-34a is a p53 target that induces apoptosis and G1-arrest
-
Tarasov V, Jung P, Verdoodt B, Lodygin D, Epanchintsev A, Menssen A, Meister G, Hermeking H (2007) Differential regulation of microRNAs by p53 revealed by massively parallel sequencing: miR-34a is a p53 target that induces apoptosis and G1-arrest. Cell Cycle 6: 1586-1593
-
(2007)
Cell Cycle
, vol.6
, pp. 1586-1593
-
-
Tarasov, V.1
Jung, P.2
Verdoodt, B.3
Lodygin, D.4
Epanchintsev, A.5
Menssen, A.6
Meister, G.7
Hermeking, H.8
-
27
-
-
33845901313
-
MDM2 inhibitors for cancer therapy
-
Vassilev LT (2007) MDM2 inhibitors for cancer therapy. Trends Mol Med 13: 23-31
-
(2007)
Trends Mol Med
, vol.13
, pp. 23-31
-
-
Vassilev, L.T.1
-
28
-
-
77952543499
-
The p53 orchestra: Mdm2 and Mdmx set the tone
-
Wade M, Wang YV, Wahl GM (2010) The p53 orchestra: Mdm2 and Mdmx set the tone. Trends Cell Biol 20: 299-309
-
(2010)
Trends Cell Biol
, vol.20
, pp. 299-309
-
-
Wade, M.1
Wang, Y.V.2
Wahl, G.M.3
-
29
-
-
0036733645
-
+ channel: A regulator of tumor cell apoptosis and proliferation
-
+ channel: a regulator of tumor cell apoptosis and proliferation. Cancer Res 62: 4843-4848
-
(2002)
Cancer Res
, vol.62
, pp. 4843-4848
-
-
Wang, H.1
Zhang, Y.2
Cao, L.3
Han, H.4
Wang, J.5
Yang, B.6
Nattel, S.7
Wang, Z.8
-
30
-
-
76149111139
-
Patented inhibitors of p53-Mdm2 interaction (2006- 2008)
-
Weber L (2010) Patented inhibitors of p53-Mdm2 interaction (2006- 2008). Expert Opin Ther Pat 20: 179-191
-
(2010)
Expert Opin Ther Pat
, vol.20
, pp. 179-191
-
-
Weber, L.1
-
31
-
-
34249812122
-
MicroRNA-34a functions as a potential tumor suppressor by inducing apoptosis in neuroblas-toma cells
-
Welch C, Chen Y, Stallings RL (2007) MicroRNA-34a functions as a potential tumor suppressor by inducing apoptosis in neuroblas-toma cells. Oncogene 26: 5017-5022
-
(2007)
Oncogene
, vol.26
, pp. 5017-5022
-
-
Welch, C.1
Chen, Y.2
Stallings, R.L.3
-
32
-
-
34250378330
-
+ channel expression contributing to QT prolongation in diabetic hearts
-
+ channel expression contributing to QT prolongation in diabetic hearts. J Biol Chem 282: 12363-12367
-
(2007)
J Biol Chem
, vol.282
, pp. 12363-12367
-
-
Xiao, J.1
Luo, X.2
Lin, H.3
Zhang, Y.4
Lu, Y.5
Wang, N.6
Zhang, Y.7
Yang, B.8
Wang, Z.9
-
33
-
-
34948829119
-
The muscle-specific microRNAs miR-1 and miR-133 produce opposing effects on apoptosis via targeting HSP60/HSP70 and caspase-9 in cardiomyocytes
-
Xu C, Lu Y, Lin H, Xiao J, Wang H, Luo X, Li B, Wang Z, Yang B (2007) The muscle-specific microRNAs miR-1 and miR-133 produce opposing effects on apoptosis via targeting HSP60/HSP70 and caspase-9 in cardiomyocytes. J Cell Sci 120: 3045-3052
-
(2007)
J Cell Sci
, vol.120
, pp. 3045-3052
-
-
Xu, C.1
Lu, Y.2
Lin, H.3
Xiao, J.4
Wang, H.5
Luo, X.6
Li, B.7
Wang, Z.8
Yang, B.9
-
34
-
-
34147095310
-
The muscle-specific microRNA miR-1 causes cardiac arrhythmias by targeting GJA1 and KCNJ2 genes
-
Yang B, Lin H, Xiao J, Lu Y, Luo X, Li B, Zhang Y, Xu C, Bai Y, Wang H, Chen G, Wang Z (2007) The muscle-specific microRNA miR-1 causes cardiac arrhythmias by targeting GJA1 and KCNJ2 genes. Nat Med 13: 486-491
-
(2007)
Nat Med
, vol.13
, pp. 486-491
-
-
Yang, B.1
Lin, H.2
Xiao, J.3
Lu, Y.4
Luo, X.5
Li, B.6
Zhang, Y.7
Xu, C.8
Bai, Y.9
Wang, H.10
Chen, G.11
Wang, Z.12
|