MiR-31 and its host gene lncRNA LOC554202 are regulated by promoter hypermethylation in triple-negative breast cancer

Molecular Cancer

Volumn 11, Issue , 2012, Pages

  Augoff, Katarzyna ^a   McCue, Brian ^a   Plow, Edward F ^a   Sossey Alaoui, Khalid ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

Author keywords

CpG hypermethylation; Invasion metastasis cascade; LncRNA; LOC554202; Mir 31; Triple negative breast cancer

Indexed keywords

LONG NON CODING RNA; MICRORNA; MICRORNA 31; UNCLASSIFIED DRUG; UNTRANSLATED RNA; MIRN31 MICRORNA, HUMAN;

ACETYLATION; ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CANCER PROGNOSIS; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; EPIGENETICS; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE LOCUS; GENE SILENCING; HUMAN; HUMAN CELL; METASTASIS; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; TRANSCRIPTION REGULATION; TRIPLE NEGATIVE BREAST CANCER; TUMOR GROWTH; BREAST TUMOR; DOWN REGULATION; FEMALE; GENE ORDER; GENETIC EPIGENESIS; GENETIC TRANSCRIPTION; GENETICS; INTRON; METABOLISM; PROMOTER REGION; TUMOR CELL LINE;

BREAST NEOPLASMS; CELL LINE, TUMOR; CPG ISLANDS; DNA METHYLATION; DOWN-REGULATION; EPIGENESIS, GENETIC; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE ORDER; GENE SILENCING; HUMANS; INTRONS; MICRORNAS; PROMOTER REGIONS, GENETIC; RNA, UNTRANSLATED; TRANSCRIPTION, GENETIC;

EID: 84856283173     PISSN: None     EISSN: 14764598     Source Type: Journal    
DOI: 10.1186/1476-4598-11-5     Document Type: Article

References (53)

1. Berx G, Raspe E, Christofori G, Thiery JP, Sleeman JP. Pre-EMTing metastasis? Recapitulation of morphogenetic processes in cancer. Clin Exp Metastasis 2007, 24:587-597. 10.1007/s10585-007-9114-6, 17978854.
2. Chiang AC, Massague J. Molecular basis of metastasis. N Engl J Med 2008, 359:2814-2823. 10.1056/NEJMra0805239, 19109576.
3. Spaderna S, Schmalhofer O, Hlubek F, Jung A, Kirchner T, Brabletz T. Epithelial-mesenchymal and mesenchymal-epithelial transitions during cancer progression. Verh Dtsch Ges Pathol 2007, 91:21-28.
4. Nguyen DX, Bos PD, Massague J. Metastasis: from dissemination to organ-specific colonization. Nat Rev Cancer 2009, 9:274-284. 10.1038/nrc2622, 19308067.
5. May CD, Sphyris N, Evans KW, Werden SJ, Guo W, Mani SA. Epithelial-mesenchymal transition and cancer stem cells: a dangerously dynamic duo in breast cancer progression. Breast Cancer Res 2011, 13:202. 3109556, 21392411.
6. Taylor MA, Parvani JG, Schiemann WP. The pathophysiology of epithelial-mesenchymal transition induced by transforming growth factor-beta in normal and malignant mammary epithelial cells. J Mammary Gland Biol Neoplasia 2010, 15:169-190. 10.1007/s10911-010-9181-1, 20467795.
7. Yang J, Weinberg RA. Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis. Dev Cell 2008, 14:818-829. 10.1016/j.devcel.2008.05.009, 18539112.
8. Talmadge JE, Fidler IJ. AACR centennial series: the biology of cancer metastasis: historical perspective. Cancer Res 2010, 70:5649-5669. 10.1158/0008-5472.CAN-10-1040, 20610625.
9. Gupta GP, Massague J. Cancer metastasis: building a framework. Cell 2006, 127:679-695. 10.1016/j.cell.2006.11.001, 17110329.
10. Li F, Tiede B, Massague J, Kang Y. Beyond tumorigenesis: cancer stem cells in metastasis. Cell Res 2007, 17:3-14. 10.1038/sj.cr.7310118, 17179981.
11. Jemal A, Siegel R, Xu J, Ward E. Cancer statistics, 2010. CA Cancer J Clin 2010, 60:277-300. 10.3322/caac.20073, 20610543.
12. Perou CM, Sorlie T, Eisen MB, van de Rijn M, Jeffrey SS, Rees CA, et al. Molecular portraits of human breast tumours. Nature 2000, 406:747-752. 10.1038/35021093, 10963602.
13. Sorlie T, Perou CM, Tibshirani R, Aas T, Geisler S, Johnsen H, et al. Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Natl Acad Sci USA 2001, 98:10869-10874. 10.1073/pnas.191367098, 58566, 11553815.
14. Anders C, Carey LA. Understanding and treating triple-negative breast cancer. Oncology (Williston Park) 2008, 22:1233-1239.
15. Anders CK, Carey LA. Biology, metastatic patterns, and treatment of patients with triple-negative breast cancer. Clin Breast Cancer 2009, 9(Suppl 2):S73-S81. 2919761, 19596646.
16. Carey L, Winer E, Viale G, Cameron D, Gianni L. Triple-negative breast cancer: disease entity or title of convenience?. Nat Rev Clin Oncol 2010, 7:683-692. 10.1038/nrclinonc.2010.154, 20877296.
17. Finnegan TJ, Carey LA. Gene-expression analysis and the basal-like breast cancer subtype. Future Oncol 2007, 3:55-63. 10.2217/14796694.3.1.55, 17280502.
18. Foulkes WD, Smith IE, Reis-Filho JS. Triple-negative breast cancer. N Engl J Med 2010, 363:1938-1948. 10.1056/NEJMra1001389, 21067385.
19. Jiang Z, Jones R, Liu JC, Deng T, Robinson T, Chung PE, et al. RB1 and p53 at the crossroad of EMT and triple negative breast cancer. Cell Cycle 2011, 10:1563-1570. 10.4161/cc.10.10.15703, 21502814.
20. Schneider BP, Winer EP, Foulkes WD, Garber J, Perou CM, Richardson A, et al. Triple-negative breast cancer: risk factors to potential targets. Clin Cancer Res 2008, 14:8010-8018. 10.1158/1078-0432.CCR-08-1208, 19088017.
21. Padua D, Massague J. Roles of TGFbeta in metastasis. Cell Res 2009, 19:89-102. 10.1038/cr.2008.316, 19050696.
22. Burk U, Schubert J, Wellner U, Schmalhofer O, Vincan E, Spaderna S, et al. A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells. EMBO Rep 2008, 9:582-589. 10.1038/embor.2008.74, 2396950, 18483486.
23. Esquela-Kerscher A, Slack FJ. Oncomirs-microRNAs with a role in cancer. Nat Rev Cancer 2006, 6:259-269. 10.1038/nrc1840, 16557279.
24. Sossey-Alaoui K, Downs-Kelly E, Das M, Izem L, Tubbs R, Plow EF. WAVE3, an actin remodeling protein, is regulated by the metastasis suppressor microRNA, miR-31, during the invasion-metastasis cascade. Int J Cancer 2011, 129(6):1331-1343. 10.1002/ijc.25793, 21105030.
25. Sossey-Alaoui K, Bialkowska K, Plow EF. The miR200 family of microRNAs regulates WAVE3-dependent cancer cell invasion. J Biol Chem 2009, 284:33019-33029. 10.1074/jbc.M109.034553, 2785142, 19801681.
26. Akao Y, Nakagawa Y, Naoe T. let-7 microRNA functions as a potential growth suppressor in human colon cancer cells. Biol Pharm Bull 2006, 29:903-906. 10.1248/bpb.29.903, 16651716.
27. Calin GA, Dumitru CD, Shimizu M, Bichi R, Zupo S, Noch E, et al. Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proc Natl Acad Sci USA 2002, 99:15524-15529. 10.1073/pnas.242606799, 137750, 12434020.
28. Johnson CD, Esquela-Kerscher A, Stefani G, Byrom M, Kelnar K, Ovcharenko D, et al. The let-7 microRNA represses cell proliferation pathways in human cells. Cancer Res 2007, 67:7713-7722. 10.1158/0008-5472.CAN-07-1083, 17699775.
29. Takamizawa J, Konishi H, Yanagisawa K, Tomida S, Osada H, Endoh H, et al. Reduced expression of the let-7 microRNAs in human lung cancers in association with shortened postoperative survival. Cancer Res 2004, 64:3753-3756. 10.1158/0008-5472.CAN-04-0637, 15172979.
30. Yanaihara N, Caplen N, Bowman E, Seike M, Kumamoto K, Yi M, et al. Unique microRNA molecular profiles in lung cancer diagnosis and prognosis. Cancer Cell 2006, 9:189-198. 10.1016/j.ccr.2006.01.025, 16530703.
31. He L, Thomson JM, Hemann MT, Hernando-Monge E, Mu D, Goodson S, et al. A microRNA polycistron as a potential human oncogene. Nature 2005, 435:828-833. 10.1038/nature03552, 15944707.
32. Voorhoeve PM, le SC, Schrier M, Gillis AJ, Stoop H, Nagel R, et al. A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors. Cell 2006, 124:1169-1181. 10.1016/j.cell.2006.02.037, 16564011.
33. Valastyan S, Weinberg RA. miR-31: A crucial overseer of tumor metastasis and other emerging roles. Cell Cycle 2010, 9:2124-2129. 10.4161/cc.9.11.11843, 20505365.
34. Valastyan S, Chang A, Benaich N, Reinhardt F, Weinberg RA. Activation of miR-31 function in already-established metastases elicits metastatic regression. Genes Dev 2011, 25:646-659. 10.1101/gad.2004211, 3059837, 21406558.
35. Valastyan S, Benaich N, Chang A, Reinhardt F, Weinberg RA. Concomitant suppression of three target genes can explain the impact of a microRNA on metastasis. Genes Dev 2009, 23:2592-2597. 10.1101/gad.1832709, 2779763, 19875476.
36. Valastyan S, Reinhardt F, Benaich N, Calogrias D, Szasz AM, Wang ZC, et al. A pleiotropically acting microRNA, miR-31, inhibits breast cancer metastasis. Cell 2009, 137:1032-1046. 10.1016/j.cell.2009.03.047, 2766609, 19524507.
37. Sossey-Alaoui K, Safina A, Li X, Vaughan MM, Hicks DG, Bakin AV, et al. Down-Regulation of WAVE3, a Metastasis Promoter Gene, Inhibits Invasion and Metastasis of Breast Cancer Cells. Am J Pathol 2007, 170(6):2112-2121. 10.2353/ajpath.2007.060975, 1899429, 17525277.
38. Fernando HS, Davies SR, Chhabra A, Watkins G, Douglas-Jones A, Kynaston H, et al. Expression of the WASP verprolin-homologues (WAVE members) in human breast cancer. Oncology 2007, 73:376-383. 10.1159/000136157, 18509249.
39. Fernando HS, Sanders AJ, Kynaston HG, Jiang WG. WAVE3 is associated with invasiveness in prostate cancer cells. Urol Oncol 2009, 28(3):320-327.
40. Wang W, Goswami S, Lapidus K, Wells AL, Wyckoff JB, Sahai E, et al. Identification and testing of a gene expression signature of invasive carcinoma cells within primary mammary tumors. Cancer Res 2004, 64:8585-8594. 10.1158/0008-5472.CAN-04-1136, 15574765.
41. Corcoran DL, Pandit KV, Gordon B, Bhattacharjee A, Kaminski N, Benos PV. Features of mammalian microRNA promoters emerge from polymerase II chromatin immunoprecipitation data. PLoS One 2009, 4:e5279. 10.1371/journal.pone.0005279, 2668758, 19390574.
42. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, et al. Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet 2004, 36:40-45. 10.1038/ng1285, 14702039.
43. Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci USA 2002, 99:16899-16903. 10.1073/pnas.242603899, 139241, 12477932.
44. Bachour T, Bennett K. The Role of MicroRNAs in Breast Cancer. J Assoc Genet Technol 2011, 37:21-28.
45. Andorfer CA, Necela BM, Thompson EA, Perez EA. MicroRNA signatures: clinical biomarkers for the diagnosis and treatment of breast cancer. Trends Mol Med 2011, 17:313-319. 10.1016/j.molmed.2011.01.006, 21376668.
46. Weigel MT, Dowsett M. Current and emerging biomarkers in breast cancer: prognosis and prediction. Endocr Relat Cancer 2010, 17:R245-R262. 10.1677/ERC-10-0136, 20647302.
47. Augoff K, Das M, Bialkowska K, McCue B, Plow EF, Sossey-Alaoui K. miR-31 is a broad regulator of β1-integrin expression and function in cancer cells. Mol Cancer Res 2011, 9(11):1500-1508. 10.1158/1541-7786.MCR-11-0311, 21875932.
48. Wapinski O, Chang HY. Long noncoding RNAs and human disease. Trends Cell Biol 2011, 21:354-361. 10.1016/j.tcb.2011.04.001, 21550244.
49. Nagano T, Fraser P. Emerging similarities in epigenetic gene silencing by long noncoding RNAs. Mamm Genome 2009, 20:557-562. 10.1007/s00335-009-9218-1, 19727951.
50. Sossey-Alaoui K, Kitamura E, Head K, Cowell JK. Characterization of FAM10A4, a member of the ST13 tumor suppressor gene family that maps to the 13q14.3 region associated with B-Cell leukemia, multiple myeloma, and prostate cancer. Genomics 2002, 80:5-7. 10.1006/geno.2002.6792, 12079276.
51. Sossey-Alaoui K, Ranalli TA, Li X, Bakin AV, Cowell JK. WAVE3 promotes cell motility and invasion through the regulation of MMP-1, MMP-3, and MMP-9 expression. Exp Cell Res 2005, 308:135-145. 10.1016/j.yexcr.2005.04.011, 15907837.
52. Sossey-Alaoui K, Li X, Cowell JK. c-Abl-mediated phosphorylation of WAVE3 is required for lamellipodia formation and cell migration. J Biol Chem 2007, 282:26257-26265. 10.1074/jbc.M701484200, 17623672.
53. Schmittgen TD, Livak KJ. Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc 2008, 3:1101-1108. 10.1038/nprot.2008.73, 18546601.