-
2
-
-
3042767202
-
MicroRNAs: Small RNAs with a big role in gene regulation
-
He L, Hannon GJ. MicroRNAs: small RNAs with a big role in gene regulation. Nat Rev Genet 2004;5:522-31.
-
(2004)
Nat Rev Genet
, vol.5
, pp. 522-531
-
-
He, L.1
Hannon, G.J.2
-
4
-
-
33750370444
-
MicroRNA signatures in human cancers
-
Calin GA, Croce CM. MicroRNA signatures in human cancers. Nat Rev Cancer 2006;6:857-66.
-
(2006)
Nat Rev Cancer
, vol.6
, pp. 857-866
-
-
Calin, G.A.1
Croce, C.M.2
-
5
-
-
33749504736
-
MicroRNAs and the hallmarks of cancer
-
Dalmay T, Edwards DR. MicroRNAs and the hallmarks of cancer. Oncogene 2006;25:6170-5.
-
(2006)
Oncogene
, vol.25
, pp. 6170-6175
-
-
Dalmay, T.1
Edwards, D.R.2
-
6
-
-
20444460289
-
MicroRNA expression profiles classify human cancers
-
Lu J, Getz G, Miska EA, et al. MicroRNA expression profiles classify human cancers. Nature 2005;435:834-8.
-
(2005)
Nature
, vol.435
, pp. 834-838
-
-
Lu, J.1
Getz, G.2
Miska, E.A.3
-
7
-
-
20044395613
-
RAS is regulated by the let-7 microRNA family
-
Johnson SM, Grosshans H, Shingara J, et al. RAS is regulated by the let-7 microRNA family. Cell 2005;120:635-47.
-
(2005)
Cell
, vol.120
, pp. 635-647
-
-
Johnson, S.M.1
Grosshans, H.2
Shingara, J.3
-
8
-
-
25444520537
-
miR-15 and miR-16 induce apoptosis by targeting BCL2
-
Cimmino A, Calin GA, Fabbri M, et al. miR-15 and miR-16 induce apoptosis by targeting BCL2. Proc Natl Acad Sci U S A 2005;102:13944-9.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 13944-13949
-
-
Cimmino, A.1
Calin, G.A.2
Fabbri, M.3
-
9
-
-
32944462300
-
Rapid alteration of microRNA levels by histone deacetylase inhibition
-
Scott GK, Mattie MD, Berger CE, Benz SC, Benz CC. Rapid alteration of microRNA levels by histone deacetylase inhibition. Cancer Res 2006;66:1277-81.
-
(2006)
Cancer Res
, vol.66
, pp. 1277-1281
-
-
Scott, G.K.1
Mattie, M.D.2
Berger, C.E.3
Benz, S.C.4
Benz, C.C.5
-
10
-
-
33744805399
-
Specific activation of microRNA-127 with downregulation of the protooncogene BCL6 by chromatin-modifying drugs in human cancer cells
-
Saito Y, Liang G, Egger G, et al. Specific activation of microRNA-127 with downregulation of the protooncogene BCL6 by chromatin-modifying drugs in human cancer cells. Cancer Cell 2006;9:435-43.
-
(2006)
Cancer Cell
, vol.9
, pp. 435-443
-
-
Saito, Y.1
Liang, G.2
Egger, G.3
-
11
-
-
33847763576
-
Genetic unmasking of an epigenetically silenced microRNA in human cancer cells
-
Lujambio A, Ropero S, Ballestar E, et al. Genetic unmasking of an epigenetically silenced microRNA in human cancer cells. Cancer Res 2007;67:1424-9.
-
(2007)
Cancer Res
, vol.67
, pp. 1424-1429
-
-
Lujambio, A.1
Ropero, S.2
Ballestar, E.3
-
12
-
-
0036613250
-
A genomic screen for genes upregulated by demethylation and histone deacetylase inhibition in human colorectal cancer
-
Suzuki H, Gabrielson E, Chen W, et al. A genomic screen for genes upregulated by demethylation and histone deacetylase inhibition in human colorectal cancer. Nat Genet 2002;31:141-9.
-
(2002)
Nat Genet
, vol.31
, pp. 141-149
-
-
Suzuki, H.1
Gabrielson, E.2
Chen, W.3
-
13
-
-
34848918829
-
Comparing the DNA hypermethylome with gene mutations in human colorectal cancer
-
Schuebel KE, Chen W, Cope L, et al. Comparing the DNA hypermethylome with gene mutations in human colorectal cancer. PLoS Genet 2007;3:1709-23.
-
(2007)
PLoS Genet
, vol.3
, pp. 1709-1723
-
-
Schuebel, K.E.1
Chen, W.2
Cope, L.3
-
14
-
-
33947315736
-
Cancer epigenomics: DNA methylomes and histone-modification maps
-
Esteller M. Cancer epigenomics: DNA methylomes and histone-modification maps. Nat Rev Genet 2007;8:286-98.
-
(2007)
Nat Rev Genet
, vol.8
, pp. 286-298
-
-
Esteller, M.1
-
15
-
-
34250851115
-
A microRNA component of the p53 tumour suppressor network
-
He L, He X, Lim LP, et al. A microRNA component of the p53 tumour suppressor network. Nature 2007;447:1130-4.
-
(2007)
Nature
, vol.447
, pp. 1130-1134
-
-
He, L.1
He, X.2
Lim, L.P.3
-
16
-
-
34547458550
-
p53-mediated activation of miRNA34 candidate tumor-suppressor genes
-
Bommer GT, Gerin I, Feng Y, et al. p53-mediated activation of miRNA34 candidate tumor-suppressor genes. Curr Biol 2007;17:1298-307.
-
(2007)
Curr Biol
, vol.17
, pp. 1298-1307
-
-
Bommer, G.T.1
Gerin, I.2
Feng, Y.3
-
17
-
-
34548803950
-
MicroRNA-34b and MicroRNA-34c are targets of p53 and cooperate in control of cell proliferation and adhesion-independent growth
-
Corney DC, Flesken-Nikitin A, Godwin AK, Wang W, Nikitin AY. MicroRNA-34b and MicroRNA-34c are targets of p53 and cooperate in control of cell proliferation and adhesion-independent growth. Cancer Res 2007;67:8433-8.
-
(2007)
Cancer Res
, vol.67
, pp. 8433-8438
-
-
Corney, D.C.1
Flesken-Nikitin, A.2
Godwin, A.K.3
Wang, W.4
Nikitin, A.Y.5
-
19
-
-
22344435817
-
The Ras effector RASSF2 is a novel tumor-suppressor gene in human colorectal cancer
-
Akino K, Toyota M, Suzuki H, et al. The Ras effector RASSF2 is a novel tumor-suppressor gene in human colorectal cancer. Gastroenterology 2005;129:156-69.
-
(2005)
Gastroenterology
, vol.129
, pp. 156-169
-
-
Akino, K.1
Toyota, M.2
Suzuki, H.3
-
20
-
-
18344390653
-
DNMT1 and DNMT3b cooperate to silence genes in human cancer cells
-
Rhee I, Bachman KE, Park BH, et al. DNMT1 and DNMT3b cooperate to silence genes in human cancer cells. Nature 2002;416:552-6.
-
(2002)
Nature
, vol.416
, pp. 552-556
-
-
Rhee, I.1
Bachman, K.E.2
Park, B.H.3
-
21
-
-
0032553485
-
Requirement for p53 and p21 to sustain G2 arrest after DNA damage
-
Bunz F, Dutriaux A, Lengauer C, et al. Requirement for p53 and p21 to sustain G2 arrest after DNA damage. Science 1998;282:1497-501.
-
(1998)
Science
, vol.282
, pp. 1497-1501
-
-
Bunz, F.1
Dutriaux, A.2
Lengauer, C.3
-
22
-
-
33646403420
-
Comparative genome analysis identifies the vitamin D receptor gene as a direct target of p53-mediated transcriptional activation
-
Maruyama R, Aoki F, Toyota M, et al. Comparative genome analysis identifies the vitamin D receptor gene as a direct target of p53-mediated transcriptional activation. Cancer Res 2006;66:4574-83.
-
(2006)
Cancer Res
, vol.66
, pp. 4574-4583
-
-
Maruyama, R.1
Aoki, F.2
Toyota, M.3
-
23
-
-
34447521472
-
Frequent epigenetic inactivation of SFRP genes and constitutive activation of Wnt signaling in gastric cancer
-
Nojima M, Suzuki H, Toyota M, et al. Frequent epigenetic inactivation of SFRP genes and constitutive activation of Wnt signaling in gastric cancer. Oncogene 2007;26:4699-713.
-
(2007)
Oncogene
, vol.26
, pp. 4699-4713
-
-
Nojima, M.1
Suzuki, H.2
Toyota, M.3
-
24
-
-
36949039772
-
Frequent epigenetic inactivation of DICKKOPF family genes in human gastrointestinal tumors
-
Sato H, Suzuki H, Toyota M, et al. Frequent epigenetic inactivation of DICKKOPF family genes in human gastrointestinal tumors. Carcinogenesis 2007;28:2459-66.
-
(2007)
Carcinogenesis
, vol.28
, pp. 2459-2466
-
-
Sato, H.1
Suzuki, H.2
Toyota, M.3
-
25
-
-
36849059066
-
LINE-1 hypomethylation in cancer is highly variable and inversely correlated with microsatellite instability
-
Estécio MR, Gharibyan V, Shen L, et al. LINE-1 hypomethylation in cancer is highly variable and inversely correlated with microsatellite instability. PLoS ONE 2007;2:e399.
-
(2007)
PLoS ONE
, vol.2
-
-
Estécio, M.R.1
Gharibyan, V.2
Shen, L.3
-
26
-
-
19944430797
-
Genomic maps and comparative analysis of histone modifications in human and mouse
-
Bernstein BE, Kamal M, Lindblad-Toh K, et al. Genomic maps and comparative analysis of histone modifications in human and mouse. Cell 2005;120:169-81.
-
(2005)
Cell
, vol.120
, pp. 169-181
-
-
Bernstein, B.E.1
Kamal, M.2
Lindblad-Toh, K.3
-
27
-
-
33847334699
-
Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome
-
Heintzman ND, Stuart RK, Hon G, et al. Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome. Nat Genet 2007;39:311-8.
-
(2007)
Nat Genet
, vol.39
, pp. 311-318
-
-
Heintzman, N.D.1
Stuart, R.K.2
Hon, G.3
-
28
-
-
34547624303
-
Genome-wide maps of chromatin state in pluripotent and lineage-committed cells
-
Mikkelsen TS, Ku M, Jaffe DB, et al. Genome-wide maps of chromatin state in pluripotent and lineage-committed cells. Nature 2007;448:553-60.
-
(2007)
Nature
, vol.448
, pp. 553-560
-
-
Mikkelsen, T.S.1
Ku, M.2
Jaffe, D.B.3
-
29
-
-
34249822779
-
Transcriptional activation of miR-34a contributes to p53-mediated apoptosis
-
Raver-Shapira N, Marciano E, Meiri E, et al. Transcriptional activation of miR-34a contributes to p53-mediated apoptosis. Mol Cell 2007;26:731-43.
-
(2007)
Mol Cell
, vol.26
, pp. 731-743
-
-
Raver-Shapira, N.1
Marciano, E.2
Meiri, E.3
-
30
-
-
34249817549
-
Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis
-
Chang TC, Wentzel EA, Kent OA, et al. Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis. Mol Cell 2007;26:745-52.
-
(2007)
Mol Cell
, vol.26
, pp. 745-752
-
-
Chang, T.C.1
Wentzel, E.A.2
Kent, O.A.3
-
31
-
-
34250868124
-
Differential regulation of microRNAs by p53 revealed by massively parallel sequencing: MiR-34a is a p53 target that induces apoptosis and G1-arrest
-
Tarasov V, Jung P, Verdoodt B, et al. Differential regulation of microRNAs by p53 revealed by massively parallel sequencing: miR-34a is a p53 target that induces apoptosis and G1-arrest. Cell Cycle 2007;6:1586-93.
-
(2007)
Cell Cycle
, vol.6
, pp. 1586-1593
-
-
Tarasov, V.1
Jung, P.2
Verdoodt, B.3
-
32
-
-
33646258751
-
Differentially regulated micro-RNAs and actively translated messenger RNA transcripts by tumor suppressor p53 in colon cancer
-
Xi Y, Shalgi R, Fodstad O, Pilpel Y, Ju J. Differentially regulated micro-RNAs and actively translated messenger RNA transcripts by tumor suppressor p53 in colon cancer. Clin Cancer Res 2006;12:2014-24.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 2014-2024
-
-
Xi, Y.1
Shalgi, R.2
Fodstad, O.3
Pilpel, Y.4
Ju, J.5
-
33
-
-
38349191617
-
CpG island hypermethylation of tumor suppressor microRNAs in human cancer
-
Lujambio A, Esteller M. CpG island hypermethylation of tumor suppressor microRNAs in human cancer. Cell Cycle 2007;6:1455-9.
-
(2007)
Cell Cycle
, vol.6
, pp. 1455-1459
-
-
Lujambio, A.1
Esteller, M.2
-
34
-
-
33847748913
-
The human let-7a-3 locus contains an epigenetically regulated microRNA gene with oncogenic function
-
Brueckner B, Stresemann C, Kuner R, et al. The human let-7a-3 locus contains an epigenetically regulated microRNA gene with oncogenic function. Cancer Res 2007;67:1419-23.
-
(2007)
Cancer Res
, vol.67
, pp. 1419-1423
-
-
Brueckner, B.1
Stresemann, C.2
Kuner, R.3
-
35
-
-
0034662605
-
Inactivation of the 14-3-3σ gene is associated with 5′ CpG island hypermethylation in human cancers
-
Suzuki H, Itoh F, Toyota M, Kikuchi T, Kakiuchi H, Imai K. Inactivation of the 14-3-3σ gene is associated with 5′ CpG island hypermethylation in human cancers. Cancer Res 2000;60:4353-7.
-
(2000)
Cancer Res
, vol.60
, pp. 4353-4357
-
-
Suzuki, H.1
Itoh, F.2
Toyota, M.3
Kikuchi, T.4
Kakiuchi, H.5
Imai, K.6
-
36
-
-
0034597517
-
Frequent hypermethylation of CpG islands and loss of expression of the 14-3-3σ gene in human hepatocellular carcinoma
-
Iwata N, Yamamoto H, Sasaki S, et al. Frequent hypermethylation of CpG islands and loss of expression of the 14-3-3σ gene in human hepatocellular carcinoma. Oncogene 2000;19:5298-302.
-
(2000)
Oncogene
, vol.19
, pp. 5298-5302
-
-
Iwata, N.1
Yamamoto, H.2
Sasaki, S.3
-
37
-
-
33751351899
-
Identification of DFNA5 as a target of epigenetic inactivation in gastric cancer
-
Akino K, Toyota M, Suzuki H, et al. Identification of DFNA5 as a target of epigenetic inactivation in gastric cancer. Cancer Sci 2007;98:88-95.
-
(2007)
Cancer Sci
, vol.98
, pp. 88-95
-
-
Akino, K.1
Toyota, M.2
Suzuki, H.3
-
38
-
-
0037188910
-
Bidirectional gene organization: A common architectural feature of the human genome
-
Adachi N, Lieber MR. Bidirectional gene organization: a common architectural feature of the human genome. Cell 2002;109:807-9.
-
(2002)
Cell
, vol.109
, pp. 807-809
-
-
Adachi, N.1
Lieber, M.R.2
-
39
-
-
33744911982
-
Silencing of bidirectional promoters by DNA methylation in tumorigenesis
-
Shu J, Jelinek J, Chang H, et al. Silencing of bidirectional promoters by DNA methylation in tumorigenesis. Cancer Res 2006;66:5077-84.
-
(2006)
Cancer Res
, vol.66
, pp. 5077-5084
-
-
Shu, J.1
Jelinek, J.2
Chang, H.3
-
40
-
-
0034665416
-
Cloning of PC3B, a novel member of the PC3/BTG/TOB family of growth inhibitory genes, highly expressed in the olfactory epithelium
-
Buanne P, Corrente G, Micheli L, et al. Cloning of PC3B, a novel member of the PC3/BTG/TOB family of growth inhibitory genes, highly expressed in the olfactory epithelium. Genomics 2000;68:253-63.
-
(2000)
Genomics
, vol.68
, pp. 253-263
-
-
Buanne, P.1
Corrente, G.2
Micheli, L.3
-
41
-
-
0035057256
-
The gene PC3(TIS21/BTG2), prototype member of the PC3/BTG/TOB family: Regulator in control of cell growth, differentiation, and DNA repair?
-
Tirone F. The gene PC3(TIS21/BTG2), prototype member of the PC3/BTG/TOB family: regulator in control of cell growth, differentiation, and DNA repair? J Cell Physiol 2001;187:155-65.
-
(2001)
J Cell Physiol
, vol.187
, pp. 155-165
-
-
Tirone, F.1
-
42
-
-
16144362452
-
Identification of BTG2, an antiproliferative p53-dependent component of the DNA damage cellular response pathway
-
Rouault JP, Falette N, Guéhenneux F, et al. Identification of BTG2, an antiproliferative p53-dependent component of the DNA damage cellular response pathway. Nat Genet 1996;14:482-6.
-
(1996)
Nat Genet
, vol.14
, pp. 482-486
-
-
Rouault, J.P.1
Falette, N.2
Guéhenneux, F.3
-
43
-
-
30944459963
-
A systematic search for downstream mediators of tumor suppressor function of p53 reveals a major role of BTG2 in suppression of Ras-induced transformation
-
Boiko AD, Porteous S, Razorenova OV, Krivokrysenko VI, Williams BR, Gudkov AV. A systematic search for downstream mediators of tumor suppressor function of p53 reveals a major role of BTG2 in suppression of Ras-induced transformation. Genes Dev 2006;20:236-52.
-
(2006)
Genes Dev
, vol.20
, pp. 236-252
-
-
Boiko, A.D.1
Porteous, S.2
Razorenova, O.V.3
Krivokrysenko, V.I.4
Williams, B.R.5
Gudkov, A.V.6
-
44
-
-
34548427509
-
The candidate tumor suppressor BTG3 is a transcriptional target of p53 that inhibits E2F1
-
Ou YH, Chung PH, Hsu FF, Sun TP, Chang WY, Shieh SY. The candidate tumor suppressor BTG3 is a transcriptional target of p53 that inhibits E2F1. EMBO J 2007; 26:3968-80.
-
(2007)
EMBO J
, vol.26
, pp. 3968-3980
-
-
Ou, Y.H.1
Chung, P.H.2
Hsu, F.F.3
Sun, T.P.4
Chang, W.Y.5
Shieh, S.Y.6
-
45
-
-
16844378940
-
Identification of a potential role for POU2AF1 and BTG4 in the deletion of 11q23 in chronic lymphocytic leukemia
-
Auer RL, Starczynski J, McElwaine S, et al. Identification of a potential role for POU2AF1 and BTG4 in the deletion of 11q23 in chronic lymphocytic leukemia. Genes Chromosomes Cancer 2005;43:1-10.
-
(2005)
Genes Chromosomes Cancer
, vol.43
, pp. 1-10
-
-
Auer, R.L.1
Starczynski, J.2
McElwaine, S.3
|