The human RNA surveillance factor UPF1 is required for S phase progression and genome stability

Current Biology

Volumn 16, Issue 4, 2006, Pages 433-439

  Azzalin, Claus M ^a,b   Lingner, Joachim ^a,b  

^a EPFL   (Switzerland)

^b Frontiers in Genetics National Center for Competence in Research   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ATR PROTEIN, HUMAN; CELL CYCLE PROTEIN; DNA DIRECTED DNA POLYMERASE GAMMA; PROTEIN SERINE THREONINE KINASE; RNA HELICASE;

ARTICLE; CELL CYCLE S PHASE; CHROMATIN; DNA DAMAGE; GENOMIC INSTABILITY; HELA CELL; HUMAN; PHOSPHORYLATION; PHYSIOLOGY; RNA STABILITY;

CELL CYCLE PROTEINS; CHROMATIN; DNA DAMAGE; DNA POLYMERASE III; GENOMIC INSTABILITY; HELA CELLS; HUMANS; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; RNA HELICASES; RNA STABILITY; S PHASE;

EUKARYOTA;

EID: 32944458421     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cub.2006.01.018     Document Type: Article

References (31)

1. J.A. Holbrook, G. Neu-Yilik, M.W. Hentze, and A.E. Kulozik Nonsense-mediated decay approaches the clinic Nat. Genet. 36 2004 801 808
2. J.T. Mendell, N.A. Sharifi, J.L. Meyers, F. Martinez-Murillo, and H.C. Dietz Nonsense surveillance regulates expression of diverse classes of mammalian transcripts and mutes genomic noise Nat. Genet. 36 2004 1073 1078
3. M.W. Hentze, and A.E. Kulozik A perfect message: RNA surveillance and nonsense-mediated decay Cell 96 1999 307 310
4. S.E. Mango Stop making nonsense: The C. elegans smg genes Trends Genet. 17 2001 646 653
5. F.J. Iborra, A.E. Escargueil, K.Y. Kwek, A. Akoulitchev, and P.R. Cook Molecular cross-talk between the transcription, translation, and nonsense-mediated decay machineries J. Cell Sci. 117 2004 899 906
6. L.E. Maquat Nonsense-mediated mRNA decay: Splicing, translation and mRNP dynamics Nat. Rev. Mol. Cell Biol. 5 2004 89 99
7. M.F. Wilkinson A new function for nonsense-mediated mRNA-decay factors Trends Genet. 21 2005 143 148
8. Y.K. Kim, L. Furic, L. DesGroseillers, and L.E. Maquat Mammalian Staufen1 recruits Upf1 to specific mRNA 3′UTRs so as to elicit mRNA decay Cell 120 2005 195 208
9. K.M. Brumbaugh, D.M. Otterness, C. Geisen, V. Oliveira, J. Brognard, X. Li, F. Lejeune, R.S. Tibbetts, L.E. Maquat, and R.T. Abraham The mRNA surveillance protein hSMG-1 functions in genotoxic stress response pathways in mammalian cells Mol. Cell 14 2004 585 598
10. P. Reichenbach, M. Hoss, C.M. Azzalin, M. Nabholz, P. Bucher, and J. Lingner A human homolog of yeast Est1 associates with telomerase and uncaps chromosome ends when overexpressed Curr. Biol. 13 2003 568 574
11. B.E. Snow, N. Erdmann, J. Cruickshank, H. Goldman, R.M. Gill, M.O. Robinson, and L. Harrington Functional conservation of the telomerase protein Est1p in humans Curr. Biol. 13 2003 698 704
12. J.K. Lamba, M. Adachi, D. Sun, J. Tammur, E.G. Schuetz, R. Allikmets, and J.D. Schuetz Nonsense mediated decay downregulates conserved alternatively spliced ABCC4 transcripts bearing nonsense codons Hum. Mol. Genet. 12 2003 99 109
13. J. Wittmann, E.M. Hol, and H.-M. Jack HUPF2 silencing identifies physiologic substrates of mammalian nonsense-mediated mRNA decay Mol. Cell. Biol. 26 2005 1272 1287
14. P. Madsen, and J.E. Celis S-phase patterns of cyclin (PCNA) antigen staining resemble topographical patterns of DNA synthesis. A role for cyclin in DNA replication? FEBS Lett. 193 1985 5 11
15. R. Bravo, and H. Macdonald-Bravo Existence of two populations of cyclin/proliferating cell nuclear antigen during the cell cycle: Association with DNA replication sites J. Cell Biol. 105 1987 1549 1554
16. I.M. Ward, and J. Chen Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress J. Biol. Chem. 276 2001 47759 47762
17. C.J. Bakkenist, and M.B. Kastan Initiating cellular stress responses Cell 118 2004 9 17
18. A. Sancar, L.A. Lindsey-Boltz, K. Unsal-Kaccmaz, and S. Linn Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints Annu. Rev. Biochem. 73 2004 39 85
19. P. Nghiem, P.K. Park, Y.S. Kim Ys, B.N. Desai, and S.L. Schreiber ATR is not required for p53 activation but synergizes with p53 in the replication checkpoint J. Biol. Chem. 277 2002 4428 4434
20. D.R. Krause, J.C. Jonnalagadda, M.H. Gatei, H.H. Sillje, B.B. Zhou, E.A. Nigg, and K. Khanna Suppression of Tousled-like kinase activity after DNA damage or replication block requires ATM, NBS1 and Chk1 Oncogene 22 2003 5927 5937
21. N. Zhou, H. Xiao, T.K. Li, E.K.A. Nur, and L.F. Liu DNA damage-mediated apoptosis induced by selenium compounds J. Biol. Chem. 278 2003 29532 29537
22. F. Riva, M. Savio, O. Cazzalini, L.A. Stivala, I.A. Scovassi, B. Ducommum, and E. Prosperi Distinct pools of proliferating cell nuclear antigen associated to DNA replication sites interact with the p125 subunit of DNA polymerase delta or DNA ligase I Exp. Cell Res. 293 2004 357 367
23. R. Thermann, G. Neu-Yilik, A. Deters, U. Frede, K. Wehr, C. Hagemeier, M.W. Hentze, and A.E. Kulozik Binary specification of nonsense codons by splicing and cytoplasmic translation EMBO J. 17 1998 3484 3494
24. T. Ohnishi, A. Yamashita, I. Kashima, T. Schell, K.R. Anders, A. Grimson, T. Hachiya, M.W. Hentze, P. Anderson, and S. Ohno Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7 Mol. Cell 12 2003 1187 1200
25. E.J. Brown, and D. Baltimore Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance Genes Dev. 17 2002 615 628
26. L.M. Carastro, C.K. Tan, M. Selg, H.M. Jack, A.G. So, and K.M. Downey Identification of delta helicase as the bovine homolog of HUPF1: Demonstration of an interaction with the third subunit of DNA polymerase delta Nucleic Acids Res. 30 2002 2232 2243
27. H. Kaygun, and W.F. Marzluff Regulated degradation of replication-dependent histone mRNAs requires both ATR and Upf1 Nat. Struct. Mol. Biol. 12 2005 794 800
28. S.M. Medghalchi, P.A. Frischmeyer, J.T. Mendell, A.G. Kelly, A.M. Lawler, and H.C. Dietz Rent1, a trans-effector of nonsense-mediated mRNA decay, is essential for mammalian embryonic viability Hum. Mol. Genet. 10 2001 99 105
29. K. Czaplinski, Y. Weng, K.W. Hagan, and S.W. Peltz Purification and characterization of the Upf1 protein: A factor involved in translation and mRNA degradation RNA 1 1995 610 623
30. P. Leeds, S.W. Peltz, A. Jacobson, and M.R. Culbertson The product of the yeast UPF1 gene is required for rapid turnover of mRNAs containing a premature translational termination codon Genes Dev. 5 1991 2303 2314
31. M.F. Page, B. Carr, K.R. Anders, A. Grimson, and P. Anderson SMG-2 is a phosphorylated protein required for mRNA surveillance in Caenorhabditis elegans and related to Upf1p of yeast Mol. Cell. Biol. 19 1999 5943 5951