메뉴 건너뛰기




Volumn 18, Issue 8, 2012, Pages 1563-1572

Sequential RNA degradation pathways provide a fail-safe mechanism to limit the accumulation of unspliced transcripts in Saccharomyces cerevisiae

Author keywords

Exosome; Nonsense mediated decay; RNA export; RNA quality control; Unspliced RNAs

Indexed keywords

FUNGAL RNA; MESSENGER RNA PRECURSOR; NUCLEAR FACTOR; PROTEIN MLP1P; PROTEIN MLP2P; UNCLASSIFIED DRUG;

EID: 84864063925     PISSN: 13558382     EISSN: 14699001     Source Type: Journal    
DOI: 10.1261/rna.033779.112     Document Type: Article
Times cited : (27)

References (35)
  • 2
    • 0029162673 scopus 로고
    • Autoregulation of expression of the yeast Dbp2p 'DEAD-box' protein is mediated by sequences in the conserved DBP2 intron
    • Barta I, Iggo R. 1995. Autoregulation of expression of the yeast Dbp2p 'DEAD-box' protein is mediated by sequences in the conserved DBP2 intron. EMBO J 14: 3800-3808.
    • (1995) EMBO J , vol.14 , pp. 3800-3808
    • Barta, I.1    Iggo, R.2
  • 3
    • 0034664803 scopus 로고    scopus 로고
    • Identification of a regulated pathway for nuclear pre-mRNA turnover
    • Bousquet-Antonelli C, Presutti C, Tollervey D. 2000. Identification of a regulated pathway for nuclear pre-mRNA turnover. Cell 102: 765-775.
    • (2000) Cell , vol.102 , pp. 765-775
    • Bousquet-Antonelli, C.1    Presutti, C.2    Tollervey, D.3
  • 5
    • 34247197937 scopus 로고    scopus 로고
    • The nonsense-mediated decay RNA surveillance pathway
    • Chang YF, Imam JS, Wilkinson MF. 2007. The nonsense-mediated decay RNA surveillance pathway. Annu Rev Biochem 76: 51-74.
    • (2007) Annu Rev Biochem , vol.76 , pp. 51-74
    • Chang, Y.F.1    Imam, J.S.2    Wilkinson, M.F.3
  • 6
    • 33745712580 scopus 로고    scopus 로고
    • Nuclear mRNA degradation pathway(s) are implicated in Xist regulation and X chromosome inactivation
    • doi: 10.1371/journal.pgen.00200904
    • Ciaudo C, Bourdet A, Cohen-Tannoudji M, Dietz HC, Rougeulle C, Avner P. 2006. Nuclear mRNA degradation pathway(s) are implicated in Xist regulation and X chromosome inactivation. PLoS Genet 2: e94. doi: 10.1371/journal.pgen. 00200904.
    • (2006) PLoS Genet , vol.2
    • Ciaudo, C.1    Bourdet, A.2    Cohen-Tannoudji, M.3    Dietz, H.C.4    Rougeulle, C.5    Avner, P.6
  • 7
    • 0038054468 scopus 로고    scopus 로고
    • RNAse III-mediated degradation of unspliced pre-mRNAs and lariat introns
    • DOI 10.1016/S1097-2765(03)00137-0
    • Danin-Kreiselman M, Lee CY, Chanfreau G. 2003. RNAse III-mediated degradation of unspliced pre-mRNAs and lariat introns. Mol Cell 11: 1279-1289. (Pubitemid 36645146)
    • (2003) Molecular Cell , vol.11 , Issue.5 , pp. 1279-1289
    • Danin-Kreiselman, M.1    Lee, C.Y.2    Chanfreau, G.3
  • 8
    • 33847059515 scopus 로고    scopus 로고
    • YRA1 Autoregulation Requires Nuclear Export and Cytoplasmic Edc3p-Mediated Degradation of Its Pre-mRNA
    • DOI 10.1016/j.molcel.2007.01.012, PII S1097276507000172
    • Dong S, Li C, Zenklusen D, Singer RH, Jacobson A, He F. 2007. YRA1 autoregulation requires nuclear export and cytoplasmic Edc3p-mediated degradation of its pre-mRNA. Mol Cell 25: 559-573. (Pubitemid 46274442)
    • (2007) Molecular Cell , vol.25 , Issue.4 , pp. 559-573
    • Dong, S.1    Li, C.2    Zenklusen, D.3    Singer, R.H.4    Jacobson, A.5    He, F.6
  • 9
    • 84857844645 scopus 로고    scopus 로고
    • Quality control of MATa1 splicing and exon skipping by nuclear RNA degradation
    • Egecioglu DE, Kawashima TR, Chanfreau GF. 2012. Quality control of MATa1 splicing and exon skipping by nuclear RNA degradation. Nucleic Acids Res 40: 1787-1796.
    • (2012) Nucleic Acids Res , vol.40 , pp. 1787-1796
    • Egecioglu, D.E.1    Kawashima, T.R.2    Chanfreau, G.F.3
  • 10
    • 0742304306 scopus 로고    scopus 로고
    • Nuclear Retention of Unspliced mRNAs in Yeast Is Mediated by Perinuclear Mlp1
    • DOI 10.1016/S0092-8674(03)01026-2
    • Galy V, Gadal O, Fromont-Racine M, Romano A, Jacquier A, Nehrbass U. 2004. Nuclear retention of unspliced mRNAs in yeast is mediated by perinuclear Mlp1. Cell 116: 63-73. (Pubitemid 38156184)
    • (2004) Cell , vol.116 , Issue.1 , pp. 63-73
    • Galy, V.1    Gadal, O.2    Fromont-Racine, M.3    Romano, A.4    Jacquier, A.5    Nehrbass, U.6
  • 11
    • 78149242834 scopus 로고    scopus 로고
    • Nuclear retention of unspliced pre-mRNAs by mutant DHX16/hPRP2, a spliceosomal DEAH-box protein
    • Gencheva M, Lin TY, Wu X, Yang L, Richard C, Jones M, Lin SB, Lin RJ. 2010. Nuclear retention of unspliced pre-mRNAs by mutant DHX16/hPRP2, a spliceosomal DEAH-box protein. J Biol Chem 285: 35624-35632.
    • (2010) J Biol Chem , vol.285 , pp. 35624-35632
    • Gencheva, M.1    Lin, T.Y.2    Wu, X.3    Yang, L.4    Richard, C.5    Jones, M.6    Lin, S.B.7    Lin, R.J.8
  • 13
    • 0346786528 scopus 로고    scopus 로고
    • Cytoplasmic Degradation of Splice-Defective Pre-mRNAs and Intermediates
    • DOI 10.1016/S1097-2765(03)00488-X
    • Hilleren PJ, Parker R. 2003. Cytoplasmic degradation of splice-defective pre-mRNAs and intermediates. Mol Cell 12: 1453-1465. (Pubitemid 38037014)
    • (2003) Molecular Cell , vol.12 , Issue.6 , pp. 1453-1465
    • Hilleren, P.J.1    Parker, R.2
  • 16
    • 0035975969 scopus 로고    scopus 로고
    • The DECD box putative ATPase Sub2p is an early mRNA export factor
    • DOI 10.1016/S0960-9822(01)00529-2
    • Jensen TH, Boulay J, Rosbash M, Libri D. 2001. The DECD box putative ATPase Sub2p is an early mRNA export factor. Curr Biol 11: 1711-1715. (Pubitemid 33037785)
    • (2001) Current Biology , vol.11 , Issue.21 , pp. 1711-1715
    • Jensen, T.H.1    Boulay, J.2    Rosbash, M.3    Libri, D.4
  • 17
    • 20444368818 scopus 로고    scopus 로고
    • RNA degradation by the exosome is promoted by a nuclear polyadenylation complex
    • DOI 10.1016/j.cell.2005.04.029, PII S0092867405004423
    • LaCava J, Houseley J, Saveanu C, Petfalski E, Thompson E, Jacquier A, Tollervey D. 2005. RNA degradation by the exosome is promoted by a nuclear polyadenylation complex. Cell 121: 713-724. (Pubitemid 40797594)
    • (2005) Cell , vol.121 , Issue.5 , pp. 713-724
    • LaCava, J.1    Houseley, J.2    Saveanu, C.3    Petfalski, E.4    Thompson, E.5    Jacquier, A.6    Tollervey, D.7
  • 18
    • 80053597137 scopus 로고    scopus 로고
    • A pre-mRNA degradation pathway that selectively targets intron-containing genes requires the nuclear poly(A)-binding protein
    • Lemieux C, Marguerat S, Lafontaine J, Barbezier N, Bahler J, Bachand F. 2011. A pre-mRNA degradation pathway that selectively targets intron-containing genes requires the nuclear poly(A)-binding protein. Mol Cell 44: 108-119.
    • (2011) Mol Cell , vol.44 , pp. 108-119
    • Lemieux, C.1    Marguerat, S.2    Lafontaine, J.3    Barbezier, N.4    Bahler, J.5    Bachand, F.6
  • 19
    • 0036889142 scopus 로고    scopus 로고
    • Interactions between mRNA export commitment, 3′-end quality control, and nuclear degradation
    • DOI 10.1128/MCB.22.23.8254-8266.2002
    • Libri D, Dower K, Boulay J, Thomsen R, Rosbash M, Jensen TH. 2002. Interactions between mRNA export commitment, 3′-end quality control, and nuclear degradation. Mol Cell Biol 22: 8254-8266. (Pubitemid 35304058)
    • (2002) Molecular and Cellular Biology , vol.22 , Issue.23 , pp. 8254-8266
    • Libri, D.1    Dower, K.2    Boulay, J.3    Thomsen, R.4    Rosbash, M.5    Jensen, T.H.6
  • 20
    • 0029844746 scopus 로고    scopus 로고
    • + RNA export
    • Liu Y, Liang S, Tartakoff AM. 1996. Heat shock disassembles the nucleolus and inhibits nuclear protein import and poly(A)+ RNA export. EMBO J 15: 6750-6757. (Pubitemid 26413806)
    • (1996) EMBO Journal , vol.15 , Issue.23 , pp. 6750-6757
    • Liu, Y.1    Liang, S.2    Tartakoff, A.M.3
  • 21
    • 0031820288 scopus 로고    scopus 로고
    • Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae
    • DOI 10.1002/(SICI)1097-0061(199807)14:10<953::AID-YEA293>3.0.CO;2-U
    • Longtine MS, McKenzie A 3rd, Demarini DJ, Shah NG, Wach A, Brachat A, Philippsen P, Pringle JR. 1998. Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae. Yeast 14: 953-961. (Pubitemid 28328001)
    • (1998) Yeast , vol.14 , Issue.10 , pp. 953-961
    • Longtine, M.S.1    McKenzie III, A.2    Demarini, D.J.3    Shah, N.G.4    Wach, A.5    Brachat, A.6    Philippsen, P.7    Pringle, J.R.8
  • 22
    • 0030702085 scopus 로고    scopus 로고
    • The exosome: A conserved eukaryotic RNA processing complex containing multiple 3'→5' exoribonucleases
    • Mitchell P, Petfalski E, Shevchenko A, Mann M, Tollervey D. 1997. The exosome: a conserved eukaryotic RNA processing complex containing multiple 3′ → 5′ exoribonucleases. Cell 91: 457-466. (Pubitemid 27508235)
    • (1997) Cell , vol.91 , Issue.4 , pp. 457-466
    • Mitchell, P.1    Petfalski, E.2    Shevchenko, A.3    Mann, M.4    Tollervey, D.5
  • 23
    • 0033856880 scopus 로고    scopus 로고
    • Unproductively spliced ribosomal protein mRNAs are natural targets of mRNA surveillance in C. elegans
    • Mitrovich QM, Anderson P. 2000. Unproductively spliced ribosomal protein mRNAs are natural targets of mRNA surveillance in C. elegans. Genes Dev 14: 2173-2184.
    • (2000) Genes Dev , vol.14 , pp. 2173-2184
    • Mitrovich, Q.M.1    Anderson, P.2
  • 24
    • 33845654265 scopus 로고    scopus 로고
    • Differential Recruitment of the Splicing Machinery during Transcription Predicts Genome-Wide Patterns of mRNA Splicing
    • DOI 10.1016/j.molcel.2006.12.006, PII S1097276506008422
    • Moore MJ, Schwartzfarb EM, Silver PA, Yu MC. 2006. Differential recruitment of the splicing machinery during transcription predicts genome-wide patterns of mRNA splicing. Mol Cell 24: 903-915. (Pubitemid 44960102)
    • (2006) Molecular Cell , vol.24 , Issue.6 , pp. 903-915
    • Moore, M.J.1    Schwartzfarb, E.M.2    Silver, P.A.3    Yu, M.C.4
  • 25
    • 33646882843 scopus 로고    scopus 로고
    • Autoregulation of the mRNA export factor Yra1p requires inefficient splicing of its pre-mRNA
    • DOI 10.1261/rna.6706
    • Preker PJ, Guthrie C. 2006. Autoregulation of the mRNA export factor Yra1p requires inefficient splicing of its pre-mRNA. RNA 12: 994-1006. (Pubitemid 43788118)
    • (2006) RNA , vol.12 , Issue.6 , pp. 994-1006
    • Preker, P.J.1    Guthrie, C.2
  • 26
    • 34247628538 scopus 로고    scopus 로고
    • Dissecting mechanisms of nuclear mRNA surveillance in THO/sub2 complex mutants
    • DOI 10.1038/sj.emboj.7601669, PII 7601669
    • Rougemaille M, Gudipati RK, Olesen JR, Thomsen R, Seraphin B, Libri D, Jensen TH. 2007. Dissecting mechanisms of nuclear mRNA surveillance in THO/sub2 complex mutants. EMBO J 26: 2317-2326. (Pubitemid 46685852)
    • (2007) EMBO Journal , vol.26 , Issue.9 , pp. 2317-2326
    • Rougemaille, M.1    Gudipati, R.K.2    Olesen, J.R.3    Thomsen, R.4    Seraphin, B.5    Libri, D.6    Jensen, T.H.7
  • 27
    • 48349096177 scopus 로고    scopus 로고
    • Widespread impact of nonsense-mediated mRNA decay on the yeast intronome
    • Sayani S, Janis M, Lee CY, Toesca I, Chanfreau GF. 2008. Widespread impact of nonsense-mediated mRNA decay on the yeast intronome. Mol Cell 31: 360-370.
    • (2008) Mol Cell , vol.31 , pp. 360-370
    • Sayani, S.1    Janis, M.2    Lee, C.Y.3    Toesca, I.4    Chanfreau, G.F.5
  • 28
    • 0030911425 scopus 로고    scopus 로고
    • + RNA and nuclear pores
    • DOI 10.1093/emboj/16.11.3256
    • Segref A, Sharma K, Doye V, Hellwig A, Huber J, Luhrmann R, Hurt E. 1997. Mex67p, a novel factor for nuclear mRNA export, binds to both poly(A)+ RNA and nuclear pores. EMBO J 16: 3256-3271. (Pubitemid 27234963)
    • (1997) EMBO Journal , vol.16 , Issue.11 , pp. 3256-3271
    • Segref, A.1    Sharma, K.2    Doye, V.3    Hellwig, A.4    Huber, J.5    Luhrmann, R.6    Hurt, E.7
  • 29
    • 33747603960 scopus 로고    scopus 로고
    • The imprinted Air ncRNA is an atypical RNAPII transcript that evades splicing and escapes nuclear export
    • DOI 10.1038/sj.emboj.7601245, PII 7601245
    • Seidl CI, Stricker SH, Barlow DP. 2006. The imprinted Air ncRNA is an atypical RNAPII transcript that evades splicing and escapes nuclear export. EMBO J 25: 3565-3575. (Pubitemid 44264867)
    • (2006) EMBO Journal , vol.25 , Issue.15 , pp. 3565-3575
    • Seidl, C.I.M.1    Stricker, S.H.2    Barlow, D.P.3
  • 31
    • 84455200588 scopus 로고    scopus 로고
    • Single-molecule mRNA decay measurements reveal promoter-regulated mRNA stability in yeast
    • Trcek T, Larson DR, Moldón A, Query CC, Singer RH. 2011. Single-molecule mRNA decay measurements reveal promoter-regulated mRNA stability in yeast. Cell 147: 1484-1497.
    • (2011) Cell , vol.147 , pp. 1484-1497
    • Trcek, T.1    Larson, D.R.2    Moldón, A.3    Query, C.C.4    Singer, R.H.5
  • 32
    • 0033790503 scopus 로고    scopus 로고
    • Mechanisms and control of mRNA decapping in Saccharomyces cerevisiae
    • Tucker M, Parker R. 2000. Mechanisms and control of mRNA decapping in Saccharomyces cerevisiae. Annu Rev Biochem 69: 571-595.
    • (2000) Annu Rev Biochem , vol.69 , pp. 571-595
    • Tucker, M.1    Parker, R.2
  • 33
    • 15444368318 scopus 로고    scopus 로고
    • Perinuclear Mlp proteins downregulate gene expression in response to a defect in mRNA export
    • DOI 10.1038/sj.emboj.7600527
    • Vinciguerra P, Iglesias N, Camblong J, Zenklusen D, Stutz F. 2005. Perinuclear Mlp proteins downregulate gene expression in response to a defect in mRNA export. EMBO J 24: 813-823. (Pubitemid 40396110)
    • (2005) EMBO Journal , vol.24 , Issue.4 , pp. 813-823
    • Vinciguerra, P.1    Iglesias, N.2    Camblong, J.3    Zenklusen, D.4    Stutz, F.5
  • 35
    • 0036889334 scopus 로고    scopus 로고
    • Stable mRNP formation and export require cotranscriptional recruitment of the mRNA export factors Yra1p and Sub2p by Hpr1p
    • DOI 10.1128/MCB.22.23.8241-8253.2002
    • Zenklusen D, Vinciguerra P, Wyss JC, Stutz F. 2002. Stable mRNP formation and export require cotranscriptional recruitment of the mRNA export factors Yra1p and Sub2p by Hpr1p. Mol Cell Biol 22: 8241-8253. (Pubitemid 35304057)
    • (2002) Molecular and Cellular Biology , vol.22 , Issue.23 , pp. 8241-8253
    • Zenklusen, D.1    Vinciguerra, P.2    Wyss, J.-C.3    Stutz, F.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.