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Volumn 17, Issue 3, 2005, Pages 309-315

Mechanistic links between nonsense-mediated mRNA decay and pre-mRNA splicing in mammalian cells

Author keywords

[No Author keywords available]

Indexed keywords

BETA GLOBIN; CAP BINDING PROTEIN; ELONGATION FACTOR; HEAT SHOCK PROTEIN 70; MELANOCORTIN; MELANOCORTIN 4 RECEPTOR; MESSENGER RNA;

EID: 19344366251     PISSN: 09550674     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ceb.2005.03.002     Document Type: Review
Times cited : (328)

References (68)
  • 1
    • 0035934166 scopus 로고    scopus 로고
    • Nonsense-mediated mRNA decay in Saccharomyces cerevisiae
    • C.I. Gonzalez, A. Bhattacharya, W. Wang, and S.W. Peltz Nonsense-mediated mRNA decay in Saccharomyces cerevisiae Gene 274 2001 15 25
    • (2001) Gene , vol.274 , pp. 15-25
    • Gonzalez, C.I.1    Bhattacharya, A.2    Wang, W.3    Peltz, S.W.4
  • 2
    • 8544253956 scopus 로고    scopus 로고
    • A faux 3′ UTR promotes aberrant termination and triggers nonsense-mediated mRNA decay
    • N. Amrani, R. Ganesan, S. Kervestin, D.A. Mangus, S. Ghosh, and A. Jacobson A faux 3′ UTR promotes aberrant termination and triggers nonsense-mediated mRNA decay Nature 432 2004 112 118
    • (2004) Nature , vol.432 , pp. 112-118
    • Amrani, N.1    Ganesan, R.2    Kervestin, S.3    Mangus, D.A.4    Ghosh, S.5    Jacobson, A.6
  • 3
    • 1842689543 scopus 로고    scopus 로고
    • Nonsense-mediated mRNA decay: A comparative analysis of different species
    • L.E. Maquat Nonsense-mediated mRNA decay: a comparative analysis of different species Curr Genomics 5 2004 175 190
    • (2004) Curr Genomics , vol.5 , pp. 175-190
    • Maquat, L.E.1
  • 4
    • 0032104190 scopus 로고    scopus 로고
    • A rule for termination-codon position within intron-containing genes: When nonsense affects RNA abundance
    • E. Nagy, and L.E. Maquat A rule for termination-codon position within intron-containing genes: when nonsense affects RNA abundance Trends Biochem Sci 23 1998 198 199
    • (1998) Trends Biochem Sci , vol.23 , pp. 198-199
    • Nagy, E.1    Maquat, L.E.2
  • 5
    • 11144244811 scopus 로고    scopus 로고
    • Splicing of U12-type introns deposits an exon junction complex competent to induce nonsense-mediated mRNA decay
    • T. Hirose, M.D. Shu, and J.A. Steitz Splicing of U12-type introns deposits an exon junction complex competent to induce nonsense-mediated mRNA decay Proc Natl Acad Sci USA 101 2004 17976 17981
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 17976-17981
    • Hirose, T.1    Shu, M.D.2    Steitz, J.A.3
  • 6
    • 2442579711 scopus 로고    scopus 로고
    • An unappreciated role for RNA surveillance
    • R.T. Hillman, R.E. Green, and S.E. Brenner An unappreciated role for RNA surveillance Genome Biol 5 2004 R8 Many mRNA isoforms that are generated by alternative splicing are down-regulated as a result of the presence of a nonsense codon that elicits NMD.
    • (2004) Genome Biol , vol.5 , pp. 8
    • Hillman, R.T.1    Green, R.E.2    Brenner, S.E.3
  • 7
    • 6944256813 scopus 로고    scopus 로고
    • Nonsense surveillance regulates expression of diverse classes of mammalian transcripts and mutes genomic noise
    • J.T. Mendell, N.A. Sharifi, J.L. Meyers, F. Martinez-Murillo, and H.C. Dietz Nonsense surveillance regulates expression of diverse classes of mammalian transcripts and mutes genomic noise Nat Genet 36 2004 1073 1078 Down-regulating human Upf1 down- or up-regulates the expression of ∼10% of genes studied, indicating that NMD is widely involved in modulating gene expression.
    • (2004) Nat Genet , vol.36 , pp. 1073-1078
    • Mendell, J.T.1    Sharifi, N.A.2    Meyers, J.L.3    Martinez-Murillo, F.4    Dietz, H.C.5
  • 8
    • 0035028094 scopus 로고    scopus 로고
    • Mammalian heat shock p70 and histone H4 transcripts, which derive from naturally intronless genes, are immune to nonsense-mediated decay
    • L.E. Maquat, and X. Li Mammalian heat shock p70 and histone H4 transcripts, which derive from naturally intronless genes, are immune to nonsense-mediated decay RNA 7 2001 445 456
    • (2001) RNA , vol.7 , pp. 445-456
    • Maquat, L.E.1    Li, X.2
  • 10
    • 3543032700 scopus 로고    scopus 로고
    • Molecular insights into the interaction of PYM with the Mago-Y14 core of the exon junction complex
    • F. Bono, J. Ebert, L. Unterholzner, T. Guttler, E. Izaurralde, and E. Conti Molecular insights into the interaction of PYM with the Mago-Y14 core of the exon junction complex EMBO Rep 5 2004 304 310
    • (2004) EMBO Rep , vol.5 , pp. 304-310
    • Bono, F.1    Ebert, J.2    Unterholzner, L.3    Guttler, T.4    Izaurralde, E.5    Conti, E.6
  • 11
    • 0034704201 scopus 로고    scopus 로고
    • Human Upf proteins target an mRNA for nonsense-mediated decay when bound downstream of a termination codon
    • J. Lykke-Andersen, M.D. Shu, and J.A. Steitz Human Upf proteins target an mRNA for nonsense-mediated decay when bound downstream of a termination codon Cell 103 2000 1121 1131
    • (2000) Cell , vol.103 , pp. 1121-1131
    • Lykke-Andersen, J.1    Shu, M.D.2    Steitz, J.A.3
  • 12
    • 0035823247 scopus 로고    scopus 로고
    • Communication of the position of exon-exon junctions to the mRNA surveillance machinery by the protein RNPS1
    • J. Lykke-Andersen, M.D. Shu, and J.A. Steitz Communication of the position of exon-exon junctions to the mRNA surveillance machinery by the protein RNPS1 Science 293 2001 1836 1839
    • (2001) Science , vol.293 , pp. 1836-1839
    • Lykke-Andersen, J.1    Shu, M.D.2    Steitz, J.A.3
  • 14
    • 1442354190 scopus 로고    scopus 로고
    • An eIF4AIII-containing complex required for mRNA localization and nonsense-mediated mRNA decay
    • I.M. Palacios, D. Gatfield, D. St Johnston, and E. Izaurralde An eIF4AIII-containing complex required for mRNA localization and nonsense-mediated mRNA decay Nature 427 2004 753 757
    • (2004) Nature , vol.427 , pp. 753-757
    • Palacios, I.M.1    Gatfield, D.2    St Johnston, D.3    Izaurralde, E.4
  • 15
    • 1842577707 scopus 로고    scopus 로고
    • EIF4AIII binds spliced mRNA in the exon junction complex and is essential for nonsense-mediated decay
    • T. Shibuya, T.O. Tange, N. Sonenberg, and M.J. Moore eIF4AIII binds spliced mRNA in the exon junction complex and is essential for nonsense-mediated decay Nat Struct Mol Biol 11 2004 346 351
    • (2004) Nat Struct Mol Biol , vol.11 , pp. 346-351
    • Shibuya, T.1    Tange, T.O.2    Sonenberg, N.3    Moore, M.J.4
  • 16
    • 12944327374 scopus 로고    scopus 로고
    • Mammalian Staufen1 recruits Upf1 to specific mRNA 3′UTRs so as to elicit mRNA decay
    • Y.K. Kim, L. Furic, L. DesGroseillers, and L.E. Maquat Mammalian Staufen1 recruits Upf1 to specific mRNA 3′UTRs so as to elicit mRNA decay Cell 120 2005 195 208
    • (2005) Cell , vol.120 , pp. 195-208
    • Kim, Y.K.1    Furic, L.2    Desgroseillers, L.3    Maquat, L.E.4
  • 17
    • 0029845144 scopus 로고    scopus 로고
    • Evidence that the decay of nucleus-associated nonsense mRNA for human triosephosphate isomerase involves nonsense codon recognition after splicing
    • J. Zhang, and L.E. Maquat Evidence that the decay of nucleus-associated nonsense mRNA for human triosephosphate isomerase involves nonsense codon recognition after splicing RNA 2 1996 235 243
    • (1996) RNA , vol.2 , pp. 235-243
    • Zhang, J.1    Maquat, L.E.2
  • 18
    • 0742323558 scopus 로고    scopus 로고
    • Nonsense-mediated mRNA decay: Splicing, translation and mRNP dynamics
    • L.E. Maquat Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics Nat Rev Mol Cell Biol 5 2004 89 99
    • (2004) Nat Rev Mol Cell Biol , vol.5 , pp. 89-99
    • Maquat, L.E.1
  • 19
    • 0036512117 scopus 로고    scopus 로고
    • Messenger-RNA-binding proteins and the messages they carry
    • G. Dreyfuss, V.N. Kim, and N. Kataoka Messenger-RNA-binding proteins and the messages they carry Nat Rev Mol Cell Biol 3 2002 195 205
    • (2002) Nat Rev Mol Cell Biol , vol.3 , pp. 195-205
    • Dreyfuss, G.1    Kim, V.N.2    Kataoka, N.3
  • 20
    • 0038699144 scopus 로고    scopus 로고
    • Coupling transcription, splicing and mRNA export
    • R. Reed Coupling transcription, splicing and mRNA export Curr Opin Cell Biol 15 2003 326 331
    • (2003) Curr Opin Cell Biol , vol.15 , pp. 326-331
    • Reed, R.1
  • 21
    • 0042671357 scopus 로고    scopus 로고
    • Pre-mRNA splicing: Awash in a sea of proteins
    • M.S. Jurica, and M.J. Moore Pre-mRNA splicing: awash in a sea of proteins Mol Cell 12 2003 5 14
    • (2003) Mol Cell , vol.12 , pp. 5-14
    • Jurica, M.S.1    Moore, M.J.2
  • 22
    • 0034672093 scopus 로고    scopus 로고
    • The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions
    • H. Le Hir, E. Izaurralde, L.E. Maquat, and M.J. Moore The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions EMBO J 19 2000 6860 6869
    • (2000) EMBO J , vol.19 , pp. 6860-6869
    • Le Hir, H.1    Izaurralde, E.2    Maquat, L.E.3    Moore, M.J.4
  • 23
    • 0035687504 scopus 로고    scopus 로고
    • The protein Mago provides a link between splicing and mRNA localization
    • H. Le Hir, D. Gatfield, I.C. Braun, D. Forler, and E. Izaurralde The protein Mago provides a link between splicing and mRNA localization EMBO Rep 2 2001 1119 1124
    • (2001) EMBO Rep , vol.2 , pp. 1119-1124
    • Le Hir, H.1    Gatfield, D.2    Braun, I.C.3    Forler, D.4    Izaurralde, E.5
  • 24
    • 4043118349 scopus 로고    scopus 로고
    • Association of the breast cancer protein MLN51 with the exon junction complex via its speckle localizer and RNA binding module
    • S. Degot, H. Le Hir, F. Alpy, V. Kedinger, I. Stoll, C. Wendling, B. Seraphin, M.C. Rio, and C. Tomasetto Association of the breast cancer protein MLN51 with the exon junction complex via its speckle localizer and RNA binding module J Biol Chem 279 2004 33702 33715
    • (2004) J Biol Chem , vol.279 , pp. 33702-33715
    • Degot, S.1    Le Hir, H.2    Alpy, F.3    Kedinger, V.4    Stoll, I.5    Wendling, C.6    Seraphin, B.7    Rio, M.C.8    Tomasetto, C.9
  • 27
    • 0141706348 scopus 로고    scopus 로고
    • Exon junction complexes mediate the enhancing effect of splicing on mRNA expression
    • H.L. Wiegand, S. Lu, and B.R. Cullen Exon junction complexes mediate the enhancing effect of splicing on mRNA expression Proc Natl Acad Sci USA 100 2003 11327 11332
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 11327-11332
    • Wiegand, H.L.1    Lu, S.2    Cullen, B.R.3
  • 28
    • 0942268832 scopus 로고    scopus 로고
    • Splicing enhances translation in mammalian cells: An additional function of the exon junction complex
    • A. Nott, H. Le Hir, and M.J. Moore Splicing enhances translation in mammalian cells: an additional function of the exon junction complex Genes Dev 18 2004 210 222
    • (2004) Genes Dev , vol.18 , pp. 210-222
    • Nott, A.1    Le Hir, H.2    Moore, M.J.3
  • 29
    • 0035823036 scopus 로고    scopus 로고
    • Evidence for a pioneer round of mRNA translation: MRNAs subject to nonsense-mediated decay in mammalian cells are bound by CBP80 and CBP20
    • Y. Ishigaki, X. Li, G. Serin, and L.E. Maquat Evidence for a pioneer round of mRNA translation: mRNAs subject to nonsense-mediated decay in mammalian cells are bound by CBP80 and CBP20 Cell 106 2001 607 617
    • (2001) Cell , vol.106 , pp. 607-617
    • Ishigaki, Y.1    Li, X.2    Serin, G.3    Maquat, L.E.4
  • 30
    • 0036645697 scopus 로고    scopus 로고
    • The exon junction complex is detected on CBP80-bound but not eIF4E-bound mRNA in mammalian cells: Dynamics of mRNP remodelling
    • F. Lejeune, Y. Ishigaki, X. Li, and L.E. Maquat The exon junction complex is detected on CBP80-bound but not eIF4E-bound mRNA in mammalian cells: dynamics of mRNP remodelling EMBO J 21 2002 3536 3545
    • (2002) EMBO J , vol.21 , pp. 3536-3545
    • Lejeune, F.1    Ishigaki, Y.2    Li, X.3    Maquat, L.E.4
  • 31
    • 1842682946 scopus 로고    scopus 로고
    • The pioneer translation initiation complex is functionally distinct from but structurally overlaps with the steady-state translation initiation complex
    • S.Y. Chiu, F. Lejeune, A.C. Ranganathan, and L.E. Maquat The pioneer translation initiation complex is functionally distinct from but structurally overlaps with the steady-state translation initiation complex Genes Dev 18 2004 745 754
    • (2004) Genes Dev , vol.18 , pp. 745-754
    • Chiu, S.Y.1    Lejeune, F.2    Ranganathan, A.C.3    Maquat, L.E.4
  • 32
    • 4744347153 scopus 로고    scopus 로고
    • EIF4G is required for the pioneer round of translation in mammalian cells
    • F. Lejeune, A.C. Ranganathan, and L.E. Maquat eIF4G is required for the pioneer round of translation in mammalian cells Nat Struct Mol Biol 11 2004 992 1000
    • (2004) Nat Struct Mol Biol , vol.11 , pp. 992-1000
    • Lejeune, F.1    Ranganathan, A.C.2    Maquat, L.E.3
  • 33
    • 0034193569 scopus 로고    scopus 로고
    • Pre-mRNA splicing alters mRNP composition: Evidence for stable association of proteins at exon-exon junctions
    • H. Le Hir, M.J. Moore, and L.E. Maquat Pre-mRNA splicing alters mRNP composition: evidence for stable association of proteins at exon-exon junctions Genes Dev 14 2000 1098 1108
    • (2000) Genes Dev , vol.14 , pp. 1098-1108
    • Le Hir, H.1    Moore, M.J.2    Maquat, L.E.3
  • 34
    • 17644443879 scopus 로고    scopus 로고
    • In vivo recruitment of exon junction complex proteins to transcription sites in mammalian cell nuclei
    • N. Custodio, C. Carvalho, I. Condado, M. Antoniou, B.J. Blencowe, and M. Carmo-Fonseca In vivo recruitment of exon junction complex proteins to transcription sites in mammalian cell nuclei RNA 10 2004 622 633 Components of the EJC are concentrated at the sites of transcription, suggesting that the EJC binds transcripts co-transcriptionally.
    • (2004) RNA , vol.10 , pp. 622-633
    • Custodio, N.1    Carvalho, C.2    Condado, I.3    Antoniou, M.4    Blencowe, B.J.5    Carmo-Fonseca, M.6
  • 35
    • 0036826885 scopus 로고    scopus 로고
    • 5′ exon interactions within the human spliceosome establish a framework for exon junction complex structure and assembly
    • V.L. Reichert, H. Le Hir, M.S. Jurica, and M.J. Moore 5′ exon interactions within the human spliceosome establish a framework for exon junction complex structure and assembly Genes Dev 16 2002 2778 2791
    • (2002) Genes Dev , vol.16 , pp. 2778-2791
    • Reichert, V.L.1    Le Hir, H.2    Jurica, M.S.3    Moore, M.J.4
  • 36
    • 1342325392 scopus 로고    scopus 로고
    • A simple whole cell lysate system for in vitro splicing reveals a stepwise assembly of the exon-exon junction complex
    • N. Kataoka, and G. Dreyfuss A simple whole cell lysate system for in vitro splicing reveals a stepwise assembly of the exon-exon junction complex J Biol Chem 279 2004 7009 7013
    • (2004) J Biol Chem , vol.279 , pp. 7009-7013
    • Kataoka, N.1    Dreyfuss, G.2
  • 37
    • 0029908912 scopus 로고    scopus 로고
    • A splicing-dependent regulatory mechanism that detects translation signals
    • M.S. Carter, S. Li, and M.F. Wilkinson A splicing-dependent regulatory mechanism that detects translation signals EMBO J 15 1996 5965 5975
    • (1996) EMBO J , vol.15 , pp. 5965-5975
    • Carter, M.S.1    Li, S.2    Wilkinson, M.F.3
  • 38
    • 0037025175 scopus 로고    scopus 로고
    • Alternatively spliced TCR mRNA induced by disruption of reading frame
    • J. Wang, J.I. Hamilton, M.S. Carter, S. Li, and M.F. Wilkinson Alternatively spliced TCR mRNA induced by disruption of reading frame Science 297 2002 108 110
    • (2002) Science , vol.297 , pp. 108-110
    • Wang, J.1    Hamilton, J.I.2    Carter, M.S.3    Li, S.4    Wilkinson, M.F.5
  • 39
    • 0034928832 scopus 로고    scopus 로고
    • Nonsense-mediated decay of human HEXA mRNA
    • K.S. Rajavel, and E.F. Neufeld Nonsense-mediated decay of human HEXA mRNA Mol Cell Biol 21 2001 5512 5519
    • (2001) Mol Cell Biol , vol.21 , pp. 5512-5519
    • Rajavel, K.S.1    Neufeld, E.F.2
  • 40
    • 0031870169 scopus 로고    scopus 로고
    • Intron function in the nonsense-mediated decay of β-globin mRNA: Indications that pre-mRNA splicing in the nucleus can influence mRNA translation in the cytoplasm
    • J. Zhang, X. Sun, Y. Qian, and L.E. Maquat Intron function in the nonsense-mediated decay of β-globin mRNA: indications that pre-mRNA splicing in the nucleus can influence mRNA translation in the cytoplasm RNA 4 1998 801 815
    • (1998) RNA , vol.4 , pp. 801-815
    • Zhang, J.1    Sun, X.2    Qian, Y.3    Maquat, L.E.4
  • 42
    • 0036493774 scopus 로고    scopus 로고
    • Abnormally spliced β-globin mRNAs: A single point mutation generates transcripts sensitive and insensitive to nonsense-mediated mRNA decay
    • S. Danckwardt, G. Neu-Yilik, R. Thermann, U. Frede, M.W. Hentze, and A.E. Kulozik Abnormally spliced β-globin mRNAs: a single point mutation generates transcripts sensitive and insensitive to nonsense-mediated mRNA decay Blood 99 2002 1811 1816
    • (2002) Blood , vol.99 , pp. 1811-1816
    • Danckwardt, S.1    Neu-Yilik, G.2    Thermann, R.3    Frede, U.4    Hentze, M.W.5    Kulozik, A.E.6
  • 43
    • 0031046735 scopus 로고    scopus 로고
    • Evidence that translation reinitiation abrogates nonsense-mediated mRNA decay in mammalian cells
    • J. Zhang, and L.E. Maquat Evidence that translation reinitiation abrogates nonsense-mediated mRNA decay in mammalian cells EMBO J 16 1997 826 833
    • (1997) EMBO J , vol.16 , pp. 826-833
    • Zhang, J.1    Maquat, L.E.2
  • 44
    • 0041524056 scopus 로고    scopus 로고
    • The apolipoprotein B mRNA editing complex performs a multifunctional cycle and suppresses nonsense-mediated decay
    • A. Chester, A. Somasekaram, M. Tzimina, A. Jarmuz, J. Gisbourne, R. O'Keefe, J. Scott, and N. Navaratnam The apolipoprotein B mRNA editing complex performs a multifunctional cycle and suppresses nonsense-mediated decay EMBO J 22 2003 3971 3982
    • (2003) EMBO J , vol.22 , pp. 3971-3982
    • Chester, A.1    Somasekaram, A.2    Tzimina, M.3    Jarmuz, A.4    Gisbourne, J.5    O'Keefe, R.6    Scott, J.7    Navaratnam, N.8
  • 45
    • 0032006979 scopus 로고    scopus 로고
    • Nonsense surveillance in lymphocytes?
    • S. Li, and M.F. Wilkinson Nonsense surveillance in lymphocytes? Immunity 8 1998 135 141
    • (1998) Immunity , vol.8 , pp. 135-141
    • Li, S.1    Wilkinson, M.F.2
  • 46
    • 0037166282 scopus 로고    scopus 로고
    • A quality control pathway that down-regulates aberrant T-cell receptor (TCR) transcripts by a mechanism requiring UPF2 and translation
    • J. Wang, V.M. Vock, S. Li, O.R. Olivas, and M.F. Wilkinson A quality control pathway that down-regulates aberrant T-cell receptor (TCR) transcripts by a mechanism requiring UPF2 and translation J Biol Chem 277 2002 18489 18493
    • (2002) J Biol Chem , vol.277 , pp. 18489-18493
    • Wang, J.1    Vock, V.M.2    Li, S.3    Olivas, O.R.4    Wilkinson, M.F.5
  • 47
    • 0037080771 scopus 로고    scopus 로고
    • T-cell receptor sequences that elicit strong down-regulation of premature termination codon-bearing transcripts
    • J.P. Gudikote, and M.F. Wilkinson T-cell receptor sequences that elicit strong down-regulation of premature termination codon-bearing transcripts EMBO J 21 2002 125 134
    • (2002) EMBO J , vol.21 , pp. 125-134
    • Gudikote, J.P.1    Wilkinson, M.F.2
  • 48
    • 3042796497 scopus 로고    scopus 로고
    • Efficient downregulation of immunoglobulin mu mRNA with premature translation-termination codons requires the 5′-half of the VDJ exon
    • M. Buhler, A. Paillusson, and O. Muhlemann Efficient downregulation of immunoglobulin mu mRNA with premature translation-termination codons requires the 5′-half of the VDJ exon Nucleic Acids Res 32 2004 3304 3315
    • (2004) Nucleic Acids Res , vol.32 , pp. 3304-3315
    • Buhler, M.1    Paillusson, A.2    Muhlemann, O.3
  • 51
    • 4944223388 scopus 로고    scopus 로고
    • Widespread predicted nonsense-mediated mRNA decay of alternatively- spliced transcripts of human normal and disease genes
    • R.E. Green, B.P. Lewis, R.T. Hillman, M. Blanchette, L.F. Lareau, A.T. Garnett, D.C. Rio, and S.E. Brenner Widespread predicted nonsense-mediated mRNA decay of alternatively-spliced transcripts of human normal and disease genes Bioinformatics 19 Suppl 1 2003 i118 i121
    • (2003) Bioinformatics , vol.19 , Issue.1 SUPPL.
    • Green, R.E.1    Lewis, B.P.2    Hillman, R.T.3    Blanchette, M.4    Lareau, L.F.5    Garnett, A.T.6    Rio, D.C.7    Brenner, S.E.8
  • 52
    • 0037422575 scopus 로고    scopus 로고
    • Evidence for the widespread coupling of alternative splicing and nonsense-mediated mRNA decay in humans
    • B.P. Lewis, R.E. Green, and S.E. Brenner Evidence for the widespread coupling of alternative splicing and nonsense-mediated mRNA decay in humans Proc Natl Acad Sci USA 100 2003 189 192 One-third of alternatively spliced mRNA isoforms are estimated to carry a nonsense codon that elicits NMD.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 189-192
    • Lewis, B.P.1    Green, R.E.2    Brenner, S.E.3
  • 53
    • 0035794679 scopus 로고    scopus 로고
    • SC35 autoregulates its expression by promoting splicing events that destabilize its mRNAs
    • A. Sureau, R. Gattoni, Y. Dooghe, J. Stevenin, and J. Soret SC35 autoregulates its expression by promoting splicing events that destabilize its mRNAs EMBO J 20 2001 1785 1796
    • (2001) EMBO J , vol.20 , pp. 1785-1796
    • Sureau, A.1    Gattoni, R.2    Dooghe, Y.3    Stevenin, J.4    Soret, J.5
  • 54
    • 0346124413 scopus 로고    scopus 로고
    • Autoregulation of polypyrimidine tract binding protein by alternative splicing leading to nonsense-mediated decay
    • M.C. Wollerton, C. Gooding, E.J. Wagner, M.A. Garcia-Blanco, and C.W. Smith Autoregulation of polypyrimidine tract binding protein by alternative splicing leading to nonsense-mediated decay Mol Cell 13 2004 91 100 PTB down-regulates its production by activating exon skipping during PTB pre-mRNA splicing. The consequence is a frameshift mutation, which introduces a nonsense codon that elicits NMD.
    • (2004) Mol Cell , vol.13 , pp. 91-100
    • Wollerton, M.C.1    Gooding, C.2    Wagner, E.J.3    Garcia-Blanco, M.A.4    Smith, C.W.5
  • 55
    • 8844219677 scopus 로고    scopus 로고
    • Involvement of SR proteins in mRNA surveillance
    • Z. Zhang, and A.R. Krainer Involvement of SR proteins in mRNA surveillance Mol Cell 16 2004 597 607 Over-expression of the SR proteins ASF/SF2 or SC35 is shown to increase the efficiency of NMD in a manner that depends on the RS domain of the SR protein.
    • (2004) Mol Cell , vol.16 , pp. 597-607
    • Zhang, Z.1    Krainer, A.R.2
  • 56
    • 14644431487 scopus 로고    scopus 로고
    • Broad specificity of SR (serine/arginine) proteins in the regulation of alternative splicing of pre-messenger RNA
    • C.F. Bourgeois, F. Lejeune, and J. Stevenin Broad specificity of SR (serine/arginine) proteins in the regulation of alternative splicing of pre-messenger RNA Prog Nucleic Acid Res Mol Biol 78 2004 37 88
    • (2004) Prog Nucleic Acid Res Mol Biol , vol.78 , pp. 37-88
    • Bourgeois, C.F.1    Lejeune, F.2    Stevenin, J.3
  • 57
    • 0035025061 scopus 로고    scopus 로고
    • Splicing factors SRp20 and 9G8 promote the nucleocytoplasmic export of mRNA
    • Y. Huang, and J.A. Steitz Splicing factors SRp20 and 9G8 promote the nucleocytoplasmic export of mRNA Mol Cell 7 2001 899 905
    • (2001) Mol Cell , vol.7 , pp. 899-905
    • Huang, Y.1    Steitz, J.A.2
  • 58
    • 0344211508 scopus 로고    scopus 로고
    • SR splicing factors serve as adapter proteins for TAP-dependent mRNA export
    • Y. Huang, R. Gattoni, J. Stevenin, and J.A. Steitz SR splicing factors serve as adapter proteins for TAP-dependent mRNA export Mol Cell 11 2003 837 843
    • (2003) Mol Cell , vol.11 , pp. 837-843
    • Huang, Y.1    Gattoni, R.2    Stevenin, J.3    Steitz, J.A.4
  • 59
    • 3843075319 scopus 로고    scopus 로고
    • Hypophosphorylated ASF/SF2 binds TAP and is present in messenger ribonucleoproteins
    • M.C. Lai, and W.Y. Tarn Hypophosphorylated ASF/SF2 binds TAP and is present in messenger ribonucleoproteins J Biol Chem 279 2004 31745 31749
    • (2004) J Biol Chem , vol.279 , pp. 31745-31749
    • Lai, M.C.1    Tarn, W.Y.2
  • 60
    • 1842632326 scopus 로고    scopus 로고
    • A novel role for shuttling SR proteins in mRNA translation
    • J.R. Sanford, N.K. Gray, K. Beckmann, and J.F. Caceres A novel role for shuttling SR proteins in mRNA translation Genes Dev 18 2004 755 768
    • (2004) Genes Dev , vol.18 , pp. 755-768
    • Sanford, J.R.1    Gray, N.K.2    Beckmann, K.3    Caceres, J.F.4
  • 61
    • 0037099302 scopus 로고    scopus 로고
    • A nonsense mutation in the fibrillin-1 gene of a Marfan syndrome patient induces NMD and disrupts an exonic splicing enhancer
    • M. Caputi, R.J. Kendzior Jr., and K.L. Beemon A nonsense mutation in the fibrillin-1 gene of a Marfan syndrome patient induces NMD and disrupts an exonic splicing enhancer Genes Dev 16 2002 1754 1759
    • (2002) Genes Dev , vol.16 , pp. 1754-1759
    • Caputi, M.1    Kendzior Jr., R.J.2    Beemon, K.L.3
  • 62
    • 0036544654 scopus 로고    scopus 로고
    • Disruption of an SF2/ASF-dependent exonic splicing enhancer in SMN2 causes spinal muscular atrophy in the absence of SMN1
    • L. Cartegni, and A.R. Krainer Disruption of an SF2/ASF-dependent exonic splicing enhancer in SMN2 causes spinal muscular atrophy in the absence of SMN1 Nat Genet 30 2002 377 384
    • (2002) Nat Genet , vol.30 , pp. 377-384
    • Cartegni, L.1    Krainer, A.R.2
  • 63
    • 0035158730 scopus 로고    scopus 로고
    • A mechanism for exon skipping caused by nonsense or missense mutations in BRCA1 and other genes
    • H.X. Liu, L. Cartegni, M.Q. Zhang, and A.R. Krainer A mechanism for exon skipping caused by nonsense or missense mutations in BRCA1 and other genes Nat Genet 27 2001 55 58
    • (2001) Nat Genet , vol.27 , pp. 55-58
    • Liu, H.X.1    Cartegni, L.2    Zhang, M.Q.3    Krainer, A.R.4
  • 64
    • 0037064145 scopus 로고    scopus 로고
    • Separable roles for rent1/hUpf1 in altered splicing and decay of nonsense transcripts
    • J.T. Mendell, C.M. Rhys, and H.C. Dietz Separable roles for rent1/hUpf1 in altered splicing and decay of nonsense transcripts Science 298 2002 419 422
    • (2002) Science , vol.298 , pp. 419-422
    • Mendell, J.T.1    Rhys, C.M.2    Dietz, H.C.3
  • 65
    • 1642528941 scopus 로고    scopus 로고
    • Premature termination codons do not affect the rate of splicing of neighboring introns
    • J.R. Lytle, and J.A. Steitz Premature termination codons do not affect the rate of splicing of neighboring introns RNA 10 2004 657 668 The presence of a nonsense codon within immunoglobulin μ or dihydrofolate reductase pre-mRNA does not affect the rate at which neighboring introns are removed by splicing.
    • (2004) RNA , vol.10 , pp. 657-668
    • Lytle, J.R.1    Steitz, J.A.2
  • 66
    • 0027536976 scopus 로고
    • Nonsense codons can reduce the abundance of nuclear mRNA without affecting the abundance of pre-mRNA or the half-life of cytoplasmic mRNA
    • J. Cheng, and L.E. Maquat Nonsense codons can reduce the abundance of nuclear mRNA without affecting the abundance of pre-mRNA or the half-life of cytoplasmic mRNA Mol Cell Biol 13 1993 1892 1902
    • (1993) Mol Cell Biol , vol.13 , pp. 1892-1902
    • Cheng, J.1    Maquat, L.E.2
  • 67
    • 0347623203 scopus 로고    scopus 로고
    • Regulation of splicing: The importance of being translatable
    • E. Miriami, R. Sperling, J. Sperling, and U. Motro Regulation of splicing: the importance of being translatable RNA 10 2004 1 4
    • (2004) RNA , vol.10 , pp. 1-4
    • Miriami, E.1    Sperling, R.2    Sperling, J.3    Motro, U.4
  • 68
    • 7044227587 scopus 로고    scopus 로고
    • Stop codon-mediated suppression of splicing is a novel nuclear scanning mechanism not affected by elements of protein synthesis and NMD
    • C. Wachtel, B. Li, J. Sperling, and R. Sperling Stop codon-mediated suppression of splicing is a novel nuclear scanning mechanism not affected by elements of protein synthesis and NMD RNA 10 2004 1740 1750
    • (2004) RNA , vol.10 , pp. 1740-1750
    • Wachtel, C.1    Li, B.2    Sperling, J.3    Sperling, R.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.