A strategy for disease gene identification though nonsense-mediated mRNA decay inhibition

Nature Biotechnology

Volumn 19, Issue 5, 2001, Pages 434-439

  Noensie, Erick N ^a   Dietz, Harry C ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEGRADATION; DISEASES; DNA; DRUG THERAPY; RNA;

MICROARRAYS;

GENES;

ANISOMYCIN; BETA N ACETYLHEXOSAMINIDASE B; COMPLEMENTARY DNA; CYCLOHEXIMIDE; EMETINE; GENTAMICIN; MESSENGER RNA; MUTANT PROTEIN; NEOMYCIN; NUCLEOTIDE; PACTAMYCIN; PAROMOMYCIN; PUROMYCIN;

ARTICLE; CELL CULTURE; COLON CANCER; CONTROLLED STUDY; DIAGNOSTIC VALUE; DNA MICROARRAY; GENE EXPRESSION; GENE LOCUS; GENE SEQUENCE; HUMAN; HUMAN CELL; NONSENSE MUTATION; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RNA DEGRADATION; RNA TRANSCRIPTION; SANDHOFF DISEASE; SEQUENCE ANALYSIS; STOP CODON; UNINDEXED SEQUENCE;

BACTERIAL PROTEINS; BETA-N-ACETYLHEXOSAMINIDASE; CARRIER PROTEINS; CELL LINE; CODON, NONSENSE; CODON, TERMINATOR; COLONIC NEOPLASMS; DNA-BINDING PROTEINS; HUMANS; MALE; NEOPLASM PROTEINS; NUCLEAR PROTEINS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PEPTIDE CHAIN TERMINATION, TRANSLATIONAL; RNA, MESSENGER; SANDHOFF DISEASE; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0035005985     PISSN: 10870156     EISSN: None     Source Type: Journal    
DOI: 10.1038/88099     Document Type: Article

References (23)

1. Interference of nonsense mutations with eukaryotic messenger RNA stability
2. RNA surveillance. Unforeseen consequences for gene expression, inherited genetic disorders and cancer
3. Nonsense-mediated mRNA decay in health and disease
4. The majority of yeast UPF1 co-localizes with polyribosomes in the cytoplasm
5. Relationship between yeast polyribosomes and Upf proteins required for nonsense mRNA decay
6. T cell receptor-β mRNA splicing: Regulation of unusual splicing intermediates
7. A regulatory mechanism that detects premature nonsense codons in T-cell receptor transcripts in vivo is reversed by protein synthesis inhibitors in vitro
8. Aminoglycoside suppression at UAG, UAA and UGA codons in Escherichia coli and human tissue culture cells
9. Suppression of a nonsense mutation in mammalian cells in vivo by the aminoglycoside antibiotics G-418 and paromomycin
10. Spectra of spontaneous mutations at the hprt locus in colorectal carcinoma cell lines defective in mismatch repair
11. Wild-type p53 suppresses growth of human prostate cancer cells containing mutant p53 alleles
12. Genetic mapping of a second locus predisposing to hereditary non-polyposis colon cancer
13. Tay-Sachs' and Sandhoff's diseases: The assignment of genes for hexosaminidase A and B to individual human chromosomes
14. Mammalian orthologues of a yeast regulator of nonsense transcript stability
15. A mutated human homologue to yeast Upf1 protein has a dominant-negative effect on the decay of nonsense-containing mRNAs in mammalian cells
16. Rent1, a trans-effector of nonsense-mediated mRNA decay, is essential for mammalian embryonic viability
17. Yeast Upf proteins required for RNA surveillance affect global expression of the yeast transcriptome
18. A rule for termination-codon position within intron-containing genes: When nonsense affects RNA abundance
19. Mutations in the APC gene and their implications for protein structure and function
20. Molecular diagnosis of Stickler syndrome: A COL2A1 stop codon mutation screening strategy that is not compromised by mutant mRNA instability
21. Reliable and sensitive detection of premature termination mutations using a protein truncation test designed to overcome problems of nonsense-mediated mRNA instability