Does the nonsense-mediated mRNA decay mechanism prevent the synthesis of truncated BRCA1, CHK2, and p53 proteins?

Human Mutation

Volumn 29, Issue 1, 2008, Pages 65-73

  Anczuków, Olga ^a,b   Ware, Mark D ^a,b   Buisson, Monique ^a,b   Zetoune, Almoutassem B ^a,b   Stoppa Lyonnet, Dominique ^c   Sinilnikova, Olga M ^a,b,d   Mazoyer, Sylvie ^a,b  

^a Laboratoire de Génétique Moléculaire   (France)

^b UNIVERSITÉ LYON 1   (France)

^c INSTITUT CURIE   (France)

^d HOSPICES CIVILS DE LYON   (France)

Author keywords

BRCA1; Breast cancer predisposition; CHK2; Nonsense mediated mRNA decay; p53; Truncated protein

Indexed keywords

BRCA1 PROTEIN; CHECKPOINT KINASE 2; PROTEIN P53;

ARTICLE; BREAST CANCER; CANCER SUSCEPTIBILITY; CARBOXY TERMINAL SEQUENCE; CODON; CONTROLLED STUDY; GENETIC SUSCEPTIBILITY; HUMAN; HUMAN CELL; LYMPHOBLASTOID CELL; NONSENSE MEDIATED MRNA DECAY; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; RNA ANALYSIS; RNA TRANSCRIPTION;

ALLELES; ANDROSTADIENES; BRCA1 PROTEIN; CELL LINE, TUMOR; CODON, NONSENSE; HELA CELLS; HUMANS; PROTEIN-SERINE-THREONINE KINASES; RNA STABILITY; RNA, MESSENGER; TUMOR SUPPRESSOR PROTEIN P53;

EID: 38149054906     PISSN: 10597794     EISSN: None     Source Type: Journal    
DOI: 10.1002/humu.20590     Document Type: Article

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