Functions of the nonsense-mediated mRNA decay pathway in Drosophila development

PLoS Genetics

Volumn 2, Issue 12, 2006, Pages 2143-2154

  Metzstein, Mark M ^a,b   Krasnow, Mark A ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GREEN FLUORESCENT PROTEIN; INSECT PROTEIN; MESSENGER RNA; PROTEIN SMG1; PROTEIN UPF1; PROTEIN UPF2; UNCLASSIFIED DRUG;

ARTICLE; CAENORHABDITIS ELEGANS; CELL GROWTH; CELL PROLIFERATION; CELL SURVIVAL; CELL VIABILITY; DEVELOPMENTAL STAGE; DROSOPHILA; GENE CONTROL; GENE EXPRESSION; GENE MAPPING; GENETIC ANALYSIS; IN VIVO STUDY; LARVA; NONHUMAN; NONSENSE MUTATION; PROTEIN EXPRESSION; SINGLE NUCLEOTIDE POLYMORPHISM; ANIMAL; DNA MICROARRAY; FEMALE; GENETICS; GROWTH, DEVELOPMENT AND AGING; LETHAL GENE; MALE; METABOLISM; MUTAGENESIS; TRANSGENE;

CAENORHABDITIS ELEGANS; MAMMALIA;

ANIMALS; DROSOPHILA; FEMALE; GENES, LETHAL; GREEN FLUORESCENT PROTEINS; MALE; MUTAGENESIS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; POLYMORPHISM, SINGLE NUCLEOTIDE; RNA, MESSENGER; TRANSGENES;

EID: 33846015866     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.0020180     Document Type: Article

References (56)

1. 0 thalassemia. Cell 27: 543-553.
2. Noensie EN, Dietz HC (2001) A strategy for disease gene identification through nonsense-mediated mRNA decay inhibition. Nat Biotechnol 19: 434-439.
3. Inoue K, Khajavi M, Ohyama T, Hirabayashi S, Wilson J, et al. (2004) Molecular mechanism for distinct neurological phenotypes conveyed by allelic truncating mutations. Nat Genet 36: 361-369.
4. Neu-Yilik G, Gehring NH, Hentze MW, Kulozik AE (2004) Nonsense-mediated mRNA decay: From vacuum cleaner to Swiss army knife. Genome Biol 5: 218.
5. Leeds P, Wood JM, Lee BS, Culbertson MR (1992) Gene products that promote mRNA turnover in Saccharomyces cerevisiae. Mol Cell Biol 12: 2165-2177.
6. Hodgkin J, Papp A, Pulak R, Ambros V, Anderson P (1989) A new kind of informational suppression in the nematode Caenorhabditis elegans. Genetics 123: 301-313.
7. Amrani N, Ganesan R, Kervestin S, Mangus DA, Ghosh S, et al. (2004) A faux 3′-UTR promotes aberrant termination and triggers nonsense-mediated mRNA decay. Nature 432: 112-118.
8. Lykke-Andersen J, Shu MD, Steitz JA (2000) Human Upf proteins target an mRNA for nonsense-mediated decay when bound downstream of a termination codon. Cell 103: 1121-1131.
9. Kashima I, Yamashita A, Izumi N, Kataoka N, Morishita R, et al. (2006) Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay. Genes Dev 20: 355-367.
10. Gatfield D, Unterholzner L, Ciccarelli FD, Bork P, Izaurralde E (2003) Nonsense-mediated mRNA decay in Drosophila: At the intersection of the yeast and mammalian pathways. EMBO J 22: 3960-3970.
11. Conti E, Izaurralde E (2005) Nonsense-mediated mRNA decay: Molecular insights and mechanistic variations across species. Curr Opin Cell Biol 17: 316-325.
12. Sheth U, Parker R (2006) Targeting of aberrant mRNAs to cytoplasmic processing bodies. Cell 125: 1095-1109.
13. Yamashita A, Kashima I, Ohno S (2005) The role of SMG-1 in nonsense-mediated mRNA decay. Biochim Biophys Acta 1754: 305-315.
14. Yamashita A, Ohnishi T, Kashima I, Taya Y, Ohno S (2001) Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay. Genes Dev 15: 2215-2228.
15. Lejeune F, Maquat LE (2005) Mechanistic links between nonsense-mediated mRNA decay and pre-mRNA splicing in mammalian cells. Curr Opin Cell Biol 17: 309-315.
16. Amrani N, Dong S, He F, Ganesan R, Ghosh S, et al. (2006) Aberrant termination triggers nonsense-mediated mRNA decay. Biochem Soc Trans 34: 39-42.
17. Buhler M, Steiner S, Mohn F, Paillusson A, Muhlemann O (2006) EJC-independent degradation of nonsense immunoglobulin-mu mRNA depends on 3′ UTR length. Nat Struct Mol Biol 13: 462-464.
18. Medghalchi SM, Frischmeyer PA, Mendell JT, Kelly AG, Lawler AM, et al. (2001) Rent1, a trans-effector of nonsense-mediated mRNA decay, is essential for mammalian embryonic viability. Hum Mol Genet 10: 99-105.
19. Rehwinkel J, Letunic I, Raes J, Bork P, Izaurralde E (2005) Nonsense-mediated mRNA decay factors act in concert to regulate common mRNA targets. RNA 11: 1530-1544.
20. Azzalin CM, Lingner J (2006) The human RNA surveillance factor UPF1 is required for S phase progression and genome stability. Curr Biol 16: 433-439.
21. Chen Z, Smith KR, Batterham P, Robin C (2005) Smg1 nonsense mutations do not abolish nonsense-mediated mRNA decay in Drosophila melanogaster. Genetics 171: 403-406.
22. Xu T, Rubin GM (1993) Analysis of genetic mosaics in developing and adult Drosophila tissues. Development 117: 1223-1237.
23. Lee T, Luo L (1999) Mosaic analysis with a repressible cell marker for studies of gene function in neuronal morphogenesis. Neuron 22: 451-461.
24. Wodarz A, Hinz U, Engelbert M, Knust E (1995) Expression of crumbs confers apical character on plasma membrane domains of ectodermal epithelia of Drosophila. Cell 82: 67-76.
25. He F, Brown AH, Jacobson A (1997) Upf1p, Nmd2p, and Upf3p are interacting components of the yeast nonsense-mediated mRNA decay pathway. Mol Cell Biol 17: 1580-1594.
26. n4 of Drosophila melanogaster is a nonsense mutation. Nucleic Acids Res 15: 3931.
27. Brand AH, Perrimon N (1993) Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 118: 401-415.
28. Thummel CS, Boulet AM, Lipshitz HD (1988) Vectors for Drosophila P-element-mediated transformation and tissue culture transfection. Gene 74: 445-456.
29. Kaltschmidt JA, Davidson CM, Brown NH, Brand AH (2000) Rotation and asymmetry of the mitotic spindle direct asymmetric cell division in the developing central nervous system. Nat Cell Biol 2: 7-12.
30. Ivanov IP, Simin K, Letsou A, Atkins JF, Gesteland RF (1998) The Drosophila gene for antizyme requires ribosomal frameshifting for expression and contains an intronic gene for snRNP Sm D3 on the opposite strand. Mol Cell Biol 18: 1553-1561.
31. Boggs RT, Gregor P, Idriss S, Belote JM, McKeown M (1987) Regulation of sexual differentiation in D. melanogaster via alternative splicing of RNA from the transformer gene. Cell 50: 739-747.
32. Grueber WB, Ye B, Moore AW, Jan LY, Jan YN (2003) Dendrites of distinct classes of Drosophila sensory neurons show different capacities for homotypic repulsion. Curr Biol 13: 618-626.
33. Stowers RS, Schwarz TL (1999) A genetic method for generating Drosophila eyes composed exclusively of mitotic clones of a single genotype. Genetics 152: 1631-1639.
34. Alonso CR, Akam M (2003) A Hox gene mutation that triggers nonsense-mediated RNA decay and affects alternative splicing during Drosophila development. Nucleic Acids Res 31: 3873-3880.
35. Morata G, Ripoll P (1975) Minutes: Mutants of Drosophila autonomously affecting cell division rate. Dev Biol 42: 211-221.
36. Ryoo HD, Gorenc T, Steller H (2004) Apoptotic cells can induce compensatory cell proliferation through the JNK and the Wingless signaling pathways. Dev Cell 7: 491-501.
37. Nott A, Le Hir H, Moore MJ (2004) Splicing enhances translation in mammalian cells: An additional function of the exon junction complex. Genes Dev 18: 210-222.
38. Keeling KM, Lanier J, Du M, Salas-Marco J, Gao L, et al. (2004) Leaky termination at premature stop codons antagonizes nonsense-mediated mRNA decay in S. cerevisiae. RNA 10: 691-703.
39. Wilkinson MF (2005) A new function for nonsense-mediated mRNA-decay factors. Trends Genet 21: 143-148.
40. Muhlrad D, Parker R (1999) Aberrant mRNAs with extended 3′ UTRs are substrates for rapid degradation by mRNA surveillance. RNA 5: 1299-1307.
41. Huynh CQ, Zieler H (1999) Construction of modular and versatile plasmid vectors for the high-level expression of single or multiple genes in insects and insect cell lines. J Mol Biol 288: 13-20.
42. Holbrook JA, Neu-Yilik G, Hentze MW, Kulozik AE (2004) Nonsense-mediated decay approaches the clinic. Nat Genet 36: 801-808.
43. Ainsworth C (2005) Nonsense mutations: Running the red light. Nature 438: 726-728.
44. Shiga Y, Tanaka-Matakatsu M, Hayashi S (1996) A nuclear GFP/β-galactosidase fusion protein as a marker for morphogenesis in living Drosophila. Dev Growth Differ 38: 99-106.
45. Lawrence PA, Bodmer R, Vincent JP (1995) Segmental patterning of heart precursors in Drosophila. Development 121: 4303-4308.
46. Thibault ST, Singer MA, Miyazaki WY, Milash B, Dompe NA, et al. (2004) A complementary transposon tool kit for Drosophila melanogaster using P and piggyBac. Nat Genet 36: 283-287.
47. Lewis EB, Bacher F (1968) Methods of feeding ethyl methane sulfonate (EMS) to Drosophila males. Drosoph Inf Serv 43: 193.
48. Hoskins RA, Nelson CR, Berman BP, Laverty TR, George RA, et al. (2000) A BAC-based physical map of the major autosomes of Drosophila melanogaster. Science 287: 2271-2274.
49. Lee EC, Yu D, Martinez de Velasco J, Tessarollo L, Swing DA, et al. (2001) A highly efficient Escherichia coli-based chromosome engineering system adapted for recombinogenic targeting and subcloning of BAC DNA. Genomics 73: 56-65.
50. Thummel CS, Pirrotta V (1992) Technical notes: New pCasper P-element vectors. Drosoph Inf Serv 71: 150.
51. Arbeitman MN, Furlong EE, Imam F, Johnson E, Null BH, et al. (2002) Gene expression during the life cycle of Drosophila melanogaster. Science 297: 2270-2275.
52. Gerber AP, Luschnig S, Krasnow MA, Brown PO, Herschlag D (2006) Genome-wide identification of mRNAs associated with the translational regulator PUMILIO in Drosophila melanogaster. Proc Natl Acad Sci U S A 103: 4487-4492.
53. Johnston R, Wang B, Nuttall R, Doctolero M, Edwards P, et al. (2004) FlyGEM, a full transcriptome array platform for the Drosophila community. Genome Biol 5: R19.
54. Reichhart JM, Ferrandon D (1998) Green balancers. Drosoph Inf Serv 81: 201-202.
55. Clarkson M, Saint R (1999) A His2AvDGFP fusion gene complements a lethal His2AvD mutant allele and provides an in vivo marker for Drosophila chromosome behavior. DNA Cell Biol 18: 457-462.
56. Rorth P (1998) Gal4 in the Drosophila female germline. Mech Dev 78: 113-118.