The difference of glutathione antioxidant system in newly weaned and young mice liver and its involvement in isoline-induced hepatotoxicity

Archives of Toxicology

Volumn 85, Issue 10, 2011, Pages 1267-1279

  Liang, Qing Ning ^a,c   Sheng, Yu Chen ^d   Jiang, Ping ^a   Ji, Li Li ^a,b   Xia, Yu Ye ^d   Min, Yang ^d   Wang, Zheng Tao ^a,b  

^a SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^b Shanghai R and D Centre for Standardization of Chinese Medicines   (China)

^c UNIVERSITY OF HONG KONG   (Hong Kong)

^d SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY   (China)

Author keywords

Age dependent difference; Glutathione antioxidant system; Hepatotoxicity; Isoline; Oxidative stress

Indexed keywords

ALKALOID; ANTIOXIDANT; BUTHIONINE SULFOXIMINE; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE PEROXIDASE 1; GLUTATHIONE REDUCTASE; GLUTATHIONE TRANSFERASE; GLUTATHIONE TRANSFERASE P1; ISOLINE; MESSENGER RNA; UNCLASSIFIED DRUG; GCLM PROTEIN, MOUSE; GLUTATHIONE DISULFIDE; PYRROLIZIDINE ALKALOID;

AGE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DISEASE PREDISPOSITION; DISEASE SEVERITY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ANALYSIS; GENE EXPRESSION; HISTOPATHOLOGY; LIVER CELL; LIVER LEVEL; LIVER PARENCHYMA; LIVER TOXICITY; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; WEANING; ANIMAL; DRUG EFFECT; GENETICS; INSTITUTE FOR CANCER RESEARCH MOUSE; LIVER; METABOLISM; PATHOLOGY; TOXIC HEPATITIS;

MUS;

AGE FACTORS; ANIMALS; ANTIOXIDANTS; DRUG-INDUCED LIVER INJURY; GLUTAMATE-CYSTEINE LIGASE; GLUTATHIONE; GLUTATHIONE DISULFIDE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; GLUTATHIONE TRANSFERASE; LIVER; MALE; MICE; MICE, INBRED ICR; PYRROLIZIDINE ALKALOIDS; WEANING;

EID: 80755163210     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-011-0664-7     Document Type: Article

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