Cell-based systems to assess nuclear receptor activation and their use in drug development

Drug Metabolism Reviews

Volumn 45, Issue 1, 2013, Pages 101-109

  Raucy, Judy L ^a   Lasker, Jerome M ^a  

^a Puracyp Inc   (United States)

Author keywords

AhR; CAR; Cytochrome P450; High throughput screening; Induction; Nuclear receptor; PPAR; PXR; Screening

Indexed keywords

AROMATIC HYDROCARBON RECEPTOR; CONSTITUTIVE ANDROSTANE RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PREGNANE X RECEPTOR; RETINOID X RECEPTOR;

CELL BASED GENE THERAPY; CYTOTOXICITY; DRUG INDUSTRY; ENZYME ACTIVITY; GENE EXPRESSION REGULATION; HIGH THROUGHPUT SCREENING; HUMAN; IN VIVO STUDY; PROTEIN BINDING; REVIEW; TRANSACTIVATION;

CYTOLOGICAL TECHNIQUES; DRUG DISCOVERY; DRUG INTERACTIONS; GENE EXPRESSION; HUMANS; LIGANDS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; XENOBIOTICS;

EID: 84872707359     PISSN: 03602532     EISSN: 10979883     Source Type: Journal    
DOI: 10.3109/03602532.2012.737333     Document Type: Review

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