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Volumn 15, Issue 7, 2004, Pages 324-330

Genomic and non-genomic interactions of PPARα with xenobiotic-metabolizing enzymes

Author keywords

[No Author keywords available]

Indexed keywords

5 (2,4 DIOXO 5 THIAZOLIDINYLMETHYL) 2 METHOXY N [4 (TRIFLUOROMETHYL)BENZYL] BENZAMIDE; 5 (2,4 DIOXO 5 THIAZOLIDINYLMETHYL) 2 METHOXY N [4 (TRIFLUOROMETHYL)BENZYL]BENZAMIDE; BEZAFIBRATE; BILE ACID; CERIVASTATIN; CLOFIBRATE; CYTOCHROME P450; FENOFIBRATE; FIBRIC ACID DERIVATIVE; GEMFIBROZIL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MEVINOLIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PIOGLITAZONE; PREGNANE X RECEPTOR; RAGAGLITAZAR; ROSIGLITAZONE; SIMVASTATIN; TESAGLITAZAR; TROGLITAZONE; UNCLASSIFIED DRUG; XENOBIOTIC AGENT;

EID: 4444344438     PISSN: 10432760     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tem.2004.07.007     Document Type: Review
Times cited : (40)

References (74)
  • 1
    • 0036094913 scopus 로고    scopus 로고
    • Pleiotropic actions of peroxisome proliferator-activated receptors in lipid metabolism and atherosclerosis
    • O. Barbier Pleiotropic actions of peroxisome proliferator-activated receptors in lipid metabolism and atherosclerosis Arterioscler. Thromb. Vasc. Biol. 22 2002 717 726
    • (2002) Arterioscler. Thromb. Vasc. Biol. , vol.22 , pp. 717-726
    • Barbier, O.1
  • 2
    • 1542573343 scopus 로고    scopus 로고
    • PPAR ligands for metabolic disorders
    • G.J. Etgen, and N. Mantlo PPAR ligands for metabolic disorders Curr. Top. Med. Chem. 3 2003 1649 1661
    • (2003) Curr. Top. Med. Chem. , vol.3 , pp. 1649-1661
    • Etgen, G.J.1    Mantlo, N.2
  • 3
    • 0036293873 scopus 로고    scopus 로고
    • PPARs: Transcription factors controlling lipid and lipoprotein metabolism
    • V. Bocher PPARs: transcription factors controlling lipid and lipoprotein metabolism Ann. New York Acad. Sci. 967 2002 7 18
    • (2002) Ann. New York Acad. Sci. , vol.967 , pp. 7-18
    • Bocher, V.1
  • 4
    • 0033793133 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors (PPARs): Nuclear receptors at the crossroads between lipid metabolism and inflammation
    • G. Chinetti Peroxisome proliferator-activated receptors (PPARs): nuclear receptors at the crossroads between lipid metabolism and inflammation Inflamm. Res. 49 2000 497 505
    • (2000) Inflamm. Res. , vol.49 , pp. 497-505
    • Chinetti, G.1
  • 5
    • 0001297403 scopus 로고    scopus 로고
    • Activation of human T lymphocytes is inhibited by peroxisome proliferator-activated receptor γ (PPARγ) agonists. PPARγ co-association with transcription factor NFAT
    • X.Y. Yang Activation of human T lymphocytes is inhibited by peroxisome proliferator-activated receptor γ (PPARγ) agonists. PPARγ co-association with transcription factor NFAT J. Biol. Chem. 275 2000 4541 4544
    • (2000) J. Biol. Chem. , vol.275 , pp. 4541-4544
    • Yang, X.Y.1
  • 6
    • 0035823551 scopus 로고    scopus 로고
    • Negative regulation of human fibrinogen gene expression by peroxisome proliferator-activated receptor α agonists via inhibition of CCAAT box/enhancer-binding protein β
    • P. Gervois Negative regulation of human fibrinogen gene expression by peroxisome proliferator-activated receptor α agonists via inhibition of CCAAT box/enhancer-binding protein β J. Biol. Chem. 276 2001 33471 33477
    • (2001) J. Biol. Chem. , vol.276 , pp. 33471-33477
    • Gervois, P.1
  • 7
    • 0035824518 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor γ inhibits transforming growth factor β-induced connective tissue growth factor expression in human aortic smooth muscle cells by interfering with Smad3
    • M. Fu Peroxisome proliferator-activated receptor γ inhibits transforming growth factor β-induced connective tissue growth factor expression in human aortic smooth muscle cells by interfering with Smad3 J. Biol. Chem. 276 2001 45888 45894
    • (2001) J. Biol. Chem. , vol.276 , pp. 45888-45894
    • Fu, M.1
  • 8
    • 0033998334 scopus 로고    scopus 로고
    • The PPARs: From orphan receptors to drug discovery
    • T.M. Willson The PPARs: from orphan receptors to drug discovery J. Med. Chem. 43 2000 527 550
    • (2000) J. Med. Chem. , vol.43 , pp. 527-550
    • Willson, T.M.1
  • 9
    • 0034616072 scopus 로고    scopus 로고
    • Oxidized phospholipids activate PPARα in a phospholipase A2-dependent manner
    • P. Delerive Oxidized phospholipids activate PPARα in a phospholipase A2-dependent manner FEBS Lett. 471 2000 34 38
    • (2000) FEBS Lett. , vol.471 , pp. 34-38
    • Delerive, P.1
  • 10
    • 0035844217 scopus 로고    scopus 로고
    • Oxidized alkyl phospholipids are specific, high affinity peroxisome proliferator-activated receptor γ ligands and agonists
    • S.S. Davies Oxidized alkyl phospholipids are specific, high affinity peroxisome proliferator-activated receptor γ ligands and agonists J. Biol. Chem. 276 2001 16015 16023
    • (2001) J. Biol. Chem. , vol.276 , pp. 16015-16023
    • Davies, S.S.1
  • 11
    • 0036076907 scopus 로고    scopus 로고
    • Metabolic and additional vascular effects of thiazolidinediones
    • F.M. Martens Metabolic and additional vascular effects of thiazolidinediones Drugs 62 2002 1463 1480
    • (2002) Drugs , vol.62 , pp. 1463-1480
    • Martens, F.M.1
  • 12
    • 0035821394 scopus 로고    scopus 로고
    • Identification of a subtype selective human PPARα agonist through parallel-array synthesis
    • P.J. Brown Identification of a subtype selective human PPARα agonist through parallel-array synthesis Bioorg. Med. Chem. Lett. 11 2001 1225 1227
    • (2001) Bioorg. Med. Chem. Lett. , vol.11 , pp. 1225-1227
    • Brown, P.J.1
  • 13
    • 0032989265 scopus 로고    scopus 로고
    • A novel N-aryl tyrosine activator of peroxisome proliferator-activated receptor-γ reverses the diabetic phenotype of the Zucker diabetic fatty rat
    • K.K. Brown A novel N-aryl tyrosine activator of peroxisome proliferator-activated receptor-γ reverses the diabetic phenotype of the Zucker diabetic fatty rat Diabetes 48 1999 1415 1424
    • (1999) Diabetes , vol.48 , pp. 1415-1424
    • Brown, K.K.1
  • 14
    • 0035942162 scopus 로고    scopus 로고
    • A selective peroxisome proliferator-activated receptor delta agonist promotes reverse cholesterol transport
    • W.R. Oliver Jr A selective peroxisome proliferator-activated receptor delta agonist promotes reverse cholesterol transport Proc. Natl. Acad. Sci. U. S. A. 98 2001 5306 5311
    • (2001) Proc. Natl. Acad. Sci. U. S. A. , vol.98 , pp. 5306-5311
    • Oliver Jr., W.R.1
  • 15
    • 18044404125 scopus 로고    scopus 로고
    • Bayer decides to withdraw cholesterol lowering drug
    • F. Charatan Bayer decides to withdraw cholesterol lowering drug Br. Med. J. 323 2001 359
    • (2001) Br. Med. J. , vol.323 , pp. 359
    • Charatan, F.1
  • 16
    • 0041930641 scopus 로고    scopus 로고
    • Vertebrate UDP-glucuronosyltransferases: Functional and evolutionary aspects
    • W.K. Bock Vertebrate UDP-glucuronosyltransferases: functional and evolutionary aspects Biochem. Pharmacol. 66 2003 691 696
    • (2003) Biochem. Pharmacol. , vol.66 , pp. 691-696
    • Bock, W.K.1
  • 17
    • 0034655747 scopus 로고    scopus 로고
    • Regulation of cytochrome P450 (CYP) genes by nuclear receptors
    • P. Honkakoski, and M. Negishi Regulation of cytochrome P450 (CYP) genes by nuclear receptors Biochem. J. 347 2000 321 337
    • (2000) Biochem. J. , vol.347 , pp. 321-337
    • Honkakoski, P.1    Negishi, M.2
  • 18
    • 0036783335 scopus 로고    scopus 로고
    • Pharmacogenomics, regulation and signalling pathways of phase I and II drug metabolizing enzymes
    • T.H. Rushmore, and T. Kong Pharmacogenomics, regulation and signalling pathways of phase I and II drug metabolizing enzymes Curr. Drug Metab. 3 2002 481 490
    • (2002) Curr. Drug Metab. , vol.3 , pp. 481-490
    • Rushmore, T.H.1    Kong, T.2
  • 19
    • 0037184821 scopus 로고    scopus 로고
    • Regulation of P450 4A expression by peroxisome proliferator activated receptors
    • E.F. Johnson Regulation of P450 4A expression by peroxisome proliferator activated receptors Toxicology 181/182 2002 203 206
    • (2002) Toxicology , vol.181-182 , pp. 203-206
    • Johnson, E.F.1
  • 20
    • 0033199227 scopus 로고    scopus 로고
    • Cytochrome P450 and the individuality of species
    • D.R. Nelson Cytochrome P450 and the individuality of species Arch. Biochem. Biophys. 369 1999 1 10
    • (1999) Arch. Biochem. Biophys. , vol.369 , pp. 1-10
    • Nelson, D.R.1
  • 21
    • 0034278984 scopus 로고    scopus 로고
    • UDP-glucuronosyltransferases
    • C.D. King UDP-glucuronosyltransferases Curr. Drug Metab. 1 2000 143 161
    • (2000) Curr. Drug Metab. , vol.1 , pp. 143-161
    • King, C.D.1
  • 22
    • 0037819284 scopus 로고    scopus 로고
    • Pharmacogenomics of human UDP-glucuronosyltransferase enzymes
    • C. Guillemette Pharmacogenomics of human UDP-glucuronosyltransferase enzymes Pharmacogenomics J. 3 2003 136 158
    • (2003) Pharmacogenomics J. , vol.3 , pp. 136-158
    • Guillemette, C.1
  • 24
    • 0033779317 scopus 로고    scopus 로고
    • Cytochrome P450-dependent renal arachidonic acid metabolism in deoxycorticosterone acetate-salt hypertensive mice
    • H. Honeck Cytochrome P450-dependent renal arachidonic acid metabolism in deoxycorticosterone acetate-salt hypertensive mice Hypertension 36 2000 610 616
    • (2000) Hypertension , vol.36 , pp. 610-616
    • Honeck, H.1
  • 25
    • 0037144475 scopus 로고    scopus 로고
    • The CYP4A isoforms hydroxylate epoxyeicosatrienoic acids to form high affinity ligands
    • L.A. Cowart The CYP4A isoforms hydroxylate epoxyeicosatrienoic acids to form high affinity ligands J. Biol. Chem. 277 2002 35105 35112
    • (2002) J. Biol. Chem. , vol.277 , pp. 35105-35112
    • Cowart, L.A.1
  • 26
    • 0028997684 scopus 로고
    • Targeted disruption of the α isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators
    • S.S. Lee Targeted disruption of the α isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators Mol. Cell. Biol. 15 1995 3012 3022
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 3012-3022
    • Lee, S.S.1
  • 27
    • 0031838516 scopus 로고    scopus 로고
    • Do peroxisome proliferating compounds pose a hepatocarcinogenesis hazard to humans?
    • R.C. Cattley Do peroxisome proliferating compounds pose a hepatocarcinogenesis hazard to humans? Regul. Toxicol. Pharmacol. 27 1998 47 60
    • (1998) Regul. Toxicol. Pharmacol. , vol.27 , pp. 47-60
    • Cattley, R.C.1
  • 28
    • 0042734963 scopus 로고    scopus 로고
    • Effects of clofibric acid on mRNA expression profiles in primary cultures of rat, mouse and human hepatocytes
    • L. Richert Effects of clofibric acid on mRNA expression profiles in primary cultures of rat, mouse and human hepatocytes Toxicol. Appl. Pharmacol. 191 2003 130 146
    • (2003) Toxicol. Appl. Pharmacol. , vol.191 , pp. 130-146
    • Richert, L.1
  • 29
    • 0034757015 scopus 로고    scopus 로고
    • Effect of peroxisome proliferator-activated receptor α activation on leukotriene B4 metabolism in isolated rat hepatocytes
    • J. Fiedler Effect of peroxisome proliferator-activated receptor α activation on leukotriene B4 metabolism in isolated rat hepatocytes J. Pharmacol. Exp. Ther. 299 2001 691 697
    • (2001) J. Pharmacol. Exp. Ther. , vol.299 , pp. 691-697
    • Fiedler, J.1
  • 30
    • 0038237521 scopus 로고    scopus 로고
    • The UDP-glucuronosyltransferase 1A9 enzyme is a peroxisome proliferator-activated receptor α and γ target gene
    • O. Barbier The UDP-glucuronosyltransferase 1A9 enzyme is a peroxisome proliferator-activated receptor α and γ target gene J. Biol. Chem. 278 2003 13975 13983
    • (2003) J. Biol. Chem. , vol.278 , pp. 13975-13983
    • Barbier, O.1
  • 31
    • 0142074253 scopus 로고    scopus 로고
    • Glucuronidation of arachidonic and linoleic acid metabolites by human UDP-glucuronosyltransferases
    • D. Turgeon Glucuronidation of arachidonic and linoleic acid metabolites by human UDP-glucuronosyltransferases J. Lipid Res. 44 2003 1182 1191
    • (2003) J. Lipid Res. , vol.44 , pp. 1182-1191
    • Turgeon, D.1
  • 32
    • 0042591284 scopus 로고    scopus 로고
    • Urinary metabolites of leukotriene B4 in the human subject
    • K.A. Berry Urinary metabolites of leukotriene B4 in the human subject J. Biol. Chem. 278 2003 24449 24460
    • (2003) J. Biol. Chem. , vol.278 , pp. 24449-24460
    • Berry, K.A.1
  • 33
    • 0036013438 scopus 로고    scopus 로고
    • Characterization of the human PPARα promoter: Identification of a functional nuclear receptor response element
    • I. Pineda Torra Characterization of the human PPARα promoter: identification of a functional nuclear receptor response element Mol. Endocrinol. 16 2002 1013 1028
    • (2002) Mol. Endocrinol. , vol.16 , pp. 1013-1028
    • Pineda Torra, I.1
  • 34
    • 0037205918 scopus 로고    scopus 로고
    • The peroxisome proliferator-activated receptor α (PPARα): Role in hepatocarcinogenesis
    • F. Gonzalez The peroxisome proliferator-activated receptor α (PPARα): role in hepatocarcinogenesis Mol. Cell. Endocrinol. 193 2002 71 79
    • (2002) Mol. Cell. Endocrinol. , vol.193 , pp. 71-79
    • Gonzalez, F.1
  • 35
    • 0036893378 scopus 로고    scopus 로고
    • Troglitazone glucuronidation in human liver and intestine microsomes: High catalytic activity of UGT1A8 and UGT1A10
    • Y. Watanabe Troglitazone glucuronidation in human liver and intestine microsomes: high catalytic activity of UGT1A8 and UGT1A10 Drug Metab. Dispos. 30 2002 1462 1469
    • (2002) Drug Metab. Dispos. , vol.30 , pp. 1462-1469
    • Watanabe, Y.1
  • 36
    • 0036843479 scopus 로고    scopus 로고
    • Effects of fibrates on metabolism of statins in human hepatocytes
    • T. Prueksaritanont Effects of fibrates on metabolism of statins in human hepatocytes Drug Metab. Dispos. 30 2002 1280 1287
    • (2002) Drug Metab. Dispos. , vol.30 , pp. 1280-1287
    • Prueksaritanont, T.1
  • 37
    • 0036266987 scopus 로고    scopus 로고
    • Mechanistic studies on metabolic interactions between gemfibrozil and statins
    • T. Prueksaritanont Mechanistic studies on metabolic interactions between gemfibrozil and statins J. Pharmacol. Exp. Ther. 301 2002 1042 1051
    • (2002) J. Pharmacol. Exp. Ther. , vol.301 , pp. 1042-1051
    • Prueksaritanont, T.1
  • 38
    • 0034524682 scopus 로고    scopus 로고
    • Characterization of UDP-glucuronosyltransferases (UGTs) involved in the metabolism of troglitazone in rats and humans
    • Y. Yoshigae Characterization of UDP-glucuronosyltransferases (UGTs) involved in the metabolism of troglitazone in rats and humans J. Toxicol. Sci. 25 2000 433 441
    • (2000) J. Toxicol. Sci. , vol.25 , pp. 433-441
    • Yoshigae, Y.1
  • 39
    • 0036551421 scopus 로고    scopus 로고
    • A prospective, randomized comparison of the metabolic effects of pioglitazone or rosiglitazone in patients with type 2 diabetes who were previously treated with troglitazone
    • M.A. Khan A prospective, randomized comparison of the metabolic effects of pioglitazone or rosiglitazone in patients with type 2 diabetes who were previously treated with troglitazone Diabetes Care 25 2002 708 711
    • (2002) Diabetes Care , vol.25 , pp. 708-711
    • Khan, M.A.1
  • 40
    • 0035797363 scopus 로고    scopus 로고
    • (-)3-[4-[2-(Phenoxazin-10-yl)ethoxy]phenyl]-2-ethoxypropanoic acid [(-)DRF 2725]: A dual PPAR agonist with potent antihyperglycemic and lipid modulating activity
    • B.B. Lohray (-)3-[4-[2-(Phenoxazin-10-yl)ethoxy]phenyl]-2-ethoxypropanoic acid [(-)DRF 2725]: a dual PPAR agonist with potent antihyperglycemic and lipid modulating activity J. Med. Chem. 44 2001 2675 2678
    • (2001) J. Med. Chem. , vol.44 , pp. 2675-2678
    • Lohray, B.B.1
  • 41
    • 0141731334 scopus 로고    scopus 로고
    • Tesaglitazar AstraZeneca
    • T. Davis Tesaglitazar AstraZeneca IDrugs 5 2002 924 926
    • (2002) IDrugs , vol.5 , pp. 924-926
    • Davis, T.1
  • 42
    • 0031793850 scopus 로고    scopus 로고
    • A novel insulin sensitizer acts as a coligand for peroxisome proliferator-activated receptor-α (PPAR-α) and PPAR-γ: Effect of PPAR-α activation on abnormal lipid metabolism in liver of Zucker fatty rats
    • K. Murakami A novel insulin sensitizer acts as a coligand for peroxisome proliferator-activated receptor-α (PPAR-α) and PPAR-γ: effect of PPAR-α activation on abnormal lipid metabolism in liver of Zucker fatty rats Diabetes 47 1998 1841 1847
    • (1998) Diabetes , vol.47 , pp. 1841-1847
    • Murakami, K.1
  • 43
    • 0036668184 scopus 로고    scopus 로고
    • Bile acid regulation of gene expression: Roles of nuclear hormone receptors
    • J.Y. Chiang Bile acid regulation of gene expression: roles of nuclear hormone receptors Endocr. Rev. 23 2002 443 463
    • (2002) Endocr. Rev. , vol.23 , pp. 443-463
    • Chiang, J.Y.1
  • 44
    • 0034666324 scopus 로고    scopus 로고
    • The peroxisome proliferator-activated receptor α (PPARα) regulates bile acid biosynthesis
    • M.C. Hunt The peroxisome proliferator-activated receptor α (PPARα) regulates bile acid biosynthesis J. Biol. Chem. 275 2000 28947 28953
    • (2000) J. Biol. Chem. , vol.275 , pp. 28947-28953
    • Hunt, M.C.1
  • 45
    • 0035570381 scopus 로고    scopus 로고
    • Fibrates suppress bile acid synthesis via peroxisome proliferator- activated receptor-α-mediated downregulation of cholesterol 7α-hydroxylase and sterol 27-hydroxylase expression
    • S.M. Post Fibrates suppress bile acid synthesis via peroxisome proliferator-activated receptor-α-mediated downregulation of cholesterol 7α-hydroxylase and sterol 27-hydroxylase expression Arterioscler. Thromb. Vasc. Biol. 21 2001 1840 1845
    • (2001) Arterioscler. Thromb. Vasc. Biol. , vol.21 , pp. 1840-1845
    • Post, S.M.1
  • 46
    • 0024399673 scopus 로고
    • Detoxification of lithocholic acid. Elucidation of the pathways of oxidative metabolism in rat liver microsomes
    • P. Zimniak Detoxification of lithocholic acid. Elucidation of the pathways of oxidative metabolism in rat liver microsomes J. Lipid Res. 30 1989 907 918
    • (1989) J. Lipid Res. , vol.30 , pp. 907-918
    • Zimniak, P.1
  • 47
    • 0034518420 scopus 로고    scopus 로고
    • The role of orphan nuclear receptors in the regulation of cholesterol homeostasis
    • J.J. Repa, and D.J. Mangelsdorf The role of orphan nuclear receptors in the regulation of cholesterol homeostasis Annu. Rev. Cell Dev. Biol. 16 2000 459 481
    • (2000) Annu. Rev. Cell Dev. Biol. , vol.16 , pp. 459-481
    • Repa, J.J.1    Mangelsdorf, D.J.2
  • 48
    • 2542429160 scopus 로고    scopus 로고
    • Differential regulation of cytosolic and peroxisomal bile acid amidation in mouse liver: PPARα activation favors formation of unconjugated bile acids
    • K. Solaas Differential regulation of cytosolic and peroxisomal bile acid amidation in mouse liver: PPARα activation favors formation of unconjugated bile acids J. Lipid Res. 45 2004 1051 1060
    • (2004) J. Lipid Res. , vol.45 , pp. 1051-1060
    • Solaas, K.1
  • 49
    • 0020579144 scopus 로고
    • The role of conjugation reactions in enhancing biliary secretion of bile acids
    • D.A. Vessey The role of conjugation reactions in enhancing biliary secretion of bile acids Biochem. J. 214 1983 923 927
    • (1983) Biochem. J. , vol.214 , pp. 923-927
    • Vessey, D.A.1
  • 50
    • 0033927970 scopus 로고    scopus 로고
    • Subcellular organization of bile acid amidation in human liver: A key issue in regulating the biosynthesis of bile salts
    • K. Solaas Subcellular organization of bile acid amidation in human liver: a key issue in regulating the biosynthesis of bile salts J. Lipid Res. 41 2000 1154 1162
    • (2000) J. Lipid Res. , vol.41 , pp. 1154-1162
    • Solaas, K.1
  • 51
    • 0033999108 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor α (PPARα) and agonist inhibit cholesterol 7α-hydroxylase gene (CYP7A1) transcription
    • M. Marrapodi, and J.Y. Chiang Peroxisome proliferator-activated receptor α (PPARα) and agonist inhibit cholesterol 7α-hydroxylase gene (CYP7A1) transcription J. Lipid Res. 41 2000 514 520
    • (2000) J. Lipid Res. , vol.41 , pp. 514-520
    • Marrapodi, M.1    Chiang, J.Y.2
  • 52
    • 0042858402 scopus 로고    scopus 로고
    • PPARα induces hepatic expression of the human bile acid glucuronidating UGT2B4 enzyme
    • O. Barbier PPARα induces hepatic expression of the human bile acid glucuronidating UGT2B4 enzyme J. Biol. Chem. 278 2003 32852 32860
    • (2003) J. Biol. Chem. , vol.278 , pp. 32852-32860
    • Barbier, O.1
  • 53
    • 0026691374 scopus 로고
    • Bile acid N-acetylglucosaminidation. In vivo and in vitro evidence for a selective conjugation reaction of 7 β-hydroxylated bile acids in humans
    • H.U. Marschall Bile acid N-acetylglucosaminidation. In vivo and in vitro evidence for a selective conjugation reaction of 7 β-hydroxylated bile acids in humans J. Clin. Invest. 89 1992 1981 1987
    • (1992) J. Clin. Invest. , vol.89 , pp. 1981-1987
    • Marschall, H.U.1
  • 54
    • 0242665373 scopus 로고    scopus 로고
    • Complementary roles of farnesoid X receptor, pregnane X receptor, and constitutive androstane receptor in protection against bile acid toxicity
    • G.L. Guo Complementary roles of farnesoid X receptor, pregnane X receptor, and constitutive androstane receptor in protection against bile acid toxicity J. Biol. Chem. 278 2003 45062 45071
    • (2003) J. Biol. Chem. , vol.278 , pp. 45062-45071
    • Guo, G.L.1
  • 55
    • 0033795320 scopus 로고    scopus 로고
    • Effects of model inducers on thyroxine UDP-glucuronosyl-transferase activity in vitro in rat and mouse hepatocyte cultures
    • C. Viollon-Abadie Effects of model inducers on thyroxine UDP-glucuronosyl-transferase activity in vitro in rat and mouse hepatocyte cultures Toxicol. In Vitro 14 2000 505 512
    • (2000) Toxicol. in Vitro , vol.14 , pp. 505-512
    • Viollon-Abadie, C.1
  • 56
    • 0023692775 scopus 로고
    • Inductive effects of fenofibrate and metabolism of phenobarbital
    • J. Mounie Inductive effects of fenofibrate and metabolism of phenobarbital Fundam. Clin. Pharmacol. 2 1988 259 265
    • (1988) Fundam. Clin. Pharmacol. , vol.2 , pp. 259-265
    • Mounie, J.1
  • 57
    • 0038198788 scopus 로고    scopus 로고
    • Regulation of CYP2C11 by dehydroepiandrosterone and peroxisome proliferators: Identification of the negative regulatory region of the gene
    • S.L. Ripp Regulation of CYP2C11 by dehydroepiandrosterone and peroxisome proliferators: identification of the negative regulatory region of the gene Mol. Pharmacol. 64 2003 113 122
    • (2003) Mol. Pharmacol. , vol.64 , pp. 113-122
    • Ripp, S.L.1
  • 58
    • 0344844555 scopus 로고    scopus 로고
    • Liver gene expression profiles of rats treated with clofibric Acid: Comparison of whole liver and laser capture microdissected liver
    • C. Michel Liver gene expression profiles of rats treated with clofibric Acid: comparison of whole liver and laser capture microdissected liver Am. J. Pathol. 163 2003 2191 2199
    • (2003) Am. J. Pathol. , vol.163 , pp. 2191-2199
    • Michel, C.1
  • 59
    • 0037443366 scopus 로고    scopus 로고
    • Opposing mechanisms of NADPH-cytochrome P450 oxidoreductase regulation by peroxisome proliferators
    • L.Q. Fan Opposing mechanisms of NADPH-cytochrome P450 oxidoreductase regulation by peroxisome proliferators Biochem. Pharmacol. 65 2003 949 959
    • (2003) Biochem. Pharmacol. , vol.65 , pp. 949-959
    • Fan, L.Q.1
  • 60
    • 0037325403 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor α (PPARα)-mediated regulation of Mdr2 expression and function in mice
    • T. Kok Peroxisome proliferator-activated receptor α (PPARα)-mediated regulation of Mdr2 expression and function in mice Biochem. J. 369 2003 539 547
    • (2003) Biochem. J. , vol.369 , pp. 539-547
    • Kok, T.1
  • 61
    • 0035036756 scopus 로고    scopus 로고
    • Multidrug resistance p-glycoprotein 2 is essential for the biliary excretion of indocyanine green
    • L. Huang, and M. Vore Multidrug resistance p-glycoprotein 2 is essential for the biliary excretion of indocyanine green Drug Metab. Dispos. 29 2001 634 637
    • (2001) Drug Metab. Dispos. , vol.29 , pp. 634-637
    • Huang, L.1    Vore, M.2
  • 62
    • 0036291921 scopus 로고    scopus 로고
    • Pharmacokinetic-pharmacodynamic drug interactions with HMG-CoA reductase inhibitors
    • D. Williams, and J. Feely Pharmacokinetic-pharmacodynamic drug interactions with HMG-CoA reductase inhibitors Clin. Pharmacokinet. 41 2002 343 370
    • (2002) Clin. Pharmacokinet. , vol.41 , pp. 343-370
    • Williams, D.1    Feely, J.2
  • 63
    • 0038397363 scopus 로고    scopus 로고
    • Pharmacogenomics and pharmacogenetics of cholesterol-lowering therapy
    • G. Schmitz, and W. Drobnik Pharmacogenomics and pharmacogenetics of cholesterol-lowering therapy Clin. Chem. Lab. Med. 41 2003 581 589
    • (2003) Clin. Chem. Lab. Med. , vol.41 , pp. 581-589
    • Schmitz, G.1    Drobnik, W.2
  • 64
    • 0030947754 scopus 로고    scopus 로고
    • Atorvastatin. A review of its pharmacology and therapeutic potential in the management of hyperlipidaemias
    • A.P. Lea, and D. McTavish Atorvastatin. A review of its pharmacology and therapeutic potential in the management of hyperlipidaemias Drugs 53 1997 828 847
    • (1997) Drugs , vol.53 , pp. 828-847
    • Lea, A.P.1    McTavish, D.2
  • 65
    • 0033984436 scopus 로고    scopus 로고
    • Current perspectives on statins
    • D.J. Maron Current perspectives on statins Circulation 101 2000 207 213
    • (2000) Circulation , vol.101 , pp. 207-213
    • Maron, D.J.1
  • 66
    • 0037414218 scopus 로고    scopus 로고
    • Statin-associated myopathy
    • P.D. Thompson Statin-associated myopathy J. Am. Med. Assoc. 289 2003 1681 1690
    • (2003) J. Am. Med. Assoc. , vol.289 , pp. 1681-1690
    • Thompson, P.D.1
  • 67
    • 0038004785 scopus 로고    scopus 로고
    • Lovastatin and beyond: The history of the HMG-CoA reductase inhibitors
    • J.A. Tobert Lovastatin and beyond: the history of the HMG-CoA reductase inhibitors Nat. Rev. Drug Discov. 2 2003 517 526
    • (2003) Nat. Rev. Drug Discov. , vol.2 , pp. 517-526
    • Tobert, J.A.1
  • 68
    • 0036579876 scopus 로고    scopus 로고
    • Pharmacological interactions of statins
    • R. Paoletti Pharmacological interactions of statins Atheroscler. Suppl. 3 2002 35 40
    • (2002) Atheroscler. Suppl. , vol.3 , pp. 35-40
    • Paoletti, R.1
  • 69
    • 0036918664 scopus 로고    scopus 로고
    • Gemfibrozil greatly increases plasma concentrations of cerivastatin
    • J.T. Backman Gemfibrozil greatly increases plasma concentrations of cerivastatin Clin. Pharmacol. Ther. 72 2002 685 691
    • (2002) Clin. Pharmacol. Ther. , vol.72 , pp. 685-691
    • Backman, J.T.1
  • 70
    • 0035337643 scopus 로고    scopus 로고
    • Plasma concentrations of active lovastatin acid are markedly increased by gemfibrozil but not by bezafibrate
    • C. Kyrklund Plasma concentrations of active lovastatin acid are markedly increased by gemfibrozil but not by bezafibrate Clin. Pharmacol. Ther. 69 2001 340 345
    • (2001) Clin. Pharmacol. Ther. , vol.69 , pp. 340-345
    • Kyrklund, C.1
  • 71
    • 0242468823 scopus 로고    scopus 로고
    • The safety of HMG-CoA reductase inhibitors in special populations at high cardiovascular risk
    • A. Corsini The safety of HMG-CoA reductase inhibitors in special populations at high cardiovascular risk Cardiovasc. Drugs Ther. 17 2003 265 285
    • (2003) Cardiovasc. Drugs Ther. , vol.17 , pp. 265-285
    • Corsini, A.1
  • 72
    • 0011933958 scopus 로고    scopus 로고
    • Controversy surrounding the safety of cerivastatin
    • M.H. Davidson Controversy surrounding the safety of cerivastatin Expert Opin. Drug. Saf. 1 2002 207 212
    • (2002) Expert Opin. Drug. Saf. , vol.1 , pp. 207-212
    • Davidson, M.H.1
  • 73
    • 0035657076 scopus 로고    scopus 로고
    • Association of polymorphism in the cytochrome CYP2D6 and the efficacy and tolerability of simvastatin
    • A.B. Mulder Association of polymorphism in the cytochrome CYP2D6 and the efficacy and tolerability of simvastatin Clin. Pharmacol. Ther. 70 2001 546 551
    • (2001) Clin. Pharmacol. Ther. , vol.70 , pp. 546-551
    • Mulder, A.B.1
  • 74
    • 0036043220 scopus 로고    scopus 로고
    • The genetic basis of variability in drug responses
    • D.M. Roden, and A.L. George Jr The genetic basis of variability in drug responses Nat. Rev. Drug Discov. 1 2002 37 44
    • (2002) Nat. Rev. Drug Discov. , vol.1 , pp. 37-44
    • Roden, D.M.1    George Jr., A.L.2


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