Design, synthesis, and antibacterial activities of conformationally constrained kanamycin A derivatives

Journal of Organic Chemistry

Volumn 78, Issue 2, 2013, Pages 400-409

  Zhang, Wenxuan ^a   Chen, Ying ^a   Liang, Qingzhao ^a   Li, Hui ^a   Jin, Hongwei ^a   Zhang, Liangren ^a   Meng, Xiangbao ^a   Li, Zhongjun ^a  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI-BACTERIAL ACTIVITY; BACTERIAL STRAINS; CARBON CHAINS; CESIUM CARBONATES; HYDROXYL GROUPS; KANAMYCIN A; RING-CLOSING METATHESIS REACTIONS;

CESIUM; ETHERS; ORGANIC COMPOUNDS; REACTION INTERMEDIATES;

SYNTHESIS (CHEMICAL);

1,3,6',3' TETRAAZIDO 5,2',4',6' DI O BENZYLIDENEKANAMYCIN A; 2' HYDROXYL GROUP; 5 HYDROXYL GROUP; 5,2' DI O ALLYLKANAMYCIN A; 5,2' DIALLYLKANAMYCIN A; 5,2' O (1,4 BUTYL 2 ENE) KANAMYCIN A; 5,2' O 1,2 ETHYLKANAMYCIN A; 5,2' O 1,3 PROPYLKANAMYCIN A; 5,2' O 1,4 BUTYLKANAMYCIN A; 5,2' O METHYLENEKANAMYCIN A; 5,2', 4'',6'' DI O BENZYLIDENE PROTECTED TETRAAZIDOKANAMYCIN A; CARBON; CARBONIC ACID; CESIUM; CESIUM CARBONATE; ETHER DERIVATIVE; FRAMYCETIN; HYDROXYL GROUP; KANAMYCIN A DERIVATIVE; NEAMINE; PAROMOMYCIN; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL STRAIN; CONTROLLED STUDY; DRUG CONFORMATION; DRUG DESIGN; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; RING CLOSING METATHESIS;

ANTI-BACTERIAL AGENTS; BRIDGED COMPOUNDS; KANAMYCIN; MAGNETIC RESONANCE SPECTROSCOPY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84872528259     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/jo302247x     Document Type: Article

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