Kinetic and structural analysis of bisubstrate inhibition of the Salmonella enterica aminoglycoside 6′-N-acetyltransferase

Biochemistry

Volumn 47, Issue 2, 2008, Pages 579-584

  Magalhães, Maria L B ^a   Vetting, Matthew W ^a   Gao, Feng ^b   Freiburger, Lee ^b   Auclair, Karine ^b   Blanchard, John S ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOGLYCOSIDES; PROTEIN TRANSLATION;

CARBON; COBALT COMPOUNDS; ENZYME ACTIVITY; PHOSPHORYLATION; PROTEINS;

BACTERIA;

ACYLTRANSFERASE; AMINOGLYCOSIDE 6' N ACETYLTRANSFERASE; AMINOGLYCOSIDE ANTIBIOTIC AGENT; COENZYME A; RIBOSTAMYCIN; UNCLASSIFIED DRUG;

ACETYLATION; ADENYLATION; ARTICLE; COMPLEX FORMATION; COVALENT BOND; CRYSTALLIZATION; ENTEROCOCCUS FAECIUM; ENZYME INHIBITION; ENZYME KINETICS; ENZYME PHOSPHORYLATION; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RIBOSOME SUBUNIT; SALMONELLA ENTERICA;

ACETYLTRANSFERASES; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; KINETICS; PROTEIN STRUCTURE, SECONDARY; SALMONELLA ENTERICA; SUBSTRATE SPECIFICITY;

BACTERIA (MICROORGANISMS); ENTEROCOCCUS FAECIUM; SALMONELLA ENTERICA;

EID: 38849185275     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi701957c     Document Type: Article

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