Mechanistic and structural analysis of aminoglycoside N-acetyltransferase AAC(6′)-Ib and its bifunctional, fluoroquinolone-active AAC(6′)-Ib-cr variant

Biochemistry

Volumn 47, Issue 37, 2008, Pages 9825-9835

  Vetting, Matthew W ^a   Chi, Hye Park ^b   Hegde, Subray S ^a   Jacoby, George A ^c   Hooper, David C ^b   Blanchard, John S ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c LAHEY HOSPITAL AND MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHLORINE COMPOUNDS; ENZYME INHIBITION; ESCHERICHIA COLI; FOOD ADDITIVES; HEALTH; MECHANISMS; STRUCTURAL ANALYSIS; THREE DIMENSIONAL;

AMINOGLYCOSIDE; AMINOGLYCOSIDE ACETYLTRANSFERASE; AMINOGLYCOSIDE ANTIBIOTICS; AMINOGLYCOSIDES; BACTERIAL RESISTANCE; BIFUNCTIONAL; CHEMICAL MECHANISMS; DONOR AND ACCEPTOR; ENZYMATIC MODIFICATIONS; FLUOROQUINOLONE; FLUOROQUINOLONES; INITIAL VELOCITIES; N-ACETYLTRANSFERASE; N-ACETYLTRANSFERASES; REGIO-SELECTIVE; SEQUENTIAL MECHANISMS; THREE-DIMENSIONAL STRUCTURING;

HUMAN REHABILITATION ENGINEERING;

ACYLTRANSFERASE; AMINOGLYCOSIDE; ASPARTIC ACID; QUINOLINE DERIVED ANTIINFECTIVE AGENT; TYROSINE;

AMINO ACID SUBSTITUTION; ARTICLE; CATALYSIS; CHEMICAL REACTION; CONTROLLED STUDY; DRUG ACETYLATION; DRUG BINDING; ENZYME ANALYSIS; ENZYME INHIBITION; ENZYME KINETICS; ENZYME MECHANISM; ENZYME STRUCTURE; ESCHERICHIA COLI; MOLECULAR INTERACTION; MOLECULAR MODEL; NONHUMAN; PH; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PURIFICATION; PROTON TRANSPORT; VELOCITY;

ACETYLATION; ACETYLTRANSFERASES; AMINOGLYCOSIDES; BINDING SITES; ESCHERICHIA COLI; FLUOROQUINOLONES; HYDROGEN-ION CONCENTRATION; KINETICS; MODELS, MOLECULAR; MUTATION; PROTEIN CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI;

EID: 51849143320     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi800664x     Document Type: Article

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