Conformational constraint as a means for understanding RNA-aminoglycoside specificity

Journal of the American Chemical Society

Volumn 127, Issue 27, 2005, Pages 9818-9829

  Blount, Kenneth F ^a,c   Zhao, Fang ^a   Hermann, Thomas ^b   Tor, Yitzhak ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b F HOFFMANN LA ROCHE LTD   (Switzerland)

^c YALE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; ANTIBIOTICS; BINDING ENERGY; CHEMICAL BONDS; MOLECULAR WEIGHT; PLASTICITY; POSITIVE IONS; STRUCTURE (COMPOSITION);

AMINOGLYCOSIDE COMPLEXES; GLYCOSIDIC BONDS; LIGANDS; POLYCATIONIC LIGANDS;

RNA;

AMINOGLYCOSIDE ANTIBIOTIC AGENT; DNA; NEOMYCIN; OLIGONUCLEOTIDE; PAROMOMYCIN; PHOSPHORUS 32; RIBONUCLEASE; VIRUS RNA;

ARTICLE; BINDING AFFINITY; CARBON NUCLEAR MAGNETIC RESONANCE; CHEMICAL STRUCTURE; DRUG BINDING; DRUG TARGETING; HUMAN IMMUNODEFICIENCY VIRUS 1; HYDROLYSIS; ISOTOPE LABELING; LIGAND BINDING; MOLECULAR DYNAMICS; NITROGEN NUCLEAR MAGNETIC RESONANCE; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; RNA STRUCTURE;

AMINOGLYCOSIDES; ANTI-BACTERIAL AGENTS; BINDING SITES; CARBOHYDRATE SEQUENCE; DRUG DESIGN; ENDORIBONUCLEASES; HIV LONG TERMINAL REPEAT; HIV-1; LIGANDS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR SEQUENCE DATA; NEOMYCIN; PAROMOMYCIN; PROTEIN STRUCTURE, TERTIARY; RNA; SENSITIVITY AND SPECIFICITY; SPECTRUM ANALYSIS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 22144490214     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja050918w     Document Type: Article

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