Fluorinated Aminoglycosides and Their Mechanistic Implication for Aminoglycoside 3′-Phosphotransferases from Gram-Negative Bacteria

Biochemistry

Volumn 43, Issue 9, 2004, Pages 2373-2383

  Kim, Choonkeun ^a   Haddad, Jalal ^a   Vakulenko, Sergei B ^a   Meroueh, Samy O ^a   Wu, Yan ^b   Yan, Honggao ^b   Mobashery, Shahriar ^a  

^a UNIVERSITY OF NOTRE DAME   (United States)

^b Michigan State University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTICS; BACTERIOLOGY; MUTAGENESIS; PHOSPHORUS COMPOUNDS; REACTION KINETICS; VISCOSITY;

PHOSPHORYLATION;

ENZYMES;

AMINOGLYCOSIDE 3' PHOSPHOTRANSFERASE; AMINOGLYCOSIDE 3' PHOSPHOTRANSFERASE IA; AMINOGLYCOSIDE 3' PHOSPHOTRANSFERASE IIA; AMINOGLYCOSIDE ANTIBIOTIC AGENT; BACTERIAL ENZYME; HYDROXYL GROUP; KANAMYCIN A; KANAMYCIN DERIVATIVE; NEAMINE; PHOSPHATE; PHOSPHOTRANSFERASE; UNCLASSIFIED DRUG;

ARTICLE; DRUG INACTIVATION; ENZYME ACTIVE SITE; ENZYME PHOSPHORYLATION; ENZYME SUBSTRATE; FLUORINATION; GRAM NEGATIVE BACTERIUM; MUTANT; NONHUMAN; PRIORITY JOURNAL; REACTION ANALYSIS; STEADY STATE; VISCOSITY;

AMINOGLYCOSIDES; FLUORINE; GRAM-NEGATIVE BACTERIA; KANAMYCIN; KANAMYCIN KINASE; KANAMYCIN RESISTANCE; KINETICS; MICROBIAL SENSITIVITY TESTS; SUBSTRATE SPECIFICITY;

BACTERIA (MICROORGANISMS); NEGIBACTERIA;

EID: 1542267777     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi036095+     Document Type: Article

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