Design, synthesis, and evaluation of novel fluoroquinolone - Aminoglycoside hybrid antibiotics

Journal of Medicinal Chemistry

Volumn 52, Issue 8, 2009, Pages 2243-2254

  Pokrovskaya, Varvara ^a   Belakhov, Valery ^a   Hainrichson, Mariana ^a   Yaron, Sima ^a   Baasov, Timor ^a  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOGLYCOSIDE ANTIBIOTIC AGENT; CIPROFLOXACIN PLUS NEOMYCIN; DNA TOPOISOMERASE (ATP HYDROLYSING); DNA TOPOISOMERASE IV; QUINOLINE DERIVED ANTIINFECTIVE AGENT; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ARTICLE; BACILLUS SUBTILIS; BACTERIAL STRAIN; CHEMICAL BOND; CONTROLLED STUDY; DRUG DESIGN; DRUG MECHANISM; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; ESCHERICHIA COLI; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; HYBRID; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PHARMACOPHORE; PROTEIN SYNTHESIS INHIBITION; STRUCTURE ACTIVITY RELATION;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; CIPROFLOXACIN; DNA GYRASE; DNA TOPOISOMERASE IV; DRUG DESIGN; DRUG RESISTANCE, BACTERIAL; FRAMYCETIN; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA; MICROBIAL SENSITIVITY TESTS; PROTEIN SYNTHESIS INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 65249160092     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm900028n     Document Type: Article

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