메뉴 건너뛰기




Volumn 7, Issue 1, 2013, Pages 9-16

Resveratrol: Effects on Lipids and Cardiovascular Risk

Author keywords

Adipocytes; Cardiovascular disease; Inflammation; Lipids; Oxidative stress; Resveratrol

Indexed keywords

CHOLESTEROL; CYTOKINE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GLUCOSE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; LIPID; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MONOCYTE CHEMOTACTIC PROTEIN 1; NITROUS OXIDE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PLACEBO; PLASMINOGEN ACTIVATOR INHIBITOR 1; REACTIVE OXYGEN METABOLITE; RESVERATROL; SUPEROXIDE; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA;

EID: 84872283843     PISSN: 19329520     EISSN: 19329563     Source Type: Journal    
DOI: 10.1007/s12170-012-0289-2     Document Type: Review
Times cited : (2)

References (99)
  • 1
    • 33749646867 scopus 로고    scopus 로고
    • Significance of wine and resveratrol in cardiovascular disease: French paradox revisited
    • Vidavalur R, Otani H, Singal PK, Maulik N. Significance of wine and resveratrol in cardiovascular disease: French paradox revisited. Exp Clin Cardiol. 2006; 11: 217-25.
    • (2006) Exp Clin Cardiol. , vol.11 , pp. 217-225
    • Vidavalur, R.1    Otani, H.2    Singal, P.K.3    Maulik, N.4
  • 2
    • 84865483523 scopus 로고    scopus 로고
    • Is a cardioprotective action of alcohol a myth?
    • Hansel B, Kontush A, Bruckert E. Is a cardioprotective action of alcohol a myth? Curr Opin Cardiol. 2012; 27: 550-5.
    • (2012) Curr Opin Cardiol. , vol.27 , pp. 550-555
    • Hansel, B.1    Kontush, A.2    Bruckert, E.3
  • 3
    • 84863708218 scopus 로고    scopus 로고
    • Long-term alcohol consumption in relation to all-cause and cardiovascular mortality among survivors of myocardial infarction: the Health Professionals follow-up study
    • Pai JK, Mukamal KJ, Rimm EB. Long-term alcohol consumption in relation to all-cause and cardiovascular mortality among survivors of myocardial infarction: the Health Professionals follow-up study. Eur Heart J. 2012; 33: 1598-605.
    • (2012) Eur Heart J. , vol.33 , pp. 1598-1605
    • Pai, J.K.1    Mukamal, K.J.2    Rimm, E.B.3
  • 4
    • 84860256139 scopus 로고    scopus 로고
    • Alcohol, mortality, and cardiovascular events in a 35 year follow-up of a nationwide representative cohort of 50,000 Swedish conscripts up to age 55
    • Romelsjo A, Allebeck P, Andreasson S, Leifman A. Alcohol, mortality, and cardiovascular events in a 35 year follow-up of a nationwide representative cohort of 50, 000 Swedish conscripts up to age 55. Alcohol Alcohol. 2012; 47: 322-7.
    • (2012) Alcohol Alcohol. , vol.47 , pp. 322-327
    • Romelsjo, A.1    Allebeck, P.2    Andreasson, S.3    Leifman, A.4
  • 5
  • 6
    • 0018416167 scopus 로고
    • Factors associated with cardiac mortality in developed countries with particular reference to the consumption of wine
    • St Leger AS, Cochrane AL, Moore F. Factors associated with cardiac mortality in developed countries with particular reference to the consumption of wine. Lancet. 1979; 1: 1017-20.
    • (1979) Lancet , vol.1 , pp. 1017-1020
    • St Leger, A.S.1    Cochrane, A.L.2    Moore, F.3
  • 7
    • 20444444649 scopus 로고    scopus 로고
    • Mechanism of human SIRT1 activation by resveratrol
    • Borra MT, Smith BC, Denu JM. Mechanism of human SIRT1 activation by resveratrol. J Biol Chem. 2005; 280: 17187-95.
    • (2005) J Biol Chem. , vol.280 , pp. 17187-17195
    • Borra, M.T.1    Smith, B.C.2    Denu, J.M.3
  • 8
    • 77954614584 scopus 로고    scopus 로고
    • Resveratrol regulates human adipocyte number and function in a Sirt1-dependent manner
    • Fischer-Posovszky P, Kukulus V, Tews D, et al. Resveratrol regulates human adipocyte number and function in a Sirt1-dependent manner. Am J Clin Nutr. 2010; 92: 5-15.
    • (2010) Am J Clin Nutr. , vol.92 , pp. 5-15
    • Fischer-Posovszky, P.1    Kukulus, V.2    Tews, D.3
  • 9
    • 70350524083 scopus 로고    scopus 로고
    • Resveratrol is not a direct activator of SIRT1 enzyme activity
    • Beher D, Wu J, Cumine S, et al. Resveratrol is not a direct activator of SIRT1 enzyme activity. Chem Biol Drug Des. 2009; 74: 619-24.
    • (2009) Chem Biol Drug Des. , vol.74 , pp. 619-624
    • Beher, D.1    Wu, J.2    Cumine, S.3
  • 10
    • 33845868198 scopus 로고    scopus 로고
    • Sirtuins as potential targets for metabolic syndrome
    • Guarente L. Sirtuins as potential targets for metabolic syndrome. Nature. 2006; 14(444): 868-74.
    • (2006) Nature , vol.14 , Issue.444 , pp. 868-874
    • Guarente, L.1
  • 11
    • 52649144195 scopus 로고    scopus 로고
    • Resveratrol and novel potent activators of SIRT1: effects on aging and age-related diseases
    • Knutson MD, Leeuwenburgh C. Resveratrol and novel potent activators of SIRT1: effects on aging and age-related diseases. Nutr Rev. 2008; 66: 591-6.
    • (2008) Nutr Rev. , vol.66 , pp. 591-596
    • Knutson, M.D.1    Leeuwenburgh, C.2
  • 12
    • 77952549960 scopus 로고    scopus 로고
    • Resveratrol, sirtuins, and the promise of a DR mimetic
    • Baur JA. Resveratrol, sirtuins, and the promise of a DR mimetic. Mech Ageing Dev. 2010; 131: 261-9.
    • (2010) Mech Ageing Dev. , vol.131 , pp. 261-269
    • Baur, J.A.1
  • 13
    • 42649130051 scopus 로고    scopus 로고
    • Enhanced inhibition of adipogenesis and induction of apoptosis in 3T3-L1 adipocytes with combinations of resveratrol and quercetin
    • Yang JY, Della-Fera MA, Rayalam S, et al. Enhanced inhibition of adipogenesis and induction of apoptosis in 3T3-L1 adipocytes with combinations of resveratrol and quercetin. Life Sci. 2008; 82: 1032-9.
    • (2008) Life Sci. , vol.82 , pp. 1032-1039
    • Yang, J.Y.1    Della-Fera, M.A.2    Rayalam, S.3
  • 14
    • 36048974865 scopus 로고    scopus 로고
    • Resveratrol inhibits TNF-alpha-induced changes of adipokines in 3T3-L1 adipocytes
    • Ahn J, Lee H, Kim S, Ha T. Resveratrol inhibits TNF-alpha-induced changes of adipokines in 3T3-L1 adipocytes. Biochem Biophys Res Commun. 2007; 364: 972-7.
    • (2007) Biochem Biophys Res Commun. , vol.364 , pp. 972-977
    • Ahn, J.1    Lee, H.2    Kim, S.3    Ha, T.4
  • 15
    • 77953521260 scopus 로고    scopus 로고
    • Identification of a novel proapoptotic function of resveratrol in fat cells: SIRT1-independent sensitization to TRAIL-induced apoptosis
    • Mader I, Wabitsch M, Debatin KM, Fischer-Posovszky P, Fulda S. Identification of a novel proapoptotic function of resveratrol in fat cells: SIRT1-independent sensitization to TRAIL-induced apoptosis. FASEB J. 2010; 24: 1997-2009.
    • (2010) FASEB J. , vol.24 , pp. 1997-2009
    • Mader, I.1    Wabitsch, M.2    Debatin, K.M.3    Fischer-Posovszky, P.4    Fulda, S.5
  • 16
    • 59849106498 scopus 로고    scopus 로고
    • Resveratrol, a naturally occurring diphenolic compound, affects lipogenesis, lipolysis and the antilipolytic action of insulin in isolated rat adipocytes
    • Szkudelska K, Nogowski L, Szkudelski T. Resveratrol, a naturally occurring diphenolic compound, affects lipogenesis, lipolysis and the antilipolytic action of insulin in isolated rat adipocytes. J Steroid Biochem Mol Biol. 2009; 113: 17-24.
    • (2009) J Steroid Biochem Mol Biol , vol.113 , pp. 17-24
    • Szkudelska, K.1    Nogowski, L.2    Szkudelski, T.3
  • 17
    • 44949129961 scopus 로고    scopus 로고
    • Modulation of peroxisome proliferator-activated receptor gamma stability and transcriptional activity in adipocytes by resveratrol
    • Floyd ZE, Wang ZQ, Kilroy G, Cefalu WT. Modulation of peroxisome proliferator-activated receptor gamma stability and transcriptional activity in adipocytes by resveratrol. Metabolism. 2008; 57(7 Suppl 1): S32-8.
    • (2008) Metabolism. , vol.57 , Issue.7 SUPPL. 1
    • Floyd, Z.E.1    Wang, Z.Q.2    Kilroy, G.3    Cefalu, W.T.4
  • 18
    • 70450242876 scopus 로고    scopus 로고
    • A new insight into resveratrol as an atheroprotective compound: inhibition of lipid peroxidation and enhancement of cholesterol efflux
    • Berrougui H, Grenier G, Loued S, Drouin G, Khalil A. A new insight into resveratrol as an atheroprotective compound: inhibition of lipid peroxidation and enhancement of cholesterol efflux. Atherosclerosis. 2009; 207: 420-7.
    • (2009) Atherosclerosis. , vol.207 , pp. 420-427
    • Berrougui, H.1    Grenier, G.2    Loued, S.3    Drouin, G.4    Khalil, A.5
  • 19
    • 0033038280 scopus 로고    scopus 로고
    • Resveratrol inhibits copper ion-induced and azo compound-initiated oxidative modification of human low density lipoprotein
    • Zou JG, Huang YZ, Chen Q, Wei EH, Hsieh TC, Wu JM. Resveratrol inhibits copper ion-induced and azo compound-initiated oxidative modification of human low density lipoprotein. Biochem Mol Biol Int. 1999; 47: 1089-96.
    • (1999) Biochem Mol Biol Int. , vol.47 , pp. 1089-1096
    • Zou, J.G.1    Huang, Y.Z.2    Chen, Q.3    Wei, E.H.4    Hsieh, T.C.5    Wu, J.M.6
  • 20
    • 0343091521 scopus 로고    scopus 로고
    • Effects of resveratrol on oxidative modification of human low density lipoprotein
    • Zou J, Huang Y, Chen Q, Wei E, Cao K, Wu JM. Effects of resveratrol on oxidative modification of human low density lipoprotein. Chin Med J. 2000; 113: 99-102.
    • (2000) Chin Med J. , vol.113 , pp. 99-102
    • Zou, J.1    Huang, Y.2    Chen, Q.3    Wei, E.4    Cao, K.5    Wu, J.M.6
  • 21
    • 0030740237 scopus 로고    scopus 로고
    • Resveratrol inhibits metal ion-dependent and independent peroxidation of porcine low-density lipoproteins
    • Belguendouz L, Fremont L, Linard A. Resveratrol inhibits metal ion-dependent and independent peroxidation of porcine low-density lipoproteins. Biochem Pharmacol. 1997; 53: 1347-55.
    • (1997) Biochem Pharmacol. , vol.53 , pp. 1347-1355
    • Belguendouz, L.1    Fremont, L.2    Linard, A.3
  • 22
    • 79551600855 scopus 로고    scopus 로고
    • Selective inactivation of c-Jun NH2-terminal kinase in adipose tissue protects against diet-induced obesity and improves insulin sensitivity in both liver and skeletal muscle in mice
    • Zhang X, Xu A, Chung SK, et al. Selective inactivation of c-Jun NH2-terminal kinase in adipose tissue protects against diet-induced obesity and improves insulin sensitivity in both liver and skeletal muscle in mice. Diabetes. 2011; 60: 486-95.
    • (2011) Diabetes. , vol.60 , pp. 486-495
    • Zhang, X.1    Xu, A.2    Chung, S.K.3
  • 23
    • 78651290317 scopus 로고    scopus 로고
    • Quercetin is equally or more effective than resveratrol in attenuating tumor necrosis factor- > {alpha}-mediated inflammation and insulin resistance in primary human adipocytes
    • Chuang CC, Martinez K, Xie G, et al. Quercetin is equally or more effective than resveratrol in attenuating tumor necrosis factor- > {alpha}-mediated inflammation and insulin resistance in primary human adipocytes. Am J Clin Nutr. 2010; 92: 1511-21.
    • (2010) Am J Clin Nutr. , vol.92 , pp. 1511-1521
    • Chuang, C.C.1    Martinez, K.2    Xie, G.3
  • 24
    • 46149101224 scopus 로고    scopus 로고
    • Curcumin and resveratrol inhibit nuclear factor-kappaB-mediated cytokine expression in adipocytes
    • Gonzales AM, Orlando RA. Curcumin and resveratrol inhibit nuclear factor-kappaB-mediated cytokine expression in adipocytes. Nutr Metab. 2008; 5: 17.
    • (2008) Nutr Metab. , vol.5 , pp. 17
    • Gonzales, A.M.1    Orlando, R.A.2
  • 25
    • 0019940467 scopus 로고
    • Effects of stilbene components of the roots of Polygonum cuspidatum Sieb. et Zucc. on lipid metabolism
    • Arichi H, Kimura Y, Okuda H, Baba K, Kozawa M, Arichi S. Effects of stilbene components of the roots of Polygonum cuspidatum Sieb. et Zucc. on lipid metabolism. Chem Pharm Bull. 1982; 30: 1766-70.
    • (1982) Chem Pharm Bull. , vol.30 , pp. 1766-1770
    • Arichi, H.1    Kimura, Y.2    Okuda, H.3    Baba, K.4    Kozawa, M.5    Arichi, S.6
  • 26
    • 84858140995 scopus 로고    scopus 로고
    • Resveratrol attenuates steatosis in obese Zucker rats by decreasing fatty acid availability and reducing oxidative stress
    • Gomez-Zorita S, Fernandez-Quintela A, Macarulla MT, et al. Resveratrol attenuates steatosis in obese Zucker rats by decreasing fatty acid availability and reducing oxidative stress. Br J Nutr. 2011; 28: 1-9.
    • (2011) Br J Nutr. , vol.28 , pp. 1-9
    • Gomez-Zorita, S.1    Fernandez-Quintela, A.2    Macarulla, M.T.3
  • 27
    • 84858755448 scopus 로고    scopus 로고
    • Repeated and long-term treatment with physiological concentrations of resveratrol promotes NO production in vascular endothelial cells
    • Takahashi S, Nakashima Y. Repeated and long-term treatment with physiological concentrations of resveratrol promotes NO production in vascular endothelial cells. Br J Nutr. 2012; 107: 774-80.
    • (2012) Br J Nutr. , vol.107 , pp. 774-780
    • Takahashi, S.1    Nakashima, Y.2
  • 28
    • 79961075441 scopus 로고    scopus 로고
    • Trans-resveratrol simultaneously increases cytoplasmic Ca(2+) levels and nitric oxide release in human endothelial cells
    • Elies J, Cuinas A, Garcia-Morales V, Orallo F, Campos-Toimil M. Trans-resveratrol simultaneously increases cytoplasmic Ca(2+) levels and nitric oxide release in human endothelial cells. Mol Nutr Food Res. 2011; 55: 1237-48.
    • (2011) Mol Nutr Food Res. , vol.55 , pp. 1237-1248
    • Elies, J.1    Cuinas, A.2    Garcia-Morales, V.3    Orallo, F.4    Campos-Toimil, M.5
  • 29
    • 0037167677 scopus 로고    scopus 로고
    • Resveratrol, a polyphenolic phytoalexin present in red wine, enhances expression and activity of endothelial nitric oxide synthase
    • Wallerath T, Deckert G, Ternes T, et al. Resveratrol, a polyphenolic phytoalexin present in red wine, enhances expression and activity of endothelial nitric oxide synthase. Circulation. 2002; 106: 1652-8.
    • (2002) Circulation. , vol.106 , pp. 1652-1658
    • Wallerath, T.1    Deckert, G.2    Ternes, T.3
  • 31
    • 84861345431 scopus 로고    scopus 로고
    • Resveratrol inhibits neointimal formation after arterial injury through an endothelial nitric oxide synthase-dependent mechanism
    • Breen DM, Dolinsky VW, Zhang H, et al. Resveratrol inhibits neointimal formation after arterial injury through an endothelial nitric oxide synthase-dependent mechanism. Atherosclerosis. 2012; 222: 375-81.
    • (2012) Atherosclerosis. , vol.222 , pp. 375-381
    • Breen, D.M.1    Dolinsky, V.W.2    Zhang, H.3
  • 32
    • 84861346095 scopus 로고    scopus 로고
    • Resveratrol augments nitric oxide generation and causes store calcium release in chromaffin cells
    • Padin JF, de Diego AM, Fernandez-Morales JC, et al. Resveratrol augments nitric oxide generation and causes store calcium release in chromaffin cells. Eur J Pharmacol. 2012; 685: 99-107.
    • (2012) Eur J Pharmacol. , vol.685 , pp. 99-107
    • Padin, J.F.1    de Diego, A.M.2    Fernandez-Morales, J.C.3
  • 33
    • 34247600642 scopus 로고    scopus 로고
    • Resveratrol stimulates glucose transport in C2C12 myotubes by activating AMP-activated protein kinase
    • Park CE, Kim MJ, Lee JH, et al. Resveratrol stimulates glucose transport in C2C12 myotubes by activating AMP-activated protein kinase. Exp Mol Med. 2007; 39: 222-9.
    • (2007) Exp Mol Med. , vol.39 , pp. 222-229
    • Park, C.E.1    Kim, M.J.2    Lee, J.H.3
  • 34
  • 35
    • 47749148061 scopus 로고    scopus 로고
    • Stimulation of muscle cell glucose uptake by resveratrol through sirtuins and AMPK
    • Breen DM, Sanli T, Giacca A, Tsiani E. Stimulation of muscle cell glucose uptake by resveratrol through sirtuins and AMPK. Biochem Biophys Res Commun. 2008; 374: 117-22.
    • (2008) Biochem Biophys Res Commun. , vol.374 , pp. 117-122
    • Breen, D.M.1    Sanli, T.2    Giacca, A.3    Tsiani, E.4
  • 36
    • 53049091294 scopus 로고    scopus 로고
    • Resveratrol inhibits cardiac hypertrophy via AMP-activated protein kinase and Akt
    • Chan AY, Dolinsky VW, Soltys CL, et al. Resveratrol inhibits cardiac hypertrophy via AMP-activated protein kinase and Akt. J Biol Chem. 2008; 283: 24194-201.
    • (2008) J Biol Chem. , vol.283 , pp. 24194-24201
    • Chan, A.Y.1    Dolinsky, V.W.2    Soltys, C.L.3
  • 37
    • 84872325865 scopus 로고    scopus 로고
    • Control of eotaxin-1 expression and release by resveratrol and its metabolites in culture human pulmonary artery endothelial cells
    • Yang CJ, Lin CY, Hsieh TC, Olson SC, Wu JM. Control of eotaxin-1 expression and release by resveratrol and its metabolites in culture human pulmonary artery endothelial cells. Am J Cardiovasc Discussion. 2011; 1: 16-30.
    • (2011) Am J Cardiovasc Discussion , vol.1 , pp. 16-30
    • Yang, C.J.1    Lin, C.Y.2    Hsieh, T.C.3    Olson, S.C.4    Wu, J.M.5
  • 38
    • 0036202850 scopus 로고    scopus 로고
    • Effect of resveratrol on platelet aggregation in vivo and in vitro
    • Wang Z, Zou J, Huang Y, Cao K, Xu Y, Wu JM. Effect of resveratrol on platelet aggregation in vivo and in vitro. Chin Med J. 2002; 115: 378-80.
    • (2002) Chin Med J. , vol.115 , pp. 378-380
    • Wang, Z.1    Zou, J.2    Huang, Y.3    Cao, K.4    Xu, Y.5    Wu, J.M.6
  • 39
    • 0033861559 scopus 로고    scopus 로고
    • Resveratrol decreases early signaling events in washed platelets but has little effect on platelet in whole blood
    • Kirk RI, Deitch JA, Wu JM, Lerea KM. Resveratrol decreases early signaling events in washed platelets but has little effect on platelet in whole blood. Blood Cells Mol Dis. 2000; 26: 144-50.
    • (2000) Blood Cells Mol Dis. , vol.26 , pp. 144-150
    • Kirk, R.I.1    Deitch, J.A.2    Wu, J.M.3    Lerea, K.M.4
  • 41
    • 0033208676 scopus 로고    scopus 로고
    • Suppression of mitogenesis and regulation of cell cycle traverse by resveratrol in cultured smooth muscle cells
    • Zou J, Huang Y, Chen Q, et al. Suppression of mitogenesis and regulation of cell cycle traverse by resveratrol in cultured smooth muscle cells. Int J Oncol. 1999; 15: 647-51.
    • (1999) Int J Oncol. , vol.15 , pp. 647-651
    • Zou, J.1    Huang, Y.2    Chen, Q.3
  • 42
    • 34547674896 scopus 로고    scopus 로고
    • Resveratrol inhibits rat aortic vascular smooth muscle cell proliferation via estrogen receptor dependent nitric oxide production
    • Ekshyyan VP, Hebert VY, Khandelwal A, Dugas TR. Resveratrol inhibits rat aortic vascular smooth muscle cell proliferation via estrogen receptor dependent nitric oxide production. J Cardiovasc Pharmacol. 2007; 50: 83-93.
    • (2007) J Cardiovasc Pharmacol. , vol.50 , pp. 83-93
    • Ekshyyan, V.P.1    Hebert, V.Y.2    Khandelwal, A.3    Dugas, T.R.4
  • 44
    • 84867100934 scopus 로고    scopus 로고
    • Resveratrol protects adult cardiomyocytes against oxidative stress mediated cell injury
    • Movahed A, Yu L, Thandapilly SJ, Louis XL, Netticadan T. Resveratrol protects adult cardiomyocytes against oxidative stress mediated cell injury. Arch Biochem Biophys. 2012; 15(527): 74-80.
    • (2012) Arch Biochem Biophys , vol.15 , Issue.527 , pp. 74-80
    • Movahed, A.1    Yu, L.2    Thandapilly, S.J.3    Louis, X.L.4    Netticadan, T.5
  • 46
    • 26844449558 scopus 로고    scopus 로고
    • Resveratrol enhances neovascularization in the infarcted rat myocardium through the induction of thioredoxin-1, heme oxygenase-1, and vascular endothelial growth factor
    • Kaga S, Zhan L, Matsumoto M, Maulik N. Resveratrol enhances neovascularization in the infarcted rat myocardium through the induction of thioredoxin-1, heme oxygenase-1, and vascular endothelial growth factor. J Mol Cell Cardiol. 2005; 39: 813-22.
    • (2005) J Mol Cell Cardiol. , vol.39 , pp. 813-822
    • Kaga, S.1    Zhan, L.2    Matsumoto, M.3    Maulik, N.4
  • 47
    • 0037433172 scopus 로고    scopus 로고
    • Sequestering ability of butylated hydroxytoluene, propyl gallate, resveratrol, and vitamins C and E against ABTS, DPPH, and hydroxyl free radicals in chemical and biological systems
    • Soares DG, Andreazza AC, Salvador M. Sequestering ability of butylated hydroxytoluene, propyl gallate, resveratrol, and vitamins C and E against ABTS, DPPH, and hydroxyl free radicals in chemical and biological systems. J Agric Food Chem. 2003; 51: 1077-80.
    • (2003) J Agric Food Chem. , vol.51 , pp. 1077-1080
    • Soares, D.G.1    Andreazza, A.C.2    Salvador, M.3
  • 48
    • 79953773488 scopus 로고    scopus 로고
    • Antioxidant and signal modulation properties of plant polyphenols in controlling vascular inflammation
    • Kostyuk VA, Potapovich AI, Suhan TO, de Luca C, Korkina LG. Antioxidant and signal modulation properties of plant polyphenols in controlling vascular inflammation. Eur J Pharmacol. 2011; 658: 248-56.
    • (2011) Eur J Pharmacol. , vol.658 , pp. 248-256
    • Kostyuk, V.A.1    Potapovich, A.I.2    Suhan, T.O.3    de Luca, C.4    Korkina, L.G.5
  • 49
    • 84860797901 scopus 로고    scopus 로고
    • Resveratrol protects H9c2 embryonic rat heart derived cells from oxidative stress by inducing autophagy: role of p38 mitogen-activated protein kinase
    • Lv XC, Zhou HY. Resveratrol protects H9c2 embryonic rat heart derived cells from oxidative stress by inducing autophagy: role of p38 mitogen-activated protein kinase. Can J Physiol Pharmacol. 2012; 90: 655-62.
    • (2012) Can J Physiol Pharmacol. , vol.90 , pp. 655-662
    • Lv, X.C.1    Zhou, H.Y.2
  • 50
    • 84862215866 scopus 로고    scopus 로고
    • Resveratrol reduces vascular cell senescence through attenuation of oxidative stress by SIRT1/NADPH oxidase-dependent mechanisms
    • Tang Y, Xu J, Qu W, et al. Resveratrol reduces vascular cell senescence through attenuation of oxidative stress by SIRT1/NADPH oxidase-dependent mechanisms. J Nutr Biochem. 2012; 23: 1410-6.
    • (2012) J Nutr Biochem. , vol.23 , pp. 1410-1416
    • Tang, Y.1    Xu, J.2    Qu, W.3
  • 51
    • 1642493651 scopus 로고    scopus 로고
    • Isorhapontigenin and resveratrol suppress oxLDL-induced proliferation and activation of ERK1/2 mitogen-activated protein kinases of bovine aortic smooth muscle cells
    • Liu Y, Liu G. Isorhapontigenin and resveratrol suppress oxLDL-induced proliferation and activation of ERK1/2 mitogen-activated protein kinases of bovine aortic smooth muscle cells. Biochem Pharmacol. 2004; 67: 777-85.
    • (2004) Biochem Pharmacol. , vol.67 , pp. 777-785
    • Liu, Y.1    Liu, G.2
  • 52
    • 33845399894 scopus 로고    scopus 로고
    • Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha
    • Lagouge M, Argmann C, Gerhart-Hines Z, et al. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell. 2006; 127: 1109-22.
    • (2006) Cell. , vol.127 , pp. 1109-1122
    • Lagouge, M.1    Argmann, C.2    Gerhart-Hines, Z.3
  • 53
    • 33751072349 scopus 로고    scopus 로고
    • Resveratrol improves health and survival of mice on a high-calorie diet
    • Baur JA, Pearson KJ, Price NL, et al. Resveratrol improves health and survival of mice on a high-calorie diet. Nature. 2006; 444: 337-42.
    • (2006) Nature. , vol.444 , pp. 337-342
    • Baur, J.A.1    Pearson, K.J.2    Price, N.L.3
  • 54
    • 79955611314 scopus 로고    scopus 로고
    • Resveratrol exerts anti-obesity effects via mechanisms involving down-regulation of adipogenic and inflammatory processes in mice
    • Kim S, Jin Y, Choi Y, Park T. Resveratrol exerts anti-obesity effects via mechanisms involving down-regulation of adipogenic and inflammatory processes in mice. Biochem Pharmacol. 2011; 81: 1343-51.
    • (2011) Biochem Pharmacol. , vol.81 , pp. 1343-1351
    • Kim, S.1    Jin, Y.2    Choi, Y.3    Park, T.4
  • 55
    • 77953545677 scopus 로고    scopus 로고
    • Resveratrol attenuates hyperglycemia-mediated oxidative stress, proinflammatory cytokines and protects hepatocytes ultrastructure in streptozotocin-nicotinamide-induced experimental diabetic rats
    • Palsamy P, Sivakumar S, Subramanian S. Resveratrol attenuates hyperglycemia-mediated oxidative stress, proinflammatory cytokines and protects hepatocytes ultrastructure in streptozotocin-nicotinamide-induced experimental diabetic rats. Chem Biol Interact. 2010; 186: 200-10.
    • (2010) Chem Biol Interact. , vol.186 , pp. 200-210
    • Palsamy, P.1    Sivakumar, S.2    Subramanian, S.3
  • 56
    • 77953644361 scopus 로고    scopus 로고
    • Ameliorative potential of resveratrol on proinflammatory cytokines, hyperglycemia mediated oxidative stress, and pancreatic beta-cell dysfunction in streptozotocin-nicotinamide-induced diabetic rats
    • Palsamy P, Subramanian S. Ameliorative potential of resveratrol on proinflammatory cytokines, hyperglycemia mediated oxidative stress, and pancreatic beta-cell dysfunction in streptozotocin-nicotinamide-induced diabetic rats. J Cell Physiol. 2010; 224: 423-32.
    • (2010) J Cell Physiol. , vol.224 , pp. 423-432
    • Palsamy, P.1    Subramanian, S.2
  • 57
    • 62549115284 scopus 로고    scopus 로고
    • Modulatory effects of resveratrol on attenuating the key enzymes activities of carbohydrate metabolism in streptozotocin-nicotinamide-induced diabetic rats
    • Palsamy P, Subramanian S. Modulatory effects of resveratrol on attenuating the key enzymes activities of carbohydrate metabolism in streptozotocin-nicotinamide-induced diabetic rats. Chem Biol Interact. 2009; 179: 356-62.
    • (2009) Chem Biol Interact. , vol.179 , pp. 356-362
    • Palsamy, P.1    Subramanian, S.2
  • 59
    • 80054736902 scopus 로고    scopus 로고
    • Resveratrol improves survival, hemodynamics and energetics in a rat model of hypertension leading to heart failure
    • Rimbaud S, Ruiz M, Piquereau J, et al. Resveratrol improves survival, hemodynamics and energetics in a rat model of hypertension leading to heart failure. PLoS One. 2011; 6: e26391.
    • (2011) PLoS One. , vol.6
    • Rimbaud, S.1    Ruiz, M.2    Piquereau, J.3
  • 60
    • 48349144852 scopus 로고    scopus 로고
    • Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span
    • Pearson KJ, Baur JA, Lewis KN, et al. Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span. Cell Metab. 2008; 8: 157-68.
    • (2008) Cell Metab. , vol.8 , pp. 157-168
    • Pearson, K.J.1    Baur, J.A.2    Lewis, K.N.3
  • 61
    • 67349286501 scopus 로고    scopus 로고
    • Resveratrol toxicity: effects on risk factors for atherosclerosis and hepatic oxidative stress in standard and high-fat diets
    • Rocha KK, Souza GA, Ebaid GX, Seiva FR, Cataneo AC, Novelli EL. Resveratrol toxicity: effects on risk factors for atherosclerosis and hepatic oxidative stress in standard and high-fat diets. Food Chem Toxicol. 2009; 47: 1362-7.
    • (2009) Food Chem Toxicol. , vol.47 , pp. 1362-1367
    • Rocha, K.K.1    Souza, G.A.2    Ebaid, G.X.3    Seiva, F.R.4    Cataneo, A.C.5    Novelli, E.L.6
  • 62
    • 84857945808 scopus 로고    scopus 로고
    • Resveratrol causes antiatherogenic effects in an animal model of atherosclerosis
    • Matos RS, Baroncini LA, Precoma LB, et al. Resveratrol causes antiatherogenic effects in an animal model of atherosclerosis. Arq Bras Cardiol. 2012; 98: 136-42.
    • (2012) Arq Bras Cardiol. , vol.98 , pp. 136-142
    • Matos, R.S.1    Baroncini, L.A.2    Precoma, L.B.3
  • 63
    • 60949087943 scopus 로고    scopus 로고
    • Long-term resveratrol administration reduces metabolic disturbances and lowers blood pressure in obese Zucker rats
    • Rivera L, Moron R, Zarzuelo A, Galisteo M. Long-term resveratrol administration reduces metabolic disturbances and lowers blood pressure in obese Zucker rats. Biochem Pharmacol. 2009; 77: 1053-63.
    • (2009) Biochem Pharmacol. , vol.77 , pp. 1053-1063
    • Rivera, L.1    Moron, R.2    Zarzuelo, A.3    Galisteo, M.4
  • 64
    • 84865063290 scopus 로고    scopus 로고
    • Treatment with low-dose resveratrol reverses cardiac impairment in obese prone but not in obese resistant rats
    • Louis XL, Thandapilly SJ, Mohankumar SK, et al. Treatment with low-dose resveratrol reverses cardiac impairment in obese prone but not in obese resistant rats. J Nutr Biochem. 2011; 23: 1163-9.
    • (2011) J Nutr Biochem. , vol.23 , pp. 1163-1169
    • Louis, X.L.1    Thandapilly, S.J.2    Mohankumar, S.K.3
  • 65
    • 84861444769 scopus 로고    scopus 로고
    • High-fructose corn syrup causes vascular dysfunction associated with metabolic disturbance in rats: protective effect of resveratrol
    • Akar F, Uludag O, Aydin A, et al. High-fructose corn syrup causes vascular dysfunction associated with metabolic disturbance in rats: protective effect of resveratrol. Food Chem Toxicol. 2012; 50: 2135-41.
    • (2012) Food Chem Toxicol. , vol.50 , pp. 2135-2141
    • Akar, F.1    Uludag, O.2    Aydin, A.3
  • 66
    • 84859524897 scopus 로고    scopus 로고
    • The polyphenols resveratrol and s17834 prevent the structural and functional sequelae of diet-induced metabolic heart disease in mice
    • Qin F, Siwik DA, Luptak I, et al. The polyphenols resveratrol and s17834 prevent the structural and functional sequelae of diet-induced metabolic heart disease in mice. Circulation. 2012; 125: 1757-64.
    • (2012) Circulation. , vol.125 , pp. 1757-1764
    • Qin, F.1    Siwik, D.A.2    Luptak, I.3
  • 67
    • 81155139677 scopus 로고    scopus 로고
    • Resveratrol counteracts systemic and local inflammation involved in early abdominal aortic aneurysm development
    • Palmieri D, Pane B, Barisione C, et al. Resveratrol counteracts systemic and local inflammation involved in early abdominal aortic aneurysm development. J Surg Res. 2011; 171: e237-46.
    • (2011) J Surg Res. , vol.171
    • Palmieri, D.1    Pane, B.2    Barisione, C.3
  • 68
    • 79954418374 scopus 로고    scopus 로고
    • Is red wine a SAFE sip away from cardioprotection? Mechanisms involved in resveratrol- and melatonin-induced cardioprotection
    • Lamont KT, Somers S, Lacerda L, Opie LH, Lecour S. Is red wine a SAFE sip away from cardioprotection? Mechanisms involved in resveratrol- and melatonin-induced cardioprotection. J Pineal Res. 2011; 50: 374-80.
    • (2011) J Pineal Res. , vol.50 , pp. 374-380
    • Lamont, K.T.1    Somers, S.2    Lacerda, L.3    Opie, L.H.4    Lecour, S.5
  • 69
    • 77955295236 scopus 로고    scopus 로고
    • Anti-angiogenic effect of high-dose resveratrol in a swine model of metabolic syndrome
    • Robich MP, Chu LM, Chaudray M, et al. Anti-angiogenic effect of high-dose resveratrol in a swine model of metabolic syndrome. Surgery. 2010; 148: 453-62.
    • (2010) Surgery. , vol.148 , pp. 453-462
    • Robich, M.P.1    Chu, L.M.2    Chaudray, M.3
  • 70
    • 84878012381 scopus 로고    scopus 로고
    • Resveratrol attenuates oxidative stress and prevents steatosis and hypertension in obese rats programmed by early weaning
    • doi: 10. 1016/j. jnutbio. 2012. 06. 019
    • Franco JG, Lisboa PC, Lima NS, et al. Resveratrol attenuates oxidative stress and prevents steatosis and hypertension in obese rats programmed by early weaning. J Nutr Biochem. 2012. doi: 10. 1016/j. jnutbio. 2012. 06. 019.
    • (2012) J Nutr Biochem
    • Franco, J.G.1    Lisboa, P.C.2    Lima, N.S.3
  • 71
    • 84864277111 scopus 로고    scopus 로고
    • Attenuation of insulin resistance, metabolic syndrome and hepatic oxidative stress by resveratrol in fructose-fed rats
    • Bagul PK, Middela H, Matapally S, et al. Attenuation of insulin resistance, metabolic syndrome and hepatic oxidative stress by resveratrol in fructose-fed rats. Pharmacol Res. 2012; 66: 260-8.
    • (2012) Pharmacol Res. , vol.66 , pp. 260-268
    • Bagul, P.K.1    Middela, H.2    Matapally, S.3
  • 72
    • 84861434958 scopus 로고    scopus 로고
    • Effect of resveratrol on oxidative and inflammatory stress in liver and spleen of streptozotocin-induced type 1 diabetic rats
    • Chang CC, Chang CY, Huang JP, Hung LM. Effect of resveratrol on oxidative and inflammatory stress in liver and spleen of streptozotocin-induced type 1 diabetic rats. Chin J Physiol. 2012; 55: 192-201.
    • (2012) Chin J Physiol. , vol.55 , pp. 192-201
    • Chang, C.C.1    Chang, C.Y.2    Huang, J.P.3    Hung, L.M.4
  • 73
    • 79955675928 scopus 로고    scopus 로고
    • A resveratrol and polyphenol preparation suppresses oxidative and inflammatory stress response to a high-fat, high-carbohydrate meal
    • Ghanim H, Sia CL, Korzeniewski K, et al. A resveratrol and polyphenol preparation suppresses oxidative and inflammatory stress response to a high-fat, high-carbohydrate meal. J Clin Endocrinol Metab. 2011; 96: 1409-14.
    • (2011) J Clin Endocrinol Metab. , vol.96 , pp. 1409-1414
    • Ghanim, H.1    Sia, C.L.2    Korzeniewski, K.3
  • 74
    • 77956585215 scopus 로고    scopus 로고
    • An antiinflammatory and reactive oxygen species suppressive effects of an extract of Polygonum cuspidatum containing resveratrol
    • Ghanim H, Sia CL, Abuaysheh S, et al. An antiinflammatory and reactive oxygen species suppressive effects of an extract of Polygonum cuspidatum containing resveratrol. J Clin Endocrinol Metab. 2010; 95: E1-8.
    • (2010) J Clin Endocrinol Metab. , vol.95
    • Ghanim, H.1    Sia, C.L.2    Abuaysheh, S.3
  • 75
    • 84863980958 scopus 로고    scopus 로고
    • One-year consumption of a grape nutraceutical containing resveratrol improves the inflammatory and fibrinolytic status of patients in primary prevention of cardiovascular disease
    • Tome-Carneiro J, Gonzalvez M, Larrosa M, et al. One-year consumption of a grape nutraceutical containing resveratrol improves the inflammatory and fibrinolytic status of patients in primary prevention of cardiovascular disease. Am J Cardiol. 2012; 110: 356-63.
    • (2012) Am J Cardiol. , vol.110 , pp. 356-363
    • Tome-Carneiro, J.1    Gonzalvez, M.2    Larrosa, M.3
  • 76
    • 84860131782 scopus 로고    scopus 로고
    • Pilot study of resveratrol in older adults with impaired glucose tolerance
    • Crandall JP, Oram V, Trandafirescu G, et al. Pilot study of resveratrol in older adults with impaired glucose tolerance. J Gerontol A Biol Sci Med Sci. 2012; 67: 1307-12.
    • (2012) J Gerontol A Biol Sci Med Sci. , vol.67 , pp. 1307-1312
    • Crandall, J.P.1    Oram, V.2    Trandafirescu, G.3
  • 77
    • 80455143206 scopus 로고    scopus 로고
    • Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans
    • Timmers S, Konings E, Bilet L, et al. Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans. Cell Metab. 2011; 14: 612-22.
    • (2011) Cell Metab. , vol.14 , pp. 612-622
    • Timmers, S.1    Konings, E.2    Bilet, L.3
  • 78
    • 84860276621 scopus 로고    scopus 로고
    • High urinary levels of resveratrol metabolites are associated with a reduction in the prevalence of cardiovascular risk factors in high-risk patients
    • Zamora-Ros R, Urpi-Sarda M, Lamuela-Raventos RM, et al. High urinary levels of resveratrol metabolites are associated with a reduction in the prevalence of cardiovascular risk factors in high-risk patients. Pharmacol Res. 2012; 65: 615-20.
    • (2012) Pharmacol Res. , vol.65 , pp. 615-620
    • Zamora-Ros, R.1    Urpi-Sarda, M.2    Lamuela-Raventos, R.M.3
  • 79
    • 84950170835 scopus 로고    scopus 로고
    • Acute resveratrol supplementation improves flow-mediated dilatation in overweight/obese individuals with mildly elevated blood pressure
    • Wong RH, Howe PR, Buckley JD, Coates AM, Kunz I, Berry NM. Acute resveratrol supplementation improves flow-mediated dilatation in overweight/obese individuals with mildly elevated blood pressure. Nutr Metab Cardiovasc Dis. 2010; 21: 851-6.
    • (2010) Nutr Metab Cardiovasc Dis. , vol.21 , pp. 851-856
    • Wong, R.H.1    Howe, P.R.2    Buckley, J.D.3    Coates, A.M.4    Kunz, I.5    Berry, N.M.6
  • 80
    • 84872362245 scopus 로고    scopus 로고
    • ClinicalTrials. gov. Effects of resveratrol supplements on vascular health in postmenopausal women. Available at, Accessed May 16, 2012
    • ClinicalTrials. gov. Effects of resveratrol supplements on vascular health in postmenopausal women. Available at: http://clinicaltrials. gov/ct2/show/NCT01564381?term=resveratrol+cardiovascular& rank=2. Accessed May 16, 2012.
  • 81
    • 84872292657 scopus 로고    scopus 로고
    • ClinicalTrials. gov. Resveratrol and serum Apo A-I. Available at, Accessed May 16, 2012
    • ClinicalTrials. gov. Resveratrol and serum Apo A-I. Available at: http://clinicaltrials. gov/ct2/show/NCT01364961?term=resveratrol+cardiovascular& rank=6. Accessed May 16, 2012.
  • 83
    • 84863011114 scopus 로고    scopus 로고
    • Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases
    • Park SJ, Ahmad F, Philp A, et al. Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases. Cell. 2012; 148: 421-33.
    • (2012) Cell. , vol.148 , pp. 421-433
    • Park, S.J.1    Ahmad, F.2    Philp, A.3
  • 85
    • 77950353854 scopus 로고    scopus 로고
    • SIRT1 takes a backseat to AMPK in the regulation of insulin sensitivity by resveratrol
    • Fullerton MD, Steinberg GR. SIRT1 takes a backseat to AMPK in the regulation of insulin sensitivity by resveratrol. Diabetes. 2010; 59: 551-3.
    • (2010) Diabetes. , vol.59 , pp. 551-553
    • Fullerton, M.D.1    Steinberg, G.R.2
  • 86
    • 80054899332 scopus 로고    scopus 로고
    • Resveratrol inhibition of inducible nitric oxide synthase in skeletal muscle involves AMPK but not SIRT1
    • Centeno-Baez C, Dallaire P, Marette A. Resveratrol inhibition of inducible nitric oxide synthase in skeletal muscle involves AMPK but not SIRT1. Am J Physiol Endocrinol Metab. 2011; 301: E922-30.
    • (2011) Am J Physiol Endocrinol Metab. , vol.301
    • Centeno-Baez, C.1    Dallaire, P.2    Marette, A.3
  • 87
    • 77950348878 scopus 로고    scopus 로고
    • AMP-activated protein kinase-deficient mice are resistant to the metabolic effects of resveratrol
    • Um JH, Park SJ, Kang H, et al. AMP-activated protein kinase-deficient mice are resistant to the metabolic effects of resveratrol. Diabetes. 2010; 59: 554-63.
    • (2010) Diabetes. , vol.59 , pp. 554-563
    • Um, J.H.1    Park, S.J.2    Kang, H.3
  • 88
    • 3943071801 scopus 로고    scopus 로고
    • Sirtuin activators mimic caloric restriction and delay ageing in metazoans
    • Wood JG, Rogina B, Lavu S, et al. Sirtuin activators mimic caloric restriction and delay ageing in metazoans. Nature. 2004; 430: 686-9.
    • (2004) Nature. , vol.430 , pp. 686-689
    • Wood, J.G.1    Rogina, B.2    Lavu, S.3
  • 89
    • 33646892170 scopus 로고    scopus 로고
    • Resveratrol and the pharmacology of aging: a new vertebrate model to validate an old molecule
    • Valenzano DR, Cellerino A. Resveratrol and the pharmacology of aging: a new vertebrate model to validate an old molecule. Cell Cycle. 2006; 5: 1027-32.
    • (2006) Cell Cycle. , vol.5 , pp. 1027-1032
    • Valenzano, D.R.1    Cellerino, A.2
  • 90
    • 20444431507 scopus 로고    scopus 로고
    • Substrate-specific activation of sirtuins by resveratrol
    • Kaeberlein M, McDonagh T, Heltweg B, et al. Substrate-specific activation of sirtuins by resveratrol. J Biol Chem. 2005; 280: 17038-45.
    • (2005) J Biol Chem. , vol.280 , pp. 17038-17045
    • Kaeberlein, M.1    McDonagh, T.2    Heltweg, B.3
  • 91
    • 0141719702 scopus 로고    scopus 로고
    • Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
    • Howitz KT, Bitterman KJ, Cohen HY, et al. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature. 2003; 425: 191-6.
    • (2003) Nature. , vol.425 , pp. 191-196
    • Howitz, K.T.1    Bitterman, K.J.2    Cohen, H.Y.3
  • 92
    • 79951794971 scopus 로고    scopus 로고
    • Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice
    • Miller RA, Harrison DE, Astle CM, et al. Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice. J Gerontol A Biol Sci Med Sci. 2010; 66: 191-201.
    • (2010) J Gerontol A Biol Sci Med Sci. , vol.66 , pp. 191-201
    • Miller, R.A.1    Harrison, D.E.2    Astle, C.M.3
  • 93
    • 84859586430 scopus 로고    scopus 로고
    • Revelations into resveratrol's mechanism
    • Baur JA. Revelations into resveratrol's mechanism. Nat Med. 2012; 18: 500-1.
    • (2012) Nat Med. , vol.18 , pp. 500-501
    • Baur, J.A.1
  • 94
    • 77957975705 scopus 로고    scopus 로고
    • A review of the sirtuin system, its clinical implications, and the potential role of dietary activators like resveratrol: part 2
    • Kelly GS. A review of the sirtuin system, its clinical implications, and the potential role of dietary activators like resveratrol: part 2. Altern Med Rev. 2010; 15: 313-28.
    • (2010) Altern Med Rev. , vol.15 , pp. 313-328
    • Kelly, G.S.1
  • 95
    • 77249158771 scopus 로고    scopus 로고
    • SIRT1 regulates oxidant- and cigarette smoke-induced eNOS acetylation in endothelial cells: Role of resveratrol
    • Arunachalam G, Yao H, Sundar IK, Caito S, Rahman I. SIRT1 regulates oxidant- and cigarette smoke-induced eNOS acetylation in endothelial cells: Role of resveratrol. Biochem Biophys Res Commun. 2010; 393: 66-72.
    • (2010) Biochem Biophys Res Commun. , vol.393 , pp. 66-72
    • Arunachalam, G.1    Yao, H.2    Sundar, I.K.3    Caito, S.4    Rahman, I.5
  • 96
    • 77749254621 scopus 로고    scopus 로고
    • Resveratrol, an activator of SIRT1, upregulates sarcoplasmic calcium ATPase and improves cardiac function in diabetic cardiomyopathy
    • Sulaiman M, Matta MJ, Sunderesan NR, Gupta MP, Periasamy M, Gupta M. Resveratrol, an activator of SIRT1, upregulates sarcoplasmic calcium ATPase and improves cardiac function in diabetic cardiomyopathy. Am J Physiol Heart Circ Physiol. 2010; 298: H833-43.
    • (2010) Am J Physiol Heart Circ Physiol. , vol.298
    • Sulaiman, M.1    Matta, M.J.2    Sunderesan, N.R.3    Gupta, M.P.4    Periasamy, M.5    Gupta, M.6
  • 97
    • 46249095235 scopus 로고    scopus 로고
    • SIRT1, a longevity gene, downregulates angiotensin II type 1 receptor expression in vascular smooth muscle cells
    • Miyazaki R, Ichiki T, Hashimoto T, et al. SIRT1, a longevity gene, downregulates angiotensin II type 1 receptor expression in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol. 2008; 28: 1263-9.
    • (2008) Arterioscler Thromb Vasc Biol. , vol.28 , pp. 1263-1269
    • Miyazaki, R.1    Ichiki, T.2    Hashimoto, T.3
  • 98
    • 84860540855 scopus 로고    scopus 로고
    • Resveratrol in medicinal chemistry: a critical review of its pharmacokinetics, drug-delivery, and membrane interactions
    • Neves AR, Lucio M, Lima JL, Reis S. Resveratrol in medicinal chemistry: a critical review of its pharmacokinetics, drug-delivery, and membrane interactions. Curr Med Chem. 2012; 19: 1663-81.
    • (2012) Curr Med Chem. , vol.19 , pp. 1663-1681
    • Neves, A.R.1    Lucio, M.2    Lima, J.L.3    Reis, S.4
  • 99
    • 84859909860 scopus 로고    scopus 로고
    • SRT1720 improves survival and healthspan of obese mice
    • Minor RK, Baur JA, Gomes AP, et al. SRT1720 improves survival and healthspan of obese mice. Sci Rep. 2011; 1: 70.
    • (2011) Sci Rep. , vol.1 , pp. 70
    • Minor, R.K.1    Baur, J.A.2    Gomes, A.P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.