Resveratrol decreases early signaling events in washed platelets but has little effect on platelet aggregation in whole blood

Blood Cells, Molecules, and Diseases

Volumn 26, Issue 2, 2000, Pages 144-150

  Kirk, Rita I ^a   Deitch, Joshua A ^a   Wu, Joseph M ^a   Lerea, Kenneth M ^a  

^a NEW YORK MEDICAL COLLEGE   (United States)

Author keywords

MAP kinases; Platelets; Resveratrol; Whole blood

Indexed keywords

RESVERATROL;

ARTICLE; CORONARY RISK; DRUG EFFECT; HEART PROTECTION; HUMAN; HUMAN CELL; ISCHEMIC HEART DISEASE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; THROMBOCYTE AGGREGATION; WINE;

EID: 0033861559     PISSN: 10799796     EISSN: None     Source Type: Journal    
DOI: 10.1006/bcmd.2000.0289     Document Type: Article

References (23)

1. Renaud S, DeLorgeril M. Wine, alcohol, platelets, and the French paradox for coronary heart disease. Lancet. 339:1992;1523-1526.
2. Artaud-Wild S M, Connor S L, Sexton G, Connor W E. Differences in coronary mortality can be explained by differences in cholesterol and saturated fat intakes in 40 countries but not in France and Finland. A paradox. Circulation. 88:1993;2771-2779.
3. Moore R D, Pearson T A. Moderate alcohol consumption and coronary artery disease. A review. Medicine. 65:1986;242-267.
4. Ross R. Cell biology of atherosclerosis. Annu. Rev. Physiol. 57:1995;791-915.
5. Raines, EW, Ross R. Multiple growth factors are associated with lesions of atherosclerosis: Specificity or redundancy? BioEssays. 18:1996;271-282.
6. Langer R D, Criqui M H, Reed D M. Lipoproteins and blood pressure as biological pathways for effect of moderate alcohol consumption on coronary heart disease. Circulation. 85:1992;910-915.
7. DeWalley C V, Rankin S M, Hoult J RS, Jessup W, Leake D S. Flavonoids inhibit the oxidative modification of low density lipoproteins by macrophages. Biochem. Pharmacol. 39:1990;1743-1750.
8. Fenn C G, Littleton J M. Inhibition of platelet aggregation by ethanol in vitro shows specificity for aggregating agent used and is influenced by platelet lipid composition. Thromb. Haemostasis. 48:1982;49-53.
9. Renaud S C, Beswick A D, Fehily A M, Sharp D S, Elwood P C. Alcohol and platelet aggregation: The Caerphilly Prospective Heart Disease Study. Am. J. Clin. Nutr. 55:1992;1012-1017.
10. Veenstra J, Kluft C, Ockhuizen T, Pol H VD, Wedel M, Schaafsma G. Effects of moderate alcohol consumption on platelet function, tissue-type plasminogen activator and plasminogen activator inhibitor. Thromb. Haemostasis. 63:1990;345-348.
11. Bertelli A AE, Giovannini L, DeCaterina R, Bernini W, Migliori M, Fregoni M, Bavaresco L, Bertelli A. Antiplatelet activity of cis-resveratrol. Drugs Exp. Clin. Res. 222:1996;61-63.
12. Pace-Asciak C R, Hahn S, Diamandis E P, Soleas G, Goldberg D M. The red wine phenolics trans-resveratrol and quercetin block human platelet aggregation and eicosanoid synthesis: Implications for protection against coronary heart disease. Clin. Chim. Acta. 235:1995;207-219.
13. Rotondo S, Totilio D, Cerletti C, deGaetano G. Red wine, aspirin and platelet function. Thromb. Haemostasis. 76:1996;818-819.
14. Ferrero M E, Bertelli A ES, Fulgenzi A, Pellegatta F, Corsi M M, Bonfrate M, Ferrara F, DeCaterina R, Giovannini L, Bertelli A. Activity in vitro of resveratrol on granulocyte and monocyte adhesion to endothelium. Am. J. Clin. Nutr. 68:1998;1208-1214.
15. 3 in platelets. J. Biol. Chem. 272:1997;22381-22384.
16. Papkoff J, Chen R-H, Blenis J, Forsman J. p42 mitogen-activated protein kinase and p90 ribosomal S6 kinase are selectively phosphorylated and activated during thrombin-induced platelet activation and aggregation. Mol. Cell. Biol. 14:1994;463-472.
17. Shattil S J, Kashiwagi H, Pampori N. Integrin signaling: The platelet paradigm. Blood. 91:1998;2645-2657.
18. Goto S, Salomon D R, Ikeda Y, Ruggeri Z M. Characterization of the unique mechanism mediating the shear-dependent binding of soluble von Willebrand factor to platelets. J. Biol. Chem. 270:1995;23352-23361.
19. Siess W. Molecular mechanisms of platelet activation. Physiol. Rev. 69:1989;58-178.
20. Miyamoto S, Akiyama S K, Yamada K M. Synergistic roles for receptor occupancy and aggregation in integrin transmembrane function. Science. 267:1995;883-885.
21. Bertelli A, Bertelli, AAE, Gozzini A, Giovannini L. Plasma and tissue resveratrol concentrations and pharmacological activity. Drugs Exp. Clin. Res. 24:1998;133-138.
22. Kopp P. Resveratrol, a phytoestrogen found in red wine. A possible explanation for the conundrum of the 'French paradox'? Eur. J. Endocrinol. 138:1998;619-620.
23. Blache D, Rustan I, Durand P, Lesgards G, Loreau N. Gas chromatographic analysis of resveratrol in plasma, lipoproteins and cells after in vitro incubations. J. Chromatogr. B. 702:1997;103-110.