Resveratrol causes antiatherogenic effects in an animal model of atherosclerosis

Arquivos Brasileiros de Cardiologia

Volumn 98, Issue 2, 2012, Pages 136-141

  Matos, Rossane Serafim ^a   Baroncini, Liz Andréa Villela ^a   Précoma, Leonardo Brandão ^a   Winter, Guilherme ^a   Caron, Pedro Henrique Lambach ^a   Kaiber, Flávia ^a   Précoma, Dalton Bertolim ^a  

^a PONTIFICAL CATHOLIC UNIVERSITY OF PARANÁ   (Brazil)

Author keywords

Antioxidants; Atherosclerosis; Dyslipidemias; Revesratrol

Indexed keywords

HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; RESVERATROL; TRIACYLGLYCEROL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA ATHEROSCLEROSIS; ARTICLE; ATHEROGENESIS; ATHEROSCLEROSIS; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; HYPERCHOLESTEROLEMIA; INTIMA; MALE; NONHUMAN; RABBIT;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ATHEROSCLEROSIS; CHOLESTEROL, DIETARY; DISEASE MODELS, ANIMAL; DRUG EVALUATION, PRECLINICAL; HYPERCHOLESTEROLEMIA; MALE; PLATELET AGGREGATION INHIBITORS; RABBITS; RANDOM ALLOCATION; STATISTICS, NONPARAMETRIC; STILBENES;

EID: 84857945808     PISSN: 0066782X     EISSN: 16784170     Source Type: Journal    
DOI: 10.1590/S0066-782X2012005000006     Document Type: Article

References (29)

1. Turner RT, Evans GL, Zhang M, Maran A, Sibonga JD. Is resveratrol an estrogen agonist in growing rats? Endocrinology. 1999;140(1):50-54.
2. Pendurthi US, Rao LVM. Resveratrol suppresses agonist-induced monocyte adhesion to cultured human endothelial cells. Thromb Res. 2002;106(4-5):243-248.
3. Wilson T, Knight TJ, Beitz DC, Lewis DS, Engen RL. Resveratrol promotes atherosclerosis in hypercholesterolemic rabbits. Life Sci. 1996;59(1):PL15-PL21.
4. Pace-Asciak CR, Rounova O, Hahn SE, Diamandis E P, Goldberb DM. Wines and grape juices as modulators of platelet aggregation in healthy human subjects. Clin Chim Acta. 1996;246(1-2):163-182.
5. Pace-Asciak CR, Hahn S, Diamandis E P, Soleas G, Goldberg DM. The red wine phenolics trans-resveratrol and quercetin block human platelet aggregation and eicosanoid synthesis: implications for protection against coronary heart disease. Clin Chim Acta. 1995;235(2):207-219.
6. Zou JG, Wang ZR, Huanhg YZ, Cao KJ, Wu JM. Effect of red wine and wine polyphenol resveratrol on endothelial function in hypercholesterolemic rabbits. Int J Mol Med. 2003;11(3):317-320.
7. Stary HC, Blankenhorn DH, Chandler AB, Glagov S, Insull W Jr, Richardson M, et al. A definition of the intima of human arteries and of its atherosclerosis- prone regions: a report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association. Circulation. 1992;85(1):391-405.
8. Stary HC, Chandler AB, Glagov S, Guyton JR, Insull W Jr, Rosenfeld ME, et al. A definition of initial, fatty streak, and intermediate lesions of atherosclerosis: a report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association. Circulation. 1994;89(5):2462-2478.
9. Stary HC, Chandler AB, Dinsmore RE, Fuster V, Glagov S, Insull W Jr, et al. A definition of advanced types of atherosclerotic lesions and a histological classification of atherosclerosis: a report from the Committee on Vascular Lesions of the Council on Arterisoclerosis, American Heart Association. Circulation. 1995;92(5):355-374.
10. Fulgenzi A, Bertelli AAE, Magni E, Ferrero E, Ferrero ME. In vivo inhibition of TNFa-induced vascular permeability by resveratrol. Transplant Proc. 2001;33(3):2341-2343.
11. Olas B, Wachowicz B. Resveratrol and vitamin C as antioxidants in blood platelets. Thromb Res. 2002;106(2):143-148.
12. Slater SJ, Seiz JL, Cook AC, Stagliano BA, Buzas CJ. Inhibition of protein kinase C by resveratrol. Biochim Biophys Acta. 2003;1637(1):59-69.
13. Poussier B, Cordova AC, Becquemin J P, Sumpio BE. Resveratrol inhibits vascular smooth muscle cell proliferation and induces apoptosis. J Vasc Surg. 2005;42(6):1190-1197.
14. Chao HH, Juan SH, Liu JC, Yang HY, Yang E, Cheng TH, et al. Resveratrol inhibits angiotensin II-induced endothelin-1 gene expression and subsequent proliferation in rat aortic smooth muscle cells. Eur J Pharmacol. 2005;515(1-3):1-9.
15. Rocha KK, Souza GA, Ebaid GX, Seiva FR, Cataneo AC, Novelli EL. Resveratrol toxicity: effects on risk factors for atherosclerosis and hepatic oxidative stress in standard and high-fat diets. Food Chem Toxicol. 2009;47(6):1362-1367.
16. Castro M, Pacheco MMR, Machado MRF. Morphology of aortic arch in rabbits with atherosclerosis treated with resveratrol. Intern J Appl Res Vet Med. 2009;7(4):190-5.
17. Fan E, Zhang L, Jiang S, Bai Y. Beneficial effects of resveratrol on atherosclerosis. J Med Food. 2008;11(4):610-614.
18. Nigdikar S V, Williams NR, Griffin BA, Howard AN. Consumption of red wine polyphenols reduces the susceptibility of low-density lipoproteins to oxidation in vivo. Am J Clin Nutr. 1998;68(2):258-265.
19. Shanmuganayagam D, Warner T F, Krueger CG, Reed JD, Folts JD. Concord grape juice attenuates platelet aggregation, serum cholesterol and development of atheroma in hypercholesterolemic rabbits. Atherosclerosis. 2007;190(1):135-142.
20. Castro M, Veiga APM, Pacheco MR. Plasma lipid profile of experimentally induced hyperlipidemic New Zealand white rabbits is not affected by resveratrol. J Appl Res. 2009;9(1):18-22.
21. Daugherty A, Schonfeld G, Sobel BE, Lange LG. Metabolism of very low density lipoproteins after cessation of cholesterol feeding in rabbits: a factor potentially contributing to the slow regression of atheromatous plaques. J Clin Invest. 1986;77(4):1108-1115.
22. Tang W, Pankow JS, Carr JJ, Tracy R P, Bielinski SJ, North KE, et al. Association of sICAM-1 and MCP-1 with coronary artery calcification in families enriched for coronary heart disease or hypertension: the NHLBI Family Heart Study. BMC Cardiovasc Disord. 2007;7:30.
23. Ferrero ME, Bertelli AE, Fulgenzi A, Pellegatta F, Corsi MM, Bonfrate M, et al. Activity in vitro of resveratrol on granulocyte and monocyte adhesion to endothelium Am J Clin Nutr. 1998;68(6):1208-1214.
24. Carluccio MA, Siculella L, Ancora MA, Massaro M, Scoditti E, Storelli C, et al. Olive oil and red wine antioxidant polyphenols inhibit endothelial activation: antiatherogenic properties of mediterranean diet phytochemicals. Arterioscler Thromb Vasc Biol. 2003;23(4):622-629.
25. Wung BS, Hsu MC, Wu CC, Hsieh CW. Resveratrol suppreses IL-6-induced ICAM-1 gene expression in endothelial cells: effects on the inhibition of STAT3 phosphorylation. Life Sci. 2005;78(4):389-397.
26. McLaren JE, Ramji D P. Interferon gamma: a master regulator of atherosclerosis. Cytokine Growth Factor Rev. 2009;20(2):125-135.
27. Saha P, Modarai B, Humphries J, Mattock K, Waltham M, Burnand KG, et al. The monocyte/macrophage as a therapeutic target in atherosclerosis. Curr Opin Pharmacol. 2009;9(2):109-118.
28. Ghosh S, Zhao B, Bie J, Song J. Macrophage cholesteryl ester mobilization and atherosclerosis. Vascul Pharmacol. 2010;52(1-2):1-10.
29. Prieur X, Rõszer T, Ricote M. Lipotoxicity in macrophages: evidence from diseases associated with the metabolic syndrome. Biochim Biophys Acta. 2010;1801(3):327-337.