-
1
-
-
33751072349
-
Resveratrol improves health and survival of mice on a high-calorie diet
-
Baur JA, Pearson KJ, Price NL, Jamieson HA, Lerin C, Kalra A, Prabhu VV, Allard JS, Lopez-Lluch G, Lewis K, Pistell PJ, Poosala S, Becker KG, Boss O, Gwinn D, Wang M, Ramaswamy S, Fishbein KW, Spencer RG, Lakatta EG, Le Couteur D, Shaw RJ, Navas P, Puigserver P, Ingram DK, de Cabo R, Sinclair DA. Resveratrol improves health and survival of mice on a high-calorie diet. Nature 444: 337-342, 2006.
-
(2006)
Nature
, vol.444
, pp. 337-342
-
-
Baur, J.A.1
Pearson, K.J.2
Price, N.L.3
Jamieson, H.A.4
Lerin, C.5
Kalra, A.6
Prabhu, V.V.7
Allard, J.S.8
Lopez-Lluch, G.9
Lewis, K.10
Pistell, P.J.11
Poosala, S.12
Becker, K.G.13
Boss, O.14
Gwinn, D.15
Wang, M.16
Ramaswamy, S.17
Fishbein, K.W.18
Spencer, R.G.19
Lakatta, E.G.20
le Couteur, D.21
Shaw, R.J.22
Navas, P.23
Puigserver, P.24
Ingram, D.K.25
de Cabo, R.26
Sinclair, D.A.27
more..
-
2
-
-
33745962138
-
Therapeutic potential of resveratrol: The in vivo evidence
-
Baur JA, Sinclair DA. Therapeutic potential of resveratrol: the in vivo evidence. Nat Rev Drug Discov 5: 493-506, 2006.
-
(2006)
Nat Rev Drug Discov
, vol.5
, pp. 493-506
-
-
Baur, J.A.1
Sinclair, D.A.2
-
3
-
-
0030872258
-
Cytokines modulate glucose transport in skeletal muscle by inducing the expression of inducible nitric oxide synthase
-
Bedard S, Marcotte B, Marette A. Cytokines modulate glucose transport in skeletal muscle by inducing the expression of inducible nitric oxide synthase. Biochem J 325: 487-493, 1997.
-
(1997)
Biochem J
, vol.325
, pp. 487-493
-
-
Bedard, S.1
Marcotte, B.2
Marette, A.3
-
4
-
-
10344228747
-
Resveratrol inhibits nitric oxide and TNF-alpha production by lipopolysaccharide-activated microglia
-
Bi XL, Yang JY, Dong YX, Wang JM, Cui YH, Ikeshima T, Zhao YQ, Wu CF. Resveratrol inhibits nitric oxide and TNF-alpha production by lipopolysaccharide-activated microglia. Int Immunopharmacol 5: 185-193, 2005.
-
(2005)
Int Immunopharmacol
, vol.5
, pp. 185-193
-
-
Bi, X.L.1
Yang, J.Y.2
Dong, Y.X.3
Wang, J.M.4
Cui, Y.H.5
Ikeshima, T.6
Zhao, Y.Q.7
Wu, C.F.8
-
5
-
-
0037025356
-
AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling
-
Bolster DR, Crozier SJ, Kimball SR, Jefferson LS. AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling. J Biol Chem 277: 23977-23980, 2002.
-
(2002)
J Biol Chem
, vol.277
, pp. 23977-23980
-
-
Bolster, D.R.1
Crozier, S.J.2
Kimball, S.R.3
Jefferson, L.S.4
-
6
-
-
17144429302
-
Calorie restriction, SIRT1 and metabolism: Understanding longevity
-
Bordone L, Guarente L. Calorie restriction, SIRT1 and metabolism: understanding longevity. Nat Rev Mol Cell Biol 6: 298-305, 2005.
-
(2005)
Nat Rev Mol Cell Biol
, vol.6
, pp. 298-305
-
-
Bordone, L.1
Guarente, L.2
-
7
-
-
0038460016
-
Effects of resveratrol on lymphocyte proliferation and cytokine release
-
Boscolo P, del Signore A, Sabbioni E, Di Gioacchino M, Di Giampaolo L, Reale M, Conti P, Paganelli R, Giaccio M. Effects of resveratrol on lymphocyte proliferation and cytokine release. Ann Clin Lab Sci 33: 226-231, 2003.
-
(2003)
Ann Clin Lab Sci
, vol.33
, pp. 226-231
-
-
Boscolo, P.1
del Signore, A.2
Sabbioni, E.3
di Gioacchino, M.4
di Giampaolo, L.5
Reale, M.6
Conti, P.7
Paganelli, R.8
Giaccio, M.9
-
8
-
-
47749148061
-
Stimulation of muscle cell glucose uptake by resveratrol through sirtuins and AMPK
-
Breen DM, Sanli T, Giacca A, Tsiani E. Stimulation of muscle cell glucose uptake by resveratrol through sirtuins and AMPK. Biochem Biophys Res Commun 374: 117-122, 2008.
-
(2008)
Biochem Biophys Res Commun
, vol.374
, pp. 117-122
-
-
Breen, D.M.1
Sanli, T.2
Giacca, A.3
Tsiani, E.4
-
9
-
-
33748470543
-
Targeted disruption of iNOS prevents LPS-induced S-nitrosation of IRβ/IRS-1 and Akt and insulin resistance in muscle of mice
-
Carvalho-Filho MA, Ueno M, Carvalheira JB, Velloso LA, Saad MJ. Targeted disruption of iNOS prevents LPS-induced S-nitrosation of IRβ/IRS-1 and Akt and insulin resistance in muscle of mice. Am J Physiol Endocrinol Metab 291: E476-E482, 2006.
-
(2006)
Am J Physiol Endocrinol Metab
, vol.291
-
-
Carvalho-Filho, M.A.1
Ueno, M.2
Carvalheira, J.B.3
Velloso, L.A.4
Saad, M.J.5
-
10
-
-
28844474597
-
SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling
-
Chen J, Zhou Y, Mueller-Steiner S, Chen LF, Kwon H, Yi S, Mucke L, Gan L. SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling. J Biol Chem 280: 40364-40374, 2005.
-
(2005)
J Biol Chem
, vol.280
, pp. 40364-40374
-
-
Chen, J.1
Zhou, Y.2
Mueller-Steiner, S.3
Chen, L.F.4
Kwon, H.5
Yi, S.6
Mucke, L.7
Gan, L.8
-
11
-
-
50949133177
-
Obese mice lacking inducible nitric oxide synthase are sensitized to the metabolic actions of peroxisome proliferator-activated receptor-gamma agonism
-
Dallaire P, Bellmann K, Laplante M, Gelinas S, Centeno-Baez C, Penfornis P, Peyot ML, Latour MG, Lamontagne J, Trujillo ME, Scherer PE, Prentki M, Deshaies Y, Marette A. Obese mice lacking inducible nitric oxide synthase are sensitized to the metabolic actions of peroxisome proliferator-activated receptor-gamma agonism. Diabetes 57: 1999-2011, 2008.
-
(2008)
Diabetes
, vol.57
, pp. 1999-2011
-
-
Dallaire, P.1
Bellmann, K.2
Laplante, M.3
Gelinas, S.4
Centeno-Baez, C.5
Penfornis, P.6
Peyot, M.L.7
Latour, M.G.8
Lamontagne, J.9
Trujillo, M.E.10
Scherer, P.E.11
Prentki, M.12
Deshaies, Y.13
Marette, A.14
-
12
-
-
0031827241
-
Regulation by cytokines of the inducible nitric oxide synthase promoter in insulin-producing cells
-
Darville MI, Eizirik DL. Regulation by cytokines of the inducible nitric oxide synthase promoter in insulin-producing cells. Diabetologia 41: 1101-1108, 1998.
-
(1998)
Diabetologia
, vol.41
, pp. 1101-1108
-
-
Darville, M.I.1
Eizirik, D.L.2
-
13
-
-
34249846128
-
Resveratrol stimulates AMP kinase activity in neurons
-
Dasgupta B, Milbrandt J. Resveratrol stimulates AMP kinase activity in neurons. Proc Natl Acad Sci USA 104: 7217-7222, 2007.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 7217-7222
-
-
Dasgupta, B.1
Milbrandt, J.2
-
14
-
-
25144496904
-
The Sir 2 family of protein deacetylases
-
Denu JM. The Sir 2 family of protein deacetylases. Curr Opin Chem Biol 9: 431-440, 2005.
-
(2005)
Curr Opin Chem Biol
, vol.9
, pp. 431-440
-
-
Denu, J.M.1
-
15
-
-
65249183838
-
Resveratrol prevents the prohypertrophic effects of oxidative stress on LKB1
-
Dolinsky VW, Chan AY, Robillard Frayne I, Light PE, Des Rosiers C, Dyck JR. Resveratrol prevents the prohypertrophic effects of oxidative stress on LKB1. Circulation 119: 1643-1652, 2009.
-
(2009)
Circulation
, vol.119
, pp. 1643-1652
-
-
Dolinsky, V.W.1
Chan, A.Y.2
Robillard, F.I.3
Light, P.E.4
des Rosiers, C.5
Dyck, J.R.6
-
16
-
-
0037067666
-
The anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways
-
Fryer LG, Parbu-Patel A, Carling D. The anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways. J Biol Chem 277: 25226-25232, 2002.
-
(2002)
J Biol Chem
, vol.277
, pp. 25226-25232
-
-
Fryer, L.G.1
Parbu-Patel, A.2
Carling, D.3
-
17
-
-
17844367159
-
A role for iNOS in fasting hyperglycemia and impaired insulin signaling in the liver of obese diabetic mice
-
Fujimoto M, Shimizu N, Kunii K, Martyn JA, Ueki K, Kaneki M. A role for iNOS in fasting hyperglycemia and impaired insulin signaling in the liver of obese diabetic mice. Diabetes 54: 1340-1348, 2005.
-
(2005)
Diabetes
, vol.54
, pp. 1340-1348
-
-
Fujimoto, M.1
Shimizu, N.2
Kunii, K.3
Martyn, J.A.4
Ueki, K.5
Kaneki, M.6
-
18
-
-
0035503936
-
Immunomodulatory activity of resveratrol: Suppression of lymphocyte proliferation, development of cell-mediated cytotoxicity, and cytokine production
-
Gao X, Xu YX, Janakiraman N, Chapman RA, Gautam SC. Immunomodulatory activity of resveratrol: suppression of lymphocyte proliferation, development of cell-mediated cytotoxicity, and cytokine production. Biochem Pharmacol 62: 1299-1308, 2001.
-
(2001)
Biochem Pharmacol
, vol.62
, pp. 1299-1308
-
-
Gao, X.1
Xu, Y.X.2
Janakiraman, N.3
Chapman, R.A.4
Gautam, S.C.5
-
20
-
-
33845866857
-
Inflammation and metabolic disorders
-
Hotamisligil GS. Inflammation and metabolic disorders. Nature 444: 860-867, 2006.
-
(2006)
Nature
, vol.444
, pp. 860-867
-
-
Hotamisligil, G.S.1
-
21
-
-
0141719702
-
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
-
Howitz KT, Bitterman KJ, Cohen HY, Lamming DW, Lavu S, Wood JG, Zipkin RE, Chung P, Kisielewski A, Zhang LL, Scherer B, Sinclair DA. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 425: 191-196, 2003.
-
(2003)
Nature
, vol.425
, pp. 191-196
-
-
Howitz, K.T.1
Bitterman, K.J.2
Cohen, H.Y.3
Lamming, D.W.4
Lavu, S.5
Wood, J.G.6
Zipkin, R.E.7
Chung, P.8
Kisielewski, A.9
Zhang, L.L.10
Scherer, B.11
Sinclair, D.A.12
-
22
-
-
77955287742
-
Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner
-
Kalender A, Selvaraj A, Kim SY, Gulati P, Brule S, Viollet B, Kemp BE, Bardeesy N, Dennis P, Schlager JJ, Marette A, Kozma SC, Thomas G. Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner. Cell Metab 11: 390-401, 2010.
-
(2010)
Cell Metab
, vol.11
, pp. 390-401
-
-
Kalender, A.1
Selvaraj, A.2
Kim, S.Y.3
Gulati, P.4
Brule, S.5
Viollet, B.6
Kemp, B.E.7
Bardeesy, N.8
Dennis, P.9
Schlager, J.J.10
Marette, A.11
Kozma, S.C.12
Thomas, G.13
-
23
-
-
0030714681
-
Expression of nitric oxide synthase in skeletal muscle: A novel role for nitric oxide as a modulator of insulin action
-
Kapur S, Bedard S, Marcotte B, Cote CH, Marette A. Expression of nitric oxide synthase in skeletal muscle: a novel role for nitric oxide as a modulator of insulin action. Diabetes 46: 1691-1700, 1997.
-
(1997)
Diabetes
, vol.46
, pp. 1691-1700
-
-
Kapur, S.1
Bedard, S.2
Marcotte, B.3
Cote, C.H.4
Marette, A.5
-
25
-
-
0031969571
-
Effect of antioxidants, resveratrol, quercetin, and N-acetylcysteine, on the functions of cultured rat hepatic stellate cells and Kupffer cells
-
Kawada N, Seki S, Inoue M, Kuroki T. Effect of antioxidants, resveratrol, quercetin, and N-acetylcysteine, on the functions of cultured rat hepatic stellate cells and Kupffer cells. Hepatology 27: 1265-1274, 1998.
-
(1998)
Hepatology
, vol.27
, pp. 1265-1274
-
-
Kawada, N.1
Seki, S.2
Inoue, M.3
Kuroki, T.4
-
26
-
-
0029881321
-
Interleukin 1 beta markedly stimulates nitric oxide formation in the absence of other cytokines or lipopolysaccharide in primary cultured rat hepatocytes but not in Kupffer cells
-
Kitade H, Sakitani K, Inoue K, Masu Y, Kawada N, Hiramatsu Y, Kamiyama Y, Okumura T, Ito S. Interleukin 1 beta markedly stimulates nitric oxide formation in the absence of other cytokines or lipopolysaccharide in primary cultured rat hepatocytes but not in Kupffer cells. Hepatology 23: 797-802, 1996.
-
(1996)
Hepatology
, vol.23
, pp. 797-802
-
-
Kitade, H.1
Sakitani, K.2
Inoue, K.3
Masu, Y.4
Kawada, N.5
Hiramatsu, Y.6
Kamiyama, Y.7
Okumura, T.8
Ito, S.9
-
27
-
-
22744459004
-
Effect of apigenin, kaempferol and resveratrol on the expression of interleukin-1beta and tumor necrosis factor-alpha genes in J774.2 macrophages
-
Kowalski J, Samojedny A, Paul M, Pietsz G, Wilczok T. Effect of apigenin, kaempferol and resveratrol on the expression of interleukin-1beta and tumor necrosis factor-alpha genes in J774.2 macrophages. Pharmacol Rep 57: 390-394, 2005.
-
(2005)
Pharmacol Rep
, vol.57
, pp. 390-394
-
-
Kowalski, J.1
Samojedny, A.2
Paul, M.3
Pietsz, G.4
Wilczok, T.5
-
28
-
-
33144467664
-
Resveratrol protects against 4-hydroxynonenal- induced apoptosis by blocking JNK and c-JUN/AP-1 signaling
-
Kutuk O, Poli G, Basaga H. Resveratrol protects against 4-hydroxynonenal- induced apoptosis by blocking JNK and c-JUN/AP-1 signaling. Toxicol Sci 90: 120-132, 2006.
-
(2006)
Toxicol Sci
, vol.90
, pp. 120-132
-
-
Kutuk, O.1
Poli, G.2
Basaga, H.3
-
29
-
-
33845399894
-
Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha
-
Lagouge M, Argmann C, Gerhart-Hines Z, Meziane H, Lerin C, Daussin F, Messadeq N, Milne J, Lambert P, Elliott P, Geny B, Laakso M, Puigserver P, Auwerx J. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell 127: 1109-1122, 2006.
-
(2006)
Cell
, vol.127
, pp. 1109-1122
-
-
Lagouge, M.1
Argmann, C.2
Gerhart-Hines, Z.3
Meziane, H.4
Lerin, C.5
Daussin, F.6
Messadeq, N.7
Milne, J.8
Lambert, P.9
Elliott, P.10
Geny, B.11
Laakso, M.12
Puigserver, P.13
Auwerx, J.14
-
30
-
-
0034705129
-
The silencing protein SIR2 and its homologs are NADdependent protein deacetylases
-
Landry J, Sutton A, Tafrov ST, Heller RC, Stebbins J, Pillus L, Sternglanz R. The silencing protein SIR2 and its homologs are NADdependent protein deacetylases. Proc Natl Acad Sci USA 97: 5807-5811, 2000.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 5807-5811
-
-
Landry, J.1
Sutton, A.2
Tafrov, S.T.3
Heller, R.C.4
Stebbins, J.5
Pillus, L.6
Sternglanz, R.7
-
31
-
-
63249112836
-
Overexpression of SIRT1 protects pancreatic beta-cells against cytokine toxicity by suppressing the nuclear factorkappaB signaling pathway
-
Lee JH, Song MY, Song EK, Kim EK, Moon WS, Han MK, Park JW, Kwon KB, Park BH. Overexpression of SIRT1 protects pancreatic beta-cells against cytokine toxicity by suppressing the nuclear factorkappaB signaling pathway. Diabetes 58: 344-351, 2009.
-
(2009)
Diabetes
, vol.58
, pp. 344-351
-
-
Lee, J.H.1
Song, M.Y.2
Song, E.K.3
Kim, E.K.4
Moon, W.S.5
Han, M.K.6
Park, J.W.7
Kwon, K.B.8
Park, B.H.9
-
32
-
-
0242662063
-
Oxyresveratrol and resveratrol are potent antioxidants and free radical scavengers: Effect on nitrosative and oxidative stress derived from microglial cells
-
Lorenz P, Roychowdhury S, Engelmann M, Wolf G, Horn TF. Oxyresveratrol and resveratrol are potent antioxidants and free radical scavengers: effect on nitrosative and oxidative stress derived from microglial cells. Nitric Oxide 9: 64-76, 2003.
-
(2003)
Nitric Oxide
, vol.9
, pp. 64-76
-
-
Lorenz, P.1
Roychowdhury, S.2
Engelmann, M.3
Wolf, G.4
Horn, T.F.5
-
33
-
-
0035913911
-
Negative control of p53 by Sir2alpha promotes cell survival under stress
-
Luo J, Nikolaev AY, Imai S, Chen D, Su F, Shiloh A, Guarente L, Gu W. Negative control of p53 by Sir2alpha promotes cell survival under stress. Cell 107: 137-148, 2001.
-
(2001)
Cell
, vol.107
, pp. 137-148
-
-
Luo, J.1
Nikolaev, A.Y.2
Imai, S.3
Chen, D.4
Su, F.5
Shiloh, A.6
Guarente, L.7
Gu, W.8
-
34
-
-
36749087548
-
Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes
-
Milne JC, Lambert PD, Schenk S, Carney DP, Smith JJ, Gagne DJ, Jin L, Boss O, Perni RB, Vu CB, Bemis JE, Xie R, Disch JS, Ng PY, Nunes JJ, Lynch AV, Yang H, Galonek H, Israelian K, Choy W, Iffland A, Lavu S, Medvedik O, Sinclair DA, Olefsky JM, Jirousek MR, Elliott PJ, Westphal CH. Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature 450: 712-716, 2007.
-
(2007)
Nature
, vol.450
, pp. 712-716
-
-
Milne, J.C.1
Lambert, P.D.2
Schenk, S.3
Carney, D.P.4
Smith, J.J.5
Gagne, D.J.6
Jin, L.7
Boss, O.8
Perni, R.B.9
Vu, C.B.10
Bemis, J.E.11
Xie, R.12
Disch, J.S.13
Ng, P.Y.14
Nunes, J.J.15
Lynch, A.V.16
Yang, H.17
Galonek, H.18
Israelian, K.19
Choy, W.20
Iffland, A.21
Lavu, S.22
Medvedik, O.23
Sinclair, D.A.24
Olefsky, J.M.25
Jirousek, M.R.26
Elliott, P.J.27
Westphal, C.H.28
more..
-
35
-
-
0037122766
-
Leptin stimulates fatty-acid oxidation by activating AMPactivated protein kinase
-
Minokoshi Y, Kim YB, Peroni OD, Fryer LG, Muller C, Carling D, Kahn BB. Leptin stimulates fatty-acid oxidation by activating AMPactivated protein kinase. Nature 415: 339-343, 2002.
-
(2002)
Nature
, vol.415
, pp. 339-343
-
-
Minokoshi, Y.1
Kim, Y.B.2
Peroni, O.D.3
Fryer, L.G.4
Muller, C.5
Carling, D.6
Kahn, B.B.7
-
36
-
-
0025883342
-
Nitric oxide: Physiology, pathophysiology, pharmacology
-
Moncada S, Palmer RM, Higgs EA. Nitric oxide: physiology, pathophysiology, pharmacology. Pharmacol Rev 43: 109-142, 1991.
-
(1991)
Pharmacol Rev
, vol.43
, pp. 109-142
-
-
Moncada, S.1
Palmer, R.M.2
Higgs, E.A.3
-
37
-
-
0036182269
-
Association of a functional inducible nitric oxide synthase promoter variant with complications in type 2 diabetes
-
Morris BJ, Markus A, Glenn CL, Adams DJ, Colagiuri S, Wang L. Association of a functional inducible nitric oxide synthase promoter variant with complications in type 2 diabetes. J Mol Med 80: 96-104, 2002.
-
(2002)
J Mol Med
, vol.80
, pp. 96-104
-
-
Morris, B.J.1
Markus, A.2
Glenn, C.L.3
Adams, D.J.4
Colagiuri, S.5
Wang, L.6
-
38
-
-
67650252237
-
Chemoprevention with phytochemicals targeting inducible nitric oxide synthase
-
Murakami A. Chemoprevention with phytochemicals targeting inducible nitric oxide synthase. Forum Nutr 61: 193-203, 2009.
-
(2009)
Forum Nutr
, vol.61
, pp. 193-203
-
-
Murakami, A.1
-
39
-
-
0036299982
-
Metformin increases AMP-activated protein kinase activity in skeletal muscle of subjects with type 2 diabetes
-
Musi N, Hirshman MF, Nygren J, Svanfeldt M, Bavenholm P, Rooyackers O, Zhou G, Williamson JM, Ljunqvist O, Efendic S, Moller DE, Thorell A, Goodyear LJ. Metformin increases AMP-activated protein kinase activity in skeletal muscle of subjects with type 2 diabetes. Diabetes 51: 2074-2081, 2002.
-
(2002)
Diabetes
, vol.51
, pp. 2074-2081
-
-
Musi, N.1
Hirshman, M.F.2
Nygren, J.3
Svanfeldt, M.4
Bavenholm, P.5
Rooyackers, O.6
Zhou, G.7
Williamson, J.M.8
Ljunqvist, O.9
Efendic, S.10
Moller, D.E.11
Thorell, A.12
Goodyear, L.J.13
-
40
-
-
0030780758
-
Inducible nitric oxide synthase: What difference does it make?
-
Nathan C. Inducible nitric oxide synthase: what difference does it make? J Clin Invest 100: 2417-2423, 1997.
-
(1997)
J Clin Invest
, vol.100
, pp. 2417-2423
-
-
Nathan, C.1
-
41
-
-
17944365806
-
Rat liver slices as a tool to study LPS-induced inflammatory response in the liver
-
Olinga P, Merema MT, de Jager MH, Derks F, Melgert BN, Moshage H, Slooff MJ, Meijer DK, Poelstra K, Groothuis GM. Rat liver slices as a tool to study LPS-induced inflammatory response in the liver. J Hepatol 35: 187-194, 2001.
-
(2001)
J Hepatol
, vol.35
, pp. 187-194
-
-
Olinga, P.1
Merema, M.T.2
de Jager, M.H.3
Derks, F.4
Melgert, B.N.5
Moshage, H.6
Slooff, M.J.7
Meijer, D.K.8
Poelstra, K.9
Groothuis, G.M.10
-
42
-
-
77950246109
-
SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1
-
Pacholec M, Bleasdale JE, Chrunyk B, Cunningham D, Flynn D, Garofalo RS, Griffith D, Griffor M, Loulakis P, Pabst B, Qiu X, Stockman B, Thanabal V, Varghese A, Ward J, Withka J, Ahn K. SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1. J Biol Chem 285: 8340-8351, 2010.
-
(2010)
J Biol Chem
, vol.285
, pp. 8340-8351
-
-
Pacholec, M.1
Bleasdale, J.E.2
Chrunyk, B.3
Cunningham, D.4
Flynn, D.5
Garofalo, R.S.6
Griffith, D.7
Griffor, M.8
Loulakis, P.9
Pabst, B.10
Qiu, X.11
Stockman, B.12
Thanabal, V.13
Varghese, A.14
Ward, J.15
Withka, J.16
Ahn, K.17
-
43
-
-
0034770292
-
Targeted disruption of inducible nitric oxide synthase protects against obesity-linked insulin resistance in muscle
-
Perreault M, Marette A. Targeted disruption of inducible nitric oxide synthase protects against obesity-linked insulin resistance in muscle. Nat Med 7: 1138-1143, 2001.
-
(2001)
Nat Med
, vol.7
, pp. 1138-1143
-
-
Perreault, M.1
Marette, A.2
-
44
-
-
0031720795
-
Is type II diabetes mellitus a disease of the innate immune system?
-
Pickup JC, Crook MA. Is type II diabetes mellitus a disease of the innate immune system? Diabetologia 41: 1241-1248, 1998.
-
(1998)
Diabetologia
, vol.41
, pp. 1241-1248
-
-
Pickup, J.C.1
Crook, M.A.2
-
45
-
-
2442713803
-
Inhibition of inducible nitric-oxide synthase by activators of AMP-activated protein kinase: A new mechanism of action of insulin-sensitizing drugs
-
Pilon G, Dallaire P, Marette A. Inhibition of inducible nitric-oxide synthase by activators of AMP-activated protein kinase: a new mechanism of action of insulin-sensitizing drugs. J Biol Chem 279: 20767-20774, 2004.
-
(2004)
J Biol Chem
, vol.279
, pp. 20767-20774
-
-
Pilon, G.1
Dallaire, P.2
Marette, A.3
-
46
-
-
0034470239
-
Nitric oxide production by adipocytes: A role in the pathogenesis of insulin resistance?
-
Pilon G, Penfornis P, Marette A. Nitric oxide production by adipocytes: a role in the pathogenesis of insulin resistance? Horm Metab Res 32: 480-484, 2000.
-
(2000)
Horm Metab Res
, vol.32
, pp. 480-484
-
-
Pilon, G.1
Penfornis, P.2
Marette, A.3
-
47
-
-
0032543101
-
Fluorometric assay of nitrite and nitrate in brain tissue after traumatic brain injury and cerebral ischemia
-
Rao AM, Dogan A, Hatcher JF, Dempsey RJ. Fluorometric assay of nitrite and nitrate in brain tissue after traumatic brain injury and cerebral ischemia. Brain Res 793: 265-270, 1998.
-
(1998)
Brain Res
, vol.793
, pp. 265-270
-
-
Rao, A.M.1
Dogan, A.2
Hatcher, J.F.3
Dempsey, R.J.4
-
48
-
-
14544282413
-
Nutrient control of glucose homeostasis through a complex of PGC- 1alpha and SIRT1
-
Rodgers JT, Lerin C, Haas W, Gygi SP, Spiegelman BM, Puigserver P. Nutrient control of glucose homeostasis through a complex of PGC- 1alpha and SIRT1. Nature 434: 113-118, 2005.
-
(2005)
Nature
, vol.434
, pp. 113-118
-
-
Rodgers, J.T.1
Lerin, C.2
Haas, W.3
Gygi, S.P.4
Spiegelman, B.M.5
Puigserver, P.6
-
49
-
-
77953541690
-
Resveratrol, a red wine polyphenol, attenuates lipopolysaccharide- induced oxidative stress in rat liver
-
Sebai H, Sani M, Yacoubi MT, Aouani E, Ghanem-Boughanmi N, Ben-Attia M. Resveratrol, a red wine polyphenol, attenuates lipopolysaccharide- induced oxidative stress in rat liver. Ecotoxicol Environ Saf 73: 1078-1083, 2010.
-
(2010)
Ecotoxicol Environ Saf
, vol.73
, pp. 1078-1083
-
-
Sebai, H.1
Sani, M.2
Yacoubi, M.T.3
Aouani, E.4
Ghanem-Boughanmi, N.5
Ben-Attia, M.6
-
50
-
-
0031827788
-
Hepatocyte nitric oxide production is induced by Kupffer cells
-
Shiratori Y, Ohmura K, Hikiba Y, Matsumura M, Nagura T, Okano K, Kamii K, Omata M. Hepatocyte nitric oxide production is induced by Kupffer cells. Dig Dis Sci 43: 1737-1745, 1998.
-
(1998)
Dig Dis Sci
, vol.43
, pp. 1737-1745
-
-
Shiratori, Y.1
Ohmura, K.2
Hikiba, Y.3
Matsumura, M.4
Nagura, T.5
Okano, K.6
Kamii, K.7
Omata, M.8
-
52
-
-
17144413748
-
Inducible nitric-oxide synthase and NO donor induce insulin receptor substrate-1 degradation in skeletal muscle cells
-
Sugita H, Fujimoto M, Yasukawa T, Shimizu N, Sugita M, Yasuhara S, Martyn JA, Kaneki M. Inducible nitric-oxide synthase and NO donor induce insulin receptor substrate-1 degradation in skeletal muscle cells. J Biol Chem 280: 14203-14211, 2005.
-
(2005)
J Biol Chem
, vol.280
, pp. 14203-14211
-
-
Sugita, H.1
Fujimoto, M.2
Yasukawa, T.3
Shimizu, N.4
Sugita, M.5
Yasuhara, S.6
Martyn, J.A.7
Kaneki, M.8
-
53
-
-
3042842603
-
Inflammation and nitric oxide production in skeletal muscle of type 2 diabetic patients
-
Torres SH, De Sanctis JB, de LBM, Hernandez N, Finol HJ. Inflammation and nitric oxide production in skeletal muscle of type 2 diabetic patients. J Endocrinol 181: 419-427, 2004.
-
(2004)
J Endocrinol
, vol.181
, pp. 419-427
-
-
Torres, S.H.1
de Sanctis, J.B.2
De, L.B.M.3
Hernandez, N.4
Finol, H.J.5
-
54
-
-
0033023541
-
Suppression of nitric oxide synthase and the down-regulation of the activation of NFkappaB in macrophages by resveratrol
-
Tsai SH, Lin-Shiau SY, Lin JK. Suppression of nitric oxide synthase and the down-regulation of the activation of NFkappaB in macrophages by resveratrol. Br J Pharmacol 126: 673-680, 1999.
-
(1999)
Br J Pharmacol
, vol.126
, pp. 673-680
-
-
Tsai, S.H.1
Lin-Shiau, S.Y.2
Lin, J.K.3
-
55
-
-
77950348878
-
AMP-activated protein kinase-deficient mice are resistant to the metabolic effects of resveratrol
-
Um JH, Park SJ, Kang H, Yang S, Foretz M, McBurney MW, Kim MK, Viollet B, Chung JH. AMP-activated protein kinase-deficient mice are resistant to the metabolic effects of resveratrol. Diabetes 59: 554-563, 2010.
-
(2010)
Diabetes
, vol.59
, pp. 554-563
-
-
Um, J.H.1
Park, S.J.2
Kang, H.3
Yang, S.4
Foretz, M.5
McBurney, M.W.6
Kim, M.K.7
Viollet, B.8
Chung, J.H.9
-
56
-
-
0035913903
-
Hsir2(SIRT1) functions as an NAD-dependent p53 deacetylase
-
Vaziri H, Dessain SK, Ng Eaton E, Imai SI, Frye RA, Pandita TK, Guarente L, Weinberg RA. hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. Cell 107: 149-159, 2001.
-
(2001)
Cell
, vol.107
, pp. 149-159
-
-
Vaziri, H.1
Dessain, S.K.2
Eaton, N.E.3
Imai, S.I.4
Frye, R.A.5
Pandita, T.K.6
Guarente, L.7
Weinberg, R.A.8
-
57
-
-
0033561579
-
Effects of the wine polyphenolics quercetin and resveratrol on pro-inflammatory cytokine expression in RAW 264.7 macrophages
-
Wadsworth TL, Koop DR. Effects of the wine polyphenolics quercetin and resveratrol on pro-inflammatory cytokine expression in RAW 264.7 macrophages. Biochem Pharmacol 57: 941-949, 1999.
-
(1999)
Biochem Pharmacol
, vol.57
, pp. 941-949
-
-
Wadsworth, T.L.1
Koop, D.R.2
-
58
-
-
0035212387
-
Resveratrol inhibits interleukin-6 production in cortical mixed glial cells under hypoxia/hypoglycemia followed by reoxygenation
-
Wang MJ, Huang HM, Hsieh SJ, Jeng KC, Kuo JS. Resveratrol inhibits interleukin-6 production in cortical mixed glial cells under hypoxia/hypoglycemia followed by reoxygenation. J Neuroimmunol 112: 28-34, 2001.
-
(2001)
J Neuroimmunol
, vol.112
, pp. 28-34
-
-
Wang, M.J.1
Huang, H.M.2
Hsieh, S.J.3
Jeng, K.C.4
Kuo, J.S.5
-
59
-
-
0348230958
-
Obesity is associated with macrophage accumulation in adipose tissue
-
Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL, Ferrante AW Jr. Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 112: 1796-1808, 2003.
-
(2003)
J Clin Invest
, vol.112
, pp. 1796-1808
-
-
Weisberg, S.P.1
McCann, D.2
Desai, M.3
Rosenbaum, M.4
Leibel, R.L.5
Ferrante Jr., A.W.6
-
60
-
-
18244370762
-
Inflammation, stress, diabetes
-
Wellen KE, Hotamisligil GS. Inflammation, stress, diabetes. J Clin Invest 115: 1111-1119, 2005.
-
(2005)
J Clin Invest
, vol.115
, pp. 1111-1119
-
-
Wellen, K.E.1
Hotamisligil, G.S.2
-
61
-
-
1842482424
-
Resveratrol inhibits phorbol myristate acetate-induced matrix metalloproteinase-9 expression by inhibiting JNK and PKC delta signal transduction
-
Woo JH, Lim JH, Kim YH, Suh SI, Min DS, Chang JS, Lee YH, Park JW, Kwon TK. Resveratrol inhibits phorbol myristate acetate-induced matrix metalloproteinase-9 expression by inhibiting JNK and PKC delta signal transduction. Oncogene 23: 1845-1853, 2004.
-
(2004)
Oncogene
, vol.23
, pp. 1845-1853
-
-
Woo, J.H.1
Lim, J.H.2
Kim, Y.H.3
Suh, S.I.4
Min, D.S.5
Chang, J.S.6
Lee, Y.H.7
Park, J.W.8
Kwon, T.K.9
-
62
-
-
67651162136
-
Targeted disruption of carcinoembryonic antigen-related cell adhesion molecule 1 promotes diet-induced hepatic steatosis and insulin resistance
-
Xu E, Dubois MJ, Leung N, Charbonneau A, Turbide C, Avramoglu RK, DeMarte L, Elchebly M, Streichert T, Levy E, Beauchemin N, Marette A. Targeted disruption of carcinoembryonic antigen-related cell adhesion molecule 1 promotes diet-induced hepatic steatosis and insulin resistance. Endocrinology 150: 3503-3512, 2009.
-
(2009)
Endocrinology
, vol.150
, pp. 3503-3512
-
-
Xu, E.1
Dubois, M.J.2
Leung, N.3
Charbonneau, A.4
Turbide, C.5
Avramoglu, R.K.6
Demarte, L.7
Elchebly, M.8
Streichert, T.9
Levy, E.10
Beauchemin, N.11
Marette, A.12
-
63
-
-
0036851817
-
Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase
-
Yamauchi T, Kamon J, Minokoshi Y, Ito Y, Waki H, Uchida S, Yamashita S, Noda M, Kita S, Ueki K, Eto K, Akanuma Y, Froguel P, Foufelle F, Ferre P, Carling D, Kimura S, Nagai R, Kahn BB, Kadowaki T. Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat Med 8: 1288-1295, 2002.
-
(2002)
Nat Med
, vol.8
, pp. 1288-1295
-
-
Yamauchi, T.1
Kamon, J.2
Minokoshi, Y.3
Ito, Y.4
Waki, H.5
Uchida, S.6
Yamashita, S.7
Noda, M.8
Kita, S.9
Ueki, K.10
Eto, K.11
Akanuma, Y.12
Froguel, P.13
Foufelle, F.14
Ferre, P.15
Carling, D.16
Kimura, S.17
Nagai, R.18
Kahn, B.B.19
Kadowaki, T.20
more..
-
64
-
-
14844300857
-
S-nitrosylation-dependent inactivation of Akt/protein kinase B in insulin resistance
-
Yasukawa T, Tokunaga E, Ota H, Sugita H, Martyn JA, Kaneki M. S-nitrosylation-dependent inactivation of Akt/protein kinase B in insulin resistance. J Biol Chem 280: 7511-7518, 2005.
-
(2005)
J Biol Chem
, vol.280
, pp. 7511-7518
-
-
Yasukawa, T.1
Tokunaga, E.2
Ota, H.3
Sugita, H.4
Martyn, J.A.5
Kaneki, M.6
-
65
-
-
61749095297
-
SIRT1 exerts antiinflammatory effects and improves insulin sensitivity in adipocytes
-
Yoshizaki T, Milne JC, Imamura T, Schenk S, Sonoda N, Babendure JL, Lu JC, Smith JJ, Jirousek MR, Olefsky JM. SIRT1 exerts antiinflammatory effects and improves insulin sensitivity in adipocytes. Mol Cell Biol 29: 1363-1374, 2009.
-
(2009)
Mol Cell Biol
, vol.29
, pp. 1363-1374
-
-
Yoshizaki, T.1
Milne, J.C.2
Imamura, T.3
Schenk, S.4
Sonoda, N.5
Babendure, J.L.6
Lu, J.C.7
Smith, J.J.8
Jirousek, M.R.9
Olefsky, J.M.10
-
66
-
-
33749349202
-
Polyphenols stimulate AMPactivated protein kinase, lower lipids, and inhibit accelerated atherosclerosis in diabetic LDL receptor-deficient mice
-
Zang M, Xu S, Maitland-Toolan KA, Zuccollo A, Hou X, Jiang B, Wierzbicki M, Verbeuren TJ, Cohen RA. Polyphenols stimulate AMPactivated protein kinase, lower lipids, and inhibit accelerated atherosclerosis in diabetic LDL receptor-deficient mice. Diabetes 55: 2180-2191, 2006.
-
(2006)
Diabetes
, vol.55
, pp. 2180-2191
-
-
Zang, M.1
Xu, S.2
Maitland-Toolan, K.A.3
Zuccollo, A.4
Hou, X.5
Jiang, B.6
Wierzbicki, M.7
Verbeuren, T.J.8
Cohen, R.A.9
-
67
-
-
0033129760
-
Inhibitory effect of resveratrol on interleukin 6 release by stimulated peritoneal macrophages of mice
-
Zhong M, Cheng GF, Wang WJ, Guo Y, Zhu XY, Zhang JT. Inhibitory effect of resveratrol on interleukin 6 release by stimulated peritoneal macrophages of mice. Phytomedicine 6: 79-84, 1999.
-
(1999)
Phytomedicine
, vol.6
, pp. 79-84
-
-
Zhong, M.1
Cheng, G.F.2
Wang, W.J.3
Guo, Y.4
Zhu, X.Y.5
Zhang, J.T.6
|