Stable isotope-assisted metabolomics to detect metabolic flux changes in mammalian cell cultures

Current Opinion in Biotechnology

Volumn 24, Issue 1, 2013, Pages 54-59

  Mueller, Daniel ^a   Heinzle, Elmar ^a  

^a SAARLAND UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BIOTECHNOLOGICAL PRODUCTION; CELLULAR PHYSIOLOGY; DRUG DEVELOPMENT; MAMMALIAN CELL CULTURE; MAMMALIAN CELLS; METABOLIC FLUX; METABOLIC FLUX ANALYSIS; METABOLOMICS; MICROBIAL CULTURE; PHARMACEUTICAL PROCESS;

BIOTECHNOLOGY; CELL CULTURE; ISOTOPES;

METABOLISM;

CARBON 13; DOXORUBICIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; VERAPAMIL;

ANALYSIS; BIOTECHNOLOGICAL PRODUCTION; CELL CULTURE; CELL METABOLISM; CHO CELL; CITRIC ACID CYCLE; DRUG CYTOTOXICITY; ISOTOPE LABELING; MAMMAL CELL; METABOLIC FLUX; METABOLIC FLUX ANALYSIS; METABOLIC RATE; METABOLITE; METABOLOME; METABOLOMICS; NONHUMAN; PRIORITY JOURNAL; REVIEW; TOXICITY TESTING;

ANIMALS; BIOTECHNOLOGY; CARBON ISOTOPES; CELL CULTURE TECHNIQUES; DRUG DISCOVERY; HUMANS; ISOTOPE LABELING; METABOLIC NETWORKS AND PATHWAYS; METABOLOMICS; MODELS, BIOLOGICAL; TOXICITY TESTS;

MAMMALIA;

EID: 84872270542     PISSN: 09581669     EISSN: 18790429     Source Type: Journal    
DOI: 10.1016/j.copbio.2012.10.015     Document Type: Review

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