Toward preclinical predictive drug testing for metabolism and hepatotoxicity by using in vitro models derived from human embryonic stem cells and human cell lines - A report on the vitrocellomics EU-project

Alternatives to Laboratory Animals

Volumn 39, Issue 2, 2011, Pages 147-171

  Mandenius, Carl Fredrik ^a   Andersson, Tommy B ^b,c   Alves, Paula M ^d   Batzl Hartmann, Christine ^e   Björquist, Petter ^f   Carrondo, Manuel J T ^d   Chesne, Christophe ^g   Coecke, Sandra ^h   Edsbagge, Josefina ^f   Fredriksson, J Magnus ^a   Gerlach, Jörg C ⁱ   Heinzle, Elmar ^j   Ingelman Sundberg, Magnus ^b   Johansson, Inger ^b   Küppers Munther, Barbara ^f   Müller Vieira, Ursula ^e   Noor, Fozia ^j   Zeilinger, Katrin ⁱ  

^a LINKÖPING UNIVERSITY   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

^c ASTRAZENECA R AND D   (Sweden)

^d IBET   (Portugal)

^e Pharmacelsus GmbH   (Germany)

^f Cellartis AB   (Sweden)

^g BioPredic SA   (France)

^h JOINT RESEARCH CENTRE   (Italy)

ⁱ CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^j SAARLAND UNIVERSITY   (Germany)

more..

Author keywords

3 D microstructures; ADMET; Artificial liver devices; Bioreactors; Biosensors; Human embryonic stem cells; In vitro toxicity testing; Induction assay; Metabolic flux analysis; Respiratory assay

Indexed keywords

ALBUMIN; ALPHA 1 ANTITRYPSIN; ALPHA FETOPROTEIN; AMFEBUTAMONE; AMIODARONE; BETA NAPHTHOFLAVONE; CARBAMAZEPINE; CLOZAPINE; CYTOKERATIN 18; CYTOKERATIN 8; DICLOFENAC; DIPHENHYDRAMINE; DRUG METABOLIZING ENZYME; FATTY ACID BINDING PROTEIN; FIBROBLAST GROWTH FACTOR; GLYCEROL; HEPATOCYTE NUCLEAR FACTOR 3BETA; LIVER FATTY ACID BINDING PROTEIN; METHOTREXATE; MIDAZOLAM; PHENACETIN; PHENOBARBITAL; RIFAMPICIN; SCATTER FACTOR RECEPTOR; TACRINE; TROGLITAZONE; UNCLASSIFIED DRUG; VERAPAMIL;

BIOARTIFICIAL LIVER; BIOREACTOR; BIOSENSOR; CELL DIFFERENTIATION; CELL FUNCTION; CELL LINE; CELL RESPIRATION; CELL STRUCTURE; DEFINITIVE ENDODERM; DRUG ABSORPTION; DRUG CYTOTOXICITY; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG EXCRETION; DRUG METABOLISM; DRUG SAFETY; DRUG SCREENING; EMBRYONIC STEM CELL; ENDODERM; ENZYME ACTIVITY; HUMAN; IMMUNOCYTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL; LIVER FUNCTION; LIVER TOXICITY; NONHUMAN; PHARMACOLOGICAL PARAMETERS; PHENOTYPE; PRIORITY JOURNAL; REVIEW; STOICHIOMETRY; SURFACE PLASMON RESONANCE; TOXICITY TESTING; TOXICOGENETICS;

EID: 79958019157     PISSN: 02611929     EISSN: None     Source Type: Journal    
DOI: 10.1177/026119291103900210     Document Type: Review

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