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Volumn 31, Issue 3, 2011, Pages 191-205

Cardiotoxicity testing using pluripotent stem cell-derived human cardiomyocytes and state-of-the-art bioanalytics: A review

Author keywords

Cardiomyocyte; Cardiotoxicity; Cytotoxicity; Electrophysiology; Human embryonic stem cells; in vitro toxicity; Metabolomics; Multielectrode array; Respiration; Surface plasmon resonance

Indexed keywords

AMIODARONE; ASTEMIZOLE; BUPIVACAINE; DAUNORUBICIN; DESIPRAMINE; DICLOFENAC; DIMETHYL SULFOXIDE; DOXORUBICIN; FLUOROURACIL; HALOPERIDOL; NIFEDIPINE; PARACETAMOL; QUINIDINE; SOTALOL; TERFENADINE; VERAPAMIL;

EID: 79954999150     PISSN: 0260437X     EISSN: 10991263     Source Type: Journal    
DOI: 10.1002/jat.1663     Document Type: Review
Times cited : (66)

References (101)
  • 3
    • 35549006752 scopus 로고    scopus 로고
    • Transgenic enrichment of cardiomyocytes from human embryonic stem cells
    • Anderson D, Self T, Mellor IR, Goh G, Hill SJ, Denning C. 2007. Transgenic enrichment of cardiomyocytes from human embryonic stem cells. Mol. Ther. 15: 2027-2036.
    • (2007) Mol. Ther. , vol.15 , pp. 2027-2036
    • Anderson, D.1    Self, T.2    Mellor, I.R.3    Goh, G.4    Hill, S.J.5    Denning, C.6
  • 5
    • 77957846807 scopus 로고    scopus 로고
    • Monitoring of troponin release from cardiomyocytes during exposure of toxic substances using surface plasmon resonance biosensing
    • Andersson H, Kågedal B, Mandenius CF. 2010b. Monitoring of troponin release from cardiomyocytes during exposure of toxic substances using surface plasmon resonance biosensing. Anal. Bioanal. Chem. 398: 1395-1402.
    • (2010) Anal. Bioanal. Chem. , vol.398 , pp. 1395-1402
    • Andersson, H.1    Kågedal, B.2    Mandenius, C.F.3
  • 7
    • 76749146181 scopus 로고    scopus 로고
    • High throughput, non-invasive and dynamic toxicity screening on adherent cells using respiratory measurements
    • Beckers S, Noor F, Muller-Vieira U, Mayer M, Strigun A, Heinzle E. 2010. High throughput, non-invasive and dynamic toxicity screening on adherent cells using respiratory measurements. Toxicol. in Vitro 24: 686-694.
    • (2010) Toxicol. in Vitro , vol.24 , pp. 686-694
    • Beckers, S.1    Noor, F.2    Muller-Vieira, U.3    Mayer, M.4    Strigun, A.5    Heinzle, E.6
  • 9
    • 77952250654 scopus 로고    scopus 로고
    • Human stem cell models for predictive cardiac safety pharmacology
    • Braam SR, Mummery CL. 2010. Human stem cell models for predictive cardiac safety pharmacology. Stem Cell Res. 4: 155-156.
    • (2010) Stem Cell Res. , vol.4 , pp. 155-156
    • Braam, S.R.1    Mummery, C.L.2
  • 11
    • 39449096154 scopus 로고    scopus 로고
    • Beta (1)- and beta (2)-adrenoceptor responses in cardiomyocytes derived from human embryonic stem cells: comparison with failing and non-failing adult human heart
    • Brito-Martins M, Harding SE, Ali NN. 2008. Beta (1)- and beta (2)-adrenoceptor responses in cardiomyocytes derived from human embryonic stem cells: comparison with failing and non-failing adult human heart. Br. J. Pharmacol. 153: 751-759.
    • (2008) Br. J. Pharmacol. , vol.153 , pp. 751-759
    • Brito-Martins, M.1    Harding, S.E.2    Ali, N.N.3
  • 12
    • 34147124971 scopus 로고    scopus 로고
    • Improved human embryonic stem cell embryoid body homogeneity and cardiomyocyte differentiation from a novel V-96 plate aggregation system highlights interline variability
    • Burridge PW, Anderson D, Priddle H, Barbadillo Muñoz MD, Chamberlain S, Allegrucci C, Young LE, Denning C. 2007. Improved human embryonic stem cell embryoid body homogeneity and cardiomyocyte differentiation from a novel V-96 plate aggregation system highlights interline variability. Stem Cells 25: 929-938.
    • (2007) Stem Cells , vol.25 , pp. 929-938
    • Burridge, P.W.1    Anderson, D.2    Priddle, H.3    Barbadillo Muñoz, M.D.4    Chamberlain, S.5    Allegrucci, C.6    Young, L.E.7    Denning, C.8
  • 15
    • 33645022523 scopus 로고    scopus 로고
    • Evidences of the gender-related differences in cardiac repolarization and the underlying mechanisms in different animal species and human
    • Cheng J. 2006. Evidences of the gender-related differences in cardiac repolarization and the underlying mechanisms in different animal species and human. Fundam. Clin. Pharmacol. 20: 1-8.
    • (2006) Fundam. Clin. Pharmacol. , vol.20 , pp. 1-8
    • Cheng, J.1
  • 17
    • 0001200879 scopus 로고
    • The role of prevalidation in the development, validation and acceptance of alternative methods
    • Curren S, Spielmann L, Liebsch FB. 1995. The role of prevalidation in the development, validation and acceptance of alternative methods. ATLA 23: 211-217.
    • (1995) ATLA , vol.23 , pp. 211-217
    • Curren, S.1    Spielmann, L.2    Liebsch, F.B.3
  • 18
    • 23144433095 scopus 로고    scopus 로고
    • Microplates with integrated oxygen sensors for kinetic cell respiration measurement and cytotoxicity testing in primary and secondary cell lines
    • Deshpande R, Kirsch Y, Maas R, John G, Krause C, Heinzle E. 2005. Microplates with integrated oxygen sensors for kinetic cell respiration measurement and cytotoxicity testing in primary and secondary cell lines. Assay Drug Devel. Technol. 3: 299-307.
    • (2005) Assay Drug Devel. Technol. , vol.3 , pp. 299-307
    • Deshpande, R.1    Kirsch, Y.2    Maas, R.3    John, G.4    Krause, C.5    Heinzle, E.6
  • 21
    • 79955436122 scopus 로고    scopus 로고
    • EMA. European Medicinal Agency: London.
    • EMA. 2008. Guideline on Repeated Dose Toxicity. European Medicinal Agency: London.
    • (2008) Guideline on Repeated Dose Toxicity
  • 22
    • 77955983741 scopus 로고    scopus 로고
    • Cell-based sensor systems for toxicity testing using novel fluorescence spectroscopic approaches
    • Fritzsche M, Mandenius CF. 2010. Cell-based sensor systems for toxicity testing using novel fluorescence spectroscopic approaches. Anal. Bioanal. Chem. 398: 181-191.
    • (2010) Anal. Bioanal. Chem. , vol.398 , pp. 181-191
    • Fritzsche, M.1    Mandenius, C.F.2
  • 23
    • 61849170097 scopus 로고    scopus 로고
    • A cell-based sensor system for toxicity testing using multiwavelength fluorescence spectroscopy
    • Fritzsche M, Fredriksson JM, Carlsson M, Mandenius CF. 2009. A cell-based sensor system for toxicity testing using multiwavelength fluorescence spectroscopy. Anal. Biochem. 387: 271-275.
    • (2009) Anal. Biochem. , vol.387 , pp. 271-275
    • Fritzsche, M.1    Fredriksson, J.M.2    Carlsson, M.3    Mandenius, C.F.4
  • 25
    • 0035092543 scopus 로고    scopus 로고
    • Evaluation of the characteristics of safety withdrawal of prescription drugs from worldwide pharmaceuticals markets - 1960 to 1999
    • Fung M, Thornton A, Mybeck K, Wu JH, Hornbuckle K, Muniz E. 2001. Evaluation of the characteristics of safety withdrawal of prescription drugs from worldwide pharmaceuticals markets - 1960 to 1999. Drug Inform. J. 35: 293-317.
    • (2001) Drug Inform. J. , vol.35 , pp. 293-317
    • Fung, M.1    Thornton, A.2    Mybeck, K.3    Wu, J.H.4    Hornbuckle, K.5    Muniz, E.6
  • 26
    • 70350605496 scopus 로고    scopus 로고
    • Generation and characterization of functional cardiomyocytes using induced pluripotent stem cells derived from human fibroblasts
    • Gai H, Leung EL, Costantino PD, Aguila JR, Nguyen DM, Fink LM, Ward DC, Ma Y. 2009. Generation and characterization of functional cardiomyocytes using induced pluripotent stem cells derived from human fibroblasts. Cell Biol. Int. 33: 1184-1193.
    • (2009) Cell Biol. Int. , vol.33 , pp. 1184-1193
    • Gai, H.1    Leung, E.L.2    Costantino, P.D.3    Aguila, J.R.4    Nguyen, D.M.5    Fink, L.M.6    Ward, D.C.7    Ma, Y.8
  • 29
    • 0038300672 scopus 로고    scopus 로고
    • Human embryonic stem cells develop into multiple types of cardiac myocytes: action potential characterization
    • He JQ, Ma Y, Lee Y, Thomson JA, Kamp TJ. 2003. Human embryonic stem cells develop into multiple types of cardiac myocytes: action potential characterization. Circul. Res. 93: 32-39.
    • (2003) Circul. Res. , vol.93 , pp. 32-39
    • He, J.Q.1    Ma, Y.2    Lee, Y.3    Thomson, J.A.4    Kamp, T.J.5
  • 31
    • 79955048681 scopus 로고    scopus 로고
    • ICH. Single Dose Toxicity Tests. ICH Safety Guideline S4. The International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use.
    • ICH. 1997. Single Dose Toxicity Tests. ICH Safety Guideline S4. The International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use.
    • (1997)
  • 32
    • 79955041035 scopus 로고    scopus 로고
    • ICH. Safety Pharmacology Studies for Human Pharmaceuticals. ICH Safety Guideline S7A. The International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use.
    • ICH. 2000. Safety Pharmacology Studies for Human Pharmaceuticals. ICH Safety Guideline S7A. The International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use.
    • (2000)
  • 33
    • 79955032253 scopus 로고    scopus 로고
    • ICH. The Nonclinical Evaluation of the Potential for Delayed Ventricular Repolarization (QT Interval Prolongation) by Human Pharmaceuticals. ICH Safety Guideline S7B. The International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use.
    • ICH. 2005. The Nonclinical Evaluation of the Potential for Delayed Ventricular Repolarization (QT Interval Prolongation) by Human Pharmaceuticals. ICH Safety Guideline S7B. The International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use.
    • (2005)
  • 39
    • 0030886937 scopus 로고    scopus 로고
    • Managing the drug discovery/development interface
    • Kennedy T. 1997. Managing the drug discovery/development interface. Drug Discov. Today 2: 436-444.
    • (1997) Drug Discov. Today , vol.2 , pp. 436-444
    • Kennedy, T.1
  • 41
    • 77954202607 scopus 로고    scopus 로고
    • Non-cardiomyocytes influence the electrophysiological maturation of human embryonic stem cell-derived cardiomyocytes during differentiation
    • Kim C, Majdi M, Xia P, Wei KA, Talantova M, Spiering S, Nelson B, Mercola M, Chen HS. 2010. Non-cardiomyocytes influence the electrophysiological maturation of human embryonic stem cell-derived cardiomyocytes during differentiation. Stem Cells Dev. 19: 783-895.
    • (2010) Stem Cells Dev. , vol.19 , pp. 783-895
    • Kim, C.1    Majdi, M.2    Xia, P.3    Wei, K.A.4    Talantova, M.5    Spiering, S.6    Nelson, B.7    Mercola, M.8    Chen, H.S.9
  • 42
    • 0037335625 scopus 로고    scopus 로고
    • Role of the transverse-axial tubule system in generating calcium local Ca events and calcium transients in rat atrial myocytes
    • Kirk MM, Izu LT, Chen-Izu Y, McCulle SL, Wier WG, Balke CW, Shorofsky SR. 2003. Role of the transverse-axial tubule system in generating calcium local Ca events and calcium transients in rat atrial myocytes. J. Physiol. 547: 441-451.
    • (2003) J. Physiol. , vol.547 , pp. 441-451
    • Kirk, M.M.1    Izu, L.T.2    Chen-Izu, Y.3    McCulle, S.L.4    Wier, W.G.5    Balke, C.W.6    Shorofsky, S.R.7
  • 43
    • 4344645978 scopus 로고    scopus 로고
    • Can the pharmaceutical industry reduce attrition rates?
    • Kola I, Landis J. 2004. Can the pharmaceutical industry reduce attrition rates? Nat. Rev. Drug Discov. 3: 711-715.
    • (2004) Nat. Rev. Drug Discov. , vol.3 , pp. 711-715
    • Kola, I.1    Landis, J.2
  • 44
    • 34250860104 scopus 로고    scopus 로고
    • Methods for inducing embryoid body formation: in vitro differentiation system of embryonic stem cells
    • Kurosawa HJ. 2007. Methods for inducing embryoid body formation: in vitro differentiation system of embryonic stem cells. Biosci. Bioeng. 103: 389-398.
    • (2007) Biosci. Bioeng. , vol.103 , pp. 389-398
    • Kurosawa, H.J.1
  • 47
    • 15244362887 scopus 로고    scopus 로고
    • Drug withdrawals from the Canadian market for safety reasons, 1963-2004
    • Lexchin J. 2005. Drug withdrawals from the Canadian market for safety reasons, 1963-2004. CMAJ 172: 765-767.
    • (2005) CMAJ , vol.172 , pp. 765-767
    • Lexchin, J.1
  • 48
    • 0035145286 scopus 로고    scopus 로고
    • Species plays an important role in drug-induced prolongation of action potential duration and early after depolarizations in isolated Purkinje fibers
    • Lu HR, Marien R, Saels A, De Clerck F. 2001. Species plays an important role in drug-induced prolongation of action potential duration and early after depolarizations in isolated Purkinje fibers. J. Cardiovasc. Electrophysiol. 12: 93-110.
    • (2001) J. Cardiovasc. Electrophysiol. , vol.12 , pp. 93-110
    • Lu, H.R.1    Marien, R.2    Saels, A.3    De Clerck, F.4
  • 53
    • 70349767923 scopus 로고    scopus 로고
    • Effects of drugs in subtoxic concentrations on the metabolic fluxes in human hepatoma cell line Hep G2
    • Niklas J, Noor F, Heinzle E. 2009. Effects of drugs in subtoxic concentrations on the metabolic fluxes in human hepatoma cell line Hep G2. Toxicol. Appl. Pharmacol. 240: 327-336.
    • (2009) Toxicol. Appl. Pharmacol. , vol.240 , pp. 327-336
    • Niklas, J.1    Noor, F.2    Heinzle, E.3
  • 55
    • 67349222520 scopus 로고    scopus 로고
    • An integrated approach to improved toxicity prediction for the safety assessment during preclinical drug development using Hep G2 cells
    • Noor F, Niklas J, Muller-Vieira U, Heinzle E. 2009. An integrated approach to improved toxicity prediction for the safety assessment during preclinical drug development using Hep G2 cells. Toxicol. Appl. Pharmacol. 237: 221-231.
    • (2009) Toxicol. Appl. Pharmacol. , vol.237 , pp. 221-231
    • Noor, F.1    Niklas, J.2    Muller-Vieira, U.3    Heinzle, E.4
  • 57
    • 79955016498 scopus 로고    scopus 로고
    • OECD. Guidance Document 34 on the Validation and International Acceptance of New or Updated Test Methods for Hazard Assessment. Available from: (accessed 31 October 2010).
    • OECD. 2005. Guidance Document 34 on the Validation and International Acceptance of New or Updated Test Methods for Hazard Assessment. Available from: (accessed 31 October 2010).
    • (2005)
  • 58
    • 77952253259 scopus 로고    scopus 로고
    • Progressive maturation in contracting cardiomyocytes derived from human embryonic stem cells: qualitative effects on electrophysiological responses to drugs
    • Otsuji TG, Minami I, Kurose Y, Yamauchi K, Tada M, Nakatsuji N. 2010. Progressive maturation in contracting cardiomyocytes derived from human embryonic stem cells: qualitative effects on electrophysiological responses to drugs. Stem Cell Res. 4: 201-213.
    • (2010) Stem Cell Res. , vol.4 , pp. 201-213
    • Otsuji, T.G.1    Minami, I.2    Kurose, Y.3    Yamauchi, K.4    Tada, M.5    Nakatsuji, N.6
  • 59
    • 1642443176 scopus 로고    scopus 로고
    • Methods in optical oxygen sensing: protocols and critical analyses
    • Papkovsky DB. 2004. Methods in optical oxygen sensing: protocols and critical analyses. Meth. Enzymol. 381: 715-735.
    • (2004) Meth. Enzymol. , vol.381 , pp. 715-735
    • Papkovsky, D.B.1
  • 62
    • 67449100336 scopus 로고    scopus 로고
    • Substantial variation in the cardiac differentiation of human embryonic stem cell lines derived and propagated under the same conditions, a comparison of multiple cell lines
    • Pekkanen-Mattila M, Kerkelä E, Tanskanen JM, Pietilä M, Pelto-Huikko M, Hyttinen J, Skottman H, Suuronen R, Aalto-Setälä K. 2009. Substantial variation in the cardiac differentiation of human embryonic stem cell lines derived and propagated under the same conditions, a comparison of multiple cell lines. Ann. Med. 41: 360-370.
    • (2009) Ann. Med. , vol.41 , pp. 360-370
    • Pekkanen-Mattila, M.1    Kerkelä, E.2    Tanskanen, J.M.3    Pietilä, M.4    Pelto-Huikko, M.5    Hyttinen, J.6    Skottman, H.7    Suuronen, R.8    Aalto-Setälä, K.9
  • 65
    • 77950855126 scopus 로고    scopus 로고
    • Mechanisms of drug induced QT interval prolongation
    • Ponte ML, Keller GA, Girolamo G. 2010. Mechanisms of drug induced QT interval prolongation. Curr. Drug Saf. 5: 44-53.
    • (2010) Curr. Drug Saf. , vol.5 , pp. 44-53
    • Ponte, M.L.1    Keller, G.A.2    Girolamo, G.3
  • 69
    • 26444470807 scopus 로고    scopus 로고
    • Human embryonic stem cells as a model for studying epigenetic regulation during early development
    • Rugg-Gunn PJ, Ferguson-Smith AC, Pedersen RA. 2005. Human embryonic stem cells as a model for studying epigenetic regulation during early development. Cell Cycle 4: 1323-1326.
    • (2005) Cell Cycle , vol.4 , pp. 1323-1326
    • Rugg-Gunn, P.J.1    Ferguson-Smith, A.C.2    Pedersen, R.A.3
  • 70
    • 65549167805 scopus 로고    scopus 로고
    • Cardiomyocyte enrichment from human embryonic stem cell cultures by selection of ALCAM surface expression
    • Rust W, Balakrishnan T, Zweigerdt R. 2009. Cardiomyocyte enrichment from human embryonic stem cell cultures by selection of ALCAM surface expression. Regen. Med. 4: 225-237.
    • (2009) Regen. Med. , vol.4 , pp. 225-237
    • Rust, W.1    Balakrishnan, T.2    Zweigerdt, R.3
  • 72
    • 34247580093 scopus 로고    scopus 로고
    • Developmental changes in cardiomyocytes differentiated from human embryonic stem cells: a molecular and electrophysiological approach
    • Sartiani L, Bettiol E, Stillitano F, Mugelli A, Cerbai E, Jaconi ME. 2007. Developmental changes in cardiomyocytes differentiated from human embryonic stem cells: a molecular and electrophysiological approach. Stem Cells 25: 1136-1144.
    • (2007) Stem Cells , vol.25 , pp. 1136-1144
    • Sartiani, L.1    Bettiol, E.2    Stillitano, F.3    Mugelli, A.4    Cerbai, E.5    Jaconi, M.E.6
  • 73
    • 68549118772 scopus 로고    scopus 로고
    • Regulation of 'stemness' and stem cell differentiation by microRNAs
    • Sartipy P, Olsson B, Hyllner J, Synnergren J. 2009. Regulation of 'stemness' and stem cell differentiation by microRNAs. IDrugs 12: 492-496.
    • (2009) IDrugs , vol.12 , pp. 492-496
    • Sartipy, P.1    Olsson, B.2    Hyllner, J.3    Synnergren, J.4
  • 75
    • 58049196595 scopus 로고    scopus 로고
    • 1,4,5-Inositol trisphosphate-operated intracellular Ca(2+) stores and angiotensin-II/endothelin-1 signaling pathway are functional in human embryonic stem cell-derived cardiomyocytes
    • Sedan O, Dolnikov K, Zeevi-Levin N, Leibovich N, Amit M, Itskovitz-Eldor J, Binah O. 2008. 1, 4, 5-Inositol trisphosphate-operated intracellular Ca(2+) stores and angiotensin-II/endothelin-1 signaling pathway are functional in human embryonic stem cell-derived cardiomyocytes. Stem Cells 26: 3130-3138.
    • (2008) Stem Cells , vol.26 , pp. 3130-3138
    • Sedan, O.1    Dolnikov, K.2    Zeevi-Levin, N.3    Leibovich, N.4    Amit, M.5    Itskovitz-Eldor, J.6    Binah, O.7
  • 76
    • 77649112701 scopus 로고    scopus 로고
    • The effect of mechanical loads in the differentiation of precursor cells into mature cells
    • Shav D, Einav S. 2010. The effect of mechanical loads in the differentiation of precursor cells into mature cells. Ann. NY Acad. Sci. 1188: 25-31.
    • (2010) Ann. NY Acad. Sci. , vol.1188 , pp. 25-31
    • Shav, D.1    Einav, S.2
  • 78
    • 79955028112 scopus 로고    scopus 로고
    • Metabolic flux analysis on HL-1 cardiomyocytes reveals alterations in glucose and lactate metabolism induced by verapamil (submitted).
    • Strigun A, Noor F, Pironti A, Niklas J, Yang TH, Heinzle E. 2011. Metabolic flux analysis on HL-1 cardiomyocytes reveals alterations in glucose and lactate metabolism induced by verapamil (submitted).
    • (2011)
    • Strigun, A.1    Noor, F.2    Pironti, A.3    Niklas, J.4    Yang, T.H.5    Heinzle, E.6
  • 79
    • 79955004261 scopus 로고    scopus 로고
    • Metabolic profiling using HPLC allows classificaion of drugs according to their mechanisms of action in HL-1 cells (submitted).
    • Strigun A, Wahrheit J, Beckers S, Heinzle E, Noor F. 2011. Metabolic profiling using HPLC allows classificaion of drugs according to their mechanisms of action in HL-1 cells (submitted).
    • (2011)
    • Strigun, A.1    Wahrheit, J.2    Beckers, S.3    Heinzle, E.4    Noor, F.5
  • 81
  • 83
    • 74549220695 scopus 로고    scopus 로고
    • Reducing QT liability and proarrhythmic risk in drug discovery and development
    • Valentin JP. 2010. Reducing QT liability and proarrhythmic risk in drug discovery and development. Br. J. Pharmacol. 159: 5-11.
    • (2010) Br. J. Pharmacol. , vol.159 , pp. 5-11
    • Valentin, J.P.1
  • 86
    • 35748944864 scopus 로고    scopus 로고
    • Metabolic flux screening of Saccharomyces cerevisiae single knockout strains on glucose and galactose supports elucidation of gene function
    • Velagapudi VR, Wittmann C, Schneider K, Heinzle E. 2007. Metabolic flux screening of Saccharomyces cerevisiae single knockout strains on glucose and galactose supports elucidation of gene function. J. Biotechnol. 132: 395-404.
    • (2007) J. Biotechnol. , vol.132 , pp. 395-404
    • Velagapudi, V.R.1    Wittmann, C.2    Schneider, K.3    Heinzle, E.4
  • 87
    • 77949293236 scopus 로고    scopus 로고
    • Differentiation of human embryonic stem cells to cardiomyocytes for in vitro and in vivo applications
    • Vidarsson H, Hyllner J, Sartipy P. 2010. Differentiation of human embryonic stem cells to cardiomyocytes for in vitro and in vivo applications. Stem Cell Rev. 6: 108-120.
    • (2010) Stem Cell Rev. , vol.6 , pp. 108-120
    • Vidarsson, H.1    Hyllner, J.2    Sartipy, P.3
  • 89
    • 33845250184 scopus 로고    scopus 로고
    • Isotopomer analysis of myocardial substrate metabolism: a systems biology approach
    • Vo TD, Palsson BO. 2006. Isotopomer analysis of myocardial substrate metabolism: a systems biology approach. Biotechnol. Bioeng. 95: 972-983.
    • (2006) Biotechnol. Bioeng. , vol.95 , pp. 972-983
    • Vo, T.D.1    Palsson, B.O.2
  • 91
    • 1342346691 scopus 로고    scopus 로고
    • Cardiac physiology at the cellular level: use of cultured HL-1 cardiomyocytes for studies of cardiac muscle cell structure and function
    • White SM, Constantin PE, Claycomb WC. 2004. Cardiac physiology at the cellular level: use of cultured HL-1 cardiomyocytes for studies of cardiac muscle cell structure and function Am. J. Physiol. Heart Circul. Physiol. 286: 823-829.
    • (2004) Am. J. Physiol. Heart Circul. Physiol. , vol.286 , pp. 823-829
    • White, S.M.1    Constantin, P.E.2    Claycomb, W.C.3
  • 92
    • 0031554635 scopus 로고    scopus 로고
    • Bidirectional reaction steps in metabolic networks. 1. Modeling and simulation of carbon isotope labeling experiments
    • Wiechert W, de Graaf AA. 1997. Bidirectional reaction steps in metabolic networks. 1. Modeling and simulation of carbon isotope labeling experiments. Biotechnol. Bioeng. 55: 101-117.
    • (1997) Biotechnol. Bioeng. , vol.55 , pp. 101-117
    • Wiechert, W.1    de Graaf, A.A.2
  • 93
    • 0031554628 scopus 로고    scopus 로고
    • Bidirectional reaction steps in metabolic networks. 2. Flux estimation and statistical analysis
    • Wiechert W, Siefke C, de Graaf AA, Marx A. 1997. Bidirectional reaction steps in metabolic networks. 2. Flux estimation and statistical analysis. Biotechnol. Bioeng. 55: 118-135.
    • (1997) Biotechnol. Bioeng. , vol.55 , pp. 118-135
    • Wiechert, W.1    Siefke, C.2    de Graaf, A.A.3    Marx, A.4
  • 94
    • 0033586461 scopus 로고    scopus 로고
    • Mass spectrometry for metabolic flux analysis
    • Wittmann C, Heinzle E. 1999. Mass spectrometry for metabolic flux analysis. Biotechnol. Bioeng. 62: 739-750.
    • (1999) Biotechnol. Bioeng. , vol.62 , pp. 739-750
    • Wittmann, C.1    Heinzle, E.2
  • 95
    • 0037144701 scopus 로고    scopus 로고
    • Characterization and enrichment of cardiomyocytes derived from human embryonic stem cells
    • Xu C, Police S, Rao N, Carpenter MK. 2002. Characterization and enrichment of cardiomyocytes derived from human embryonic stem cells. Circul. Res. 91: 501-508.
    • (2002) Circul. Res. , vol.91 , pp. 501-508
    • Xu, C.1    Police, S.2    Rao, N.3    Carpenter, M.K.4
  • 96
    • 42649132891 scopus 로고    scopus 로고
    • 13C metabolic flux analysis using systems parametrized by compactification
    • 13C metabolic flux analysis using systems parametrized by compactification. BMC Systems Biol. 2: 29.
    • (2008) BMC Systems Biol. , vol.2 , pp. 29
    • Yang, T.H.1    Frick, O.2    Heinzle, E.3
  • 97
    • 33646113360 scopus 로고    scopus 로고
    • Enhanced differentiation of human embryonic stem cells into cardiomyocytes by combining hanging drop culture and 5-azacytidine treatment
    • Yoon BS, Yoo SJ, Lee JE, You S, Lee HT, Yoon HS. 2006. Enhanced differentiation of human embryonic stem cells into cardiomyocytes by combining hanging drop culture and 5-azacytidine treatment. Differentiation 74: 149-159.
    • (2006) Differentiation , vol.74 , pp. 149-159
    • Yoon, B.S.1    Yoo, S.J.2    Lee, J.E.3    You, S.4    Lee, H.T.5    Yoon, H.S.6
  • 99
    • 73049103566 scopus 로고    scopus 로고
    • Control of the cardiac action potential: The role of repolarization dynamics
    • Zaza A. 2010. Control of the cardiac action potential: The role of repolarization dynamics. J. Mol. Cell Cardiol. 48: 106-111.
    • (2010) J. Mol. Cell Cardiol. , vol.48 , pp. 106-111
    • Zaza, A.1
  • 101
    • 76349084460 scopus 로고    scopus 로고
    • Phospholamban ablation rescues sarcoplasmic reticulum Ca(2+) handling but exacerbates cardiac dysfunction in CaMKIIdelta(C) transgenic mice
    • Zhang T, Guo T, Mishra S, Dalton ND, Kranias EG, Peterson KL, Bers DM, Brown JH. 2010. Phospholamban ablation rescues sarcoplasmic reticulum Ca(2+) handling but exacerbates cardiac dysfunction in CaMKIIdelta(C) transgenic mice. Circul. Res. 106: 354-362.
    • (2010) Circul. Res. , vol.106 , pp. 354-362
    • Zhang, T.1    Guo, T.2    Mishra, S.3    Dalton, N.D.4    Kranias, E.G.5    Peterson, K.L.6    Bers, D.M.7    Brown, J.H.8


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