Quantification of statin effects on hepatic cholesterol synthesis by transient 13C-flux analysis

Metabolic Engineering

Volumn 11, Issue 4-5, 2009, Pages 292-309

  Maier, Klaus ^a   Hofmann, Ute ^b   Bauer, Alexander ^c   Niebel, Anja ^a   Vacun, Gabriele ^a   Reuss, Matthias ^a   Mauch, Klaus ^d  

^a UNIVERSITY OF STUTTGART   (Germany)

^b UNIVERSITY OF TÜBINGEN   (Germany)

^c TU DORTMUND UNIVERSITY   (Germany)

^d INSILICO Biotechnology GmbH   (Germany)

Author keywords

Atorvastatin; Hepatic metabolism; HMG CoA reductase; Intracellular metabolite concentrations; Mammalian cells; Metabolic control analysis; Metabolic flux analysis; Non stationary 13C labeling

Indexed keywords

ATORVASTATIN; HEPATIC METABOLISM; HMG-COA REDUCTASE; INTRACELLULAR METABOLITE CONCENTRATIONS; MAMMALIAN CELLS; METABOLIC CONTROL ANALYSIS; METABOLIC FLUX ANALYSIS; NON-STATIONARY 13C-LABELING;

AMINO ACIDS; BIOCHEMISTRY; CHOLESTEROL; ENZYME ACTIVITY; LABELS; MAMMALS; METABOLITES;

METABOLISM;

ATORVASTATIN; CARBON 13; CHOLESTEROL; FUMARIC ACID; GLUTAMINE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; SUCCINIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CARBON METABOLISM; CHOLESTEROL LIVER LEVEL; CHOLESTEROL SYNTHESIS; CITRIC ACID CYCLE; DRUG EFFECT; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; STEADY STATE;

ANIMALS; ANTICHOLESTEREMIC AGENTS; CARBON; CARBON ISOTOPES; CELLS, CULTURED; CHOLESTEROL; HEPATOCYTES; HYDROXYMETHYLGLUTARYL COA REDUCTASES; ISOTOPE LABELING; KINETICS; LIVER; MALE; RATS; RATS, WISTAR;

MAMMALIA; RATTUS;

EID: 68049129530     PISSN: 10967176     EISSN: 10967184     Source Type: Journal    
DOI: 10.1016/j.ymben.2009.06.001     Document Type: Article

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