메뉴 건너뛰기




Volumn 45, Issue 7, 2012, Pages 396-401

Central energy metabolism remains robust in acute steatotic hepatocytes challenged by a high free fatty acid load

Author keywords

Isotope labeling; Liver; Metabolic flux; Non alcoholic fatty liver disease NAFLD; Steatosis; Transient 13C MFA

Indexed keywords

FATTY ACID;

EID: 84866594013     PISSN: 19766696     EISSN: 1976670X     Source Type: Journal    
DOI: 10.5483/BMBRep.2012.45.7.070     Document Type: Article
Times cited : (16)

References (28)
  • 1
    • 21344449292 scopus 로고    scopus 로고
    • Prevalence of and risk factors for nonalcoholic fatty liver disease: the Dionysos nutrition and liver study
    • Bedogni, G., Miglioli, L., Masutti, F., Tiribelli, C., Marchesini, G. and Bellentani, S. (2005) Prevalence of and risk factors for nonalcoholic fatty liver disease: the Dionysos nutrition and liver study. Hepatology 42, 44-52.
    • (2005) Hepatology , vol.42 , pp. 44-52
    • Bedogni, G.1    Miglioli, L.2    Masutti, F.3    Tiribelli, C.4    Marchesini, G.5    Bellentani, S.6
  • 2
    • 54049150442 scopus 로고    scopus 로고
    • Molecular Mechanisms and Therapeutic Targets in Steatosis and Steatohepatitis
    • Anderson, N. and Borlak, J. (2008) Molecular Mechanisms and Therapeutic Targets in Steatosis and Steatohepatitis. Pharmacological Reviews 60, 311-357.
    • (2008) Pharmacological Reviews , vol.60 , pp. 311-357
    • Anderson, N.1    Borlak, J.2
  • 3
    • 33644850802 scopus 로고    scopus 로고
    • Lipid metabolism and liver inflammation. I. Hepatic fatty acid uptake: possible role in steatosis
    • Bradbury, M. W. (2006) Lipid metabolism and liver inflammation. I. Hepatic fatty acid uptake: possible role in steatosis. Am. J. Physiol. Gastrointest. Liver Physiol. 290, G194-198.
    • (2006) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.290
    • Bradbury, M.W.1
  • 4
    • 18244382304 scopus 로고    scopus 로고
    • Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease
    • Donnelly, K. L., Smith, C. I., Schwarzenberg, S. J., Jessurun, J., Boldt, M. D. and Parks, E. J. (2005) Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease. J. Clin. Invest. 115, 1343-1351.
    • (2005) J. Clin. Invest. , vol.115 , pp. 1343-1351
    • Donnelly, K.L.1    Smith, C.I.2    Schwarzenberg, S.J.3    Jessurun, J.4    Boldt, M.D.5    Parks, E.J.6
  • 5
    • 0022007068 scopus 로고
    • Elevated hepatic mitochondrial and peroxisomal oxidative capacities in fed and starved adult obese (ob/ob) mice
    • Brady, L. J., Brady, P. S., Romsos, D. R. and Hoppel, C. L. (1985) Elevated hepatic mitochondrial and peroxisomal oxidative capacities in fed and starved adult obese (ob/ob) mice. Biochem. J. 231, 439-444.
    • (1985) Biochem. J. , vol.231 , pp. 439-444
    • Brady, L.J.1    Brady, P.S.2    Romsos, D.R.3    Hoppel, C.L.4
  • 7
    • 46349087273 scopus 로고    scopus 로고
    • Uncoupling protein-2 (UCP2) induces mitochondrial proton leak and increases susceptibility of non-alcoholic steatohepatitis (NASH) liver to ischaemia-reperfusion injury
    • Serviddio, G., Bellanti, F., Tamborra, R., Rollo, T., Capitanio, N., Romano, A. D., Sastre, J., Vendemiale, G. and Altomare, E. (2008) Uncoupling protein-2 (UCP2) induces mitochondrial proton leak and increases susceptibility of non-alcoholic steatohepatitis (NASH) liver to ischaemia-reperfusion injury. Gut 57, 957-965.
    • (2008) Gut , vol.57 , pp. 957-965
    • Serviddio, G.1    Bellanti, F.2    Tamborra, R.3    Rollo, T.4    Capitanio, N.5    Romano, A.D.6    Sastre, J.7    Vendemiale, G.8    Altomare, E.9
  • 8
    • 0029127584 scopus 로고
    • Inhibition of mitochondrial beta-oxidation as a mechanism of hepatotoxicity
    • Fromenty, B. and Pessayre, D. (1995) Inhibition of mitochondrial beta-oxidation as a mechanism of hepatotoxicity. Pharmacol. Ther. 67, 101-154.
    • (1995) Pharmacol. Ther. , vol.67 , pp. 101-154
    • Fromenty, B.1    Pessayre, D.2
  • 11
    • 33744948514 scopus 로고    scopus 로고
    • Free fatty acids induce JNK-dependent hepatocyte lipoapoptosis
    • Malhi, H., Bronk, S. F., Werneburg, N. W. and Gores, G. J. (2006) Free fatty acids induce JNK-dependent hepatocyte lipoapoptosis. J. Biol. Chem. 281, 12093-12101.
    • (2006) J. Biol. Chem. , vol.281 , pp. 12093-12101
    • Malhi, H.1    Bronk, S.F.2    Werneburg, N.W.3    Gores, G.J.4
  • 12
    • 84882940039 scopus 로고    scopus 로고
    • Metabolic flux analysis in systems biology of Mammalian cells
    • Niklas, J. and Heinzle, E. (2012) Metabolic flux analysis in systems biology of Mammalian cells. Adv. Biochem. Eng. Biotechnol. 127, 109-132.
    • (2012) Adv. Biochem. Eng. Biotechnol. , vol.127 , pp. 109-132
    • Niklas, J.1    Heinzle, E.2
  • 14
    • 44449177159 scopus 로고    scopus 로고
    • Identification of metabolic fluxes in hepatic cells from transient 13C-labeling experiments: Part II
    • Maier, K., Hofmann, U., Reuss, M. and Mauch, K. (2008) Identification of metabolic fluxes in hepatic cells from transient 13C-labeling experiments: Part II. Flux estimation. Biotechnol. Bioeng. 100, 355-370.
    • (2008) Flux estimation. Biotechnol. Bioeng. , vol.100 , pp. 355-370
    • Maier, K.1    Hofmann, U.2    Reuss, M.3    Mauch, K.4
  • 15
    • 80052611173 scopus 로고    scopus 로고
    • The benefits of being transient: isotope-based metabolic flux analysis at the short time scale
    • Nöh, K. and Wiechert, W. (2011) The benefits of being transient: isotope-based metabolic flux analysis at the short time scale. Appl. Microbiol. Biotechnol. 91, 1247-1265.
    • (2011) Appl. Microbiol. Biotechnol. , vol.91 , pp. 1247-1265
    • Nöh, K.1    Wiechert, W.2
  • 16
    • 34548208165 scopus 로고    scopus 로고
    • Regulation of human hepatocyte gene expression by fatty acids
    • Swagell, C. D., Henly, D. C. and Morris, C. P. (2007) Regulation of human hepatocyte gene expression by fatty acids. Biochem. Biophys. Res. Commun. 362, 374-380.
    • (2007) Biochem. Biophys. Res. Commun. , vol.362 , pp. 374-380
    • Swagell, C.D.1    Henly, D.C.2    Morris, C.P.3
  • 17
    • 13444287857 scopus 로고    scopus 로고
    • Expression analysis of a human hepatic cell line in response to palmitate
    • Swagell, C. D., Henly, D. C. and Morris, C. P. (2005) Expression analysis of a human hepatic cell line in response to palmitate. Biochem. Biophys. Res. Commun. 328, 432-441.
    • (2005) Biochem. Biophys. Res. Commun. , vol.328 , pp. 432-441
    • Swagell, C.D.1    Henly, D.C.2    Morris, C.P.3
  • 18
    • 33646432007 scopus 로고    scopus 로고
    • Effect of fatty acids, glucose and insulin on hepatic glucose uptake and glycolysis
    • Swagell, C. D., Morris, C. P. and Henly, D. C. (2006) Effect of fatty acids, glucose and insulin on hepatic glucose uptake and glycolysis. Nutrition 22, 672-678.
    • (2006) Nutrition , vol.22 , pp. 672-678
    • Swagell, C.D.1    Morris, C.P.2    Henly, D.C.3
  • 19
    • 0035856949 scopus 로고    scopus 로고
    • Insulin signalling and the regulation of glucose and lipid metabolism
    • Saltiel, A. R. and Kahn, C. R. (2001) Insulin signalling and the regulation of glucose and lipid metabolism. Nature 414, 799-806.
    • (2001) Nature , vol.414 , pp. 799-806
    • Saltiel, A.R.1    Kahn, C.R.2
  • 20
    • 66949149506 scopus 로고    scopus 로고
    • Modulation of the hepatic malonyl-CoA-carnitine palmitoyltransferase 1A partnership creates a metabolic switch allowing oxidation of de novo fatty acids
    • Akkaoui, M., Cohen, I., Esnous, C., Lenoir, V., Sournac, M., Girard, J. and Prip-Buus, C. (2009) Modulation of the hepatic malonyl-CoA-carnitine palmitoyltransferase 1A partnership creates a metabolic switch allowing oxidation of de novo fatty acids. Biochem. J. 420, 429-438.
    • (2009) Biochem. J. , vol.420 , pp. 429-438
    • Akkaoui, M.1    Cohen, I.2    Esnous, C.3    Lenoir, V.4    Sournac, M.5    Girard, J.6    Prip-Buus, C.7
  • 21
    • 75449094816 scopus 로고    scopus 로고
    • Obesity and nonalcoholic fatty liver disease: biochemical, metabolic and clinical implications
    • Fabbrini, E., Sullivan, S. and Klein, S. (2010) Obesity and nonalcoholic fatty liver disease: biochemical, metabolic and clinical implications. Hepatology 51, 679-689.
    • (2010) Hepatology , vol.51 , pp. 679-689
    • Fabbrini, E.1    Sullivan, S.2    Klein, S.3
  • 23
    • 44449113808 scopus 로고    scopus 로고
    • Identification of metabolic fluxes in hepatic cells from transient 13C-labeling experiments: Part I Experimental observations
    • Hofmann, U., Maier, K., Niebel, A., Vacun, G., Reuss, M. and Mauch, K. (2008) Identification of metabolic fluxes in hepatic cells from transient 13C-labeling experiments: Part I. Experimental observations. Biotechnol. Bioeng. 100, 344-354.
    • (2008) Biotechnol. Bioeng. , vol.100 , pp. 344-354
    • Hofmann, U.1    Maier, K.2    Niebel, A.3    Vacun, G.4    Reuss, M.5    Mauch, K.6
  • 24
    • 77951531555 scopus 로고    scopus 로고
    • Dynamics and control of the central carbon metabolism in hepatoma cells
    • Maier, K., Hofmann, U., Reuss, M. and Mauch, K. (2010) Dynamics and control of the central carbon metabolism in hepatoma cells. BMC Syst. Biol. 4, 54.
    • (2010) BMC Syst. Biol. , vol.4 , pp. 54
    • Maier, K.1    Hofmann, U.2    Reuss, M.3    Mauch, K.4
  • 25
    • 36148989929 scopus 로고    scopus 로고
    • High-throughput tissue extraction protocol for NMR- and MS-based metabolomics
    • Wu, H., Southam, A. D., Hines, A. and Viant, M. R. (2008) High-throughput tissue extraction protocol for NMR- and MS-based metabolomics. Anal. Biochem. 372, 204-212.
    • (2008) Anal. Biochem. , vol.372 , pp. 204-212
    • Wu, H.1    Southam, A.D.2    Hines, A.3    Viant, M.R.4
  • 26
    • 68049129530 scopus 로고    scopus 로고
    • Quantification of statin effects on hepatic cholesterol synthesis by transient (13)C-flux analysis
    • Maier, K., Hofmann, U., Bauer, A., Niebel, A., Vacun, G., Reuss, M. and Mauch, K. (2009) Quantification of statin effects on hepatic cholesterol synthesis by transient (13)C-flux analysis. Metab. Eng. 11, 292-309.
    • (2009) Metab. Eng. , vol.11 , pp. 292-309
    • Maier, K.1    Hofmann, U.2    Bauer, A.3    Niebel, A.4    Vacun, G.5    Reuss, M.6    Mauch, K.7
  • 27
    • 0034741983 scopus 로고    scopus 로고
    • 13C metabolic flux analysis
    • 13C metabolic flux analysis. Metab. Eng. 3, 195-206.
    • (2001) Metab. Eng. , vol.3 , pp. 195-206
    • Wiechert, W.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.