메뉴 건너뛰기




Volumn 155, Issue 3, 2011, Pages 299-307

Metabolic flux analysis gives an insight on verapamil induced changes in central metabolism of HL-1 cells

Author keywords

Calcium channel blockers; Cardiomyocytes; Central metabolism; Glucose transport; Warburg effect

Indexed keywords

CALCIUM CHANNEL BLOCKERS; CARDIOMYOCYTES; CENTRAL METABOLISM; GLUCOSE TRANSPORT; WARBURG EFFECT;

EID: 80052390004     PISSN: 01681656     EISSN: 18734863     Source Type: Journal    
DOI: 10.1016/j.jbiotec.2011.07.028     Document Type: Article
Times cited : (24)

References (49)
  • 1
    • 0033952514 scopus 로고    scopus 로고
    • Improvement of CHO cell culture medium formulation: simultaneous substitution of glucose and glutamine
    • Altamirano C., Paredes C., Cairo J.J., Godia F. Improvement of CHO cell culture medium formulation: simultaneous substitution of glucose and glutamine. Biotechnol. Prog. 2000, 16:69-75.
    • (2000) Biotechnol. Prog. , vol.16 , pp. 69-75
    • Altamirano, C.1    Paredes, C.2    Cairo, J.J.3    Godia, F.4
  • 2
    • 77957846807 scopus 로고    scopus 로고
    • Monitoring of troponin release from cardiomyocytes during exposure to toxic substances using surface plasmon resonance biosensing
    • Andersson H., Kagedal B., Mandenius C.F. Monitoring of troponin release from cardiomyocytes during exposure to toxic substances using surface plasmon resonance biosensing. Anal. Bioanal. Chem. 2010, 398:1395-1402.
    • (2010) Anal. Bioanal. Chem. , vol.398 , pp. 1395-1402
    • Andersson, H.1    Kagedal, B.2    Mandenius, C.F.3
  • 3
    • 33845679072 scopus 로고    scopus 로고
    • Elementary metabolite units (EMU): a novel framework for modeling isotopic distributions
    • Antoniewicz M.R., Kelleher J.K., Stephanopoulos G. Elementary metabolite units (EMU): a novel framework for modeling isotopic distributions. Metab. Eng. 2007, 9:68-86.
    • (2007) Metab. Eng. , vol.9 , pp. 68-86
    • Antoniewicz, M.R.1    Kelleher, J.K.2    Stephanopoulos, G.3
  • 4
    • 0036074130 scopus 로고    scopus 로고
    • Calcium-independent inhibition of glucose transport in PC-12 and L6 cells by calcium channel antagonists
    • Ardizzone T.D., Lu X.H., Dwyer D.S. Calcium-independent inhibition of glucose transport in PC-12 and L6 cells by calcium channel antagonists. Am. J. Physiol. Cell Physiol. 2002, 283:C579-C586.
    • (2002) Am. J. Physiol. Cell Physiol. , vol.283
    • Ardizzone, T.D.1    Lu, X.H.2    Dwyer, D.S.3
  • 5
    • 42949161096 scopus 로고    scopus 로고
    • Verapamil toxicity dysregulates the phosphatidylinositol 3-kinase pathway
    • Bechtel L.K., Haverstick D.M., Holstege C.P. Verapamil toxicity dysregulates the phosphatidylinositol 3-kinase pathway. Acad. Emerg. Med. 2008, 15:368-374.
    • (2008) Acad. Emerg. Med. , vol.15 , pp. 368-374
    • Bechtel, L.K.1    Haverstick, D.M.2    Holstege, C.P.3
  • 6
    • 76749146181 scopus 로고    scopus 로고
    • High throughput, non-invasive and dynamic toxicity screening on adherent cells using respiratory measurements
    • Beckers S., Noor F., Muller-Vieira U., Mayer M., Strigun A., Heinzle E. High throughput, non-invasive and dynamic toxicity screening on adherent cells using respiratory measurements. Toxicol. In Vitro 2009, 24:686-694.
    • (2009) Toxicol. In Vitro , vol.24 , pp. 686-694
    • Beckers, S.1    Noor, F.2    Muller-Vieira, U.3    Mayer, M.4    Strigun, A.5    Heinzle, E.6
  • 7
    • 0035922073 scopus 로고    scopus 로고
    • Metabolic-flux analysis of continuously cultured hybridoma cells using 13CO2 mass spectrometry in combination with 13C-lactate nuclear magnetic resonance spectroscopy and metabolite balancing
    • Bonarius H.P., Ozemre A., Timmerarends B., Skrabal P., Tramper J., Schmid G., Heinzle E. Metabolic-flux analysis of continuously cultured hybridoma cells using 13CO2 mass spectrometry in combination with 13C-lactate nuclear magnetic resonance spectroscopy and metabolite balancing. Biotechnol. Bioeng. 2001, 74:528-538.
    • (2001) Biotechnol. Bioeng. , vol.74 , pp. 528-538
    • Bonarius, H.P.1    Ozemre, A.2    Timmerarends, B.3    Skrabal, P.4    Tramper, J.5    Schmid, G.6    Heinzle, E.7
  • 8
    • 0029932046 scopus 로고    scopus 로고
    • Verapamil: a review of its pharmacological properties and therapeutic use in coronary artery disease
    • Brogden R.N., Benfield P. Verapamil: a review of its pharmacological properties and therapeutic use in coronary artery disease. Drugs 1996, 51:792-819.
    • (1996) Drugs , vol.51 , pp. 792-819
    • Brogden, R.N.1    Benfield, P.2
  • 9
    • 0026639076 scopus 로고
    • Diverse effects of calcium channel blockers on skeletal muscle glucose transport
    • Cartee G.D., Briggs-Tung C., Holloszy J.O. Diverse effects of calcium channel blockers on skeletal muscle glucose transport. Am. J. Physiol. 1992, 263:R70-R75.
    • (1992) Am. J. Physiol. , vol.263
    • Cartee, G.D.1    Briggs-Tung, C.2    Holloszy, J.O.3
  • 10
    • 0035808169 scopus 로고    scopus 로고
    • Engineering of a mammalian cell line for reduction of lactate formation and high monoclonal antibody production
    • Chen K., Liu Q., Xie L., Sharp P.A., Wang D.I. Engineering of a mammalian cell line for reduction of lactate formation and high monoclonal antibody production. Biotechnol. Bioeng. 2001, 72:55-61.
    • (2001) Biotechnol. Bioeng. , vol.72 , pp. 55-61
    • Chen, K.1    Liu, Q.2    Xie, L.3    Sharp, P.A.4    Wang, D.I.5
  • 13
    • 64349111693 scopus 로고    scopus 로고
    • Towards a metabolic and isotopic steady state in CHO batch cultures for reliable isotope-based metabolic profiling
    • Deshpande R., Yang T.H., Heinzle E. Towards a metabolic and isotopic steady state in CHO batch cultures for reliable isotope-based metabolic profiling. Biotechnol. J. 2009, 4:247-263.
    • (2009) Biotechnol. J. , vol.4 , pp. 247-263
    • Deshpande, R.1    Yang, T.H.2    Heinzle, E.3
  • 15
    • 11144339470 scopus 로고    scopus 로고
    • Identification and pharmacological characterization of sarcolemmal ATP-sensitive potassium channels in the murine atrial HL-1 cell line
    • Fox J.E., Jones L., Light P.E. Identification and pharmacological characterization of sarcolemmal ATP-sensitive potassium channels in the murine atrial HL-1 cell line. J. Cardiovasc. Pharmacol. 2005, 45:30-35.
    • (2005) J. Cardiovasc. Pharmacol. , vol.45 , pp. 30-35
    • Fox, J.E.1    Jones, L.2    Light, P.E.3
  • 16
    • 61849170097 scopus 로고    scopus 로고
    • A cell-based sensor system for toxicity testing using multiwavelength fluorescence spectroscopy
    • Fritzsche M., Fredriksson J.M., Carlsson M., Mandenius C.F. A cell-based sensor system for toxicity testing using multiwavelength fluorescence spectroscopy. Anal. Biochem. 2009, 387:271-275.
    • (2009) Anal. Biochem. , vol.387 , pp. 271-275
    • Fritzsche, M.1    Fredriksson, J.M.2    Carlsson, M.3    Mandenius, C.F.4
  • 17
    • 0032808184 scopus 로고    scopus 로고
    • Alteration of cellular metabolism by consecutive fed-batch cultures of mammalian cells
    • Gambhir A., Europa A.F., Hu W.S. Alteration of cellular metabolism by consecutive fed-batch cultures of mammalian cells. J. Biosci. Bioeng. 1999, 87:805-810.
    • (1999) J. Biosci. Bioeng. , vol.87 , pp. 805-810
    • Gambhir, A.1    Europa, A.F.2    Hu, W.S.3
  • 18
    • 34447094919 scopus 로고    scopus 로고
    • Glycolysis in cancer: a potential target for therapy
    • Gatenby R.A., Gillies R.J. Glycolysis in cancer: a potential target for therapy. Int. J. Biochem. Cell Biol. 2007, 39:1358-1366.
    • (2007) Int. J. Biochem. Cell Biol. , vol.39 , pp. 1358-1366
    • Gatenby, R.A.1    Gillies, R.J.2
  • 19
    • 35448940364 scopus 로고    scopus 로고
    • Adaptive landscapes and emergent phenotypes: why do cancers have high glycolysis?
    • Gillies R.J., Gatenby R.A. Adaptive landscapes and emergent phenotypes: why do cancers have high glycolysis?. J. Bioenerg. Biomembr. 2007, 39:251-257.
    • (2007) J. Bioenerg. Biomembr. , vol.39 , pp. 251-257
    • Gillies, R.J.1    Gatenby, R.A.2
  • 20
    • 77049120710 scopus 로고    scopus 로고
    • Metabolic flux analysis of CHO cells in perfusion culture by metabolite balancing and 2D [13C, 1H] COSY NMR spectroscopy
    • Goudar C., Biener R., Boisart C., Heidemann R., Piret J., de Graaf A., Konstantinov K. Metabolic flux analysis of CHO cells in perfusion culture by metabolite balancing and 2D [13C, 1H] COSY NMR spectroscopy. Metab. Eng. 2010, 12:138-149.
    • (2010) Metab. Eng. , vol.12 , pp. 138-149
    • Goudar, C.1    Biener, R.2    Boisart, C.3    Heidemann, R.4    Piret, J.5    de Graaf, A.6    Konstantinov, K.7
  • 21
    • 0037457491 scopus 로고    scopus 로고
    • Free intracellular amino acid pools during autonomous oscillations in Saccharomyces cerevisiae
    • Hans M.A., Heinzle E., Wittmann C. Free intracellular amino acid pools during autonomous oscillations in Saccharomyces cerevisiae. Biotechnol. Bioeng. 2003, 82:143-151.
    • (2003) Biotechnol. Bioeng. , vol.82 , pp. 143-151
    • Hans, M.A.1    Heinzle, E.2    Wittmann, C.3
  • 22
    • 79955939126 scopus 로고    scopus 로고
    • Unraveling the metabolism of HEK-293 cells using lactate isotopomer analysis
    • Henry O., Jolicoeur M., Kamen A. Unraveling the metabolism of HEK-293 cells using lactate isotopomer analysis. Bioprocess Biosyst. Eng. 2011, 34:263-273.
    • (2011) Bioprocess Biosyst. Eng. , vol.34 , pp. 263-273
    • Henry, O.1    Jolicoeur, M.2    Kamen, A.3
  • 23
    • 0024402814 scopus 로고
    • Calcium entry blockers in the treatment of hypertension. Current status and future prospects
    • Kaplan N.M. Calcium entry blockers in the treatment of hypertension. Current status and future prospects. JAMA 1989, 262:817-823.
    • (1989) JAMA , vol.262 , pp. 817-823
    • Kaplan, N.M.1
  • 24
    • 33846643485 scopus 로고    scopus 로고
    • Down-regulation of lactate dehydrogenase-A by siRNAs for reduced lactic acid formation of Chinese hamster ovary cells producing thrombopoietin
    • Kim S.H., Lee G.M. Down-regulation of lactate dehydrogenase-A by siRNAs for reduced lactic acid formation of Chinese hamster ovary cells producing thrombopoietin. Appl. Microbiol. Biotechnol. 2007, 74:152-159.
    • (2007) Appl. Microbiol. Biotechnol. , vol.74 , pp. 152-159
    • Kim, S.H.1    Lee, G.M.2
  • 25
    • 15544375310 scopus 로고    scopus 로고
    • In vivo quantification of intracellular amino acids and intermediates of the methionine pathway in Corynebacterium glutamicum
    • Kromer J.O., Fritz M., Heinzle E., Wittmann C. In vivo quantification of intracellular amino acids and intermediates of the methionine pathway in Corynebacterium glutamicum. Anal. Biochem. 2005, 340:171-173.
    • (2005) Anal. Biochem. , vol.340 , pp. 171-173
    • Kromer, J.O.1    Fritz, M.2    Heinzle, E.3    Wittmann, C.4
  • 27
    • 68049129530 scopus 로고    scopus 로고
    • Quantification of statin effects on hepatic cholesterol synthesis by transient 13C-flux analysis
    • Maier K., Hofmann U., Bauer A., Niebel A., Vacun G., Reuss M., Mauch K. Quantification of statin effects on hepatic cholesterol synthesis by transient 13C-flux analysis. Metab. Eng. 2009, 11:292-309.
    • (2009) Metab. Eng. , vol.11 , pp. 292-309
    • Maier, K.1    Hofmann, U.2    Bauer, A.3    Niebel, A.4    Vacun, G.5    Reuss, M.6    Mauch, K.7
  • 28
    • 33646549629 scopus 로고    scopus 로고
    • Metabolism of PER.C6 cells cultivated under fed-batch conditions at low glucose and glutamine levels
    • Maranga L., Goochee C.F. Metabolism of PER.C6 cells cultivated under fed-batch conditions at low glucose and glutamine levels. Biotechnol. Bioeng. 2006, 94:139-150.
    • (2006) Biotechnol. Bioeng. , vol.94 , pp. 139-150
    • Maranga, L.1    Goochee, C.F.2
  • 30
    • 70349767923 scopus 로고    scopus 로고
    • Effects of drugs in subtoxic concentrations on the metabolic fluxes in human hepatoma cell line Hep G2
    • Niklas J., Noor F., Heinzle E. Effects of drugs in subtoxic concentrations on the metabolic fluxes in human hepatoma cell line Hep G2. Toxicol. Appl. Pharmacol. 2009, 240:327-336.
    • (2009) Toxicol. Appl. Pharmacol. , vol.240 , pp. 327-336
    • Niklas, J.1    Noor, F.2    Heinzle, E.3
  • 32
    • 79956205237 scopus 로고    scopus 로고
    • Quantitative characterization of metabolism and metabolic shifts during growth of the new human cell line AGE1.HN using time resolved metabolic flux analysis
    • Niklas J., Schräder E., Sandig V., Noll T., Heinzle E. Quantitative characterization of metabolism and metabolic shifts during growth of the new human cell line AGE1.HN using time resolved metabolic flux analysis. Bioprocess Biosyst. Eng. 2011, 34:533-545. 10.1007/s00449-010-0502-y.
    • (2011) Bioprocess Biosyst. Eng. , vol.34 , pp. 533-545
    • Niklas, J.1    Schräder, E.2    Sandig, V.3    Noll, T.4    Heinzle, E.5
  • 33
    • 0028979470 scopus 로고
    • On-line gas analysis in animal cell cultivation: I. Control of dissolved oxygen and pH
    • Oeggerli A., Eyer K., Heinzle E. On-line gas analysis in animal cell cultivation: I. Control of dissolved oxygen and pH. Biotechnol. Bioeng. 1995, 45:42-53.
    • (1995) Biotechnol. Bioeng. , vol.45 , pp. 42-53
    • Oeggerli, A.1    Eyer, K.2    Heinzle, E.3
  • 34
    • 0037112480 scopus 로고    scopus 로고
    • Functional expression of the hyperpolarization-activated, non-selective cation current If in immortalized HL-1 cardiomyocytes
    • Sartiani L., Bochet P., Cerbai E., Mugelli A., Fischmeister R. Functional expression of the hyperpolarization-activated, non-selective cation current If in immortalized HL-1 cardiomyocytes. J. Physiol. 2002, 545:81-92.
    • (2002) J. Physiol. , vol.545 , pp. 81-92
    • Sartiani, L.1    Bochet, P.2    Cerbai, E.3    Mugelli, A.4    Fischmeister, R.5
  • 35
    • 0023735168 scopus 로고
    • Antiproliferative effect of verapamil alone on brain tumor cells in vitro
    • Schmidt W.F., Huber K.R., Ettinger R.S., Neuberg R.W. Antiproliferative effect of verapamil alone on brain tumor cells in vitro. Cancer Res. 1988, 48:3617-3621.
    • (1988) Cancer Res. , vol.48 , pp. 3617-3621
    • Schmidt, W.F.1    Huber, K.R.2    Ettinger, R.S.3    Neuberg, R.W.4
  • 36
    • 0942265668 scopus 로고    scopus 로고
    • Inhibition of glucose uptake in murine cardiomyocyte cell line HL-1 by cardioprotective drugs dilazep and dipyridamole
    • Shuralyova I., Tajmir P., Bilan P.J., Sweeney G., Coe I.R. Inhibition of glucose uptake in murine cardiomyocyte cell line HL-1 by cardioprotective drugs dilazep and dipyridamole. Am. J. Physiol. Heart Circ. Physiol. 2004, 286:H627-H632.
    • (2004) Am. J. Physiol. Heart Circ. Physiol. , vol.286
    • Shuralyova, I.1    Tajmir, P.2    Bilan, P.J.3    Sweeney, G.4    Coe, I.R.5
  • 37
    • 42049113587 scopus 로고    scopus 로고
    • Comparison of metabolic flux distributions for MDCK cell growth in glutamine- and pyruvate-containing media
    • Sidorenko Y., Wahl A., Dauner M., Genzel Y., Reichl U. Comparison of metabolic flux distributions for MDCK cell growth in glutamine- and pyruvate-containing media. Biotechnol. Prog. 2008, 24:311-320.
    • (2008) Biotechnol. Prog. , vol.24 , pp. 311-320
    • Sidorenko, Y.1    Wahl, A.2    Dauner, M.3    Genzel, Y.4    Reichl, U.5
  • 39
    • 0019430432 scopus 로고
    • Overcoming of vincristine resistance in P388 Leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil
    • Tsuruo T., Iida H., Tsukagoshi S., Sakurai Y. Overcoming of vincristine resistance in P388 Leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil. Cancer Res. 1981, 41:1967-1972.
    • (1981) Cancer Res. , vol.41 , pp. 1967-1972
    • Tsuruo, T.1    Iida, H.2    Tsukagoshi, S.3    Sakurai, Y.4
  • 40
    • 33845250184 scopus 로고    scopus 로고
    • Isotopomer analysis of myocardial substrate metabolism: a systems biology approach
    • Vo T.D., Palsson B.O. Isotopomer analysis of myocardial substrate metabolism: a systems biology approach. Biotechnol. Bioeng. 2006, 95:972-983.
    • (2006) Biotechnol. Bioeng. , vol.95 , pp. 972-983
    • Vo, T.D.1    Palsson, B.O.2
  • 41
    • 0036022002 scopus 로고    scopus 로고
    • Modeling of mixing in 96-well microplates observed with fluorescence indicators
    • Weiss S., John G.T., Klimant I., Heinzle E. Modeling of mixing in 96-well microplates observed with fluorescence indicators. Biotechnol. Prog. 2002, 18:821-830.
    • (2002) Biotechnol. Prog. , vol.18 , pp. 821-830
    • Weiss, S.1    John, G.T.2    Klimant, I.3    Heinzle, E.4
  • 42
    • 1342346691 scopus 로고    scopus 로고
    • Cardiac physiology at the cellular level: use of cultured HL-1 cardiomyocytes for studies of cardiac muscle cell structure and function
    • White S.M., Constantin P.E., Claycomb W.C. Cardiac physiology at the cellular level: use of cultured HL-1 cardiomyocytes for studies of cardiac muscle cell structure and function. Am. J. Physiol. Heart Circ. Physiol. 2004, 286:H823-H829.
    • (2004) Am. J. Physiol. Heart Circ. Physiol. , vol.286
    • White, S.M.1    Constantin, P.E.2    Claycomb, W.C.3
  • 45
    • 64249155974 scopus 로고    scopus 로고
    • Numerical bias estimation for mass spectrometric mass isotopomer analysis
    • Yang T.H., Bolten C.J., Coppi M.V., Sun J., Heinzle E. Numerical bias estimation for mass spectrometric mass isotopomer analysis. Anal. Biochem. 2009, 388:192-203.
    • (2009) Anal. Biochem. , vol.388 , pp. 192-203
    • Yang, T.H.1    Bolten, C.J.2    Coppi, M.V.3    Sun, J.4    Heinzle, E.5
  • 46
    • 42649132891 scopus 로고    scopus 로고
    • Hybrid optimization for 13C metabolic flux analysis using systems parametrized by compactification
    • Yang T.H., Frick O., Heinzle E. Hybrid optimization for 13C metabolic flux analysis using systems parametrized by compactification. BMC Syst. Biol. 2008, 2:29.
    • (2008) BMC Syst. Biol. , vol.2 , pp. 29
    • Yang, T.H.1    Frick, O.2    Heinzle, E.3
  • 47
    • 61449207399 scopus 로고    scopus 로고
    • Effect of verapamil on the expression of EGFR and NM23 in A549 human lung cancer cells
    • Zhang C., Lv F., Zhou L., Li X., Wu X.X., Hoffman R.M. Effect of verapamil on the expression of EGFR and NM23 in A549 human lung cancer cells. Anticancer Res. 2009, 29:27-32.
    • (2009) Anticancer Res. , vol.29 , pp. 27-32
    • Zhang, C.1    Lv, F.2    Zhou, L.3    Li, X.4    Wu, X.X.5    Hoffman, R.M.6
  • 48
    • 34347373652 scopus 로고    scopus 로고
    • Reversing adriamycin resistance of human breast cancer cells by hyperthermia combined with Interferon alpha and Verapamil
    • Zhang L., Yang Y., Wei X.Y., Shi Y.R., Liu H.Y., Niu R.F., Hao X.S. Reversing adriamycin resistance of human breast cancer cells by hyperthermia combined with Interferon alpha and Verapamil. J. Exp. Clin. Cancer Res. 2007, 26:201-207.
    • (2007) J. Exp. Clin. Cancer Res. , vol.26 , pp. 201-207
    • Zhang, L.1    Yang, Y.2    Wei, X.Y.3    Shi, Y.R.4    Liu, H.Y.5    Niu, R.F.6    Hao, X.S.7
  • 49
    • 0029059493 scopus 로고
    • High viable cell concentration fed-batch cultures of hybridoma cells through on-line nutrient feeding
    • Zhou W., Rehm J., Hu W.S. High viable cell concentration fed-batch cultures of hybridoma cells through on-line nutrient feeding. Biotechnol. Bioeng. 1995, 46:579-587.
    • (1995) Biotechnol. Bioeng. , vol.46 , pp. 579-587
    • Zhou, W.1    Rehm, J.2    Hu, W.S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.