Deregulated Cdk5 triggers aberrant activation of cell cycle kinases and phosphatases inducing neuronal death

Journal of Cell Science

Volumn 125, Issue 21, 2012, Pages 5124-5137

  Chang, Kuei Hua ^a   Vincent, Fabien ^a   Shah, Kavita ^a  

^a PURDUE UNIVERSITY   (United States)

Author keywords

Alzheimer's disease; Cdc25; Cdk5; Chemical genetic screen

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; CDC25A PROTEIN; CDC25B PROTEIN; CDC25C PROTEIN; CELL CYCLE PROTEIN; CYCLIN DEPENDENT KINASE 5; PHOSPHATASE; PHOSPHOTRANSFERASE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ARTICLE; CELL ACTIVATION; CELL DEATH; CELL LYSATE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; GENETIC SCREENING; HUMAN; IN VITRO STUDY; NEURONAL DEATH; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN PHOSPHORYLATION; UPREGULATION;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; CDC2 PROTEIN KINASE; CDC25 PHOSPHATASES; CELL DEATH; CELLS, CULTURED; CYCLIN-DEPENDENT KINASE 5; ENZYME ACTIVATION; FEMALE; HUMANS; MICE; NEURONS; PEPTIDE FRAGMENTS; PHOSPHORYLATION; PRIMARY CELL CULTURE; PROTEIN PROCESSING, POST-TRANSLATIONAL; RATS; RATS, SPRAGUE-DAWLEY; UP-REGULATION;

EID: 84872256294     PISSN: 00219533     EISSN: 14779137     Source Type: Journal    
DOI: 10.1242/jcs.108183     Document Type: Article

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