메뉴 건너뛰기




Volumn 115, Issue 6, 2010, Pages 1309-1321

Regulation and role of cyclin-dependent kinase activity in neuronal survival and death

Author keywords

cyclin dependent kinase 5; death; neurodegenerative diseases; phosphorylation; survival

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CYCLIN B; CYCLIN DEPENDENT KINASE 1; CYCLIN DEPENDENT KINASE 5; CYTOCHROME C; MITOGEN ACTIVATED PROTEIN KINASE 10; NEU DIFFERENTIATION FACTOR; PROTEIN P39;

EID: 78650004185     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2010.07050.x     Document Type: Review
Times cited : (98)

References (142)
  • 1
    • 0036470547 scopus 로고    scopus 로고
    • Cyclin-dependent kinase 5 (cdk5) activation requires interaction with three domains of p35
    • Amin N. D., Albers W., and, Pant H. C., (2002) Cyclin-dependent kinase 5 (cdk5) activation requires interaction with three domains of p35. J. Neurosci. Res. 67, 354-362.
    • (2002) J. Neurosci. Res. , vol.67 , pp. 354-362
    • Amin, N.D.1    Albers, W.2    Pant, H.C.3
  • 2
    • 48249132446 scopus 로고    scopus 로고
    • Myristoylation of p39 and p35 is a determinant of cytoplasmic or nuclear localization of active cycline-dependent kinase 5 (Cdk5) complexes
    • Asada A., Yamamoto N., Gohda M., Saito T., Hayashi N., and, Hisanaga S., (2008) Myristoylation of p39 and p35 is a determinant of cytoplasmic or nuclear localization of active cycline-dependent kinase 5 (Cdk5) complexes. J. Neurochem. 106, 1325-1336.
    • (2008) J. Neurochem. , vol.106 , pp. 1325-1336
    • Asada, A.1    Yamamoto, N.2    Gohda, M.3    Saito, T.4    Hayashi, N.5    Hisanaga, S.6
  • 4
    • 10444252648 scopus 로고    scopus 로고
    • Role of Cdk5 in drug abuse and plasticity
    • Benavides D. R., and, Bibb J. A., (2004) Role of Cdk5 in drug abuse and plasticity. Ann. N Y Acad. Sci. 1025, 335-344.
    • (2004) Ann. N y Acad. Sci. , vol.1025 , pp. 335-344
    • Benavides, D.R.1    Bibb, J.A.2
  • 5
    • 34147135990 scopus 로고    scopus 로고
    • AKT and CDK5/p35 mediate brain-derived neurotrophic factor induction of DARPP-32 in medium size spiny neurons in vitro
    • Bogush A., Pedrini S., Pelta-Heller J., Chan T., Yang Q., Mao Z., Sluzas E., Gieringer T., and, Ehrlich M. E., (2007) AKT and CDK5/p35 mediate brain-derived neurotrophic factor induction of DARPP-32 in medium size spiny neurons in vitro. J. Biol. Chem. 282, 7352-7359.
    • (2007) J. Biol. Chem. , vol.282 , pp. 7352-7359
    • Bogush, A.1    Pedrini, S.2    Pelta-Heller, J.3    Chan, T.4    Yang, Q.5    Mao, Z.6    Sluzas, E.7    Gieringer, T.8    Ehrlich, M.E.9
  • 7
    • 77953593623 scopus 로고    scopus 로고
    • Cyclin I-Cdk5 governs survival in post-mitotic cells
    • Brinkkoetter P. T., Pippin J. W., and, Shankland S. J., (2010) Cyclin I-Cdk5 governs survival in post-mitotic cells. Cell Cycle 9, 1729-1971.
    • (2010) Cell Cycle , vol.9 , pp. 1729-1971
    • Brinkkoetter, P.T.1    Pippin, J.W.2    Shankland, S.J.3
  • 8
    • 0036703779 scopus 로고    scopus 로고
    • Deregulation of cdk5, hyperphosphorylation, and cytoskeletal pathology in the Niemann-Pick type C murine model
    • Bu B., Li J., Davies P., and, Vincent I., (2002) Deregulation of cdk5, hyperphosphorylation, and cytoskeletal pathology in the Niemann-Pick type C murine model. J. Neurosci. 22, 6515-6525.
    • (2002) J. Neurosci. , vol.22 , pp. 6515-6525
    • Bu, B.1    Li, J.2    Davies, P.3    Vincent, I.4
  • 10
    • 0031018336 scopus 로고    scopus 로고
    • Mice lacking p35, a neuronal specific activator of Cdk5, display cortical lamination defects, seizures, and adult lethality
    • Chae T, Kwon Y. T., Bronson R., Dikkes P., Li E., and, Tsai L. H., (1997) Mice lacking p35, a neuronal specific activator of Cdk5, display cortical lamination defects, seizures, and adult lethality. Neuron 18, 29-42.
    • (1997) Neuron , vol.18 , pp. 29-42
    • Chae, T.1    Kwon, Y.T.2    Bronson, R.3    Dikkes, P.4    Li, E.5    Tsai, L.H.6
  • 11
    • 33645507078 scopus 로고    scopus 로고
    • Role of heat-shock factor 2 in cerebral cortex formation and as a regulator of p35 expression
    • Chang Y., Ostling P., Akerfelt M., et al. (2006) Role of heat-shock factor 2 in cerebral cortex formation and as a regulator of p35 expression. Genes Dev. 20, 836-847.
    • (2006) Genes Dev. , vol.20 , pp. 836-847
    • Chang, Y.1    Ostling, P.2    Akerfelt, M.3
  • 12
    • 77951932919 scopus 로고    scopus 로고
    • Cdk5 is a major regulator of p38 cascade: Relevance to neurotoxicity in Alzheimer's disease
    • Chang K. H., De Pablo Y., Lee H. P., Lee H. G., Smith M. A., and, Shah K., (2010) Cdk5 is a major regulator of p38 cascade: relevance to neurotoxicity in Alzheimer's disease. J. Neurochem. 113, 1221-1229.
    • (2010) J. Neurochem. , vol.113 , pp. 1221-1229
    • Chang, K.H.1    De Pablo, Y.2    Lee, H.P.3    Lee, H.G.4    Smith, M.A.5    Shah, K.6
  • 14
    • 2342634487 scopus 로고    scopus 로고
    • Cdk5: Mediator of neuronal death and survival
    • Cheung Z. H., and, Ip N. Y., (2004) Cdk5: mediator of neuronal death and survival. Neurosci. Lett. 361, 47-51.
    • (2004) Neurosci. Lett. , vol.361 , pp. 47-51
    • Cheung, Z.H.1    Ip, N.Y.2
  • 15
    • 34548496016 scopus 로고    scopus 로고
    • The roles of cyclin-dependent kinase 5 in dendrite and synapse development
    • Cheung Z. H., and, Ip NY., (2007) The roles of cyclin-dependent kinase 5 in dendrite and synapse development. Biotechnol. J. 2, 949-957.
    • (2007) Biotechnol. J. , vol.2 , pp. 949-957
    • Cheung, Z.H.1    Ip, N.Y.2
  • 16
    • 34247342131 scopus 로고    scopus 로고
    • Cdk5 is involved in BDNF-stimulated dendritic growth in hippocampal neurons
    • Cheung Z. H., Chin W. H., Chen Y., Ng Y. P., and, Ip N. Y., (2007) Cdk5 is involved in BDNF-stimulated dendritic growth in hippocampal neurons. PLoS Biol. 5, 865-877.
    • (2007) PLoS Biol. , vol.5 , pp. 865-877
    • Cheung, Z.H.1    Chin, W.H.2    Chen, Y.3    Ng, Y.P.4    Ip, N.Y.5
  • 17
    • 44949105375 scopus 로고    scopus 로고
    • Cyclin-dependent kinase 5 supports neuronal survival through phosphorylation of Bcl-2
    • Cheung Z. H., Gong K., and, Ip N. Y., (2008) Cyclin-dependent kinase 5 supports neuronal survival through phosphorylation of Bcl-2. J. Neurosci. 28, 4872-4877.
    • (2008) J. Neurosci. , vol.28 , pp. 4872-4877
    • Cheung, Z.H.1    Gong, K.2    Ip, N.Y.3
  • 18
    • 37249036671 scopus 로고    scopus 로고
    • Activity-dependent control of bulk endocytosis by protein dephosphorylation in central nerve terminals
    • Clayton E. L., Evancs G. J. O., and, Cousin M. A., (2007) Activity-dependent control of bulk endocytosis by protein dephosphorylation in central nerve terminals. J. Physiol. 585, 687-691.
    • (2007) J. Physiol. , vol.585 , pp. 687-691
    • Clayton, E.L.1    Evancs, G.J.O.2    Cousin, M.A.3
  • 19
    • 35248821113 scopus 로고    scopus 로고
    • Collapsin response mediator protein-2 hyperphosphorylation is an early event in Alzheimer's disease progression
    • Cole A. R., Noble W., Van Aalten L., et al. (2007) Collapsin response mediator protein-2 hyperphosphorylation is an early event in Alzheimer's disease progression. J. Neurochem. 103, 1132-1144.
    • (2007) J. Neurochem. , vol.103 , pp. 1132-1144
    • Cole, A.R.1    Noble, W.2    Van Aalten, L.3
  • 20
    • 4444262625 scopus 로고    scopus 로고
    • Cdk5 deregulation in the pathogenesis of Alzheimer's disease
    • Cruz J. C., and, Tsai L. H., (2004) Cdk5 deregulation in the pathogenesis of Alzheimer's disease. Trends Mol. Med. 10, 452-458.
    • (2004) Trends Mol. Med. , vol.10 , pp. 452-458
    • Cruz, J.C.1    Tsai, L.H.2
  • 21
    • 0345405447 scopus 로고    scopus 로고
    • Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles
    • Cruz J. C., Tseng H. C., Goldman J. A., Shih H., and, Tsai L. H., (2003) Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles. Neuron 40, 471-483.
    • (2003) Neuron , vol.40 , pp. 471-483
    • Cruz, J.C.1    Tseng, H.C.2    Goldman, J.A.3    Shih, H.4    Tsai, L.H.5
  • 22
    • 33749826587 scopus 로고    scopus 로고
    • P25/cyclin-dependent kinase 5 induces production and intraneuronal accumulation of amyloid β in vivo
    • Cruz J. C., Kim D., Moy L. Y., Dobbin M. M., Sun X., Bronson R. T., and, Tsai L-H., (2006) p25/cyclin-dependent kinase 5 induces production and intraneuronal accumulation of amyloid β in vivo. J. Neurosci. 26, 10536-10541.
    • (2006) J. Neurosci. , vol.26 , pp. 10536-10541
    • Cruz, J.C.1    Kim, D.2    Moy, L.Y.3    Dobbin, M.M.4    Sun, X.5    Bronson, R.T.6    Tsai, L.-H.7
  • 25
    • 70350031561 scopus 로고    scopus 로고
    • Commitment of MPP+-induced neuronal cell death by proteasome-mediated degradation of p35 Cdk5 activator
    • Endo R., Saito T., Asada A., Kawahara H., Ohshima T., and, Hisanaga S., (2009) Commitment of MPP+-induced neuronal cell death by proteasome-mediated degradation of p35 Cdk5 activator. J. Biol. Chem. 284, 26029-26039.
    • (2009) J. Biol. Chem. , vol.284 , pp. 26029-26039
    • Endo, R.1    Saito, T.2    Asada, A.3    Kawahara, H.4    Ohshima, T.5    Hisanaga, S.6
  • 26
    • 0031297716 scopus 로고    scopus 로고
    • Myt1: A Wee1-type kinase that phosphorylates Cdc2 on residue Thr14
    • Fattaey A., and, Booher R. N., (1997) Myt1: a Wee1-type kinase that phosphorylates Cdc2 on residue Thr14. Prog. Cell Cycle Res. 3, 233-240.
    • (1997) Prog. Cell Cycle Res. , vol.3 , pp. 233-240
    • Fattaey, A.1    Booher, R.N.2
  • 27
    • 2342483179 scopus 로고    scopus 로고
    • Cyclin-dependent kinase 5 phosphorylates signal transducer and activator of transcription 3 and regulates its transcriptional activity
    • Fu A. K., Fu W. Y., Ng A. K., Chien W. W., Ng Y. P., Wang J. H., and, Ip N. Y., (2004) Cyclin-dependent kinase 5 phosphorylates signal transducer and activator of transcription 3 and regulates its transcriptional activity. Proc. Natl Acad. Sci. USA 101, 6728-6233.
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , pp. 6728-6233
    • Fu, A.K.1    Fu, W.Y.2    Ng, A.K.3    Chien, W.W.4    Ng, Y.P.5    Wang, J.H.6    Ip, N.Y.7
  • 28
    • 33845899093 scopus 로고    scopus 로고
    • Cdk5 regulates EphA4-mediated dendritic spine retraction through an ephexin1-dependent mechanism
    • Fu W. Y., Chen Y., Sahin M., et al. (2007) Cdk5 regulates EphA4-mediated dendritic spine retraction through an ephexin1-dependent mechanism. Nat. Neurosci. 10, 67-76.
    • (2007) Nat. Neurosci. , vol.10 , pp. 67-76
    • Fu, W.Y.1    Chen, Y.2    Sahin, M.3
  • 29
    • 0037431130 scopus 로고    scopus 로고
    • Cdk5-mediated inhibition of the protective effects of transcription factor MEF2 in neurotoxicity-induced apoptosis
    • Gong X., Tang X., Wiedmann M., Wang X., Peng J., Zheng D., Blair L. A. C., Marshall J., and, Mao Z., (2003) Cdk5-mediated inhibition of the protective effects of transcription factor MEF2 in neurotoxicity-induced apoptosis. Neuron 38, 33-46.
    • (2003) Neuron , vol.38 , pp. 33-46
    • Gong, X.1    Tang, X.2    Wiedmann, M.3    Wang, X.4    Peng, J.5    Zheng, D.6    Blair, L.A.C.7    Marshall, J.8    Mao, Z.9
  • 30
    • 0034681926 scopus 로고    scopus 로고
    • Neurofibrillary tangle-associated collapsin response mediator protein-2 (CRMP-2) is highly phosphorylated on Thr-509, Ser-518, and Ser-522
    • Gu Y., Hamajima N., and, Ihara Y., (2000) Neurofibrillary tangle-associated collapsin response mediator protein-2 (CRMP-2) is highly phosphorylated on Thr-509, Ser-518, and Ser-522. Biochemistry 39, 4267-4275.
    • (2000) Biochemistry , vol.39 , pp. 4267-4275
    • Gu, Y.1    Hamajima, N.2    Ihara, Y.3
  • 32
    • 0035021950 scopus 로고    scopus 로고
    • ERK induces p35, a neuron-specific activator of Cdk5, through induction of Egr1
    • Harada T., Morooka T., Ogawa S., and, Nishida E., (2001) ERK induces p35, a neuron-specific activator of Cdk5, through induction of Egr1. Nat. Cell Biol. 3, 453-459.
    • (2001) Nat. Cell Biol. , vol.3 , pp. 453-459
    • Harada, T.1    Morooka, T.2    Ogawa, S.3    Nishida, E.4
  • 33
    • 0347785492 scopus 로고    scopus 로고
    • Truncation of CDK5 activator p35 induces intensive phosphorylation of Ser202/Thr205 of human tau
    • Hashiguchi M., Saito T., Hisanaga S., and, Hashiguchi T., (2002) Truncation of CDK5 activator p35 induces intensive phosphorylation of Ser202/Thr205 of human tau. J. Biol. Chem. 277, 44525-44530.
    • (2002) J. Biol. Chem. , vol.277 , pp. 44525-44530
    • Hashiguchi, M.1    Saito, T.2    Hisanaga, S.3    Hashiguchi, T.4
  • 34
    • 34548515717 scopus 로고    scopus 로고
    • Alternative roles for Cdk5 in learning and synaptic plasticity
    • Hawasli A. H., and, Bibb J. A., (2007) Alternative roles for Cdk5 in learning and synaptic plasticity. Biotechnol. J. 2, 941-948.
    • (2007) Biotechnol. J. , vol.2 , pp. 941-948
    • Hawasli, A.H.1    Bibb, J.A.2
  • 36
    • 0348010572 scopus 로고    scopus 로고
    • The regulation of cyclin-dependent kinase 5 activity through the metabolism of p35 or p39 Cdk5 activator
    • Hisanaga S., and, Saito T., (2003) The regulation of cyclin-dependent kinase 5 activity through the metabolism of p35 or p39 Cdk5 activator. Neurosignals 12, 221-229.
    • (2003) Neurosignals , vol.12 , pp. 221-229
    • Hisanaga, S.1    Saito, T.2
  • 40
    • 0038030381 scopus 로고    scopus 로고
    • P39 activates cdk5 in neurons, and is associated with the actin cytoskeleton
    • Humbert S., Dhavan R., and, Tsai L.-H., (2000) p39 activates cdk5 in neurons, and is associated with the actin cytoskeleton. J. Cell Sci. 113, 975-983.
    • (2000) J. Cell Sci. , vol.113 , pp. 975-983
    • Humbert, S.1    Dhavan, R.2    Tsai, L.-H.3
  • 41
    • 0037426613 scopus 로고    scopus 로고
    • The cyclin-dependent kinase 5 activator, p39, is expressed in stripes in the mouse cerebellum
    • Jeong Y. G., Rosales J. L., Marzban H., Sillitoe R. V., Park D. G., Hawkes R., and, Lee K. Y., (2003) The cyclin-dependent kinase 5 activator, p39, is expressed in stripes in the mouse cerebellum. Neuroscience 118, 323-334.
    • (2003) Neuroscience , vol.118 , pp. 323-334
    • Jeong, Y.G.1    Rosales, J.L.2    Marzban, H.3    Sillitoe, R.V.4    Park, D.G.5    Hawkes, R.6    Lee, K.Y.7
  • 44
    • 33748710614 scopus 로고    scopus 로고
    • Cyclin-dependent kinase 5 influences Rohon-Beard neuron survival in zebrafish
    • Kanungo J., Li B-S., Zheng Y., and, Pant H. C., (2006) Cyclin-dependent kinase 5 influences Rohon-Beard neuron survival in zebrafish. J. Neurochem. 99, 251-259.
    • (2006) J. Neurochem. , vol.99 , pp. 251-259
    • Kanungo, J.1    Li, B.-S.2    Zheng, Y.3    Pant, H.C.4
  • 45
    • 37149056530 scopus 로고    scopus 로고
    • Molecular pathways regulating cytoskeletal organization and morphological changes in migrating neurons
    • Kawauchi T., and, Hoshino M., (2008) Molecular pathways regulating cytoskeletal organization and morphological changes in migrating neurons. Dev. Neurosci. 30, 36-46.
    • (2008) Dev. Neurosci. , vol.30 , pp. 36-46
    • Kawauchi, T.1    Hoshino, M.2
  • 46
    • 0037109186 scopus 로고    scopus 로고
    • Influence of phosphorylation of p35, an activator of cyclin-dependent kinase 5 (cdk5), on the proteolysis of p35
    • DOI 10.1016/S0169-328X(02)00409-6, PII S0169328X02004096
    • Kerokoski P., Suuronen T., Salminen A., Soininen H., and, Pirttila T., (2002) Influence of phosphorylation of p35, an activator of cyclin-dependent kinase 5 (cdk5), on the proteolysis of p35. Brain Res. Mol. Brain Res. 106, 50-56. (Pubitemid 35223279)
    • (2002) Molecular Brain Research , vol.106 , Issue.1-2 , pp. 50-56
    • Kerokoski, P.1    Suuronen, T.2    Salminen, A.3    Soininen, H.4    Pirttila, T.5
  • 47
    • 1542269015 scopus 로고    scopus 로고
    • Neuronal cyclin-dependent kinase 5: Role in nervous system function and its specific inhibition by the Cdk5 inhibitory peptide
    • Kesavapany S., Li B.-S., Amin N., Zhen Y.-L., Grant P., and, Pant H. C., (2004) Neuronal cyclin-dependent kinase 5: role in nervous system function and its specific inhibition by the Cdk5 inhibitory peptide. Biochim. Biophys. Acta 1697, 143-153.
    • (2004) Biochim. Biophys. Acta , vol.1697 , pp. 143-153
    • Kesavapany, S.1    Li, B.-S.2    Amin, N.3    Zhen, Y.-L.4    Grant, P.5    Pant, H.C.6
  • 48
    • 0242493699 scopus 로고    scopus 로고
    • Kinetic simulation of signal transduction system in hippocampal long-term potentiation with dynamic modeling of protein phosphatase 2A
    • Kikuchi S., Fujimoto K., Kitagawa N., Fuchikawa T., Abe M., Oka K., Takei K., and, Tomita M., (2003) Kinetic simulation of signal transduction system in hippocampal long-term potentiation with dynamic modeling of protein phosphatase 2A. Neural Netw. 16, 1389-1398.
    • (2003) Neural Netw. , vol.16 , pp. 1389-1398
    • Kikuchi, S.1    Fujimoto, K.2    Kitagawa, N.3    Fuchikawa, T.4    Abe, M.5    Oka, K.6    Takei, K.7    Tomita, M.8
  • 49
    • 57049177826 scopus 로고    scopus 로고
    • Deregulation of HDAC1 by p25/Cdk5 in neurotoxicity
    • Kim D., Frank C. L., Dobbin M. M., et al. (2008) Deregulation of HDAC1 by p25/Cdk5 in neurotoxicity. Neuron 60, 803-817.
    • (2008) Neuron , vol.60 , pp. 803-817
    • Kim, D.1    Frank, C.L.2    Dobbin, M.M.3
  • 50
    • 0035448915 scopus 로고    scopus 로고
    • P35 and p39 are essential for cyclin-dependent kinase 5 function during neurodevelopment
    • Ko J., Humbert S., Bronson R. T., Takahashi S., Kulkarni A. B., Li E., and, Tsai L.-H., (2001) p35 and p39 are essential for cyclin-dependent kinase 5 function during neurodevelopment. J. Neurosci. 21, 6758-6871.
    • (2001) J. Neurosci. , vol.21 , pp. 6758-6871
    • Ko, J.1    Humbert, S.2    Bronson, R.T.3    Takahashi, S.4    Kulkarni, A.B.5    Li, E.6    Tsai, L.-H.7
  • 51
    • 0034595834 scopus 로고    scopus 로고
    • Calpain-dependent proteolytic cleavage of the p35 cyclin-dependent kinase 5 activator to p25
    • Kusakawa G., Saito T., Onuki R., Ishiguro K., Kishimoto T., and, Hisanaga S., (2000) Calpain-dependent proteolytic cleavage of the p35 cyclin-dependent kinase 5 activator to p25. J. Biol. Chem. 275, 17166-17172.
    • (2000) J. Biol. Chem. , vol.275 , pp. 17166-17172
    • Kusakawa, G.1    Saito, T.2    Onuki, R.3    Ishiguro, K.4    Kishimoto, T.5    Hisanaga, S.6
  • 52
    • 67651121690 scopus 로고    scopus 로고
    • Recent advances in understanding the roles of Cdk5 in synaptic plasticity
    • Lai K. O., and, Ip N. Y., (2009) Recent advances in understanding the roles of Cdk5 in synaptic plasticity. Biochim. Biophys. Acta 1792, 741-745.
    • (2009) Biochim. Biophys. Acta , vol.1792 , pp. 741-745
    • Lai, K.O.1    Ip, N.Y.2
  • 53
    • 20444404218 scopus 로고    scopus 로고
    • A specific interaction between muskelin and the cyclin-dependent kinase 5 activator p39 promotes peripheral localization of muskelin
    • Ledee D. R., Gao C. Y., Seth R., Fariss R. N., Tripathi B. K., and, Zelenka P. S., (2005) A specific interaction between muskelin and the cyclin-dependent kinase 5 activator p39 promotes peripheral localization of muskelin. J. Biol. Chem. 280, 21376-21383.
    • (2005) J. Biol. Chem. , vol.280 , pp. 21376-21383
    • Ledee, D.R.1    Gao, C.Y.2    Seth, R.3    Fariss, R.N.4    Tripathi, B.K.5    Zelenka, P.S.6
  • 54
    • 7244260747 scopus 로고    scopus 로고
    • Induction of cyclin-dependent kinase 5 and its activator p35 through the extracellular-signal-regulated kinase and protein kinase A pathways during retinoic-acid mediated neuronal differentiation in human neuroblastoma SK-N-BE(2)C cells
    • Lee J.-H., and, Kim K.-T., (2004) Induction of cyclin-dependent kinase 5 and its activator p35 through the extracellular-signal-regulated kinase and protein kinase A pathways during retinoic-acid mediated neuronal differentiation in human neuroblastoma SK-N-BE(2)C cells. J. Neurochem. 91, 634-647.
    • (2004) J. Neurochem. , vol.91 , pp. 634-647
    • Lee, J.-H.1    Kim, K.-T.2
  • 55
    • 0030049968 scopus 로고    scopus 로고
    • Interaction of cyclin-dependent kinase 5 (Cdk5) and neuronal Cdk5 activator in bovine brain
    • Lee K. Y., Rosales J. L., Tang D., and, Wang J. H., (1996) Interaction of cyclin-dependent kinase 5 (Cdk5) and neuronal Cdk5 activator in bovine brain. J. Biol. Chem. 271, 1538-1543.
    • (1996) J. Biol. Chem. , vol.271 , pp. 1538-1543
    • Lee, K.Y.1    Rosales, J.L.2    Tang, D.3    Wang, J.H.4
  • 56
    • 0031054972 scopus 로고    scopus 로고
    • Neuronal Cdc2-like kinase (Nclk) binds and phosphorylates the retinoblastoma protein
    • Lee K. Y., Helbing C. C., Choi K. S, Johnston R. N., and, Wang J. H., (1997a) Neuronal Cdc2-like kinase (Nclk) binds and phosphorylates the retinoblastoma protein. J. Biol. Chem. 272, 5622-5626.
    • (1997) J. Biol. Chem. , vol.272 , pp. 5622-5626
    • Lee, K.Y.1    Helbing, C.C.2    Choi, K.S.3    Johnston, R.N.4    Wang, J.H.5
  • 57
    • 0030669604 scopus 로고    scopus 로고
    • Neuronal Cdc2-like kinases: Neuron-specific forms of Cdk5
    • Lee K. Y., Qi Z., Yu Y. P., and, Wang J. H., (1997b) Neuronal Cdc2-like kinases: neuron-specific forms of Cdk5. Int. J. Biochem. Cell Biol. 29, 951-958.
    • (1997) Int. J. Biochem. Cell Biol. , vol.29 , pp. 951-958
    • Lee, K.Y.1    Qi, Z.2    Yu, Y.P.3    Wang, J.H.4
  • 59
    • 34447498931 scopus 로고    scopus 로고
    • Stabilization and activation of p53 induced by Cdk5 contributes to neuronal cell death
    • Lee J.-H., Kim H.-S., Lee S.-H., and, Kim K.-T., (2007) Stabilization and activation of p53 induced by Cdk5 contributes to neuronal cell death. J. Cell Sci. 120, 2259-2271.
    • (2007) J. Cell Sci. , vol.120 , pp. 2259-2271
    • Lee, J.-H.1    Kim, H.-S.2    Lee, S.-H.3    Kim, K.-T.4
  • 60
    • 50349083183 scopus 로고    scopus 로고
    • Cooperative roles of c-Able and Cdk5 in regulation of p53 in response to oxidative stress
    • Lee J.-H., Jeong M.-W., Kim W., Choi Y. H., and, Kim K.-T., (2008) Cooperative roles of c-Able and Cdk5 in regulation of p53 in response to oxidative stress. J. Biol. Chem. 283, 19826-19835.
    • (2008) J. Biol. Chem. , vol.283 , pp. 19826-19835
    • Lee, J.-H.1    Jeong, M.-W.2    Kim, W.3    Choi, Y.H.4    Kim, K.-T.5
  • 61
    • 0034663040 scopus 로고    scopus 로고
    • 1-mediated activation of cyclin-dependent kinase 5 activity is involved in neurite outgrowth and human neurofilament protein H Lys-Ser-Pro tail domain phosphorylation
    • 1-mediated activation of cyclin-dependent kinase 5 activity is involved in neurite outgrowth and human neurofilament protein H Lys-Ser-Pro tail domain phosphorylation. J. Neurosci. 20, 6055-6062.
    • (2000) J. Neurosci. , vol.20 , pp. 6055-6062
    • Li, B.S.1    Zhang, L.2    Gu, J.3    Amin, N.D.4    Pant, H.C.5
  • 62
    • 0036469286 scopus 로고    scopus 로고
    • Cyclin-dependent kinase 5 prevents neuronal apoptosis by negative regulation of c-Jun N-terminal kinase 3
    • Li B. S., Zhang L., Takahashi S., Ma W., Jaffe H., Kulkarni A. B., and, Pant H. C., (2002) Cyclin-dependent kinase 5 prevents neuronal apoptosis by negative regulation of c-Jun N-terminal kinase 3. EMBO J. 21, 324-333.
    • (2002) EMBO J. , vol.21 , pp. 324-333
    • Li, B.S.1    Zhang, L.2    Takahashi, S.3    Ma, W.4    Jaffe, H.5    Kulkarni, A.B.6    Pant, H.C.7
  • 63
    • 0042817922 scopus 로고    scopus 로고
    • Cyclin-dependent kinase-5 is involved in neuregulin-dependent activation of phosphatidylinositol 3-kinase and Akt activity mediating neuronal survival
    • Li B. S., Ma W., Jaffe H., Zheng Y., Takahashi S., Zhang L., Kulkarni A. B., and, Pant H. C., (2003) Cyclin-dependent kinase-5 is involved in neuregulin-dependent activation of phosphatidylinositol 3-kinase and Akt activity mediating neuronal survival. J. Biol. Chem. 278, 35702-35709.
    • (2003) J. Biol. Chem. , vol.278 , pp. 35702-35709
    • Li, B.S.1    Ma, W.2    Jaffe, H.3    Zheng, Y.4    Takahashi, S.5    Zhang, L.6    Kulkarni, A.B.7    Pant, H.C.8
  • 64
    • 34250312098 scopus 로고    scopus 로고
    • Phosphorylation of protein phosphatase 1 (PP1) by cyclin-dependent protein kinase 5 during nerve growth factor-induced PC12 cell differentiation
    • Li T., Chalifour L. E., and, Paudel H. K., (2007) Phosphorylation of protein phosphatase 1 (PP1) by cyclin-dependent protein kinase 5 during nerve growth factor-induced PC12 cell differentiation. J. Biol. Chem. 282, 6619-6628.
    • (2007) J. Biol. Chem. , vol.282 , pp. 6619-6628
    • Li, T.1    Chalifour, L.E.2    Paudel, H.K.3
  • 65
    • 33847025578 scopus 로고    scopus 로고
    • Abl deregulates Cdk5 kinase activity and subcellular localization in Drosophila neurodegeneration
    • Lin H., Lin T. Y., and, Juang J. L., (2007) Abl deregulates Cdk5 kinase activity and subcellular localization in Drosophila neurodegeneration. Cell Death Differ. 14, 607-615.
    • (2007) Cell Death Differ. , vol.14 , pp. 607-615
    • Lin, H.1    Lin, T.Y.2    Juang, J.L.3
  • 66
    • 0346749691 scopus 로고    scopus 로고
    • The structural perspective on CDK5
    • Mapelli M., and, Musacchio A., (2003) The structural perspective on CDK5. Neurosignals 12, 164-172.
    • (2003) Neurosignals , vol.12 , pp. 164-172
    • Mapelli, M.1    Musacchio, A.2
  • 67
    • 0029880475 scopus 로고    scopus 로고
    • Demonstration of cyclin-dependent kinase inhibitory serine/threonine kinase in bovine thymus
    • Matsuura I., and, Wang J. H., (1996) Demonstration of cyclin-dependent kinase inhibitory serine/threonine kinase in bovine thymus. J. Biol. Chem. 271, 5443-5450.
    • (1996) J. Biol. Chem. , vol.271 , pp. 5443-5450
    • Matsuura, I.1    Wang, J.H.2
  • 68
    • 33947356299 scopus 로고    scopus 로고
    • Cyclin-dependenti kinase 5 is an upstream regulator of mitochondrial fission during neuronal apoptosis
    • Meuer K., Suppanz I. E., Lingor P., et al. (2007) Cyclin-dependenti kinase 5 is an upstream regulator of mitochondrial fission during neuronal apoptosis. Cell Death Diff. 14, 651-661.
    • (2007) Cell Death Diff. , vol.14 , pp. 651-661
    • Meuer, K.1    Suppanz, I.E.2    Lingor, P.3
  • 70
    • 77954187920 scopus 로고    scopus 로고
    • Membrane association facilitates degradation and cleavage of the cyclin-dependent kinase 5 activators p35 and p39
    • Minegishi S., Asada A., Miyauchi S., Fuchigami T., Saito T., and, Hisanaga S., (2010) Membrane association facilitates degradation and cleavage of the cyclin-dependent kinase 5 activators p35 and p39. Biochemistry 49, 5482-5493.
    • (2010) Biochemistry , vol.49 , pp. 5482-5493
    • Minegishi, S.1    Asada, A.2    Miyauchi, S.3    Fuchigami, T.4    Saito, T.5    Hisanaga, S.6
  • 71
    • 51149123070 scopus 로고    scopus 로고
    • Cdk5 phosphorylation of WAVE2 regulates oligodendrocyte precursor cell migration through nonreceptor tyrosine kinase Fyn
    • Miyamoto Y., Yamauchi J., and, Tanoue A., (2008) Cdk5 phosphorylation of WAVE2 regulates oligodendrocyte precursor cell migration through nonreceptor tyrosine kinase Fyn. J. Neurosci. 28, 8326-8337.
    • (2008) J. Neurosci. , vol.28 , pp. 8326-8337
    • Miyamoto, Y.1    Yamauchi, J.2    Tanoue, A.3
  • 72
    • 0031466305 scopus 로고    scopus 로고
    • Cyclin-dependent kinases: Engines, clocks, and microprocessors
    • Morgan D. O., (1997) Cyclin-dependent kinases: engines, clocks, and microprocessors. Annu. Rev. Cell Dev. Biol. 13, 261-291.
    • (1997) Annu. Rev. Cell Dev. Biol. , vol.13 , pp. 261-291
    • Morgan, D.O.1
  • 74
    • 33646345376 scopus 로고    scopus 로고
    • Ubiquitin ligases: Cell-cycle control and cancer
    • Nakayama K.-I., and, Nakayama K., (2006) Ubiquitin ligases: cell-cycle control and cancer. Nat. Rev. Cancer 6, 369-381.
    • (2006) Nat. Rev. Cancer , vol.6 , pp. 369-381
    • Nakayama, K.-I.1    Nakayama, K.2
  • 75
    • 17744368458 scopus 로고    scopus 로고
    • Deregulation of Cdk5 in a mouse model of ALS: Toxicity alleviated by perikaryal neurofilament inclusions
    • Nguyen M. D., Larivière R. C., and, Julien J. P., (2001) Deregulation of Cdk5 in a mouse model of ALS: toxicity alleviated by perikaryal neurofilament inclusions. Neuron 30, 135-147.
    • (2001) Neuron , vol.30 , pp. 135-147
    • Nguyen, M.D.1    Larivière, R.C.2    Julien, J.P.3
  • 77
    • 0038689162 scopus 로고    scopus 로고
    • Cdk5 is a key factor in tau aggregation and tangle formation in vivo
    • Noble W., Olm V., Takata K., et al. (2003) Cdk5 is a key factor in tau aggregation and tangle formation in vivo. Neuron 38, 555-565.
    • (2003) Neuron , vol.38 , pp. 555-565
    • Noble, W.1    Olm, V.2    Takata, K.3
  • 80
    • 23844442114 scopus 로고    scopus 로고
    • Impairment of hippocampal long-term depression and defective spatial learning and memory in p35 mice
    • Ohshima T., Ogura H., Tomizawa K., et al. (2005) Impairment of hippocampal long-term depression and defective spatial learning and memory in p35 mice. J. Neurochem. 94, 917-925.
    • (2005) J. Neurochem. , vol.94 , pp. 917-925
    • Ohshima, T.1    Ogura, H.2    Tomizawa, K.3
  • 81
    • 0032403434 scopus 로고    scopus 로고
    • Evidence for the participation of the neuron-specific CDK5 activator p35 during laminin-enhanced axonal growth
    • Paglini G., Pigino G., Kunda P., Morfini G., Maccioni R., Quiroga S., Ferreira A., and, Caceres A., (1998) Evidence for the participation of the neuron-specific CDK5 activator p35 during laminin-enhanced axonal growth. J. Neurosci. 18, 9858-9869.
    • (1998) J. Neurosci. , vol.18 , pp. 9858-9869
    • Paglini, G.1    Pigino, G.2    Kunda, P.3    Morfini, G.4    MacCioni, R.5    Quiroga, S.6    Ferreira, A.7    Caceres, A.8
  • 82
    • 54049089271 scopus 로고    scopus 로고
    • Dopaminergic and glutamatergic signaling crosstalk in Huntington's disease neurodegeneration: The role of p25/cyclin-dependent kinase 5
    • Paoletti P., Vila I., Rifé M., Lizcano J. M., Alberch J., and, Ginés S., (2008) Dopaminergic and glutamatergic signaling crosstalk in Huntington's disease neurodegeneration: the role of p25/cyclin-dependent kinase 5. J. Neurosci. 28, 10090-10101.
    • (2008) J. Neurosci. , vol.28 , pp. 10090-10101
    • Paoletti, P.1    Vila, I.2    Rifé, M.3    Lizcano, J.M.4    Alberch, J.5    Ginés, S.6
  • 84
    • 0032508698 scopus 로고    scopus 로고
    • P35, the neuronal-specific activator of cyclin-dependent kinase 5 (Cdk5) is degraded by the ubiquitin-proteasome pathway
    • Patrick G. N., Zhou P., Kwon Y. T., Howley P. M., and, Tsai L.-H., (1998) p35, the neuronal-specific activator of cyclin-dependent kinase 5 (Cdk5) is degraded by the ubiquitin-proteasome pathway. J. Biol. Chem. 273, 24057-24064.
    • (1998) J. Biol. Chem. , vol.273 , pp. 24057-24064
    • Patrick, G.N.1    Zhou, P.2    Kwon, Y.T.3    Howley, P.M.4    Tsai, L.-H.5
  • 85
    • 0033540060 scopus 로고    scopus 로고
    • Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration
    • Patrick G. N., Zukerberg L., Nikolic M., De La Monte S., Dikkes P., and, Tsai L.-H., (1999) Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration. Nature 402, 615-622.
    • (1999) Nature , vol.402 , pp. 615-622
    • Patrick, G.N.1    Zukerberg, L.2    Nikolic, M.3    De La Monte, S.4    Dikkes, P.5    Tsai, L.-H.6
  • 86
    • 0037040934 scopus 로고    scopus 로고
    • Calpain-mediated cleavage of the cyclin-dependent kinase-5 activator p39 to p29
    • Patzke H., and, Tsai L.-H., (2002) Calpain-mediated cleavage of the cyclin-dependent kinase-5 activator p39 to p29. J. Biol. Chem. 277, 8054-8060.
    • (2002) J. Biol. Chem. , vol.277 , pp. 8054-8060
    • Patzke, H.1    Tsai, L.-H.2
  • 87
    • 77649250664 scopus 로고    scopus 로고
    • No difference in kinetics of tau or histone phosphorylation by CDK5/p25 versus CDK5/p35 in vitro
    • Peterson D. W., Ando D. M., Taketa D. A., Zhou H., Dahlquist F. W., and, Lew J., (2010) No difference in kinetics of tau or histone phosphorylation by CDK5/p25 versus CDK5/p35 in vitro. Proc. Natl Acad. Sci. USA 107, 2884-2889.
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 2884-2889
    • Peterson, D.W.1    Ando, D.M.2    Taketa, D.A.3    Zhou, H.4    Dahlquist, F.W.5    Lew, J.6
  • 88
    • 0031058048 scopus 로고    scopus 로고
    • Identification of functional domains in the neuronal Cdk5 activator protein
    • Poon R. Y., Lew J, and, Hunter T., (1997) Identification of functional domains in the neuronal Cdk5 activator protein. J. Biol. Chem. 272, 5703-5708.
    • (1997) J. Biol. Chem. , vol.272 , pp. 5703-5708
    • Poon, R.Y.1    Lew, J.2    Hunter, T.3
  • 89
    • 0028970204 scopus 로고
    • Reconstitution of neuronal Cdc2-like kinase from bacteria-expressed Cdk5 and an active fragment of the brain-specific activator
    • Qi Z., Huang Q. Q., Lee K. Y., Lew J., and, Wang J. H., (1995) Reconstitution of neuronal Cdc2-like kinase from bacteria-expressed Cdk5 and an active fragment of the brain-specific activator. J. Biol. Chem. 27, 10847-10854.
    • (1995) J. Biol. Chem. , vol.27 , pp. 10847-10854
    • Qi, Z.1    Huang, Q.Q.2    Lee, K.Y.3    Lew, J.4    Wang, J.H.5
  • 90
    • 34250897267 scopus 로고    scopus 로고
    • Role of Cdk5-meidiated phosphorylation of Prx2 in MPTP toxicity and Parkinson's disease
    • Qu D., Rashidian J., Mount M. P., et al. (2007) Role of Cdk5-meidiated phosphorylation of Prx2 in MPTP toxicity and Parkinson's disease. Neuron 55, 37-52.
    • (2007) Neuron , vol.55 , pp. 37-52
    • Qu, D.1    Rashidian, J.2    Mount, M.P.3
  • 91
    • 70349868418 scopus 로고    scopus 로고
    • Essential role of cytoplasmic cdk5 and Prx2 in multiple ischemic injury models, in vivo
    • Rashidian J., Rousseaux M. W., Venderova K., et al. (2009) Essential role of cytoplasmic cdk5 and Prx2 in multiple ischemic injury models, in vivo. J. Neurosci. 29, 12497-12505.
    • (2009) J. Neurosci. , vol.29 , pp. 12497-12505
    • Rashidian, J.1    Rousseaux, M.W.2    Venderova, K.3
  • 92
    • 0029767016 scopus 로고    scopus 로고
    • Structural basis of cyclin-dependent kinase activation by phosphorylation
    • Russo A. A., Jeffrey P. D., and, Pavletich N. P., (1996) Structural basis of cyclin-dependent kinase activation by phosphorylation. Nat. Struct. Biol. 3, 696-700.
    • (1996) Nat. Struct. Biol. , vol.3 , pp. 696-700
    • Russo, A.A.1    Jeffrey, P.D.2    Pavletich, N.P.3
  • 93
  • 95
    • 34250200796 scopus 로고    scopus 로고
    • P25/Cyclin-dependent kinase 5 promotes the progression of cell death in nucleus of endoplasmic reticulum-stressed neurons
    • Saito T., Konno T., Hosokawa T., Asada A., Ishiguro K., and, Hisanaga S., (2007) p25/Cyclin-dependent kinase 5 promotes the progression of cell death in nucleus of endoplasmic reticulum-stressed neurons. J. Neurochem. 102, 133-140.
    • (2007) J. Neurochem. , vol.102 , pp. 133-140
    • Saito, T.1    Konno, T.2    Hosokawa, T.3    Asada, A.4    Ishiguro, K.5    Hisanaga, S.6
  • 96
    • 24744462506 scopus 로고    scopus 로고
    • Phosphorylation of FTDP-17 mutant tau by cyclin-dependent kinase 5 complexed with p35, p25, or p39
    • Sakaue F., Saito T., Sato Y., Asada A., Ishiguro K., Hasegawa M., and, Hisanaga S., (2005) Phosphorylation of FTDP-17 mutant tau by cyclin-dependent kinase 5 complexed with p35, p25, or p39. J. Biol. Chem. 280, 31522-31529.
    • (2005) J. Biol. Chem. , vol.280 , pp. 31522-31529
    • Sakaue, F.1    Saito, T.2    Sato, Y.3    Asada, A.4    Ishiguro, K.5    Hasegawa, M.6    Hisanaga, S.7
  • 98
    • 18644374595 scopus 로고    scopus 로고
    • Fyn and Cdk5 mediate semaphorin-3A signaling, which is involved in regulation of dendrite orientation in cerebral cortex
    • Sasaki Y., Cheng C., Uchida Y., et al. (2002) Fyn and Cdk5 mediate semaphorin-3A signaling, which is involved in regulation of dendrite orientation in cerebral cortex. Neuron 35, 907-920.
    • (2002) Neuron , vol.35 , pp. 907-920
    • Sasaki, Y.1    Cheng, C.2    Uchida, Y.3
  • 99
    • 36749023969 scopus 로고    scopus 로고
    • Regulation of the interaction of Disabled-1 with CIN85 by phosphorylation with Cyclin-dependent kinase 5
    • DOI 10.1111/j.1365-2443.2007.01139.x
    • Sato Y., Taoka M., Sugiyama N., Kubo K., Fuchigami T., Asada A., Saito T., Nakajima K., Isobe T., and, Hisanaga S., (2007) Regulation of the interaction of disabled-1 with CIN85 by phosphorylation with cyclin-dependent kinase 5. Genes Cells 12, 1315-1327. (Pubitemid 350215136)
    • (2007) Genes to Cells , vol.12 , Issue.12 , pp. 1315-1327
    • Sato, Y.1    Taoka, M.2    Sugiyama, N.3    Kubo, K.-I.4    Fuchigami, T.5    Asada, A.6    Saito, T.7    Nakajima, K.8    Isobe, T.9    Hisanaga, S.-I.10
  • 101
    • 0344823864 scopus 로고    scopus 로고
    • Cyclin-dependent kinase 5 is a mediator of dopaminergic neuron loss in a mouse model of Parkinson's disease
    • Smith P. D., Crocker S. J., Jackson-Lewis V., et al. (2003) Cyclin-dependent kinase 5 is a mediator of dopaminergic neuron loss in a mouse model of Parkinson's disease. Proc. Natl Acad. Sci. USA 100, 13650-13655.
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , pp. 13650-13655
    • Smith, P.D.1    Crocker, S.J.2    Jackson-Lewis, V.3
  • 102
    • 32544441845 scopus 로고    scopus 로고
    • Calpain-regulated p35/cdk5 plays a central role in dopaminergic neuron death through modulation of the transcription factor myocyte enhancer factor 2
    • Smith P. D., Mount M. P., Shree R., Callaghan S., Slack R. S., Anisman H., Vincent I., Wang X., Mao Z., and, Park D. S., (2006) Calpain-regulated p35/cdk5 plays a central role in dopaminergic neuron death through modulation of the transcription factor myocyte enhancer factor 2. J. Neurosci. 26, 440-447.
    • (2006) J. Neurosci. , vol.26 , pp. 440-447
    • Smith, P.D.1    Mount, M.P.2    Shree, R.3    Callaghan, S.4    Slack, R.S.5    Anisman, H.6    Vincent, I.7    Wang, X.8    Mao, Z.9    Park, D.S.10
  • 103
    • 16844379776 scopus 로고    scopus 로고
    • Interferon γ induces neurite outgrowth by up-regulation of p35 neuron-specific cyclin-dependent kinase 5 activator via activation of ERK1/2 pathway
    • Song J. H., Wang C. X., Song D. K., Wang P., Shuaib A., and, Hao C., (2005) Interferon γ induces neurite outgrowth by up-regulation of p35 neuron-specific cyclin-dependent kinase 5 activator via activation of ERK1/2 pathway. J. Biol. Chem. 280, 12896-128901.
    • (2005) J. Biol. Chem. , vol.280 , pp. 12896-128901
    • Song, J.H.1    Wang, C.X.2    Song, D.K.3    Wang, P.4    Shuaib, A.5    Hao, C.6
  • 104
    • 51849133140 scopus 로고    scopus 로고
    • Deregulated Cdk5 promotes oxidative stress and mitochondrial dysfunction
    • Sun K. H., De Pablo Y., Vincent F., and, Shah K., (2008) Deregulated Cdk5 promotes oxidative stress and mitochondrial dysfunction. J. Neurochem. 107, 2652-2678.
    • (2008) J. Neurochem. , vol.107 , pp. 2652-2678
    • Sun, K.H.1    De Pablo, Y.2    Vincent, F.3    Shah, K.4
  • 105
    • 73949151138 scopus 로고    scopus 로고
    • Direct and indirect roles of cyclin-dependent kinase 5 as an upstream regulator in the c-Jun NH2-terminal kinase cascade: Relevance to neurotoxic insults in Alzheimer's disease
    • Sun K-H., Lee H.-G., Smith M. A., and, Shah K., (2009) Direct and indirect roles of cyclin-dependent kinase 5 as an upstream regulator in the c-Jun NH2-terminal kinase cascade: relevance to neurotoxic insults in Alzheimer's disease. Mol. Biol. Cell 20, 4611-4619.
    • (2009) Mol. Biol. Cell , vol.20 , pp. 4611-4619
    • Sun, K.-H.1    Lee, H.-G.2    Smith, M.A.3    Shah, K.4
  • 106
    • 0037855706 scopus 로고    scopus 로고
    • Tau phosphorylation by cyclin-dependent kinase 5/p39 during brain development reduces its affinity for microtubules
    • Takahashi S., Saito T., Hisanaga S., Pant H. C., and, Kulkarni A. B., (2003) Tau phosphorylation by cyclin-dependent kinase 5/p39 during brain development reduces its affinity for microtubules. J. Biol. Chem. 278, 10506-10515.
    • (2003) J. Biol. Chem. , vol.278 , pp. 10506-10515
    • Takahashi, S.1    Saito, T.2    Hisanaga, S.3    Pant, H.C.4    Kulkarni, A.B.5
  • 107
    • 73949155834 scopus 로고    scopus 로고
    • Conditional deletion of neuronal cyclin-dependent kinase 5 in developing fore brain results in microglial activation and neurodegeneration
    • Takahashi S., Ohshima T., Hirasawa M., Pareek T. K., Bugge T. H., Morozov A., Fujieda K., Brady R. O., and, Kulkarni A. B., (2010) Conditional deletion of neuronal cyclin-dependent kinase 5 in developing fore brain results in microglial activation and neurodegeneration. Am. J. Pathol. 176, 320-329.
    • (2010) Am. J. Pathol. , vol.176 , pp. 320-329
    • Takahashi, S.1    Ohshima, T.2    Hirasawa, M.3    Pareek, T.K.4    Bugge, T.H.5    Morozov, A.6    Fujieda, K.7    Brady, R.O.8    Kulkarni, A.B.9
  • 109
    • 0041803010 scopus 로고    scopus 로고
    • Brain levels of CDK5 activator p25 are not increased in Alzheimer's or other neurodegenerative diseases with neurofibrillary tangles
    • Tandon A., Yu H., Wang L., et al. (2003) Brain levels of CDK5 activator p25 are not increased in Alzheimer's or other neurodegenerative diseases with neurofibrillary tangles. J. Neurochem. 86, 572-581.
    • (2003) J. Neurochem. , vol.86 , pp. 572-581
    • Tandon, A.1    Yu, H.2    Wang, L.3
  • 110
    • 0030308965 scopus 로고    scopus 로고
    • Cyclin-dependent kinase 5 (Cdk5) and neuron-specific Cdk5 activators
    • Tang D., and, Wang J. H., (1996) Cyclin-dependent kinase 5 (Cdk5) and neuron-specific Cdk5 activators. Prog. Cell Cycle Res. 2, 205-216.
    • (1996) Prog. Cell Cycle Res. , vol.2 , pp. 205-216
    • Tang, D.1    Wang, J.H.2
  • 112
    • 0030979022 scopus 로고    scopus 로고
    • Cyclin-dependent kinase 5 (Cdk5) activation domain of neuronal Cdk5 activator
    • Tang D., Chun A. C., Zhang M., and, Wang J. H., (1997) Cyclin-dependent kinase 5 (Cdk5) activation domain of neuronal Cdk5 activator. J. Biol. Chem. 272, 2318-2327.
    • (1997) J. Biol. Chem. , vol.272 , pp. 2318-2327
    • Tang, D.1    Chun, A.C.2    Zhang, M.3    Wang, J.H.4
  • 113
    • 18644380959 scopus 로고    scopus 로고
    • Cyclin-dependent kinase 5 mediates neurotoxin-induced degradation of the transcription factor myocyte enhancer factor2
    • Tang X., Wang X., Gong X., Tong M., Park D., Xia Z., and, Mao Z., (2005) Cyclin-dependent kinase 5 mediates neurotoxin-induced degradation of the transcription factor myocyte enhancer factor2. J. Neurosci. 25, 4823-4834.
    • (2005) J. Neurosci. , vol.25 , pp. 4823-4834
    • Tang, X.1    Wang, X.2    Gong, X.3    Tong, M.4    Park, D.5    Xia, Z.6    Mao, Z.7
  • 116
    • 59649128916 scopus 로고    scopus 로고
    • Phosphorylaiton of ATM by Cdk5 mediates DNA damage signaling and regulates neuronal death
    • Tian B., Yang Q., and, Mao Z., (2009) Phosphorylaiton of ATM by Cdk5 mediates DNA damage signaling and regulates neuronal death. Nat. Cell Biol. 11, 211-218.
    • (2009) Nat. Cell Biol. , vol.11 , pp. 211-218
    • Tian, B.1    Yang, Q.2    Mao, Z.3
  • 117
    • 0034127033 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor-induced phosphorylation of neurofilament-H subunit in primary cultures of embryo rat cortical neurons
    • Tokuoka H., Saito T., Yorifuji H., Wei F., Kishimoto T., and, Hisanaga S., (2000) Brain-derived neurotrophic factor-induced phosphorylation of neurofilament-H subunit in primary cultures of embryo rat cortical neurons. J. Cell Sci. 113, 1059-1068.
    • (2000) J. Cell Sci. , vol.113 , pp. 1059-1068
    • Tokuoka, H.1    Saito, T.2    Yorifuji, H.3    Wei, F.4    Kishimoto, T.5    Hisanaga, S.6
  • 118
    • 0027425599 scopus 로고
    • Activity and expression pattern of cyclin-dependent kinase 5 in the embryonic mouse nervous system
    • Tsai L.-H., Takahashi T., Caviness V. S., Jr, and, Harlow E., (1993) Activity and expression pattern of cyclin-dependent kinase 5 in the embryonic mouse nervous system. Development 119, 1029-1040.
    • (1993) Development , vol.119 , pp. 1029-1040
    • Tsai, L.-H.1    Takahashi, T.2    Caviness, Jr.V.S.3    Harlow, E.4
  • 119
    • 0027978170 scopus 로고
    • P35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5
    • Tsai L.-H., Delalle I., Caviness V. S., Chae T., and, Harlow E., (1994) p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5. Nature 371, 419-423.
    • (1994) Nature , vol.371 , pp. 419-423
    • Tsai, L.-H.1    Delalle, I.2    Caviness, V.S.3    Chae, T.4    Harlow, E.5
  • 120
    • 0037125209 scopus 로고    scopus 로고
    • A survey of Cdk5 activator p35 and p25 levels in Alzheimer's disease brains
    • Tseng H. C., Zhou Y., Shen Y., and, Tsai L.-H., (2002) A survey of Cdk5 activator p35 and p25 levels in Alzheimer's disease brains. FEBS Lett. 523, 58-62.
    • (2002) FEBS Lett. , vol.523 , pp. 58-62
    • Tseng, H.C.1    Zhou, Y.2    Shen, Y.3    Tsai, L.-H.4
  • 121
    • 59049083003 scopus 로고    scopus 로고
    • Tumor necrosis factor-α regulates cyclin-dependent kinase 5 activity during pain signaling through transcriptional activation of p35
    • Utreras E., Futatsugi A., Rudrabhatla P., Keller J., Iadarol M. J., Pant H. C., and, Kulkarni A.B., (2009) Tumor necrosis factor-α regulates cyclin-dependent kinase 5 activity during pain signaling through transcriptional activation of p35. J. Biol. Chem. 284, 2275-2284.
    • (2009) J. Biol. Chem. , vol.284 , pp. 2275-2284
    • Utreras, E.1    Futatsugi, A.2    Rudrabhatla, P.3    Keller, J.4    Iadarol, M.J.5    Pant, H.C.6    Kulkarni, A.B.7
  • 122
    • 0036069555 scopus 로고    scopus 로고
    • Aspirin provides cyclin-dependent kinase 5-dependent protection against subsequent hypoxia/reoxygenation damage in culture
    • Vartiainen N., Keksa-Goldsteine V., Goldsteins G., and, Koistinaho J., (2002) Aspirin provides cyclin-dependent kinase 5-dependent protection against subsequent hypoxia/reoxygenation damage in culture. J. Neurochem. 82, 329-335.
    • (2002) J. Neurochem. , vol.82 , pp. 329-335
    • Vartiainen, N.1    Keksa-Goldsteine, V.2    Goldsteins, G.3    Koistinaho, J.4
  • 124
    • 0031006939 scopus 로고    scopus 로고
    • Aberrant expression of mitotic cdc2/cyclin B1 kinase in degenerating neurons of Alzheimer's disease brain
    • Vincent I., Jicha G., Rosado M., and, Dickson D. W., (1997) Aberrant expression of mitotic cdc2/cyclin B1 kinase in degenerating neurons of Alzheimer's disease brain. J. Neurosci. 17, 3588-3598.
    • (1997) J. Neurosci. , vol.17 , pp. 3588-3598
    • Vincent, I.1    Jicha, G.2    Rosado, M.3    Dickson, D.W.4
  • 125
    • 33745192268 scopus 로고    scopus 로고
    • Cyclin-dependent kinase-5 prevents neuronal apoptosis through ERK-mediated upregulation of Bcl-2
    • Wang C. X., Song J. H., Song D. K., Yong V. W., Shuaib A., and, Hao C., (2006a) Cyclin-dependent kinase-5 prevents neuronal apoptosis through ERK-mediated upregulation of Bcl-2. Cell Death Differ. 13, 1203-1212.
    • (2006) Cell Death Differ. , vol.13 , pp. 1203-1212
    • Wang, C.X.1    Song, J.H.2    Song, D.K.3    Yong, V.W.4    Shuaib, A.5    Hao, C.6
  • 126
    • 33750626424 scopus 로고    scopus 로고
    • Role of CDK5 in neuroprotection from serum deprivation by μ-opioid receptor agonist
    • Wang Y., Xie W. Y., He Y., et al. (2006b) Role of CDK5 in neuroprotection from serum deprivation by μ-opioid receptor agonist. Exp. Neurol. 202, 313-323.
    • (2006) Exp. Neurol. , vol.202 , pp. 313-323
    • Wang, Y.1    Xie, W.Y.2    He, Y.3
  • 127
    • 34848913528 scopus 로고    scopus 로고
    • Activation of cyclin-dependent kinase 5 by calpains contributes to human immunodeficiency virus-induced neurotoxicity
    • Wang Y., White M. G., Akay C., et al. (2007) Activation of cyclin-dependent kinase 5 by calpains contributes to human immunodeficiency virus-induced neurotoxicity. J. Neurochem. 103, 439-455.
    • (2007) J. Neurochem. , vol.103 , pp. 439-455
    • Wang, Y.1    White, M.G.2    Akay, C.3
  • 128
    • 20244377072 scopus 로고    scopus 로고
    • Control of cyclin-dependent kinase 5 (Cdk5) activity by glutamatergic regulation of p35 stability
    • Wei F. Y., Tomizawa K., Ohshima T., et al. (2005) Control of cyclin-dependent kinase 5 (Cdk5) activity by glutamatergic regulation of p35 stability. J. Neurochem. 93, 502-512.
    • (2005) J. Neurochem. , vol.93 , pp. 502-512
    • Wei, F.Y.1    Tomizawa, K.2    Ohshima, T.3
  • 129
    • 40249114794 scopus 로고    scopus 로고
    • Transcriptional regulation of b-secretase by p25/Cdk5 leads to enhanced amyloidogenic processing
    • Wen Y., Yu W. H., Maloney B., et al. (2008) Transcriptional regulation of b-secretase by p25/Cdk5 leads to enhanced amyloidogenic processing. Neuron 57, 680-690.
    • (2008) Neuron , vol.57 , pp. 680-690
    • Wen, Y.1    Yu, W.H.2    Maloney, B.3
  • 130
    • 0033870174 scopus 로고    scopus 로고
    • The expression of Cdk5, p35, p39, and Cdk5 kinase activity in developing, adult, and aged rat brains
    • Wu D. C., Yu Y. P., Lee N. T., Yu A. C., Wang J. H., and, Han Y. F., (2000) The expression of Cdk5, p35, p39, and Cdk5 kinase activity in developing, adult, and aged rat brains. Neurochem. Res. 25, 923-929.
    • (2000) Neurochem. Res. , vol.25 , pp. 923-929
    • Wu, D.C.1    Yu, Y.P.2    Lee, N.T.3    Yu, A.C.4    Wang, J.H.5    Han, Y.F.6
  • 132
    • 14944346310 scopus 로고    scopus 로고
    • Loss of neuronal cell cycle control in ataxia-telangiectasia: A unified disease mechanism
    • Yang Y., and, Herrup K., (2005) Loss of neuronal cell cycle control in ataxia-telangiectasia: a unified disease mechanism. J. Neurosci. 25, 2522-2529.
    • (2005) J. Neurosci. , vol.25 , pp. 2522-2529
    • Yang, Y.1    Herrup, K.2
  • 133
    • 0035871660 scopus 로고    scopus 로고
    • DNA replication precedes neuronal cell death in Alzheimer's disease
    • Yang Y., Geldmacher D. S., and, Herrup K., (2001) DNA replication precedes neuronal cell death in Alzheimer's disease. J. Neurosci. 21, 2661-2668.
    • (2001) J. Neurosci. , vol.21 , pp. 2661-2668
    • Yang, Y.1    Geldmacher, D.S.2    Herrup, K.3
  • 134
    • 33845656473 scopus 로고    scopus 로고
    • Activation of cyclin-dependent kinase 5 (Cdk5) in primary sensory and dorsal horn neurons by peripheral inflammation contributes to heat hyperalgesia
    • Yang Y. R., He Y., Zhang Y., Li Y., Li Y., Han Y., Zhu H., and, Wang Y., (2007) Activation of cyclin-dependent kinase 5 (Cdk5) in primary sensory and dorsal horn neurons by peripheral inflammation contributes to heat hyperalgesia. Pain 127, 109-120.
    • (2007) Pain , vol.127 , pp. 109-120
    • Yang, Y.R.1    He, Y.2    Zhang, Y.3    Li, Y.4    Li, Y.5    Han, Y.6    Zhu, H.7    Wang, Y.8
  • 135
    • 0035859053 scopus 로고    scopus 로고
    • P25 protein in neurodegeneration
    • Yoo B. C., and, Lubec G., (2001) p25 protein in neurodegeneration. Nature 411, 763-764.
    • (2001) Nature , vol.411 , pp. 763-764
    • Yoo, B.C.1    Lubec, G.2
  • 136
    • 0036312755 scopus 로고    scopus 로고
    • Cdk5 phosphorylates p53 and regulates its activity
    • Zhang J., Krishnamurthy P. K., and, Johnson G. V. W., (2002) Cdk5 phosphorylates p53 and regulates its activity. J. Neurochem. 81, 307-313.
    • (2002) J. Neurochem. , vol.81 , pp. 307-313
    • Zhang, J.1    Krishnamurthy, P.K.2    Johnson, G.V.W.3
  • 137
    • 77950962922 scopus 로고    scopus 로고
    • Cdk5 suppresses the neuronal cell cycle by disrupting the E2F1-DP1 complex
    • Zhang J., Li H., Yabut O., Fitzpatrick H., D'Arcangelo G., and, Herrup K., (2010) Cdk5 suppresses the neuronal cell cycle by disrupting the E2F1-DP1 complex. J. Neurosci. 30, 5219-5228.
    • (2010) J. Neurosci. , vol.30 , pp. 5219-5228
    • Zhang, J.1    Li, H.2    Yabut, O.3    Fitzpatrick, H.4    D'Arcangelo, G.5    Herrup, K.6
  • 139
    • 0031955853 scopus 로고    scopus 로고
    • Region-specific expression of cyclin-dependent kinase 5 (cdk5) and its activators, p35 and p39, in the developing and adult rat central nervous system
    • Zheng M., Leung C. L., and, Liem R. K. H., (1998) Region-specific expression of cyclin-dependent kinase 5 (cdk5) and its activators, p35 and p39, in the developing and adult rat central nervous system. J. Neurobiol. 35, 141-159.
    • (1998) J. Neurobiol. , vol.35 , pp. 141-159
    • Zheng, M.1    Leung, C.L.2    Liem, R.K.H.3
  • 140
    • 33846828462 scopus 로고    scopus 로고
    • Cdk5 modulation of mitogen-activated protein kinase signaling regulates neuronal survival
    • Zheng Y. L., Li B. S., Kanungo J., Kesavapany S., Amin N., Grant P., and, Pant H. C., (2007) Cdk5 modulation of mitogen-activated protein kinase signaling regulates neuronal survival. Mol. Biol. Cell 18, 404-413.
    • (2007) Mol. Biol. Cell , vol.18 , pp. 404-413
    • Zheng, Y.L.1    Li, B.S.2    Kanungo, J.3    Kesavapany, S.4    Amin, N.5    Grant, P.6    Pant, H.C.7
  • 141
    • 24944439808 scopus 로고    scopus 로고
    • Activation of latent cyclin-dependent kinase 5 (Cdk5)-p35 complexes by membrane dissociation
    • Zhu Y. S., Saito T., Asada A., Maekawa S., and, Hisanaga S., (2005) Activation of latent cyclin-dependent kinase 5 (Cdk5)-p35 complexes by membrane dissociation. J. Neurochem. 94, 1535-1545.
    • (2005) J. Neurochem. , vol.94 , pp. 1535-1545
    • Zhu, Y.S.1    Saito, T.2    Asada, A.3    Maekawa, S.4    Hisanaga, S.5
  • 142
    • 0033710860 scopus 로고    scopus 로고
    • Cables links Cdk5 and c-Abl and facilitates Cdk5 tyrosine phosphorylation, kinase upregulation, and neurite outgrowth
    • Zukerberg L. R., Patrick G. N., Nikolic M., et al. (2000) Cables links Cdk5 and c-Abl and facilitates Cdk5 tyrosine phosphorylation, kinase upregulation, and neurite outgrowth. Neuron 26, 633-646.
    • (2000) Neuron , vol.26 , pp. 633-646
    • Zukerberg, L.R.1    Patrick, G.N.2    Nikolic, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.