Cyclin-dependent kinase-1: Linking apoptosis to cell cycle and mitotic catastrophe

Cell Death and Differentiation

Volumn 9, Issue 12, 2002, Pages 1287-1293

  Castedo, M ^a   Perfettini, J L ^a   Roumier, T ^b   Kroemer, G ^a  

^a CNRS   (France)

^b NONE

Author keywords

Apoptosis; Caspases; Cell death

Indexed keywords

CASPASE 9; CYCLIN B1; CYCLIN DEPENDENT KINASE 1; FLAVOPIRIDOL; MITOXANTRONE; OLOMOUCINE; ONCOPROTEIN; PACLITAXEL; PROTEIN BAD; PROTEIN BAX; PROTEIN KINASE; PROTEIN P185; PROTEIN P53; RAPAMYCIN; ROSCOVITINE; STAUROSPORINE; SURVIVIN; TENIPOSIDE; TRASTUZUMAB; VINCRISTINE; VPR PROTEIN;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; BREAST CANCER; CANCER CELL; CELL CYCLE; CELL KILLING; CELL PERMEABILIZATION; CELL TYPE; DEGENERATIVE DISEASE; DNA DAMAGE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME REGULATION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; IRRADIATION; METAPHASE; MITOCHONDRION; MITOSIS; NONHUMAN; PATHOGENICITY; PRIORITY JOURNAL; PROPHASE; PROTEIN PROTEIN INTERACTION; REVIEW;

ANIMALS; APOPTOSIS; CDC2 PROTEIN KINASE; DNA DAMAGE; EUKARYOTIC CELLS; HIV-1; HUMANS; MITOSIS; NEURODEGENERATIVE DISEASES;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0036952736     PISSN: 13509047     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cdd.4401130     Document Type: Review

References (66)

1. cdc2 activation required for apoptosis. Science 263: 1143-1145
2. Freeman RS, Estus S and Johnson Jr EM (1994) Analysis of cell cycle-related gene expression in postmitotic neurons: selective induction of Cyclin D1 during programmed cell death. Neuron 12: 343-355
3. Oberhammer FA, Hochegger K and Froschl G (1994) Chromatin condensation during apoptosis is accompanied by degradation of lamin A+B, without enhanced activation of cdc-2 kinase. J. Cell Biol. 126: 827-837
4. Norbury C, MacFarlande M, Fearnhead H and Cohen GM (1994) CDC2 activation is not required for thymocyte apoptosis. Biochem. Biophys. Res. Comm. 202: 1400-1406
5. Nigg EA (2001) Mitotic kinases as regulators of cell division and its checkpoints. Nat. Rev. Mol. Cell Biol. 2: 21-32
6. Smits VA and Medema RH (2001) Checking out the G2/M transition. Biochim. Biophys. Acta 1519: 1-12
7. Yun J, Chae HD, Choy HE, Chung J, Yoo HS, Han MH and Shin DY (1999) p53 negatively regulates cdc2 transcription via the CCAAT-binding NF-Y transcription factor. J. Biol. Chem. 274: 29677-29682
8. Taylor WR, DePrimo SE, Agarwal A, Agarwal ML, Schonthal AH, Katula KS and Stark GR (1999) Mechanisms of G2 arrest in response to overexpression of p53. Mol. Biol. Cell 10: 3607-3622
9. Peters JM (2002) The anaphase-promoting complex: proteolysis in mitosis and beyond. Mol. Cell. 9: 931-943
10. Ruchaud S, Korfali N, Villa P, Kottke TJ, Dingwall C, Kaufmann SH and EarnshawWC (2002) Caspase-6gene disruption reveals a requirement for lamin A cleavage in apoptotic chromatin condensation. EMBO J. 21: 1967-1977
11. Melo J and Toczyski D (2002) A unified view of the DNA-damage checkpoint. Curr. Opin. Cell. Biol. 14: 237-245
12. Ferri KF and Kroemer GK (2001) Organelle-specific initiation of cell death pathways. Nature Cell Biol. 3: E255-E263
13. Ongkeko W, Ferguson DJP, Harris AL and Norbury C (1995) Inactivation of Cdc2 increases the level of apoptosis induced by DNA damage. J. Cell Science 108: 2897-2904
14. Itzhaki JE, Gilbert CS and Porter AC (1997) Construction by gene targeting in human cells of a'conditional' CDC2 mutant that rereplicates its DNA. Nat. Genet 15: 258-265
15. Patel V, Senderowicz AM, Pinto Jr D, Igishi T, Rafted M, Quintanilla-Martinez L, Ensley JF, Sausville EA and Gutkind JS (1998) Flavopiridol, a novel cyclin-dependent kinase inhibitor, suppresses the growth of head and neck squamous cell carcinomas by inducing apoptosis. J. Clin. Invest. 102: 1674-1681
16. Zhai S, Senderowicz AM, Sausville EA and Figg WD (2002) Flavopiridol, a novel cyclin-dependent kinase inhibitor, in clinical development. Ann. Pharmacother. 36: 905-911
17. O'Connor DS, Grossman D, Plescia J, Li F, Zhang H, Villa A, Tognin S, Marchisio PC and Altieri DC (2000) Regulation of apoptosis at cell division by p34cdc2 phosphorylation of survivin. Proc. Natl. Acad. Sci. USA 97: 13103-13107
18. Vantieghem A, Xu Y, Assefa Z, Piette J, Vandenheede JR, Merlevede W, De Witte PA and Agostinis P (2002) Phosphorylation of BCL-2 in G2/M phase arrested cells following photodynamic therapy with hypericin involves a CDK1-mediated signal and delays the onset of apoptosis. J. Biol. Chem. in press.
19. Zhou BB, Li H, Yuan J and Kirschner MW (1998) Caspase-dependent activation of cyclin-dependent kinases during Fas- induced apoptosis in Jurkat cells. Proc. Natl. Acad. Sci. USA 95: 6785-6790
20. Shen SC, Huang TS, Jee SH and Kuo ML (1998) Taxol-incluced p34cdc2 kinase activation and apoptosis inhibited by 12-O-tetradecanoylphorbol-13-acetate in human breast MCF-7 carcinoma cells. Cell Growth Differ. 9: 23-29
21. Yu D, Jing T, Liu B, Yao J, Tan M, McDonnell TJ and Hung MC (1998). Overexpression of ErbB2 blocks Taxol-induced apoptosis by upregulation of p21Cip1, which inhibits p34Cdc2 kinase. Mol. Cell 2: 581-591
22. Stewart ZA, Mays D and Pietenpol JA (1999) Defective G1-S cell cycle checkpoint function sensitizes cells to microtubule inhibitor-induced apoptosis. Cancer Res., 59: 3831-3837
23. Tan M, Jing T, Lan KH, Neal CL, Li P, Lee S, Fang D, Nagata Y, Liu J, Arlinghaus R, Hung MC and Yu D (2002) Phosphorylation on tyrosine-15 of p34(Cdc2) by ErbB2 inhibits p34(Cdc2) activation and is involved in resistance to taxol-induced apoptosis. Mol. Cell 9: 993-1004
24. Slamon DJ, Leyland-Jones B, Shak S, Fuchs H, Paton V, Bajamonde A, Fleming T, Eiermann W, Wolter J, Pegram M, Baselga J and Norton L (2001) Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N. Engl. J. Med. 344: 783-792
25. Ibrado AM, Kim CN and Bhalla K (1998). Temporal relationship of CDK1 activation and mitotic arrest to cytosolic accumulation of cytochrome C and caspase-3 activity during Taxol-induced apoptosis of human AML HL-60 cells. Leukemia 12: 1930-1936
26. Kroemer G and Reed JC (2000) Mitochondrial control of cell death. Nat. Med. 6: 513-519
27. Konishi Y, Lehtinen M, Donovan N and Bonni A (2002) Cdc2 phosphorylation of BAD links the cell cycle to the cell death machinery. Mol. Cell. 9: 1005-1016
28. Debatin K-M, Poncet D and Kroemer G (2002) Chemotherapy: Targeting the mitochondrial pathway. Oncogene in press
29. Pathan N, Aime-Sempe C, Kitada S, Haldar S and Reed JC (2001) Microtubule-targeting drugs induce Bcl-2 phosphorylation and association with Pin1. Neoplasia 3: 70-79
30. Scatena CD, Stewart ZA, Mays D, Tang LJ, Keefer CJ, Leach SD and Pietenpol JA (1998) Mitotic phosphorylation of Bcl-2 during normal cell cycle progression and Taxol-induced growth arrest. J. Biol. Chem. 273: 30777-30784
31. Yamamoto K, Ichijo H and Korsmeyer SJ (1999) BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G(2)/M. Mol. Cell. Biol. 19: 8469-8478
32. Vincent I, Jicha G, Rosado M and Dickson DW (1997) Aberrant expression of mitotic cdc2/cyclin B1 kinase in degenerating neurons of Alzheimer's disease brain. J. Neurosci. 17: 3588-3598
33. Vincent I, Bu B, Hudson K, Husseman J, Nochlin D and Jin L (2001) Constitutive Cdc25B tyrosine phosphatase activity in adult brain neurons with M phase-type alterations in Alzheimer's disease. Neuroscience 105: 639-650
34. Roninson IB, Broude EV and Chang B-D (2002) If not apoptosis, then what? Treatment-induced senescence and mitotic catastrophe in tumor cells. Drug Resistance Updates 4: 303-313
35. Lock RB and Stribinskiene L (1996) Dual modes of death induced by etoposide in human epithelial tumor cells allow Bcl-2 to inhibit apoptosis without affecting clonogenic survival. Cancer Res. 56: 4006-4012
36. Mackey MA, Zhang XF, Hunt CR, Sullivan SJ, Blum J, Laszlo A and Roti Roti JL (1996) Uncoupling of M-phase kinase activation from the completion of S-phase by heat shock. Cancer Res. 56: 1770-1774
37. Heald R, McLoughlin M and McKeon F (1993) Human wee1 maintains mitotic timing by protecting the nucleus from cytoplasmically activated Cdc2 kinase. Cell 74: 463-474
38. Jin P, Hardy S and Morgan DO (1998) Nuclear localization of cyclin B1 controls mitotic entry after DNA damage. J. Cell. Biol. 141: 875-885
39. Chang BD, Broude EV, Fang J, Kalinichenko TV, Abdryashitov R, Poole JC and Roninson IB (2000) p21Waf1/Cip1/Sdi1-induced growth arrest is associated with depletion of mitosis-control proteins and leads to abnormal mitosis and endoreduplication in recovering cells. Oncogene 19: 2165-2170
40. Graves PR, Yu L, Schwarz JK, Gales J, Sausville EA, O'Connor PM and Piwnica-Worms H (2000) The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01. J. Bol. Chem. 275: 5600-5605
41. Curman D, Cinel B, Williams DE, Rundle N, Block WD, Goodarzi AA, Hutchins JR, Clarke PR, Zhou BB, Lees-Miller SP, Andersen RJ and Roberge M (2001). Inhibition of the G2 DNA damage checkpoint and of protein kinases Chk1 and Chk2 by the marine sponge alkaloid debromohymenialdisine. J. Biol. Chem. 276: 17914-17919
42. Hu B, Zhou XY, Wang X, Zeng ZC, Iliakis G and Wang Y (2001) The radioresistance to killing of A1-5 cells derives from activation of the Chk1 pathway. J. Biol. Chem. 276: 17693-17698
43. Hirose Y, Berger MS and Pieper RO (2001) Abrogation of the Chk1-mediated G(2) checkpoint pathway potentiates temozolomide-induced toxicity in a p53-independent manner in human glioblastoma cells. Cancer Res. 61: 5843-5849
44. Piedimonte G, Corsi D, Paiardini M, Cannavo G, lentile R, Picerno I, Montroni M, Silvestri G and Magnani M (1999) Unscheduled cyclin B expression and p34 cdc2 activation in T lymphocytes from HIV-infected patients. Aids 13: 1159-1164
45. Paiardini M, Galati D, Cervasi B, Cannavo G, Galluzzi L, Montroni M, Guetard D, Magnani M, Piedimonte G and Silvestri G (2001) Exogenous interleukin-2 administration corrects the cell cycle perturbation of lymphocytes from human immunodeficiency virus-infected individuals. J. Virol. 75: 10843-10855
46. Kolesnitchenko V, Wahl LM, Tian H, Sunila I, Tani Y, Hartmann D-P, Cossman J, Raffeld M, Orenstein J, Samelson E and Cohen DI (1995) Human immunodeficiency virus 1 envelope-initiated G2-phase programmed cell death. Proc . Natl. Acad. Sci. USA 92: 11889-11893
47. Ferri KF, Jacotot E, Blanco J, Esté JA, Zamzami A, Susin SA, Brothers G, Reed JC, Penninger JM and Kroemer G (2000) Apoptosis control in syncytia induced by the HIV-1-envelope glycoprotein complex. Role of mitochondria and caspases. J. Exp. Med. 192:1081-1092
48. Castedo M and Kroemer G (2002)The beauty of death. Trends Cell Biol. in press
49. Castedo M, RoumierT, Blanco J, Ferri KF, Barretina J, Andreau K, Perfettini J-L, Armendola A, Nardacci R, LeDuc P, Ingber DE, Este JA, Modjtahedi N, Piacentini M and Kroemer G (2002) Sequential involvement of Cdk1, mTOR and p53 in apoptosis induced by the human immunodeficiency virus-1 envelope. EMBO J. 15: 4070-4080
50. Ferri KF, Jacotot E, Geuskens M and Kroemer G (2000) Apoptosis and karyogamy in syncytia induced by HIV-1-ENV/CD4 interaction. Cell Death Differ. 7: 1137-1139
51. Castedo M, Ferri KF, Blanco J, RoumierT, Larochette N, Barretina J, Amendola A, Nardacci R, Metivier D, Este JA, Piacentini M and Kroemer G (2001) Human immunodeficiency virus 1 envelope glycoprotein complex-induced apoptosis involves mammalian target of rapamycin/FKBP12-rapamycin-associated protein-mediated p53 phosphorylation. J. Exp. Med. 194: 1097-1110
52. Castedo M, Ferri KF and Kroemer G (2002). Mammalian target of rapamycin (mTOR): pro- and anti-apoptotic. Cell Death Differ. 9: 99-100
53. Genini D, Sheeter D, Rought S, Zaunders JJ, Susin SA, Kroemer G, Richman DD, Carson DA, Corbeil J and Leoni, LM (2001) HIV induced lymphocyte apoptosis by a p53-initiated, mitochondrion-mediated mechanism. FASEBJ. 15: 5-6
54. He J, Choe S, Walker R, Di Marzio P, Morgan DO and Landau NR (1995) Human immunodeficiency virus type 1 viral protein R (Vpr) arrests cells in the G2 phase of the cell cycle by inhibiting p34cdc2 activity. J. Virol. 69: 6705-6711
55. Stewart SA, Poon B, Jowett JB and Chen IS (1997) Human immunodeficiency virus type 1 vpr induces apoptosis following cell cycle arrest. J. Virol. 71: 5579-5592
56. Nishizawa M, Kamata M, Katsumata R and Aida Y (2000) A carboxy-terminally truncated form of the human immunodeficiency virus type 1 Vpr protein induces apoptosis via G1 cell cycle arrest. J. Virol. 74: 6058-6067
57. Somasundaran M, Sharkey M, Brichacek B, Luzuriaga K, Emerman M, Sullivan JL and Stevenson M (2002) Evidence for a cytopathogenicity determinant in HIV-1 Vpr. Proc. Natl. Acad. Sci. USA 99: 9503-9508
58. Jacotot E, Ravagnan L, Loeffler M, Ferri KF, Vieira HLA, Zamzami N, Costantini P, Druillennec S, Hoebeke J, Brian JP, Irinopoulos T, Daugas E, Susin SA, Cointe D, Xie ZH, Reed JC, Roques BP and Kroemer G (2000) The HIV-1 viral protein R induces apoptosis via a direct effect on the mitochondrial permeability transition pore. J. Exp. Med. 191: 33-45
59. Roumier T, Vieira HLA, Castedo M, Ferri KF, Boya P, Andreau K, Druillennec S, Joza N, Penninger JM, Roques B and Kroemer G (2002) The C-terminal moiety of HIV-1 Vpr induces cell death via acaspase-independent mitochondrial pathway, Cell Death Differ. in press
60. Jacotot E, Ferri KF, El Hamel C, Brenner C, Druillennec S, Hoebeke J, Rustin P, Métivier D, Lenoir C, Geuskens M, Vieira HLA, Loeffler M, Belzacq A-S, Briand J-P, Zamzami N, Edelman L, Xie ZH, Reed JC, Roques BP and Kroemer G (2001) Control of mitochondrial membrane permeabilization by adenine nucleotide translocator interacting with HIV-1 Vpr and Bcl-2. J. Exp. Med. 193: 509-520
61. Wang B, Ge YC, Palasnthiran P, Xiang SH, Ziegler J, Dwyer DE, Randle C, Dowton D, Cunningham A and Saksena NK (1996) Gene defects clustered at the C-terminus of the vpr gene of HIV-1 in long-term non progressing mother and child pair: in vivo evolution of vpr quasispecies in blood and plasma. Virology 223: 224-232
62. Zhang L, Huang Y, Yuan H, Tuttleton S and Ho DD (1997) Genetic characterization of vit, vpr and vpu sequences from long-term survivors of human immunodeficiency virus type 1 infection. Virology 228: 340-349
63. Meikrantz W and Schlegel R (1996). Suppression of apoptosis by dominant negative mutants of cyclin-dependent protein kinases. J. Biol. Chem. 271: 10205-10209
64. Yao SL, McKenna KA, Sharkis SJ and Bodi A (1996) Requirementof p34cdc2 kinase for apoptosis mediated by the Fas/APO-1 receptor and interleukin 1beta-converting enzyme-related proteases. Cancer Res. 56: 4551-4555
65. Porter LA, Singh G and Lee JM (2000) Abundance of cyclin B1 regulates gamma-radiation-induced apoptosis. Blood 95: 2645-2650
66. Fotedar R, Flatt J, Gupta S, Margolis RL, Fitzgerald P, Messier H and Fotedar A (1995) Activation-induced T-cell death is cell cycle dependent and regulated by cyclin B. Mol. Cell. Biol, 15: 932-942