Divergent roles of c-Src in controlling platelet-derived growth factor-dependent signaling in fibroblasts

Molecular Biology of the Cell

Volumn 16, Issue 11, 2005, Pages 5418-5432

  Shah, Kavita ^a   Vincent, Fabien ^a,b  

^a PURDUE UNIVERSITY   (United States)

^b EVOTEC AG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; PHOSPHATIDYLINOSITOL 3 KINASE; PLATELET DERIVED GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR BETA; PROTEIN C SRC; PROTEIN TYROSINE KINASE; RAS PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CHEMOTAXIS; CYTOSKELETON; DNA SYNTHESIS; FIBROBLAST; GENE CONTROL; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; TRANSLATION REGULATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ACTINS; ANIMALS; CELL LINE; CHEMOTAXIS; CLONE CELLS; DNA; FIBROBLASTS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENES, SRC; MICE; NIH 3T3 CELLS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHOSPHOLIPASE C GAMMA; PHOSPHORYLATION; PLATELET-DERIVED GROWTH FACTOR; RAS PROTEINS; SIGNAL TRANSDUCTION; SRC-FAMILY KINASES;

EID: 27644454764     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.E05-03-0263     Document Type: Article

References (55)

1. Abedi, H., Dawes, K. E., and Zachary, I. (1995). Differential effects of platelet-derived growth factor BB on p125 focal adhesion kinase and paxillin tyrosine phosphorylation and on cell migration in rabbit aortic vascular smooth muscle cells and Swiss 3T3 fibroblasts. J. Biol. Chem. 270, 11367-11376.
2. Abram, C. L., and Courtneidge, S. A. (2000). Src family tyrosine kinases and growth factor signaling. Exp. Cell Res. 254, 1-13.
3. Adilakshmi, T., and Laine, R. O. (2002). Ribosomal protein S25 mRNA partners with MTF-1 and La to provide a p53-mediated mechanism for survival or death. J. Biol. Chem. 277, 4147-4151.
4. Aligayer, H., Boyd, D. D., Heiss, M. M., Abdalla, E. K., Curley, S. A., and Gallick, G. E. (2002). Activation of Src kinase in primary colorectal carcinoma: an indicator of poor clinical prognosis. Cancer. 94, 344-351.
5. Barone, M. V., and Courtneidge, S. A. (1995). Myc but not Fos rescue of platelet-derived growth factor signalling block caused by kinase-inactive Src. Nature. 378, 509-512.
6. Bishop, A. C., et al. (2000). A chemical switch for inhibitor-sensitive alleles of any protein kinase. Nature. 407, 395-401.
7. Blake, R. A., Broome, M. A., Liu, X., Wu, J., Gishizky, M., Sun, L., and Courtneidge, S. A. (2000). SU6656, a selective src family kinase inhibitor, used to probe growth factor signaling. Mol. Cell. Biol. 20, 9018-9027.
8. Blasi, F. (1997). uPA, uPAR, PAI-1, key intersection of proteolytic, adhesive and chemotactic highways? Immunol Today 18, 415-417.
9. Bonacchi, A., et al. (2001). Signal transduction by the chemokine receptor CXCR 3, activation of Ras/ERK, Src, and phosphatidylinositol 3-kinase/Akt controls cell migration and proliferation in human vascular pericytes. J. Biol. Chem. 276, 9945-9954.
10. Bondeva, T., Balla, A., Varnai, P., and Balla, T. (2002). Structural determinants of Ras-Raf interaction analyzed in live cells. Mol. Biol. Cell. 13, 2323-2333.
11. Broome, M. A., and Courtneidge, S. A. (2000). No requirement for src family kinases for platelet-derived growth factor signaling in fibroblasts expressing SV40 large T antigen. Oncogene 19, 2867-2869.
12. Bromann, P. A., Korkaya, H., and Courtneidge, S. A. (2004). The interplay between Src family kinases and receptor tyrosine kinases. Oncogene 23, 7957-7968.
13. Brown, M. T., and Cooper, J. A. (1996). Regulation, substrates and functions of src. Biochim. Biophys. Acta 1287, 121-149.
14. Chiarugi, P., et al. (2002). New perspectives in platelet-derived growth factor receptor downregulation: the main role of phosphotyrosine phosphatases. J. Cell Sci. 115, 2219-2232.
15. de Rooij, J., and Bos, J. L. (1997). Minimal Ras-binding domain of Raf1 can be used as an activation-specific probe for Ras. Oncogene 14, 623-625.
16. DeMali, K. A., Godwin, S. L., Soltoff, S. P., and Kazlauskas, A. (1999). Multiple roles for Src in a platelet-derived growth factor-stimulated cell. Exp. Cell Res. 253, 271-279.
17. DeMali, K. A., and Kazlauskas, A. (1998). Activation of Src family members is not required for the platelet-derived growth factor beta receptor to initiate mitogenesis. Mol. Cell. Biol. 18, 2014-2022.
18. DeMali, K. A., Whiteford, C. C., Ulug, E. T., and Kazlauskas, A. (1997). Platelet-derived growth factor-dependent cellular transformation requires either phospholipase Cy or phosphatidylinositol 3 kinase. J. Biol. Chem. 272, 9011-9018.
19. Eblen, S. T., Kumar, N. V., Shah, K., Henderson, M. J., Watts, C. K., Shokat, K. M., and Weber, M. J. (2003). Identification of novel ERK2 substrates through use of an engineered kinase and ATP analogs. J. Biol. Chem. 278, 14926-14935.
20. Elenius, K., Paul, S., Allison, G., Sun, J., and Klagsbrun, M. (1997). Activation of HER4 by heparin-binding EGF-like growth factor stimulates chemotaxis but not proliferation. EMBO J. 16, 1268-1278.
21. Falasca, M., Logan, S. K., Lehto, V. P., Baccante, G., Lemmon, M. A., and Schlessinger, J. (1998). Activation of phospholipase C gamma by PI 3-kinase-induced PH domain-mediated membrane targeting. EMBO J. 17, 414-422.
22. Fambrough, D., McClure, K., Kazlauskas, A., and Lander, E. S. (1999). Diverse signaling pathways activated by growth factor receptors induce broadly overlapping, rather than independent, sets of genes. Cell 97, 727-741.
23. Feig, L. A., and Schaffhausen, B. (1994). Signal transduction. The hunt for Ras targets. Nature 370, 508-509.
24. Furstoss, O., Dorey, K., Simon, V., Barila, D., Superti-Furga, G., and Roche, S. (2002). c-Abl is an effector of Src for growth factor-induced c-myc expression and DNA synthesis. EMBO J. 21, 514-524.
25. Habelhah, H., Shah, K., Huang, L., Ostareck-Lederer, A., Burlingame, A. L., Shokat, K. M., Hentze, M. W., and Ronai, Z. (2001). ERK phosphorylation drives cytoplasmic accumulation of hnRNP-K and inhibition of mRNA translation. Nat. Cell Biol. 3, 325-330.
26. Hall, A. (1998). Rho GTPases and the actin cytoskeleton. Science 279, 509-514.
27. Heldin, C. H., Ostman, A., and Ronnstrand, L. (1998). Signal transduction via platelet-derived growth factor receptors. Biochim. Biophys. Acta 1378, F79-F113.
28. Jackson, T. R., Kearns, B. G., and Theibert, A. B. (2000). Cytohesins and centaurins: mediators of PI 3-kinase-regulated Arf signaling. Trends Biochem. Sci. 25, 489-495.
29. Jimenez, C., Portela, R. A., Mellado, M., Rodriguez-Frade, J. M., Collard, J., Serrano, A., Martinez, A. C., Avila, J., and Carrera, A. C. (2000). Role of the PI3K regulatory subunit in the control of actin organization and cell migration. J. Cell Biol. 151, 249-262.
30. Jones, S. M., and Kazlauskas, A. (2001). Growth-factor-dependent mitogenesis requires two distinct phases of signalling. Nat. Cell Biol. 3, 165-172.
31. Jones, S. M., Klinghoffer, R., Prestwich, G. D., Toker, A., and Kazlauskas, A. (1999). Platelet-derived growth factor induces an early and a late wave of PI 3-kinase activity, and only the late wave is required for progression through G1. Curr. Biol. 9, 512-521.
32. Kettenhofen, R., Hoppe, J., Eberhard, G., Seul, C., Ko, Y., and Sachinidis, A. (2001). Regulation of Gadd45a mRNA expression in vascular smooth muscle under growth and stress conditions. Cell Signal. 13, 787-799.
33. Klinghoffer, R. A., Sachsenmaier, C., Cooper, J. A., and Soriano, P. (1999). Src family kinases are required for integrin but not PDGFR signal transduction. EMBO J. 18, 2459-2471.
34. Kypta, R. M., Goldberg, Y., Ulug, E. T., and Courtneidge, S. A. (1990). Association between the platelet-derived growth factor receptor and members of the src family of tyrosine kinases. Cell 62, 481-492.
35. Liu, X., and Erikson, R. L. (2002). Activation of Cdc2/cyclin B and inhibition of centrosome amplification in cells depleted of Plk1 by siRNA. Proc. Natl. Acad. Sci. USA 99, 8672-8676.
36. Liu, Y., Shah, K., Yang, F., Witucki, L., and Shokat, K. M. (1998). A molecular gate which controls unnatural ATP analogue recognition by the tyrosine kinase v-Src. Bioorg. Med. Chem. 6, 1219-1226.
37. Mureebe, L., Nelson, P. R., Yamamura, S., Lawitts, J., and Kent, K. C. (1997). Activation of pp60c-src is necessary for human vascular smooth muscle cell migration. Surgery 122, 144-145.
38. Rosenkranz, S., Ikuno, Y., Leong, F. L., Klinghoffer, R. A., Miyak, S., Band, H., and Kazlauskas, A. (2000). Src family kinases negatively regulate platelet-derived growth factor alpha receptor-dependent signaling and disease progression. J. Biol. Chem. 275, 9620-9627.
39. Sendo, F., and Araki, Y. (1999). Regulation of leukocyte adherence and migration by glycosylphosphatidyl-inositol-anchored proteins. J. Leukoc. Biol. 66, 369-374.
40. Shah, K., Liu, Y., Deirmengian, C., and Shokat, K. M. (1997). Engineering unnatural nucleotide specificity for Rous sarcoma virus tyrosine kinase to uniquely label its direct substrates. Proc. Natl. Acad. Sci. USA 94, 3565-3570.
41. Shah, K., and Shokat, K. M. (2002). A chemical genetic screen for direct v-Src substrates reveals ordered assembly of a retrograde signaling pathway. Chem. Biol. 9, 35-47.
42. Shinohara, H., Yasuda, T., and Yamanashi, Y. (2004). Dok-1 tyrosine residues at 336 and 340 are essential for the negative regulation of Ras-Erk signalling, but dispensable for rasGAP-binding. Genes Cells 9, 601-607.
43. Sieg, D. J., Hauck, C. R., Ilic, D., Klingbeil, C. K., Schaefer, E., Damsky, C. H., and Schlaepfer, D. D. (2000). FAK integrates growth-factor and integrin signals to promote cell migration. Nat. Cell Biol. 2, 249-256.
44. Tallquist, M., and Kazlauskas, A. (2004). Cytokine growth factor Rev. 15, 205-213.
45. Tatton L., Morley, G. M., Chopra, R., and Khwaja, A. (2003). The Src-selective kinase inhibitor PP1 also inhibits Kit and Bcr-Abl tyrosine kinases. J. Biol. Chem. 278, 4847-4853.
46. Ubersax, J. A., Woodbury, E. L., Quang, P. N., Paraz, M., Blethrow, J. D., Shah, K., Shokat, K. M., and Morgan, D. O. (2003). Targets of the cyclin-dependent kinase Cdk1. Nature. 425, 859-864.
47. Valgeirsdottir, S., Claesson-Welsh, L., Bongcam-Rudloff, E., Hellman, U., Westermark, B., and Heldin, C. H. (1998). PDGF induces reorganization of vimentin filaments. J. Cell Sci. 111, 1973-1980.
48. Waltenberger, J., et al. (1999). A dual inhibitor of platelet-derived growth factor beta-receptor and Src kinase activity potently interferes with motogenic and mitogenic responses to platelet-derived growth factor in vascular smooth muscle cells. A novel candidate for prevention of vascular remodeling. Circ. Res. 85, 12-22.
49. Weed, S. A., and Parsons, J. T. (2001). Cortactin: coupling membrane dynamics to cortical actin assembly. Oncogene. 20, 6418-6434.
50. Winter, C. G., Wang, B., Ballew, A., Royou, A., Karess, R., Axelrod, J. D., and Luo, L. (2001). Drosophila Rho-associated kinase (Drok) links Frizzled-mediated planar cell polarity signaling to the actin cytoskeleton. Cell 105, 81-91.
51. Witucki, L. A., Huang, X., Shah, K., Liu, Y., Kyin, S., Eck, M. J., and Shokat, K. M. (2002). Mutant tyrosine kinases with unnatural nucleotide specificity retain the structure and phospho-acceptor specificity of the wild-type enzyme. Chem. Biol. 9, 25-33.
52. Yang, F., Liu, Y., Bixby, S. D., Friedman, J. D., and Shokat, K. M. (1999). Highly efficient green fluorescent protein-based kinase substrates. Anal. Biochem. 266, 167-173.
53. Zhao, M., Liu, Y., Bao, M., Kato, Y., Han, J., and Eaton, J. W. (2002). Vascular smooth muscle cell proliferation requires both p38 and BMK1 MAP kinases. Arch. Biochem. Biophys. 400, 199-207.
54. Zhao, M., Schmitz, A. A., Qin, Y., DiCristofano, A., Pandolfi, P. P., and Van Aelst, L. (2001). Phosphoinositide 3-kinase-dependent membrane recruitment of p62(dok) is essential for its negative effect on mitogen-activated protein (MAP) kinase activation. J. Exp. Med. 194, 265-274.
55. Zhao, R., and Zhao, Z. J. (1999). Tyrosine phosphatase SHP-2 dephosphorylates the platelet-derived growth factor receptor but enhances its downstream signalling. Biochem. J. 338, 35-39.