메뉴 건너뛰기




Volumn 97, Issue 12, 2012, Pages 1895-1903

Alternative TEL-JAK2 fusions associated with T-cell acute lymphoblastic leukemia and atypical chronic myelogenous leukemia dissected in zebrafish

Author keywords

Leukemia; Oncogenesis; TEL JAK2; Zebrafish

Indexed keywords

GELATINASE B; JANUS KINASE 2; STAT3 PROTEIN; STAT5 PROTEIN; TRANSCRIPTION FACTOR ETV6;

EID: 84870410309     PISSN: 03906078     EISSN: 15928721     Source Type: Journal    
DOI: 10.3324/haematol.2012.064659     Document Type: Article
Times cited : (37)

References (70)
  • 1
    • 34547108380 scopus 로고    scopus 로고
    • JAK-STAT signaling: From interferons to cytokines
    • Schindler C, Levy DE, Decker T. JAK-STAT signaling: from interferons to cytokines. J Biol Chem. 2007;282(28):20059-63.
    • (2007) J Biol Chem , vol.282 , Issue.28 , pp. 20059-20063
    • Schindler, C.1    Levy, D.E.2    Decker, T.3
  • 3
    • 52449119447 scopus 로고    scopus 로고
    • Somatic mutations of JAK1 and JAK3 in acute leukemias and solid cancers
    • Jeong EG, Kim MS, Nam HK, Min CK, Lee S, Chung YJ, et al. Somatic mutations of JAK1 and JAK3 in acute leukemias and solid cancers. Clin Cancer Res. 2008;14(12):3716-21.
    • (2008) Clin Cancer Res , vol.14 , Issue.12 , pp. 3716-3721
    • Jeong, E.G.1    Kim, M.S.2    Nam, H.K.3    Min, C.K.4    Lee, S.5    Chung, Y.J.6
  • 4
    • 42249091014 scopus 로고    scopus 로고
    • Somatically acquired JAK1 mutations in adult acute lymphoblastic leukemia
    • Flex E, Petrangeli V, Stella L, Chiaretti S, Hornakova T, Knoops L, et al. Somatically acquired JAK1 mutations in adult acute lymphoblastic leukemia. J Exp Med. 2008;205 (4):751-8.
    • (2008) J Exp Med , vol.205 , Issue.4 , pp. 751-758
    • Flex, E.1    Petrangeli, V.2    Stella, L.3    Chiaretti, S.4    Hornakova, T.5    Knoops, L.6
  • 5
    • 47149115129 scopus 로고    scopus 로고
    • Identification of somatic JAK1 mutations in patients with acute myeloid leukemia
    • Xiang Z, Zhao Y, Mitaksov V, Fremont DH, Kasai Y, Molitoris A, et al. Identification of somatic JAK1 mutations in patients with acute myeloid leukemia. Blood. 2008;111 (9):4809-12.
    • (2008) Blood , vol.111 , Issue.9 , pp. 4809-4812
    • Xiang, Z.1    Zhao, Y.2    Mitaksov, V.3    Fremont, D.H.4    Kasai, Y.5    Molitoris, A.6
  • 7
    • 33847202261 scopus 로고    scopus 로고
    • JAK3 mutations occur in acute megakaryoblastic leukemia both in Down syndrome children and non-Down syndrome adults
    • Kiyoi H, Yamaji S, Kojima S, Naoe T. JAK3 mutations occur in acute megakaryoblastic leukemia both in Down syndrome children and non-Down syndrome adults. Leukemia. 2007;21(3):574-6.
    • (2007) Leukemia , vol.21 , Issue.3 , pp. 574-576
    • Kiyoi, H.1    Yamaji, S.2    Kojima, S.3    Naoe, T.4
  • 8
    • 20144363192 scopus 로고    scopus 로고
    • Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders
    • Baxter EJ, Scott LM, Campbell PJ, East C, Fourouclas N, Swanton S, et al. Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders. Lancet. 2005;365(9464):1054-61.
    • (2005) Lancet , vol.365 , Issue.9464 , pp. 1054-1061
    • Baxter, E.J.1    Scott, L.M.2    Campbell, P.J.3    East, C.4    Fourouclas, N.5    Swanton, S.6
  • 10
    • 17844383458 scopus 로고    scopus 로고
    • A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera
    • James C, Ugo V, Le Couedic JP, Staerk J, Delhommeau F, Lacout C, et al. A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera. Nature. 2005;434(7037):1144-8.
    • (2005) Nature , vol.434 , Issue.7037 , pp. 1144-1148
    • James, C.1    Ugo, V.2    Le Couedic, J.P.3    Staerk, J.4    Delhommeau, F.5    Lacout, C.6
  • 11
    • 21344440357 scopus 로고    scopus 로고
    • The JAK2 V617F activating tyrosine kinase mutation is an infrequent event in both atypical myeloproliferative disorders and myelodysplastic syndromes
    • Steensma DP, Dewald GW, Lasho TL, Powell HL, McClure RF, Levine RL, et al. The JAK2 V617F activating tyrosine kinase mutation is an infrequent event in both atypical myeloproliferative disorders and myelodysplastic syndromes. Blood. 2005;106(4):1207-9.
    • (2005) Blood , vol.106 , Issue.4 , pp. 1207-1209
    • Steensma, D.P.1    Dewald, G.W.2    Lasho, T.L.3    Powell, H.L.4    McClure, R.F.5    Levine, R.L.6
  • 12
    • 33644752653 scopus 로고    scopus 로고
    • The JAK2 V617F mutation in de novo acute myelogenous leukemias
    • Lee JW, Kim YG, Soung YH, Han KJ, Kim SY, Rhim HS, et al. The JAK2 V617F mutation in de novo acute myelogenous leukemias. Oncogene. 2006;25(9):1434-6.
    • (2006) Oncogene , vol.25 , Issue.9 , pp. 1434-1436
    • Lee, J.W.1    Kim, Y.G.2    Soung, Y.H.3    Han, K.J.4    Kim, S.Y.5    Rhim, H.S.6
  • 13
    • 13344279401 scopus 로고    scopus 로고
    • STAT- related transcription factors are constitutively activated in peripheral blood cells from acute leukemia patients
    • Gouilleux-Gruart B, Gouilleux F, Desaint C, Claisse JF, Capiod JC, Delobel J, et al. STAT- related transcription factors are constitutively activated in peripheral blood cells from acute leukemia patients. Blood. 1996;87 (5):1692-7.
    • (1996) Blood , vol.87 , Issue.5 , pp. 1692-1697
    • Gouilleux-Gruart, B.1    Gouilleux, F.2    Desaint, C.3    Claisse, J.F.4    Capiod, J.C.5    Delobel, J.6
  • 14
    • 0031573141 scopus 로고    scopus 로고
    • Constitutive activation of JAKs and STATs in BCR-Abl-expressing cell lines and peripheral blood cells derived from leukemic patients
    • Chai SK, Nichols GL, Rothman P. Constitutive activation of JAKs and STATs in BCR-Abl-expressing cell lines and peripheral blood cells derived from leukemic patients. J Immunol. 1997;159(10):4720-8.
    • (1997) J Immunol , vol.159 , Issue.10 , pp. 4720-4728
    • Chai, S.K.1    Nichols, G.L.2    Rothman, P.3
  • 15
    • 0033976059 scopus 로고    scopus 로고
    • The Jak-Stat pathway in normal and perturbed hematopoiesis
    • Ward AC, Touw I, Yoshimura A. The Jak-Stat pathway in normal and perturbed hematopoiesis. Blood. 2000;95(1):19-29.
    • (2000) Blood , vol.95 , Issue.1 , pp. 19-29
    • Ward, A.C.1    Touw, I.2    Yoshimura, A.3
  • 16
    • 0030852328 scopus 로고    scopus 로고
    • Fusion of TEL, the ETS-variant gene 6 (ETV6), to the receptor-associated kinase JAK2 as a result of t(9;12) in a lymphoid and t(9;15;12) in a myeloid leukemia
    • Peeters P, Raynaud SD, Cools J, Wlodarska I, Grosgeorge J, Philip P, et al. Fusion of TEL, the ETS-variant gene 6 (ETV6), to the receptor-associated kinase JAK2 as a result of t(9;12) in a lymphoid and t(9;15;12) in a myeloid leukemia. Blood. 1997;90(7):2535-40.
    • (1997) Blood , vol.90 , Issue.7 , pp. 2535-2540
    • Peeters, P.1    Raynaud, S.D.2    Cools, J.3    Wlodarska, I.4    Grosgeorge, J.5    Philip, P.6
  • 17
    • 27944481825 scopus 로고    scopus 로고
    • The t(8;9)(p22;p24) translocation in atypical chronic myeloid leukaemia yields a new PCM1-JAK2 fusion gene
    • Bousquet M, Quelen C, De Mas V, Duchayne E, Roquefeuil B, Delsol G, et al. The t(8;9)(p22;p24) translocation in atypical chronic myeloid leukaemia yields a new PCM1-JAK2 fusion gene. Oncogene. 2005;24(48):7248-52.
    • (2005) Oncogene , vol.24 , Issue.48 , pp. 7248-7252
    • Bousquet, M.1    Quelen, C.2    de Mas, V.3    Duchayne, E.4    Roquefeuil, B.5    Delsol, G.6
  • 18
    • 15444339209 scopus 로고    scopus 로고
    • A TEL- JAK2 fusion protein with constitutive kinase activity in human leukemia
    • Lacronique V, Boureux A, Valle VD, Poirel H, Quang CT, Mauchauffe M, et al. A TEL- JAK2 fusion protein with constitutive kinase activity in human leukemia. Science. 1997;278(5341):1309-12.
    • (1997) Science , vol.278 , Issue.5341 , pp. 1309-1312
    • Lacronique, V.1    Boureux, A.2    Valle, V.D.3    Poirel, H.4    Quang, C.T.5    Mauchauffe, M.6
  • 19
    • 0032530972 scopus 로고    scopus 로고
    • Transformation of hematopoietic cell lines to growth-factor independence and induction of a fatal myeloand lymphoproliferative disease in mice by retrovirally transduced TEL/JAK2 fusion genes
    • Schwaller J, Frantsve J, Aster J, Williams IR, Tomasson MH, Ross TS, et al. Transformation of hematopoietic cell lines to growth-factor independence and induction of a fatal myeloand lymphoproliferative disease in mice by retrovirally transduced TEL/JAK2 fusion genes. EMBO J. 1998;17(18):5321-33.
    • (1998) EMBO J , vol.17 , Issue.18 , pp. 5321-5333
    • Schwaller, J.1    Frantsve, J.2    Aster, J.3    Williams, I.R.4    Tomasson, M.H.5    Ross, T.S.6
  • 21
    • 0034653478 scopus 로고    scopus 로고
    • Transforming properties of chimeric TEL- JAK proteins in Ba/F3 cells
    • Lacronique V, Boureux A, Monni R, Dumon S, Mauchauffe M, Mayeux P, et al. Transforming properties of chimeric TEL- JAK proteins in Ba/F3 cells. Blood. 2000;95(6):2076-83.
    • (2000) Blood , vol.95 , Issue.6 , pp. 2076-2083
    • Lacronique, V.1    Boureux, A.2    Monni, R.3    Dumon, S.4    Mauchauffe, M.5    Mayeux, P.6
  • 22
    • 0031017533 scopus 로고    scopus 로고
    • Mutation in the Jak kinase JH2 domain hyperactivates Drosophila and mammalian Jak-Stat pathways
    • Luo H, Rose P, Barber D, Hanratty WP, Lee S, Roberts TM, et al. Mutation in the Jak kinase JH2 domain hyperactivates Drosophila and mammalian Jak-Stat pathways. Mol Cell Biol. 1997;17(3):1562-71.
    • (1997) Mol Cell Biol , vol.17 , Issue.3 , pp. 1562-1571
    • Luo, H.1    Rose, P.2    Barber, D.3    Hanratty, W.P.4    Lee, S.5    Roberts, T.M.6
  • 23
    • 2442642830 scopus 로고    scopus 로고
    • Tyrosine phosphorylation of Jak2 in the JH2 domain inhibits cytokine signalling
    • Feener EP, Rosario F, Dunn SL, Stancheva Z, Myers MGJ. Tyrosine phosphorylation of Jak2 in the JH2 domain inhibits cytokine signalling. Mol Cell Biol. 2004;24(11):4968-78.
    • (2004) Mol Cell Biol , vol.24 , Issue.11 , pp. 4968-4978
    • Feener, E.P.1    Rosario, F.2    Dunn, S.L.3    Stancheva, Z.4    Myers, M.G.J.5
  • 24
    • 80052492285 scopus 로고    scopus 로고
    • The pseudokinase domain of JAK2 is a dual-specificity protein kinase that negatively regulates cytokine signaling
    • Ungureanu D, Wu J, Pekkala T, Niranjan Y, Young C, Jensen ON, et al. The pseudokinase domain of JAK2 is a dual-specificity protein kinase that negatively regulates cytokine signaling. Nat Struct Mol Biol. 2011;18(9):971-6.
    • (2011) Nat Struct Mol Biol , vol.18 , Issue.9 , pp. 971-976
    • Ungureanu, D.1    Wu, J.2    Pekkala, T.3    Niranjan, Y.4    Young, C.5    Jensen, O.N.6
  • 25
    • 0344517071 scopus 로고    scopus 로고
    • Fusion of the ets transcription factor TEL to Jak2 results in constitutive Jak-Stat signaling
    • Ho JM-Y, Beattie BK, Squire JA, Frank DA, Barber DL. Fusion of the ets transcription factor TEL to Jak2 results in constitutive Jak-Stat signaling. Blood. 1999;93(12):4354-64.
    • (1999) Blood , vol.93 , Issue.12 , pp. 4354-4364
    • Ho, J.M.-Y.1    Beattie, B.K.2    Squire, J.A.3    Frank, D.A.4    Barber, D.L.5
  • 26
    • 33644976909 scopus 로고    scopus 로고
    • A transgenic mouse model for TEL-JAK2-induced B-cell lymphoma/leukemia
    • dos Santos NR, Ghysdael J. A transgenic mouse model for TEL-JAK2-induced B-cell lymphoma/leukemia. Leukemia. 2006;20 (1):182-5.
    • (2006) Leukemia , vol.20 , Issue.1 , pp. 182-185
    • dos Santos, N.R.1    Ghysdael, J.2
  • 27
    • 0033639119 scopus 로고    scopus 로고
    • Stat5 is essential for the myeloand lymphoproliferative disease induced by TEL/JAK2
    • Schwaller J, Parganas E, Wang D, Cain D, Aster JC, Williams IR, et al. Stat5 is essential for the myeloand lymphoproliferative disease induced by TEL/JAK2. Mol Cell. 2000;6(3):693-704.
    • (2000) Mol Cell , vol.6 , Issue.3 , pp. 693-704
    • Schwaller, J.1    Parganas, E.2    Wang, D.3    Cain, D.4    Aster, J.C.5    Williams, I.R.6
  • 28
    • 0035864739 scopus 로고    scopus 로고
    • The TEL-Jak2 oncoprotein induces Socs1 expression and altered cytokine response in Ba/F3 cells
    • Monni R, Santos SC, Mauchauffe M, Berger R, Ghysdael J, Gouilleux F, et al. The TEL-Jak2 oncoprotein induces Socs1 expression and altered cytokine response in Ba/F3 cells. Oncogene. 2001;20(7):849-58.
    • (2001) Oncogene , vol.20 , Issue.7 , pp. 849-858
    • Monni, R.1    Santos, S.C.2    Mauchauffe, M.3    Berger, R.4    Ghysdael, J.5    Gouilleux, F.6
  • 29
    • 0035036625 scopus 로고    scopus 로고
    • Socs-1 inhibits TEL-JAK2- mediated transformation of hematopoietic cells through inhibition of JAK2 kinase activity and induction of proteosomal-mediated degradation
    • Frantsve J, Schwaller J, Sternberg DW, Kutok J, Gilliland DG. Socs-1 inhibits TEL-JAK2- mediated transformation of hematopoietic cells through inhibition of JAK2 kinase activity and induction of proteosomal-mediated degradation. Mol Cell Biol. 2001;21(10):3547-57.
    • (2001) Mol Cell Biol , vol.21 , Issue.10 , pp. 3547-3557
    • Frantsve, J.1    Schwaller, J.2    Sternberg, D.W.3    Kutok, J.4    Gilliland, D.G.5
  • 30
    • 0035918239 scopus 로고    scopus 로고
    • The SOCS box of SOCS-1 accelerates ubiquitin-dependent proteolysis of TEL-JAK2
    • Kamizono S, Hanada T, Yasukawa H, Minoguchi S, Kato R, Minoguchi M, et al. The SOCS box of SOCS-1 accelerates ubiquitin-dependent proteolysis of TEL-JAK2. J Biol Chem. 2001;276(16):12530-8.
    • (2001) J Biol Chem , vol.276 , Issue.16 , pp. 12530-12538
    • Kamizono, S.1    Hanada, T.2    Yasukawa, H.3    Minoguchi, S.4    Kato, R.5    Minoguchi, M.6
  • 32
    • 0036337052 scopus 로고    scopus 로고
    • Runx1 is required for zebrafish blood and vessel development and expression of a human RUNX1-CBF2T1 transgene advances a model for studies of leukemogenesis
    • Kalev-Zylinska ML, Horsfield JA, Flores MV, Postlethwait JH, Vitas MR, Baas AM, et al. Runx1 is required for zebrafish blood and vessel development and expression of a human RUNX1-CBF2T1 transgene advances a model for studies of leukemogenesis. Development. 2002;129(8):2015-30.
    • (2002) Development , vol.129 , Issue.8 , pp. 2015-2030
    • Kalev-Zylinska, M.L.1    Horsfield, J.A.2    Flores, M.V.3    Postlethwait, J.H.4    Vitas, M.R.5    Baas, A.M.6
  • 35
    • 70449337685 scopus 로고    scopus 로고
    • A novel zebrafish jak2a(V581F) model shared features of human JAK2(V617F) polycythemia vera
    • Ma AC, Fan A, Ward AC, Liongue C, Lewis RS, Cheng SH, et al. A novel zebrafish jak2a(V581F) model shared features of human JAK2(V617F) polycythemia vera. Exp Hematol. 2009;37(12):1379-86.
    • (2009) Exp Hematol , vol.37 , Issue.12 , pp. 1379-1386
    • Ma, A.C.1    Fan, A.2    Ward, A.C.3    Liongue, C.4    Lewis, R.S.5    Cheng, S.H.6
  • 36
    • 13044263117 scopus 로고    scopus 로고
    • Gene duplication of zebrafish JAK2 homologs is accompanied by divergent embryonic expression patterns: Only jak2a is expressed during erythropoiesis
    • Oates AC, Brownlie A, Pratt SJ, Irvine DV, Liao EC, Paw BH, et al. Gene duplication of zebrafish JAK2 homologs is accompanied by divergent embryonic expression patterns: only jak2a is expressed during erythropoiesis. Blood. 1999;94(8):2622-36.
    • (1999) Blood , vol.94 , Issue.8 , pp. 2622-2636
    • Oates, A.C.1    Brownlie, A.2    Pratt, S.J.3    Irvine, D.V.4    Liao, E.C.5    Paw, B.H.6
  • 37
    • 0028306459 scopus 로고
    • Expression of achaete-scute homolog 3 in Xenopus embryos converts ectoderm cells to a neural fate
    • Turner DL, Weintraub H. Expression of achaete-scute homolog 3 in Xenopus embryos converts ectoderm cells to a neural fate. Genes Dev. 1994;8(12):1434-47.
    • (1994) Genes Dev , vol.8 , Issue.12 , pp. 1434-1447
    • Turner, D.L.1    Weintraub, H.2
  • 38
    • 34548822125 scopus 로고    scopus 로고
    • The role of jak2a in zebrafish hematopoiesis
    • Ma AC, Ward AC, Liang R, Leung AY. The role of jak2a in zebrafish hematopoiesis. Blood. 2007;110(6):1824-30.
    • (2007) Blood , vol.110 , Issue.6 , pp. 1824-1830
    • Ma, A.C.1    Ward, A.C.2    Liang, R.3    Leung, A.Y.4
  • 39
    • 79955045608 scopus 로고    scopus 로고
    • Suppressor of cytokine signaling 1 regulates embryonic myelopoiesis independently of its effects on T cell development
    • O'Sullivan LA, Noor SM, Trengove MC, Lewis RS, Liongue C, Sprigg NS, et al. Suppressor of cytokine signaling 1 regulates embryonic myelopoiesis independently of its effects on T cell development. J Immunol. 2011;186(8):4751-61.
    • (2011) J Immunol , vol.186 , Issue.8 , pp. 4751-4761
    • O'Sullivan, L.A.1    Noor, S.M.2    Trengove, M.C.3    Lewis, R.S.4    Liongue, C.5    Sprigg, N.S.6
  • 40
    • 0142245607 scopus 로고    scopus 로고
    • The zebrafish spi1 promoter drives myeloid-specific expression in stable transgenic fish
    • Ward AC, McPhee DO, Condron MM, Varma S, Cody SH, Onnebo SMN, et al. The zebrafish spi1 promoter drives myeloid-specific expression in stable transgenic fish. Blood. 2003;102(9):3238-40.
    • (2003) Blood , vol.102 , Issue.9 , pp. 3238-3240
    • Ward, A.C.1    McPhee, D.O.2    Condron, M.M.3    Varma, S.4    Cody, S.H.5    Onnebo, S.M.N.6
  • 42
    • 0036066227 scopus 로고    scopus 로고
    • Zebrafish SPI- 1(PU.1) marks a site of myeloid development independent of primitive erythropoiesis: Implications for axial patterning
    • Lieschke GJ, Oates AC, Paw BH, Thompson MA, Hall NE, Ward AC, et al. Zebrafish SPI- 1(PU.1) marks a site of myeloid development independent of primitive erythropoiesis: implications for axial patterning. Dev Biol. 2002;246(2):274-95.
    • (2002) Dev Biol , vol.246 , Issue.2 , pp. 274-295
    • Lieschke, G.J.1    Oates, A.C.2    Paw, B.H.3    Thompson, M.A.4    Hall, N.E.5    Ward, A.C.6
  • 45
    • 33750802678 scopus 로고    scopus 로고
    • Characterization of the zebrafish matrix metalloproteinase 9 gene and its developmental expression pattern
    • Yoong S, O'Connell B, Soanes A, Crowhurst MO, Lieschke GJ, Ward AC. Characterization of the zebrafish matrix metalloproteinase 9 gene and its developmental expression pattern. Gene Expr Patterns. 2007;7(1-2):39-46.
    • (2007) Gene Expr Patterns , vol.7 , Issue.1-2 , pp. 39-46
    • Yoong, S.1    O'Connell, B.2    Soanes, A.3    Crowhurst, M.O.4    Lieschke, G.J.5    Ward, A.C.6
  • 46
    • 0030728460 scopus 로고    scopus 로고
    • GATA-1 expression pattern can be recapitulated in living transgenic zebrafish using GFP reporter gene
    • Long Q, Meng A, Wang H, Jessen JR, Farrell MJ, Lin S. GATA-1 expression pattern can be recapitulated in living transgenic zebrafish using GFP reporter gene. Development. 1997;124(20):4105-11.
    • (1997) Development , vol.124 , Issue.20 , pp. 4105-4111
    • Long, Q.1    Meng, A.2    Wang, H.3    Jessen, J.R.4    Farrell, M.J.5    Lin, S.6
  • 47
    • 0030958773 scopus 로고    scopus 로고
    • Promoter analysis in living zebrafish embryos identifies a cis-acting motif required for neuronal expression of GATA-2
    • Meng A, Tang H, Ong BA, Farrell MJ, Lin S. Promoter analysis in living zebrafish embryos identifies a cis-acting motif required for neuronal expression of GATA-2. Proc Natl Acad Sci USA. 1997;94(12):6267-72.
    • (1997) Proc Natl Acad Sci USA , vol.94 , Issue.12 , pp. 6267-6272
    • Meng, A.1    Tang, H.2    Ong, B.A.3    Farrell, M.J.4    Lin, S.5
  • 49
    • 0032902009 scopus 로고    scopus 로고
    • Early hematopoiesis and developing lymphoid organs in the zebrafish
    • Willett CE, Cortes A, Zuasti A, Zapata A. Early hematopoiesis and developing lymphoid organs in the zebrafish. Dev Dyn. 1999;214(4):323-36.
    • (1999) Dev Dyn , vol.214 , Issue.4 , pp. 323-336
    • Willett, C.E.1    Cortes, A.2    Zuasti, A.3    Zapata, A.4
  • 50
    • 31844435122 scopus 로고    scopus 로고
    • Constitutive activation of zebrafish stat5 expands hematopoietic cell populations in vivo
    • Lewis RS, Stephenson SEM, Ward AC. Constitutive activation of zebrafish stat5 expands hematopoietic cell populations in vivo. Exp Hematol. 2006;34(2):179-87.
    • (2006) Exp Hematol , vol.34 , Issue.2 , pp. 179-187
    • Lewis, R.S.1    Stephenson, S.E.M.2    Ward, A.C.3
  • 52
    • 2542442633 scopus 로고    scopus 로고
    • Transcriptional control of early B cell development
    • Busslinger M. Transcriptional control of early B cell development. Annu Rev Immunol. 2004;22:55-79.
    • (2004) Annu Rev Immunol , vol.22 , pp. 55-79
    • Busslinger, M.1
  • 53
    • 33344471678 scopus 로고    scopus 로고
    • V617F mutation in JAK2 is associated with poorer survival in idiopathic myelofibrosis
    • Campbell PJ, Griesshammer M, Dohner H, Kusec R, Hasselbalch HC, Larsen TS, et al. V617F mutation in JAK2 is associated with poorer survival in idiopathic myelofibrosis. Blood. 2006;107(5):2098-100.
    • (2006) Blood , vol.107 , Issue.5 , pp. 2098-2100
    • Campbell, P.J.1    Griesshammer, M.2    Dohner, H.3    Kusec, R.4    Hasselbalch, H.C.5    Larsen, T.S.6
  • 55
    • 39649099388 scopus 로고    scopus 로고
    • A role for JAK2 mutations in myeloproliferative diseases
    • Morgan KJ, Gilliland DG. A role for JAK2 mutations in myeloproliferative diseases. Annu Rev Med. 2008;59:213-22.
    • (2008) Annu Rev Med , vol.59 , pp. 213-222
    • Morgan, K.J.1    Gilliland, D.G.2
  • 56
    • 34249728880 scopus 로고    scopus 로고
    • The myeloproliferative disorder-associated JAK2 V617F mutant escapes negative regulation by suppressor of cytokine signaling 3
    • Hookham MB, Elliott J, Suessmuth Y, Staerk J, Ward AC, Vainchenker W, et al. The myeloproliferative disorder-associated JAK2 V617F mutant escapes negative regulation by suppressor of cytokine signaling 3. Blood. 2007;109(11):4924-9.
    • (2007) Blood , vol.109 , Issue.11 , pp. 4924-4929
    • Hookham, M.B.1    Elliott, J.2    Suessmuth, Y.3    Staerk, J.4    Ward, A.C.5    Vainchenker, W.6
  • 58
    • 33745175876 scopus 로고    scopus 로고
    • Activation of the NF-kappaB pathway by the leukemogenic TEL-Jak2 and TEL-Abl fusion proteins leads to the accumulation of antiapoptotic IAP proteins and involves IKKalpha
    • Malinge S, Monni R, Bernard O, Penard-Lacronique V. Activation of the NF-kappaB pathway by the leukemogenic TEL-Jak2 and TEL-Abl fusion proteins leads to the accumulation of antiapoptotic IAP proteins and involves IKKalpha. Oncogene. 2006;25(25): 3589-97.
    • (2006) Oncogene , vol.25 , Issue.25 , pp. 3589-3597
    • Malinge, S.1    Monni, R.2    Bernard, O.3    Penard-Lacronique, V.4
  • 59
    • 0035980056 scopus 로고    scopus 로고
    • TEL-JAK2 mediates constitutive activation of the phosphatidylinositol 3'-kinase/protein kinase B signaling pathway
    • Nguyen MH, Ho JM, Beattie BK, Barber DL. TEL-JAK2 mediates constitutive activation of the phosphatidylinositol 3'-kinase/protein kinase B signaling pathway. J Biol Chem. 2001;276(35):32704-13.
    • (2001) J Biol Chem , vol.276 , Issue.35 , pp. 32704-32713
    • Nguyen, M.H.1    Ho, J.M.2    Beattie, B.K.3    Barber, D.L.4
  • 60
    • 0037103262 scopus 로고    scopus 로고
    • TEL-JAK2 constitutively activates the extracellular signal-regulated kinase (ERK), stress-activated protein/Jun kinase (SAPK/JNK), and p38 signaling pathways
    • Ho JM, Nguyen MH, Dierov JK, Badger KM, Beattie BK, Tartaro P, et al. TEL-JAK2 constitutively activates the extracellular signal-regulated kinase (ERK), stress-activated protein/Jun kinase (SAPK/JNK), and p38 signaling pathways. Blood. 2002;100(4):1438-48.
    • (2002) Blood , vol.100 , Issue.4 , pp. 1438-1448
    • Ho, J.M.1    Nguyen, M.H.2    Dierov, J.K.3    Badger, K.M.4    Beattie, B.K.5    Tartaro, P.6
  • 61
    • 56549085955 scopus 로고    scopus 로고
    • Licochalcone A is a potent inhibitor of TEL- Jak2-mediated transformation through the specific inhibition of Stat3 activation
    • Funakoshi-Tago M, Tago K, Nishizawa C, Takahashi K, Mashino T, Iwata S, et al. Licochalcone A is a potent inhibitor of TEL- Jak2-mediated transformation through the specific inhibition of Stat3 activation. Biochem Pharmacol. 2008;76(12):1681-93.
    • (2008) Biochem Pharmacol , vol.76 , Issue.12 , pp. 1681-1693
    • Funakoshi-Tago, M.1    Tago, K.2    Nishizawa, C.3    Takahashi, K.4    Mashino, T.5    Iwata, S.6
  • 62
    • 77953510760 scopus 로고    scopus 로고
    • AT9283, a potent inhibitor of the Aurora kinases and Jak2, has therapeutic potential in myeloproliferative disroders
    • Dawson MA, Curry JE, Barber K, Beer PA, Graham B, Lyons JF, et al. AT9283, a potent inhibitor of the Aurora kinases and Jak2, has therapeutic potential in myeloproliferative disroders. Br J Haematol. 2010;150(1):46-57.
    • (2010) Br J Haematol , vol.150 , Issue.1 , pp. 46-57
    • Dawson, M.A.1    Curry, J.E.2    Barber, K.3    Beer, P.A.4    Graham, B.5    Lyons, J.F.6
  • 63
    • 0037033012 scopus 로고    scopus 로고
    • The pseudokinase domain is required for suppression of basal activity of Jak2 and Jak3 tyrosine kinases and for cytokine-inducible activation of signal transduction
    • Saharinen P, Silvennoinen O. The pseudokinase domain is required for suppression of basal activity of Jak2 and Jak3 tyrosine kinases and for cytokine-inducible activation of signal transduction. J Biol Chem. 2002;277(49):47954-63.
    • (2002) J Biol Chem , vol.277 , Issue.49 , pp. 47954-47963
    • Saharinen, P.1    Silvennoinen, O.2
  • 64
    • 31444455008 scopus 로고    scopus 로고
    • Chronic myeloproliferative disorders: A tyrosine kinase tale
    • De Keersmaecker K, Cools J. Chronic myeloproliferative disorders: a tyrosine kinase tale. Leukemia. 2006;20(2):200-5.
    • (2006) Leukemia , vol.20 , Issue.2 , pp. 200-205
    • de Keersmaecker, K.1    Cools, J.2
  • 65
    • 38349035684 scopus 로고    scopus 로고
    • Development of ET, primary myelofibrosis and PV in mice expressing JAK2 V617F
    • Shide K, Shimoda HK, Kumano T, Karube K, Kameda T, Takenaka K, et al. Development of ET, primary myelofibrosis and PV in mice expressing JAK2 V617F. Leukemia. 2008;22 (1):87-95.
    • (2008) Leukemia , vol.22 , Issue.1 , pp. 87-95
    • Shide, K.1    Shimoda, H.K.2    Kumano, T.3    Karube, K.4    Kameda, T.5    Takenaka, K.6
  • 67
    • 0030607257 scopus 로고    scopus 로고
    • Comparative study on the phosphotyrosine motifs of different cytokine receptors involved in STAT5 activation
    • May P, Gerhartz C, Heesel B, Welte T, Doppler W, Graeve L, et al. Comparative study on the phosphotyrosine motifs of different cytokine receptors involved in STAT5 activation. FEBS Lett. 1996;394(2):221-6.
    • (1996) FEBS Lett , vol.394 , Issue.2 , pp. 221-226
    • May, P.1    Gerhartz, C.2    Heesel, B.3    Welte, T.4    Doppler, W.5    Graeve, L.6
  • 68
    • 0030830179 scopus 로고    scopus 로고
    • Tyrosine docking sites of the rat prolactin receptor required for association and activation of Stat5
    • Pezet A, Ferrag F, Kelly PA, Edery M. Tyrosine docking sites of the rat prolactin receptor required for association and activation of Stat5. J Biol Chem. 1997;272(40): 25043-50.
    • (1997) J Biol Chem , vol.272 , Issue.40 , pp. 25043-25050
    • Pezet, A.1    Ferrag, F.2    Kelly, P.A.3    Edery, M.4
  • 69
    • 0032938723 scopus 로고    scopus 로고
    • Tyrosine-dependent and independent mechanisms of STAT3 activation by the human granulocyte colony-stimulating factor (GCSF) receptor are differentially utilized depending on G-CSF concentration
    • Ward AC, Hermans MHA, Smith L, van Aesch YM, Schelen AM, Antonissen C, et al. Tyrosine-dependent and independent mechanisms of STAT3 activation by the human granulocyte colony-stimulating factor (GCSF) receptor are differentially utilized depending on G-CSF concentration. Blood. 1999;93(1):113-24.
    • (1999) Blood , vol.93 , Issue.1 , pp. 113-124
    • Ward, A.C.1    Hermans, M.H.A.2    Smith, L.3    van Aesch, Y.M.4    Schelen, A.M.5    Antonissen, C.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.