Suppressor of cytokine signaling 1 regulates embryonic myelopoiesis independently of its effects on T cell development

Journal of Immunology

Volumn 186, Issue 8, 2011, Pages 4751-4761

  O'Sullivan, Lynda A ^a   Noor, Suzita M ^a,b   Trengove, Monique C ^a   Lewis, Rowena S ^a,c   Liongue, Clifford ^a   Sprigg, Naomi S ^c   Nicholson, Sandra E ^c   Ward, Alister C ^a  

^a DEAKIN UNIVERSITY   (Australia)

^b UNIVERSITY OF MALAYA   (Malaysia)

^c WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

JANUS KINASE 2; JANUS KINASE 2A; STAT5 PROTEIN; STAT5.1 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL MATURATION; CONTROLLED STUDY; DEVELOPMENTAL STAGE; EMBRYO; EMBRYO DEVELOPMENT; GENE; GENE IDENTIFICATION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIVER; LYMPHOCYTE SUBPOPULATION; MESODERM; MYELOPOIESIS; NONHUMAN; NOTOCHORD; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; SOCS1 GENE; T LYMPHOCYTE; THYMUS; TISSUE DISTRIBUTION; ZEBRA FISH; ZYGOTE;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; BINDING SITES; CLONING, MOLECULAR; EMBRYO, NONMAMMALIAN; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE KNOCKOUT TECHNIQUES; HEK293 CELLS; HUMANS; IN SITU HYBRIDIZATION; MOLECULAR SEQUENCE DATA; MYELOPOIESIS; PHYLOGENY; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; PROTEIN-TYROSINE KINASES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS, DNA; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION; STAT5 TRANSCRIPTION FACTOR; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS; T-LYMPHOCYTES; ZEBRAFISH; ZEBRAFISH PROTEINS;

EID: 79955045608     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1000343     Document Type: Article

References (92)

1. O'Sullivan, L. A., C. Liongue, R. S. Lewis, S. E. M. Stephenson, and A. C. Ward. 2007. Cytokine receptor signaling through the Jak-Stat-Socs pathway in disease. Mol. Immunol. 44:2497-2506. (Pubitemid 46240311)
2. Wormald, S., and D. J. Hilton. 2004. Inhibitors of cytokine signal transduction. J. Biol. Chem. 279:821-824. (Pubitemid 38082600)
3. Hilton, D. J., R. T. Richardson, W. S. Alexander, E. M. Viney, T. A. Willson, N. S. Sprigg, R. Starr, S. E. Nicholson, D. Metcalf, and N. A. Nicola. 1998. Twenty proteins containing a C-terminal SOCS box form five structural classes. Proc. Natl. Acad. Sci. USA 95:114-119. (Pubitemid 28103916)
4. Narazaki, M., M. Fujimoto, T. Matsumoto, Y. Morita, H. Saito, T. Kajita, K. Yoshizaki, T. Naka, and T. Kishimoto. 1998. Three distinct domains of SSI-1/SOCS-1/JAB protein are required for its suppression of interleukin 6 signaling. Proc. Natl. Acad. Sci. USA 95:13130-13134. (Pubitemid 28509536)
5. Yasukawa, H., H. Misawa, H. Sakamoto, M. Masuhara, A. Sasaki, T. Wakioka, S. Ohtsuka, T. Imaizumi, T. Matsuda, J. N. Ihle, and A. Yoshimura. 1999. The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop. EMBO J. 18:1309-1320. (Pubitemid 29110315)
6. Starr, R., T. A. Willson, E. M. Viney, L. J. Murray, J. R. Rayner, B. J. Jenkins, T. J. Gonda, W. S. Alexander, D. Metcalf, N. A. Nicola, and D. J. Hilton. 1997. A family of cytokine-inducible inhibitors of signalling. Nature 387:917-921. (Pubitemid 27289594)
7. Endo, T. A., M. Masuhara, M. Yokouchi, R. Suzuki, H. Sakamoto, K. Mitsui, A. Matsumoto, S. Tanimura, M. Ohtsubo, H. Misawa, et al. 1997. A new protein containing an SH2 domain that inhibits JAK kinases. Nature 387:921-924. (Pubitemid 27289595)
8. Naka, T., M. Narazaki, M. Hirata, T. Matsumoto, S. Minamoto, A. Aono, N. Nishimoto, T. Kajita, T. Taga, K. Yoshizaki, et al. 1997. Structure and function of a new STAT-induced STAT inhibitor. Nature 387:924-929. (Pubitemid 27289596)
9. Federici, M., M. L. Giustizieri, C. Scarponi, G. Girolomoni, and C. Albanesi. 2002. Impaired IFN-gamma-dependent inflammatory responses in human keratinocytes overexpressing the suppressor of cytokine signaling 1. J. Immunol. 169:434-442. (Pubitemid 34686165)
10. Alexander, W. S., R. Starr, J. E. Fenner, C. L. Scott, E. Handman, N. S. Sprigg, J. E. Corbin, A. L. Cornish, R. Darwiche, C. M. Owczarek, et al. 1999. SOCS1 is a critical inhibitor of interferon gamma signaling and prevents the potentially fatal neonatal actions of this cytokine. Cell 98:597-608. (Pubitemid 29418951)
11. Brysha, M., J. G. Zhang, P. Bertolino, J. E. Corbin, W. S. Alexander, N. A. Nicola, D. J. Hilton, and R. Starr. 2001. Suppressor of cytokine signaling-1 attenuates the duration of interferon gamma signal transduction in vitro and in vivo. J. Biol. Chem. 276:22086-22089.
12. Starr, R., M. Fuchsberger, L. S. Lau, A. P. Uldrich, A. Goradia, T. A. Willson, A. M. Verhagen, W. S. Alexander, and M. J. Smyth. 2009. SOCS-1 binding to tyrosine 441 of IFN-gamma receptor subunit 1 contributes to the attenuation of IFN-gamma signaling in vivo. J. Immunol. 183:4537-4544.
13. Dimitriou, I. D., L. Clemenza, A. J. Scotter, G. Chen, F. M. Guerra, and R. Rottapel. 2008. Putting out the fire: coordinated suppression of the innate and adaptive immune systems by SOCS1 and SOCS3 proteins. Immunol. Rev. 224:265-283.
14. Starr, R., D. Metcalf, A. G. Elefanty, M. Brysha, T. A. Willson, N. A. Nicola, D. J. Hilton, and W. S. Alexander. 1998. Liver degeneration and lymphoid deficiencies in mice lacking suppressor of cytokine signaling-1. Proc. Natl. Acad. Sci. USA 95:14395-14399. (Pubitemid 28549378)
15. Marine, J. C., D. J. Topham, C. McKay, D. Wang, E. Parganas, D. Stravopodis, A. Yoshimura, and J. N. Ihle. 1999. SOCS1 deficiency causes a lymphocytedependent perinatal lethality. Cell 98:609-616. (Pubitemid 29418952)
16. Metcalf, D., S. Mifsud, L. Di Rago, N. A. Nicola, D. J. Hilton, and W. S. Alexander. 2002. Polycystic kidneys and chronic inflammatory lesions are the delayed consequences of loss of the suppressor of cytokine signaling-1 (SOCS-1). Proc. Natl. Acad. Sci. USA 99:943-948. (Pubitemid 34106615)
17. Cornish, A. L., G. M. Davey, D. Metcalf, J. F. Purton, J. E. Corbin, C. J. Greenhalgh, R. Darwiche, L. Wu, N. A. Nicola, D. I. Godfrey, et al. 2003. Suppressor of cytokine signaling-1 has IFN-gamma-independent actions in T cell homeostasis. J. Immunol. 170:878-886. (Pubitemid 36070541)
18. Lee, C., T. B. Kolesnik, I. Caminschi, A. Chakravorty, W. Carter, W. S. Alexander, J. Jones, G. P. Anderson, and S. E. Nicholson. 2009. Suppressor of cytokine signalling 1 (SOCS1) is a physiological regulator of the asthma response. Clin. Exp. Allergy 39:897-907.
19. Horino, J., M. Fujimoto, F. Terabe, S. Serada, T. Takahashi, Y. Soma, K. Tanaka, T. Chinen, A. Yoshimura, S. Nomura, et al. 2008. Suppressor of cytokine signaling-1 ameliorates dextran sulfate sodium-induced colitis in mice. Int. Immunol. 20:753-762. (Pubitemid 351791519)
20. Cornish, A. L., M. M. Chong, G. M. Davey, R. Darwiche, N. A. Nicola, D. J. Hilton, T. W. Kay, R. Starr, and W. S. Alexander. 2003. Suppressor of cytokine signaling-1 regulates signaling in response to interleukin-2 and other gamma c-dependent cytokines in peripheral T cells. J. Biol. Chem. 278:22755-22761. (Pubitemid 36830336)
21. Eyles, J. L., D. Metcalf, M. J. Grusby, D. J. Hilton, and R. Starr. 2002. Negative regulation of interleukin-12 signaling by suppressor of cytokine signaling-1. J. Biol. Chem. 277:43735-43740. (Pubitemid 36157791)
22. Kinjyo, I., T. Hanada, K. Inagaki-Ohara, H. Mori, D. Aki, M. Ohishi, H. Yoshida, M. Kubo, and A. Yoshimura. 2002. SOCS1/JAB is a negative regulator of LPS-induced macrophage activation. Immunity 17:583-591. (Pubitemid 35351504)
23. Hanada, T., H. Yoshida, S. Kato, K. Tanaka, K. Masutani, J. Tsukada, Y. Nomura, H. Mimata, M. Kubo, and A. Yoshimura. 2003. Suppressor of cytokine signaling-1 is essential for suppressing dendritic cell activation and systemic autoimmunity. Immunity 19:437-450. (Pubitemid 37153419)
24. Fenner, J. E., R. Starr, A. L. Cornish, J. G. Zhang, D. Metcalf, R. D. Schreiber, K. Sheehan, D. J. Hilton, W. S. Alexander, and P. J. Hertzog. 2006. Suppressor of cytokine signaling 1 regulates the immune response to infection by a unique inhibition of type I interferon activity. Nat. Immunol. 7:33-39. (Pubitemid 41823866)
25. Gingras, S., E. Parganas, A. de Pauw, J. N. Ihle, and P. J. Murray. 2004. Reexamination of the role of suppressor of cytokine signaling 1 (SOCS1) in the regulation of toll-like receptor signaling. J. Biol. Chem. 279:54702-54707. (Pubitemid 40053214)
26. Mansell, A., R. Smith, S. L. Doyle, P. Gray, J. E. Fenner, P. J. Crack, S. E. Nicholson, D. J. Hilton, L. A. O'Neill, and P. J. Hertzog. 2006. Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mal degradation. Nat. Immunol. 7:148-155. (Pubitemid 43135880)
27. Trede, N. S., D. M. Langenau, D. Traver, A. T. Look, and L. I. Zon. 2004. The use of zebrafish to understand immunity. Immunity 20:367-379. (Pubitemid 38482116)
28. Onnebo, S. M., S. H. Yoong, and A. C. Ward. 2004. Harnessing zebrafish for the study of white blood cell development and its perturbation. Exp. Hematol. 32:789-796. (Pubitemid 39166024)
29. Oates, A. C., A. Brownlie, S. J. Pratt, D. V. Irvine, E. C. Liao, B. H. Paw, K. J. Dorian, S. L. Johnson, J. H. Postlethwait, L. I. Zon, and A. F. Wilks. 1999. Gene duplication of zebrafish JAK2 homologs is accompanied by divergent embryonic expression patterns: only jak2a is expressed during erythropoiesis. Blood 94:2622-2636. (Pubitemid 29477291)
30. Oates, A. C., P. Wollberg, S. J. Pratt, B. H. Paw, S. L. Johnson, R. K. Ho, J. H. Postlethwait, L. I. Zon, and A. F. Wilks. 1999. Zebrafish stat3 is expressed in restricted tissues during embryogenesis and stat1 rescues cytokine signaling in a STAT1-deficient human cell line. Dev. Dyn. 215:352-370. (Pubitemid 29377204)
31. Lewis, R. S., and A. C. Ward. 2004. Conservation, duplication and divergence of the zebrafish stat5 genes. Gene 338:65-74. (Pubitemid 39092412)
32. Liongue, C., and A. C. Ward. 2007. Evolution of Class I cytokine receptors. BMC Evol. Biol. 7:120.
33. Ma, A. C., A. C. Ward, R. Liang, and A. Y. Leung. 2007. The role of jak2a in zebrafish hematopoiesis. Blood 110:1824-1830. (Pubitemid 47443893)
34. Paffett-Lugassy, N., N. Hsia, P. G. Fraenkel, B. Paw, I. Leshinsky, B. Barut, N. Bahary, J. Caro, R. Handin, and L. I. Zon. 2007. Functional conservation of erythropoietin signaling in zebrafish. Blood 110:2718-2726. (Pubitemid 47523195)
35. Jin, H. J., L. X. Xiang, and J. Z. Shao. 2007. Identification and characterization of suppressor of cytokine signaling 1 (SOCS-1) homologues in teleost fish. Immunogenetics 59:673-686.
36. Yamashita, S., C. Miyagi, A. Carmany-Rampey, T. Shimizu, R. Fujii, A. F. Schier, and T. Hirano. 2002. Stat3 controls cell movements during zebrafish gastrulation. Dev. Cell 2:363-375. (Pubitemid 34266120)
37. Liongue, C., C. J. Hall, B. A. O'Connell, P. Crosier, and A. C. Ward. 2009. Zebrafish granulocyte colony-stimulating factor receptor signaling promotes myelopoiesis and myeloid cell migration. Blood 113:2535-2546.
38. Lieschke, G. J., A. C. Oates, B. H. Paw, M. A. Thompson, N. E. Hall, A. C. Ward, R. K. Ho, L. I. Zon, and J. E. Layton. 2002. Zebrafish SPI-1 (PU.1) marks a site of myeloid development independent of primitive erythropoiesis: implications for axial patterning. Dev. Biol. 246:274-295. (Pubitemid 34775347)
39. Padgett, R. A., P. J. Grabowski, M. M. Konarska, S. Seiler, and P. A. Sharp. 1986. Splicing of messenger RNA precursors. Annu. Rev. Biochem. 55:1119-1150. (Pubitemid 16070797)
40. Yandava, C. N., A. Pillari, and J. M. Drazen. 1999. Radiation hybrid and cytogenetic mapping of SOCS1 and SOCS2 to chromosomes 16p13 and 12q, respectively. Genomics 61:108-111. (Pubitemid 29487627)
41. Mizushima, S., and S. Nagata. 1990. pEF-BOS, a powerful mammalian expression vector. Nucleic Acids Res. 18:5322. (Pubitemid 20270119)
42. Onnebo, S. M. N., M. M. Condron, D. O. McPhee, G. J. Lieschke, and A. C. Ward. 2005. Hematopoietic perturbation in zebrafish expressing a tel-jak2a fusion. Exp. Hematol. 33:182-188. (Pubitemid 40164900)
43. Zhu, H., D. Traver, A. J. Davidson, A. Dibiase, C. Thisse, B. Thisse, S. Nimer, and L. I. Zon. 2005. Regulation of the lmo2 promoter during hematopoietic and vascular development in zebrafish. Dev. Biol. 281:256-269. (Pubitemid 40719151)
44. Long, Q., A. Meng, H. Wang, J. R. Jessen, M. J. Farrell, and S. Lin. 1997. GATA-1 expression pattern can be recapitulated in living transgenic zebrafish using GFP reporter gene. Development 124:4105-4111. (Pubitemid 27483335)
45. Ward, A. C., D. O. McPhee, M. M. Condron, S. Varma, S. H. Cody, S. M. N. Onnebo, B. H. Paw, L. I. Zon, and G. J. Lieschke. 2003. The zebrafish spi1 promoter drives myeloid-specific expression in stable transgenic fish. Blood 102:3238-3240. (Pubitemid 37314761)
46. Willett, C. E., H. Kawasaki, C. T. Amemiya, S. Lin, and L. A. Steiner. 2001. Ikaros expression as a marker for lymphoid progenitors during zebrafish development. Dev. Dyn. 222:694-698. (Pubitemid 33136340)
47. Willett, C. E., A. G. Zapata, N. Hopkins, and L. A. Steiner. 1997. Expression of zebrafish rag genes during early development identifies the thymus. Dev. Biol. 182:331-341. (Pubitemid 27145483)
48. Liu, F., and Z. Wen. 2002. Cloning and expression pattern of the lysozyme C gene in zebrafish. Mech. Dev. 113:69-72. (Pubitemid 34233726)
49. Yoong, S., B. O'Connell, A. Soanes, M. O. Crowhurst, G. J. Lieschke, and A. C. Ward. 2007. Characterization of the zebrafish matrix metalloproteinase 9 gene and its developmental expression pattern. Gene Expr. Patterns 7:39-46. (Pubitemid 44712723)
50. Parichy, D. M., D. G. Ransom, B. Paw, L. I. Zon, and S. L. Johnson. 2000. An orthologue of the kit-related gene fms is required for development of neural crest-derived xanthophores and a subpopulation of adult melanocytes in the zebrafish, Danio rerio. Development 127:3031-3044. (Pubitemid 30611896)
51. Herbomel, P., B. Thisse, and C. Thisse. 2001. Zebrafish early macrophages colonize cephalic mesenchyme and developing brain, retina, and epidermis through a M-CSF receptor-dependent invasive process. Dev. Biol. 238:274-288. (Pubitemid 32977296)
52. Lieschke, G. J., A. C. Oates, M. O. Crowhurst, A. C. Ward, and J. E. Layton. 2001. Morphologic and functional characterization of granulocytes and macrophages in embryonic and adult zebrafish. Blood 98:3087-3096.
53. Lewis, R. S., S. E. M. Stephenson, and A. C. Ward. 2006. Constitutive activation of zebrafish Stat5 expands hematopoietic cell populations in vivo. Exp. Hematol. 34:179-187. (Pubitemid 43184323)
54. Ma, A. C., A. Fan, A. C. Ward, C. Liongue, R. S. Lewis, S. H. Cheng, P. K. Chan, S. F. Yip, R. Liang, and A. Y. Leung. 2009. A novel zebrafish jak2a (V581F) model shared features of human JAK2 (V617F) polycythemia vera. Exp. Hematol. 37:1379-1386, e4.
55. Ward, A. C., M. H. A. Hermans, L. Smith, Y. M. van Aesch, A. M. Schelen, C. Antonissen, and I. P. Touw. 1999. Tyrosine-dependent and-independent mechanisms of STAT3 activation by the human granulocyte colony-stimulating factor (G-CSF) receptor are differentially utilized depending on G-CSF concentration. Blood 93:113-124. (Pubitemid 29019395)
56. Nicholson, S. E., T. A. Willson, A. Farley, R. Starr, J. G. Zhang, M. Baca, W. S. Alexander, D. Metcalf, D. J. Hilton, and N. A. Nicola. 1999. Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transduction. EMBO J. 18:375-385. (Pubitemid 29041946)
57. Zhang, J.-G., A. Farley, S. E. Nicholson, T. A. Willson, L. M. Zugaro, R. J. Simpson, R. L. Moritz, D. Cary, R. Richardson, G. Hausmann, et al. 1999. The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation. Proc. Natl. Acad. Sci. USA 96:2071-2076. (Pubitemid 29117869)
58. Amatruda, J. F., and L. I. Zon. 1999. Dissecting hematopoiesis and disease using the zebrafish. Dev. Biol. 216:1-15.
59. Nasevicius, A., and S. C. Ekker. 2000. Effective targeted gene 'knockdown' in zebrafish. Nat. Genet. 26:216-220.
60. Draper, B. W., P. A. Morcos, and C. B. Kimmel. 2001. Inhibition of zebrafish fgf8 pre-mRNA splicing with morpholino oligos: a quantifiable method for gene knockdown. Genesis 30:154-156. (Pubitemid 32730763)
61. Murayama, E., K. Kissa, A. Zapata, E. Mordelet, V. Briolat, H.-F. Lin, R. I. Handin, and P. Herbomel. 2006. Tracing hematopoietic precursor migration to successive hematopoietic organs during zebrafish development. Immunity 25:963-975. (Pubitemid 44894947)
62. Shivdasani, R. A., and S. H. Orkin. 1996. The transcriptional control of hematopoiesis. Blood 87:4025-4039. (Pubitemid 26152245)
63. Fouquet, B., B. M. Weinstein, F. C. Serluca, and M. C. Fishman. 1997. Vessel patterning in the embryo of the zebrafish: guidance by notochord. Dev. Biol. 183:37-48. (Pubitemid 27157831)
64. Langenau, D. M., and L. I. Zon. 2005. The zebrafish: a new model of T-cell and thymic development. Nat. Rev. Immunol. 5:307-317. (Pubitemid 40516156)
65. Ehret, G. B., P. Reichenbach, U. Schindler, C. M. Horvath, S. Fritz, M. Nabholz, and P. Bucher. 2001. DNA binding specificity of different STAT proteins. Comparison of in vitro specificity with natural target sites. J. Biol. Chem. 276:6675-6688.
66. Saito, H., Y. Morita, M. Fujimoto, M. Narazaki, T. Naka, and T. Kishimoto. 2000. IFN regulatory factor-1-mediated transcriptional activation of mouse STAT-induced STAT inhibitor-1 gene promoter by IFN-gamma. J. Immunol. 164:5833-5843. (Pubitemid 30389827)
67. Schmitt-Ney, M., W. Doppler, R. K. Ball, and B. Groner. 1991. Beta-casein gene promoter activity is regulated by the hormone-mediated relief of transcriptional repression and a mammary-gland-specific nuclear factor. Mol. Cell. Biol. 11:3745-3755. (Pubitemid 21895762)
68. Morita, Y., T. Naka, Y. Kawazoe, M. Fujimoto, M. Narazaki, R. Nakagawa, H. Fukuyama, S. Nagata, and T. Kishimoto. 2000. Signals transducers and activators of transcription (STAT)-induced STAT inhibitor-1 (SSI-1)/suppressor of cytokine signaling-1 (SOCS-1) suppresses tumor necrosis factor alphainduced cell death in fibroblasts. Proc. Natl. Acad. Sci. USA 97:5405-5410. (Pubitemid 30313731)
69. Chong, M. M., D. Metcalf, E. Jamieson, W. S. Alexander, and T. W. Kay. 2005. Suppressor of cytokine signaling-1 in T cells and macrophages is critical for preventing lethal inflammation. Blood 106:1668-1675. (Pubitemid 41208580)
70. Conway, G., A. Margoliath, S. Wong-Madden, R. J. Roberts, and W. Gilbert. 1997. Jak1 kinase is required for cell migrations and anterior specification in zebrafish embryos. Proc. Natl. Acad. Sci. USA 94:3082-3087. (Pubitemid 27157267)
71. Metcalf, D. 1999. The SOCS-1 story. Exp. Hematol. 27:1715-1723.
72. Chong, M. M., A. L. Cornish, R. Darwiche, E. G. Stanley, J. F. Purton, D. I. Godfrey, D. J. Hilton, R. Starr, W. S. Alexander, and T. W. Kay. 2003. Suppressor of cytokine signaling-1 is a critical regulator of interleukin-7-dependent CD8+ T cell differentiation. Immunity 18:475-487. (Pubitemid 36513630)
73. Ramanathan, S., J. Gagnon, C. Leblanc, R. Rottapel, and S. Ilangumaran. 2006. Suppressor of cytokine signaling 1 stringently regulates distinct functions of IL-7 and IL-15 in vivo during T lymphocyte development and homeostasis. J. Immunol. 176:4029-4041. (Pubitemid 44264381)
74. Metcalf, D., W. S. Alexander, A. G. Elefanty, N. A. Nicola, D. J. Hilton, R. Starr, S. Mifsud, and L. Di Rago. 1999. Aberrant hematopoiesis in mice with inactivation of the gene encoding SOCS-1. Leukemia 13:926-934. (Pubitemid 29292144)
75. Chen, C. Y., W. Tsay, J. L. Tang, H. L. Shen, S. W. Lin, S. Y. Huang, M. Yao, Y. C. Chen, M. C. Shen, C. H. Wang, and H. F. Tien. 2003. SOCS1 methylation in patients with newly diagnosed acute myeloid leukemia. Genes Chromosomes Cancer 37:300-305. (Pubitemid 36667568)
76. Liu, T. C., S. F. Lin, J. G. Chang, M. Y. Yang, S. Y. Hung, and C. S. Chang. 2003. Epigenetic alteration of the SOCS1 gene in chronic myeloid leukaemia. Br. J. Haematol. 123:654-661.
77. Egan, P. J., K. E. Lawlor, W. S. Alexander, and I. P. Wicks. 2003. Suppressor of cytokine signaling-1 regulates acute inflammatory arthritis and T cell activation. J. Clin. Invest. 111:915-924. (Pubitemid 37074967)
78. Jamieson, E., M. M. W. Chong, G. R. Steinberg, V. Jovanovska, B. C. Fam, D. V. R. Bullen, Y. Chen, B. E. Kemp, J. Proietto, T. W. H. Kay, and S. Andrikopoulos. 2005. Socs1 deficiency enhances hepatic insulin signaling. J. Biol. Chem. 280:31516-31521. (Pubitemid 41291894)
79. Ernst, M., M. Inglese, P. Waring, I. K. Campbell, S. Bao, F. J. Clay, W. S. Alexander, I. P. Wicks, D. M. Tarlinton, U. Novak, et al. 2001. Defective gp130-mediated signal transducer and activator of transcription (STAT) signaling results in degenerative joint disease, gastrointestinal ulceration, and failure of uterine implantation. J. Exp. Med. 194:189-203. (Pubitemid 32673352)
80. Wormald, S., J. G. Zhang, D. L. Krebs, L. A. Mielke, J. Silver, W. S. Alexander, T. P. Speed, N. A. Nicola, and D. J. Hilton. 2006. The comparative roles of suppressor of cytokine signaling-1 and-3 in the inhibition and desensitization of cytokine signaling. J. Biol. Chem. 281:11135-11143. (Pubitemid 43855538)
81. Zhuang, D., Y. Qiu, S. J. Haque, and F. Dong. 2005. Tyrosine 729 of the G-CSF receptor controls the duration of receptor signaling: involvement of SOCS3 and SOCS1. J. Leukoc. Biol. 78:1008-1015. (Pubitemid 41384418)
82. Carbia-Nagashima, A., and E. Arzt. 2004. Intracellular proteins and mechanisms involved in the control of gp130/JAK/STAT cytokine signaling. IUBMB Life 56:83-88. (Pubitemid 38418924)
83. Yoshida, K., T. Taga, M. Saito, S. Suematsu, A. Kumanogoh, T. Tanaka, H. Fujiwara, M. Hirata, T. Yamagami, T. Nakahata, et al. 1996. Targeted disruption of gp130, a common signal transducer for the interleukin 6 family of cytokines, leads to myocardial and hematological disorders. Proc. Natl. Acad. Sci. USA 93:407-411. (Pubitemid 26041485)
84. Betz, U. A. K., W. Bloch, M. van den Broek, K. Yoshida, T. Taga, T. Kishimoto, K. Addicks, K. Rajewsky, and W. Müller. 1998. Postnatally induced inactivation of gp130 in mice results in neurological, cardiac, hematopoietic, immunological, hepatic, and pulmonary defects. J. Exp. Med. 188:1955-1965. (Pubitemid 28536782)
85. Cheung, J. Y., and B. A. Miller. 2001. Molecular mechanisms of erythropoietin signaling. Nephron 87:215-222. (Pubitemid 32268562)
86. Jegalian, A. G., and H. Wu. 2002. Differential roles of SOCS family members in EpoR signal transduction. J. Interferon Cytokine Res. 22:853-860. (Pubitemid 35217516)
87. Stoiber, D., P. Kovarik, S. Cohney, J. A. Johnston, P. Steinlein, and T. Decker. 1999. Lipopolysaccharide induces in macrophages the synthesis of the suppressor of cytokine signaling 3 and suppresses signal transduction in response to the activating factor IFN-gamma. J. Immunol. 163:2640-2647. (Pubitemid 29399188)
88. Dalpke, A., and K. Heeg. 2003. Suppressors of cytokine signaling proteins in innate and adaptive immune responses. Arch. Immunol. Ther. Exp. (Warsz.) 51:91-103. (Pubitemid 36522988)
89. Matsumoto, A., Y.-i. Seki, R. Watanabe, K. Hayashi, J. A. Johnston, Y. Harada, R. Abe, A. Yoshimura, and M. Kubo. 2003. A role of suppressor of cytokine signaling 3 (SOCS3/CIS3/SSI3) in CD28-mediated interleukin 2 production. J. Exp. Med. 197:425-436. (Pubitemid 36278599)
90. Maine, G. N., X. Mao, C. M. Komarck, and E. Burstein. 2007. COMMD1 promotes the ubiquitination of NF-kappaB subunits through a cullin-containing ubiquitin ligase. EMBO J. 26:436-447. (Pubitemid 46160944)
91. Dalpke, A. H., S. Opper, S. Zimmermann, and K. Heeg. 2001. Suppressors of cytokine signaling (SOCS)-1 and SOCS-3 are induced by CpG-DNA and modulate cytokine responses in APCs. J. Immunol. 166:7082-7089. (Pubitemid 32525577)
92. Bartz, H., N. M. Avalos, A. Baetz, K. Heeg, and A. H. Dalpke. 2006. Involvement of suppressors of cytokine signaling in toll-like receptor-mediated block of dendritic cell differentiation. Blood 108:4102-4108. (Pubitemid 44913281)