Geminin functions downstream of p53 in K-ras-induced gene amplification of dihydrofolate reductase

Cancer Research

Volumn 72, Issue 23, 2012, Pages 6153-6162

  Shen, Ling ^a   Nishioka, Takashi ^a   Guo, Jinjin ^a   Chen, Changyan ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN A; DIHYDROFOLATE REDUCTASE; GEMININ; METHOTREXATE; PROTEIN P53; REACTIVE OXYGEN METABOLITE; REPLICATION LICENSING FACTOR CDT1;

ANIMAL CELL; ARTICLE; CANCER CELL; CELL CYCLE G1 PHASE; CELL CYCLE PROGRESSION; CONTROLLED STUDY; DNA REPLICATION; DNA STRAND BREAKAGE; EPITHELIUM CELL; GENE AMPLIFICATION; MOUSE; NONHUMAN; ONCOGENE K RAS; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; RAT; UPREGULATION;

ANIMALS; CELL CYCLE PROTEINS; DNA DAMAGE; EPITHELIAL CELLS; G1 PHASE; GENE AMPLIFICATION; GENE KNOCKDOWN TECHNIQUES; GENES, P53; GENES, RAS; GENOMIC INSTABILITY; LUNG; LUNG NEOPLASMS; METHOTREXATE; MICE; MICE, TRANSGENIC; NUCLEAR PROTEINS; REACTIVE OXYGEN SPECIES; TETRAHYDROFOLATE DEHYDROGENASE; UP-REGULATION;

EID: 84870314981     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-12-1862     Document Type: Article

References (58)

1. Hartwell L. Defects in a cell cycle checkpoint may be responsible for the genomic instability of cancer cells. Cell 1992;71:543-6.
2. Hartwell L, Kastan MB. Cell cycle control and cancer. Science 1994; 266:1821-8.
3. Lee JM, Bernstein A. Apoptosis, cancer and the p53 tumor suppressor gene. Cancer Metastasis Rev 1995;14:149-61.
4. Paulovich AG, Toczyski DP, Hartwell LH. When checkpoints fail. Cell 1997;88:315-21. (Pubitemid 27131373)
5. Tlsty TD. Normal diploid human and rodent cells lack a detectable frequency of gene amplification. Proc Natl Acad Sci U S A 1990;87:3132-6.
6. Wright JA, Smith HS, Watt FM, Hancock MC, Hudson DL, Stark GR. DNA amplification is rare in normal human cells. Proc Natl Acad Sci U S A 1990;87:1791-5.
7. Benner SE, Wahl GM, Von HD. Double minute chromosomes and homogeneously staining regions in tumors taken directly from patients versus in human tumor cell lines. Anticancer Drugs 1991;2:11-25.
8. Yin Y, Tainsky MA, Bischoff FZ, Strong LC, Wahl GM. Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles. Cell 1992;70:937-48.
9. Smith KA, Agarwal MI, Chernov MV, Chernova OB, Deguchi Y, Ishizaka Y, et al. Regulation and mechanisms of gene amplification. Philos Trans R Soc London 1995;B347:49-56.
10. Schwab M. Oncogene amplification in neoplastic development and progression ofhuman cancers.CRCCrit Rev Oncogene 1990;2:35-51.
11. Linke SP, Clarkin KC, Di LA, Tsou A, Wahl GM. A reversible, p53-dependent G0/G1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage. Genes Dev 1996;10:934-47. (Pubitemid 26138705)
12. Maqsood AW, Xu X, Stambrook PJ. Increased methotrexate resistance and dhfr gene amplification as a consequence of induced Ha-ras expression in NIH3T3 cells. Cancer Res 1994;54:2504-2508. (Pubitemid 24138748)
13. Kastan MB, Zhan Q, El-Deiry WS, Carrier F, Jacks T, Walsh WV, et al. A mammalina cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia. Cell 1992;71:587-597.
14. Kuerbitz SJ, Plunkett BS, Walsh WV, Kastan MB. Wild-type p53 is a cell cycle checkpoint determinant following irradiation. Proc Natl Acad Sci U S A 1992;89:7491-5.
15. Livingston LR, White A, Sprouse J, Livanos E, Jacks T, Tlsty TD. Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53. Cell 1992;70:923-5.
16. Di Leonardo A, Linke SP, Clarkin K, Wahl GM. DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts. Genes Dev 1994;8:2540-51. (Pubitemid 24347245)
17. Paulson TG, Almasan A, Brody LL, Wahl GM. Gene amplification in a p53-dificient cell line requires cell cycle progression under conditions that generate DNA breakage. Mole Cell Biol 1998;18:3089-100. (Pubitemid 28183477)
18. Mihaylov IS, Kondo T, Jones L, Ryzhikov S, Tanaka J, Zheng J, et al. Control of DNA replication and chromosome ploidy by geminin and cyclin A. Mole Cell Biol 2002;22:1868-80. (Pubitemid 34175002)
19. Saxena S, Dutta A. Geminin-Cdt1 balance is critical for genetic stability. Mutation Res 2005;569:111-21. (Pubitemid 39643261)
20. Diffley JF. DNA replication: building the prefect switch. Curr Biol 2001;11:R365-70.
21. Dutta A, Bell SP. Initiation of DNA replication in eukaryotic cells. Annu Rev Cell Dev Biol 1997;13:293-306.
22. Nishitani H, Zoi L. Control of DNA replication licensing in a cell cycle. Cell 2002;7:523-34. (Pubitemid 34679050)
23. Heichman KA, Roberts JM. Rules to replicate by. Cell 2006;79:557-62.
24. Nishitani H, Lygerou Z, Ishimoto T, Nurse P. The Cdt1 protein is required to license DNA for replication in fission yeast. Nature 2000; 404:625-8. (Pubitemid 30205063)
25. Takisawa H, Mimura S, Kubota Y. Eukaryotic DNA replication: from prereplication complex to initiation complex. Curr Opin Cell Biol 2000;4:198-207.
26. McGarry TJ, Kirschner MW. Geminin, an inhibitor of DNA replication, is degraded during mitosis. Cell 1998;93:1043-53. (Pubitemid 28280797)
27. Wohlschlegel JA, Dwyer BT, Dhar SK, Cvetic C, Walter JC, Dutta A. Inhibition of eukaryotic DNA replication by geminin binding to Cdt1. Science 2000;290:2309-12. (Pubitemid 32041574)
28. Vaziri C, Saxena S, Jeon Y, Lee C, Murata K, Machida Y, et al. A p53-dependent checkpoint pathway prevents rereplication. Mole Cell 2003;11:997-1008. (Pubitemid 36566321)
29. Winston JT, Coats SR, Wang Y-Z, Pledger WJ. Regulation of the cell cycle machinery by oncogenic ras. Oncogene 1996;12:127-34. (Pubitemid 26041248)
30. Jong J, Kang J, Krauss RS. Ras signals to the cell cycle machinery via multiple pathways to induce anchorage-independent growth. Mole Cell Biol 1998;18:2586-95. (Pubitemid 28183428)
31. Downward J. Cell cycle: routine role for Ras. Curr Biol 1997;7:R258-60. (Pubitemid 27176846)
32. Knauf JA, Quyang B, Knudsen ES, Knudsen ES, Fukasawa K, Babcock G, et al. Oncogenic Ras induces accelerated transition through G2/M and promotes defects in the G2 DNA damage and mitotic spindle checkpoints. J Biol Chem 2006;281:3800-9. (Pubitemid 43847804)
33. Liu J-J, Chao J-R, Jiang C, Ng SY, Yen JJ, Yang-Yen HF. Ras transtormation results in an elevated level of cyclin D1 and acceleration of G1 progression in NIH-3T3 cells. Mole Cell Biol 1995;15:3654-63.
34. Serrano M, Gomez-lahoz E, DePinho RA, Beach D, Bar-Sagi D. Inhibition of Ras-induced proliferation and cellular transformation by p16INK4. Science 1995;267:249-52.
35. Arber N, Sutter T, Miyake M, Kahn SM, Venkatraj VS, Sobrino A, et al. Increased expression of cyclin D1 and the Rb tumor suppressor gene in c-k-ras transformed rat enterocytes. Oncogene 1996;12:1903-8. (Pubitemid 26154662)
36. Kang J, Krauss RS. Ras induces anchorage-independent growth by subverting multiple adhesion-regulated cell cycle events. Mole Cell Biol 1996;16:3370-80.
37. Serrano M, Lin AW, McCurrach ME, Beach D, Lowe SW. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 1997;88:593-602. (Pubitemid 27152402)
38. Khosravi-Far R, Campbell S, Rossman KL, Der CJ. Increasing complexity of Ras signal transduction: involvement of Rho family proteins. Adv Cancer Res 1998;72:57-107.
39. Lee AC, Fenster BE, Ito H, Takeda K, Bae NS, Hirai T, et al. Ras proteins induce senescence by altering the intracellular levels of reactive oxygen species. J Biol Chem 1999;274:7936-40.
40. Liou JS, Chen C, Chen JS, Faller DV. Oncogenic Ras mediates apoptosis in response to protein kinase C inhibition through the generation of reactive oxygen species. J Biol Chem 2000;275: 39001-11. (Pubitemid 32058912)
41. Vafa O, Wade M, Kern S, Beeche M, Pandita TK, Hampton GM, et al. c-myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: a mechanism for oncogene-induced genetic instability. Cell 2002;9:1031-44. (Pubitemid 34626672)
42. Scandalios JG. The rise of ROS. Trends Biochem Sci 2002;27:483-6. (Pubitemid 35246258)
43. Irani K, Xia Y, Zweier JL, Sollott SJ, Der CJ, Fearon ER, et al. Mitogenic signalingmediated by oxidants in Rastransformed fibroblasts. Science 1997;275:1649-52. (Pubitemid 27120541)
44. Rhee SG. Redox signaling: hydrogen peroxide as intracellular messenger. Exp Mol Med 1999;31:53-9. (Pubitemid 29326708)
45. Benhar M, Engelberg D, Levitzki A. Ros, stress-activated kinases and stress signaling in cancer. J EMBO 2002;3:420-5. (Pubitemid 34567428)
46. Ishimi Y, Komamura-Kohno Y. Phosphorylation of MCm4 at specific sites by cyclin-dependent kinase leads to loss of Mcm4,6,7 helicase activity. J Biol Chem 2001;275:16235-41.
47. Brown PC, Schimke RT. Enhancement of methotrexate resistance and dihydrofolate reductase gene amplification by treatment of mouse 3T6 cells with hydroxyurea. Mole Cell Biol 1983;3:1097-107. (Pubitemid 13038518)
48. Hartley JM, Spanswick VJ, Gander M, Giacomini G, Whelan J, Souhami RL, et al. Measurement of DNA cross-linking in patients on ifosfamide therapy using the single cell gel electorphoresis (comet) assay. Clinical Cancer Res 1999;5:507-12. (Pubitemid 29131958)
49. Tuveson DA, Jacks T. Modeling human lung cancer in mice: similarities and shortcomings. Oncogene 1999;18:5318-24. (Pubitemid 29462367)
50. Johnson L, Mercer K, Greenbaum D, Bronson RT, Crowley D, Tuveson DA, et al. Somatic activation of the K-ras oncogene causes early onset lung cancer in mice. Nature 2001;410:1111-16. (Pubitemid 32391044)
51. Melixetian M, Ballabeni A, Masiero L, Gasparinin P, Zamponi R, Bartek J, et al. Loss of geminin induces rereplication in the presence of functional p53. J Cell Bio 2004;165:473-82. (Pubitemid 38679613)
52. Karnani N, Dutta A. The effect of the intra-S-phase checkpoint on origins of replication in human cells. Genes Dev 2011;25:621-33.
53. Stacey D, Kaziauskas A. Regulation of Ras signaling by the cell cycle. Curr Opin Genet Dev 2002;12:44-6. (Pubitemid 34094988)
54. Leist M, Jaattela M. Four deaths and a funeral: from caspases to alternative mechanisms. Nat Rev Mol Cell Biol 2001;2:1-10.
55. Deng Y, Ren X. Yang L, Lin Y, Wu X. A JNK-dependent pathway is required for TNFa-induced apoptosis. Cell 2003;115:61-70. (Pubitemid 37255318)
56. Nguyen VQ, Co C, Li JJ. Cyclin-dependent kinases prevent DNA rereplication through multiple mechanisms. Nature 2001;411:1068-73. (Pubitemid 32612333)
57. Diffley JE. Once and only once upon a time: specifying and regulating origins of DNA replication in eukaryotic cells. Genes Dev 1996;10: 2819-30.
58. Swyryd EA, Seaver SS, Stark GR. N-(Phosphonacetyl)-L-aspartate, a potent transition state analog inhibitor of aspartate transcarbamylase, blocks proliferation of mammalian cells in culture. J Biol Chem 1974;249:6945-50.