Control of DNA replication licensing in a cell cycle

Genes to Cells

Volumn 7, Issue 6, 2002, Pages 523-534

  Nishitani, Hideo ^a   Lygerou, Zoi ^b  

^a KYUSHU UNIVERSITY   (Japan)

^b UNIVERSITY OF PATRAS   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CYCLE PROTEIN; CELL CYCLE PROTEIN 6; CYCLIN DEPENDENT KINASE; DNA; ENZYME; HELICASE; PROTEIN CDC10; PROTEIN CDCT1; PROTEIN GEMININ; PROTEIN KINASE; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; CDC6 PROTEIN, S CEREVISIAE; CDT1 PROTEIN, HUMAN; DNA BINDING PROTEIN; GMNN PROTEIN, HUMAN; GMNN PROTEIN, XENOPUS; ORIGIN RECOGNITION COMPLEX; SACCHAROMYCES CEREVISIAE PROTEIN;

CELL CYCLE; CELL CYCLE G1 PHASE; CELL DIVISION; CHROMATIN; CHROMOSOME REPLICATION; COMPLEX FORMATION; CONTROLLED STUDY; DNA DENATURATION; DNA REPLICATION; DNA REPLICATION ORIGIN; ENZYME ACTIVITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; REGULATORY MECHANISM; REVIEW; ANIMAL; GENE EXPRESSION REGULATION; GENETICS; HUMAN; METABOLISM; PHYSIOLOGY; XENOPUS; YEAST;

ANIMAL; CELL CYCLE; CELL CYCLE PROTEINS; CYCLIN-DEPENDENT KINASES; DNA REPLICATION; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; HUMAN; REPLICATION ORIGIN; XENOPUS; YEASTS; ANIMALS; HUMANS; ORIGIN RECOGNITION COMPLEX; SACCHAROMYCES CEREVISIAE PROTEINS;

EUKARYOTA; MAMMALIA; XENOPUS LAEVIS;

EID: 0035998262     PISSN: 13569597     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2443.2002.00544.x     Document Type: Review

References (101)

1. Components and dynamics of DNA replication complexes in S. cerevisiae: Redistribution of MCM proteins and Cdc45p during S phase
2. Cdc18 transcription and proteolysis couple S phase to passage through mitosis
3. The multidomain structure of Orc1p reveals similarity to regulators of DNA replication and transcriptional silencing
4. ATP-dependent recognition of eukaryotic origins of DNA replication by a multiprotein complex
5. A role for the nuclear envelope in controlling DNA replication within the cell cycle
6. Involvement of p34cdc2 in establishing the dependency of S phase on mitosis
7. Cdc6 cooperates with Sic1 and Hct1 to inactivate mitotic cyclin-dependent kinase
8. Replication checkpoint: Preventing mitotic catastrophe
9. Human DNA replication initiation factors, ORC and MCM, associate with oriP of Epstein-Barr virus
10. The amyloid precursor protein-binding protein APP-BP1 drives the cell cycle through the S-M checkpoint and causes apoptosis in neurons
11. The Xenopus Cdc6 protein is essential for the initiation of a single round of DNA replication in cell-free extracts
12. p25rum1 orders S phase and mitosis by acting as an inhibitor of the p34cdc2 mitotic kinase
13. S-phase-promoting cyclin-dependent kinases prevent re-replication by inhibiting the transition of replication origins to a pre-replicative state
14. Replication from oriP of Epstein-Barr virus requires human ORC and is inhibited by geminin
15. Once and only once upon a time: Specifying and regulating origins of DNA replication in eukaryotic cells
16. Two steps in the assembly of complexes at yeast replication origins in vivo
17. The Cdc4/34/53 pathway targets Cdc6p for proteolysis in budding yeast
18. Initiation of DNA replication in eukaryotic cells
19. Endoreplication cell cycles. More for less
20. Cell cycle regulation of human CDC6 protein. Intracellular localization, interaction with the human mcm complex, and CDC2 kinase-mediated hyperphosphorylation
21. Triggering ubiquitination of a CDK inhibitor at origins of DNA replication
22. Conserved initiator proteins in eukaryotes
23. Premature structural changes at replication origins in a yeast minichromosome maintenance (MCM) mutant
24. Reconstitution of licensed replication origins on Xenopus sperm nuclei using purified proteins
25. Redundant control of rereplication in fission yeast
26. mcm5/cdc46-bob1 bypasses the requirement for the S phase activator Cdc7p
27. Temporal order of S phase and mitosis in fission yeast is determined by the state of the p34cdc2-mitotic B cyclin complex
28. Rules to replicate by
29. Sequential gene function in the initiation of Saccharomyces cerevisiae DNA synthesis
30. cdt1 is an essential target of the Cdc10/Sct1 transcription factor: Requirement for DNA replication and inhibition of mitosis
31. Mcm10 and the MCM2-7 complex interact to initiate DNA synthesis and to release replication factors from origins
32. Identification of a preinitiation step in DNA replication that is independent of origin recognition complex and cdc6, but dependent on cdk2
33. A DNA helicase activity is associated with an MCM4, -6, and -7 protein complex
34. Biochemical function of mouse minichromosome maintenance 2 protein
35. Construction by gene targeting in human cells of a 'conditional' CDC2 mutant that rereplicates its DNA
36. Regulation of the replication initiator protein p65cdc18 by CDK phosphorylation
37. Xenopus cdc7 function is dependent on licensing but not on XORC, XCdc6, or CDK activity and is required for XCdc45 loading
38. Multistep regulation of DNA replication by Cdk phosphorylation of HsCdc6
39. Sld3, which interacts with Cdc45 (Sld4), functions for chromosomal DNA replication in Saccharomyces cerevisiae
40. The fission yeast cdc18+ gene product couples S phase to START and mitosis
41. Fission yeast WD-repeat protein pop1 regulates genome ploidy through ubiquitin-proteasome-mediated degradation of the CDK inhibitor Rum1 and the S-phase initiator Cdc18
42. G1-phase and B-type cyclins exclude the DNA-replication factor Mcm4 from the nucleus
43. Uninterrupted MCM2-7 function required for DNA replication fork progression
44. Processive DNA helicase activity of the minichromosome maintenance proteins 4, 6, and 7 complex requires forked DNA structures
45. Mcm2 is a target of regulation by Cdc7-Dbf4 during the initiation of DNA synthesis
46. Mammalian Orc1 protein is selectively released from chromatin and ubiquitinated during the S-to-M transition in the cell division cycle
47. Persistent initiation of DNA replication and chromatin-bound MCM proteins during the cell cycle in cdc6 mutants
48. The fission yeast origin recognition complex is constitutively associated with chromatin and is differentially modified through the cell cycle
49. Mutants of S. cerevisiae defective in the maintenance of minichromosomes
50. XCDT1 is required for the assembly of pre-replicative complexes in Xenopus laevis
51. Human Cdc7-related kinase complex. In vitro phosphorylation of MCM by concerted actions of Cdks and Cdc7 and that of a critical threonine residue of Cdc7 by Cdks
52. CDC7 kinase complex as a molecular switch for DNA replication
53. S-Cdk-dependent phosphorylation of Sld2 essential for chromosomal DNA replication in budding yeast
54. Geminin, an inhibitor of DNA replication, is degraded during mitosis
55. Chromatin association of human origin recognition complex, cdc6, and minichromosome maintenance proteins during the cell cycle: Assembly of prereplication complexes in late mitosis
56. A lesion in the DNA replication initiation factor Mcm10 induces pausing of elongation forks through chromosomal replication origins in Saccharomyces cerevisiae
57. Central role for cdc45 in establishing an initiation complex of DNA replication in Xenopus egg extracts
58. Regulation of progression through the G1 phase of the cell cycle by the rum1+ gene
59. cdc18+ regulates initiation of DNA replication in Schizosaccharomyces pombe
60. Targeted disruption of Skp2 results in accumulation of cyclin E and p27 (Kip1), polyploidy and centrosome overduplication
61. At the heart of the budding yeast cell cycle
62. Clb/Cdc28 kinases promote nuclear export of the replication initiator proteins Mcm2-7
63. Cyclin-dependent kinases prevent DNA re-replication through multiple mechanisms
64. The Cdt1 protein is required to license DNA for replication in fission yeast
65. p65cdc18 plays a major role controlling the initiation of DNA replication in fission yeast
66. The human licensing factor for DNA replication Cdt1 accumulates in G1 and is destabilized after initiation of S-phase
67. CDK phosphorylation of Drc1 regulates DNA replication in fission yeast
68. Universal control mechanism regulating onset of M-phase
69. Ordering S phase and M phase in the cell cycle
70. Genetic control of the cell division cycle in the fission yeast Schizosaccharomyces pombe
71. Association of fission yeast Orp1 and Mcm6 proteins with chromosomal replication origins
72. A role for the Cdc7 kinase regulatory subunit DBf4 in the formation of the initiation competent origins of replication
73. Unphosphorylatable mutants of cdc6 disrupt its nuclear export but still support DNA replication once per cell cycle
74. Nucleotide-dependent prereplicative complex assembly by Cdc6p, a homolog of eukaryotic and prokaryotic clamp-loaders
75. Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization
76. Cell cycle-and cell growth-regulated proteolysis of mammalian CDC6 is dependent on APC-CDH1
77. Cdc6 is an unstable protein whose de novo synthesis in G1 is important for the onset of S phase and for preventing a 'reductional' anaphase in the budding yeast Saccharomyces cerevisiae
78. Mammalian cell fusion: Studies on the regulation of DNA synthesis and mitosis
79. Changes in association of the Xenopus origin recognition complex with chromatin on licensing of replication origins
80. Human CDC6/Cdc18 associates with Orc1 and cyclin-cdk and is selectively eliminated from the nucleus at the onset of S phase
81. Interactions between two catalytically distinct MCM subgroups are essential for coordinated ATP hydrolysis and DNA replication
82. Stepwise assembly of initiation proteins at budding yeast replication origins in vitro
83. G1 phase progression: Cycling on cue
84. Cell cycle control of DNA replication
85. Repression of origin assembly in metaphase depends on inhibition of RLF-B/Cdt1 by geminin
86. Eukaryotic DNA replication: From pre-replication complex to initiation complex
87. Interdependent nuclear accumulation of budding yeast Cdt1 and Mcm2-7 during G1 phase
88. Loading of an Mcm protein onto DNA replication origins is regulated by Cdc6p and CDKs
89. DNA synthesis at individual replication forks requires the essential initiation factor Cdc45p
90. The RLF-M component of the replication licensing system forms complexes containing all six MCM/P1 polypeptides
91. MCM proteins in DNA replication
92. Insights into DNA replication from the third domain of life
93. Uncoupled cell cycle without mitosis induced by a protein kinase inhibitor, K-252a
94. Control of DNA replication via Cdc2 phosphorylation sites in the Origin Recognition Complex
95. Initiation of eukaryotic DNA replication: Origin unwinding and sequential chromatin association of Cdc45, RPA, and DNA polymerase alpha
96. Drosophila double parked: A conserved, essential replication protein that colocalizes with the origin recognition complex and links DNA replication with mitosis and the down-regulation of S phase transcripts
97. A human protein related to yeast Cdc6p
98. Inhibition of eukaryotic DNA replication by geminin binding to cdt1
99. Regulating S phase: CDKs, licensing and proteolysis
100. Expression of Cdc18/Cdc6 and Cdt1 during G2 phase induces initiation of DNA replication
101. Assembly of a complex containing Cdc45p, replication protein A, and Mcm2p at replication origins controlled by S-phase cyclin-dependent kinases and Cdc7p-Dbf4p kinase