Regulation of Ras signaling by the cell cycle

Current Opinion in Genetics and Development

Volumn 12, Issue 1, 2002, Pages 44-46

  Stacey, Dennis ^a   Kazlauskas, Andrius ^b  

^a LERNER RESEARCH INSTITUTE   (United States)

^b SCHEPENS EYE RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN D1; DNA TOPOISOMERASE (ATP HYDROLYSING); GROWTH FACTOR; PHOSPHATIDYLINOSITOL 3 KINASE; RAS PROTEIN;

CELL CYCLE; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL MIGRATION; CELL STIMULATION; ENZYME ACTIVITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; SHORT SURVEY; SIGNAL TRANSDUCTION;

EID: 0036467497     PISSN: 0959437X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-437X(01)00262-3     Document Type: Review

References (22)

1. Integrating the MAP kinase signal into the G1 phase cell cycle machinery
2. INK4a
3. Microinjection of the ras oncogene protein into PC12 cells induces morphological differentiation
4. Ras effectors
5. G1 events and regulation of cell proliferation
6. Growth-factor-dependent mitogenesis requires two distinct phases of signalling
7. Requirement for ras proto-oncogene function during serum-stimulated growth of NIH 3T3 cells
8. kip1 downregulation passage through the restriction point, and entry into S phase in growth factor-stimulated NIH 3T3 fibroblasts
9. Cellular ras and cyclin D1 are required during different cell cycle periods in cycling NIH 3T3 cells
10. Cellular ras activity is required for passage through multiple points of the G0/G1 phase in BALB/c 3T3 cells
11. Cell cycle-dependent activation of Ras
12. Multiple ras effector pathways contribute to G1 cell cycle progression
13. MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo
14. A novel dual specificity phosphatase induced by serum stimulation and heat shock
15. PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells
16. D-3 phosphoinositide metabolism in PDGF-treated cell
17. PDGF induces an early and late wave of PI3-kinase activity, and only the late wave is required for progression through G1
18. The phosphatidylinositol 3-kinase α is required for DNA synthesis by some, but not all, growth factors
19. Identification of the receptor-associated signaling enzymes that are required for platelet-derived growth factor-AA-dependent chemotaxis and DNA synthesis
20. Membrane ruffling and chemotaxis transduced by the PDGF β-receptor require the binding site for phosphatidylinositol 3′ kinase
21. Cyclin D1 production in cycling cells depends on Ras in a cell-cycle-specific manner
22. Continuing proliferation requires G2-phase-specific stimulation of cyclin D1 by Ras