Ras signals to the cell cycle machinery via multiple pathways to induce anchorage-independent growth

Molecular and Cellular Biology

Volumn 18, Issue 5, 1998, Pages 2586-2595

  Yang, Jaw Ji ^a   Kang, Jong Sun ^a   Krauss, Robert S ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN A; CYCLIN D1; CYCLIN E; RAS PROTEIN; RETINOBLASTOMA PROTEIN;

ANCHORAGE INDEPENDENT GROWTH; ANIMAL CELL; ARTICLE; CELL ADHESION; CELL STRAIN 3T3; CONTROLLED STUDY; MOUSE; NONHUMAN; ONCOGENE H RAS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION;

EID: 0031943640     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.18.5.2586     Document Type: Article

References (51)

1. 1. Genes Dev. 7:812-821.
2. Barbacid, M. 1987. ras genes. Annu. Rev. Biochem. 56:779-827.
3. Boguski, M. S., and F. McCormick. 1993. Proteins regulating Ras and its relatives. Nature 366:643.
4. Bos, J. L. 1989. ras oncogenes in human cancer: a review. Cancer Res. 49: 4682-4689.
5. Carstens, C.-P., A. Kramer, and W. E. Fahl. 1996. Adhesion-dependent control of cyclin E/cdk2 activity and cell cycle progression in normal cells but not in Ha-ras transformed NRK cells. Exp. Cell Res. 229:86-92.
6. Chang, H. W., M. Aoki, D. Fruman, K. R. Auger, A. Bellacosa, P. N. Tsichlis, L. C. Cantley, T. M. Roberts, and P. K. Vogt. 1997. Transformation of chicken cells by the gene encoding the catalytic subunit of PI 3-kinase. Science 276:1848-1850.
7. 1 by the v-Abl tyrosine kinase do not express cyclin A despite the hyperphosphorylation of RB. J. Biol. Chem. 271:19637-19640.
8. 1-prolongation of NIH3T3 cells. Oncogene 13:1765-1771.
9. Cowley S., H. Paterson, P. Kemp, and C. J. Marshall. 1994. Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells. Cell 77:841-852.
10. Fang F., G. Orend, N. Watanabe, T. Hunter, and E. Ruoslahti. 1996. Dependence of cyclin E-CDK2 kinase activity on cell anchorage. Science 271: 499-502.
11. Feinleib, J. L., and R. S. Krauss. 1996. Dissociation of ras oncogene-induced gene expression and anchorage-independent growth in a series of somatic cell mutants. Mol. Carcinog. 16:139-148.
12. Girard, F., U. Strausfeld, A. Fernandez, and N. J. C. Lamb. 1991. Cyclin A is required for the onset of DNA replication in mammalian fibroblasts. Cell 67:1169-1179.
13. Guadagno, T. M., M. Ohtsubo, J. M. Roberts, and R. K. Assoian. 1993. A link between cyclin A expression and adhesion-dependent cell cycle progression. Science 262:1572-1575.
14. Han, L., D. Wong, A. Dhaka, D. Afar, M. White, W. Xie, H. Herschman, O. Witte, and J. Colicelli. 1997. Protein binding and signaling properties of RIN1 suggest a unique effector function. Proc. Natl. Acad. Sci. USA 94: 4954-4959.
15. Joneson, T., M. A. White, M. H. Wigler, and D. Bar-Sagi. 1996. Stimulation of membrane ruffling and MAP kinase activation by distinct effectors of RAS. Science 271:810-812.
16. Kang, J.-S., and R. S. Krauss. 1996. Ras induces anchorage-independent growth by subverting multiple adhesion-regulated cell cycle events. Mol. Cell. Biol. 16:3370-3380.
17. Katz, M. E., and F. McCormick. 1997. Signal transduction from multiple Ras effectors. Curr. Opin. Genet. Dev. 7:75-79.
18. Khosravi-Far, R., P. A. Solski, G. J. Clark, M. S. Kinch, and C. J. Der. 1995. Activation of Rac1, RhoA, and mitogen-activated protein kinases is required for Ras transformation. Mol. Cell. Biol. 15:6443-6453.
19. Khosravi-Far, R., M. A. White, J. K. Westwick, P. A. Solski, M. Chrzanowska-Wodnicka, L. Van Aelst, M. H. Wigler, and C. J. Der. 1996. Oncogenic Ras activation of Raf/mitogen-activated protein kinase-independent pathways is sufficient to cause tumorigenic transformation. Mol. Cell. Biol. 16:3923-3933.
20. Khwaja A., P. Rodriguez-Viciana, S. Wennstrom, P. H. Warne, and J. Downward. 1997. Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway. EMBO J. 16:2783-2793.
21. Kolch, W., G. Heidecker, P. Lloyd, and U. R. Rapp. 1991. Raf-1 protein kinase is required for growth of induced NIH/3T3 cells. Nature 349:426-428.
22. Krauss, R. S., S. N. Guadagno, and I. B. Weinstein. 1992. Novel revenants of H-ras oncogene-transformed R6-PKC3 cells. Mol. Cell. Biol. 12:3117-3129.
23. LaBaer, J., M. D. Garrett, L. F. Stevenson, J. M. Slingerland, C. Sandhu, H. S. Chou, A. Fattaey, and E. Harlow. 1997. New functional activities for the p21 family of CDK inhibitors. Genes Dev. 11:847-862.
24. MAPK pathway. J. Biol. Chem. 271:20608-20616.
25. Li, Y., C. W. Jenkins, M. A. Nichols, and Y. Xiong. 1994. Cell cycle expression and p53 regulation of the cyclin-dependent kinase inhibitor p21. Oncogene 9:2261-2268.
26. 1 progression in NIH 3T3 cells. Mol. Cell. Biol. 15:3654-3663.
27. H-ras-induced morphological transformation and increases in c-myc expression are independent of functional protein kinase C. EMBO J. 8: 1099-1104.
28. Marshall, C. J. 1996. Ras effectors. Curr. Opin. Cell Biol. 8:197-204.
29. Marshall, C. J. 1995. Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. Cell 80:179-185.
30. Minden, A., A. Lin, F.-X. Claret, A. Abo, and M. Karin. 1995. Selective activation of the JNK signaling cascade and c-Jun transcription activity by the small GTPases Rac and Cdc42Hs. Cell 81:1147-1157.
31. Morganstern, J. P., and H. Land. 1990. Advanced mammalian gene transfer: high titer retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line. Nucleic Acids Res. 18:3587-3596.
32. 1-to-S phase transition. Mol. Cell. Biol. 15:2612-2624.
33. Okazaki, M., S. Kishida, T. Hinoi, T. Hasegawa, M. Tamada, T. Kataoka, and A. Kikuchi. 1997. Synergistic activation of c-fos promoter activity by Raf and Ral GDP dissociation stimulator. Oncogene 14:515-521.
34. Qiu, R.-G., A. Abo, F. McCormick, and M. Symons. 1997. Cdc42 regulates anchorage-independent growth and is necessary for Ras transformation. Mol. Cell. Biol. 17:3449-3458.
35. Qiu, R.-G., J. Chen, D. Kirn, F. McCormick, and M. Symons. 1995. An essential role for Rac in Ras transformation. Nature 374:457-459.
36. 1 phase in rodent fibroblasts. Genes Dev. 7:1559-1571.
37. 1/S phase transition by expression of cyclins D1 and E with an inducible system. Mol. Cell. Biol. 14:1669-1679.
38. kip1. Mol. Cell. Biol. 15:4347-4352.
39. Rodriguez-Viciana, P., P. H. Warne, A. Khwaja, B. M. Marte, D. Pappin, P. Das, M. D. Waterfield, A. Ridley, and J. Downward. 1997. Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras. Cell 89:457-467.
40. Schulze, A., K. Zerfass-Thome, J. Berges, S. Middendorf, P. Jansen-Durr, and B. Henglein. 1996. Anchorage-dependent transcription of the cyclin A gene. Mol. Cell. Biol. 16:4632-4638.
41. Shim, H., C. Dolde, B. C. Lewis, C.-S. Wu, G. Dang, R. A. Jungmann, R. Dalla-Favera, and C. V. Dang. 1997. c-Myc transactivation of LDH-A: implications for tumor metabolism and growth. Proc. Natl. Acad. Sci. USA 94: 6658-6663.
42. Shin, S.-I., V. H. Freedman, R. Risser, and R. Pollack. 1975. Tumorigenicity of virus-transformed cells in nude mice is correlated specifically with anchorage independent growth in vitro. Proc. Natl. Acad. Sci. USA 72:4435-4439.
43. Stang, S., D. Bottorff, and J. C. Stone. 1997. Interaction of activated Ras with Raf-1 alone may be sufficient for transformation of rat2 cells. Mol. Cell. Biol. 17:3047-3055.
44. Stanton, V. P., D. W. Nichols, A. P. Laudano, and G. M. Cooper. 1989. Definition of the Raf amino-terminal regulatory region by deletion mutagenesis. Mol. Cell. Biol. 9:639-647.
45. Urano, T., R. Emkey, and L. A. Feig. 1996. Ral-GTPases mediate a distinct downstream signaling pathway from Ras that facilitates cellular transformation. EMBO J. 15:810-816.
46. White, A. M., C. Nicolette, A. Minden, A. Polverino, L. Van Aelst, M. Karin, and M. H. Wigler. 1995. Multiple Ras functions can contribute to mammalian cell transformation. Cell 80:533-541.
47. White, M. A., T. Vale, J. H. Camonis, E. Schaefer, and M. H. Wigler. 1996. A role for Ral guanine nucleotide dissociation stimulator in mediating Ras-induced transformation. J. Biol. Chem. 271:16439-16442.
48. Wigler, M., A. Pellicer, S. Silverstein, and R. Axel. 1978. Biochemical transfer of single-copy eucaryotic genes using total cellular DNA as donor. Cell 14:725-731.
49. Yang, J.-J., and R. S. Krauss. 1997. Extracellular ATP induces anchorage-independent expression of cyclin A and rescues the transformed phenotype of a Ras-resistant mutant cell line. J. Biol. Chem. 272:3103-3108.
50. KIP1 blocks cyclin E-dependent transactivation of cyclin A gene expression. Mol. Cell. Biol. 17:407-415.
51. Zhu, X., M. Ohtsubo, R. M. Bohmer, J. M. Roberts, and R. K. Assoian. 1996. Adhesion-dependent cell cycle progression linked to the expression of cyclin D1, activation of cyclin E-cdk2, and phosphorylation of the retinoblastoma protein. J. Cell Biol. 133:391-403.