-
1
-
-
79957616004
-
Intestinal hypoxia-inducible factor-2alpha (HIF-2alpha) is critical for efficient erythropoiesis
-
Anderson ER, Xue X, Shah YM. 2011. Intestinal hypoxia-inducible factor-2alpha (HIF-2alpha) is critical for efficient erythropoiesis. J. Biol. Chem. 286:19533-19540.
-
(2011)
J. Biol. Chem
, vol.286
, pp. 19533-19540
-
-
Anderson, E.R.1
Xue, X.2
Shah, Y.M.3
-
2
-
-
56049084892
-
Synergistic interaction between excess hepatic iron and alcohol ingestion in hepatic mutagenesis
-
Asare GA, Bronz M, Naidoo V, Kew MC. 2008. Synergistic interaction between excess hepatic iron and alcohol ingestion in hepatic mutagenesis. Toxicology 254:11-18.
-
(2008)
Toxicology
, vol.254
, pp. 11-18
-
-
Asare, G.A.1
Bronz, M.2
Naidoo, V.3
Kew, M.C.4
-
3
-
-
25444530350
-
Hepatic expression of hemochromatosis genes in two mouse strains after phlebotomy and iron overload
-
Bondi A, et al. 2005. Hepatic expression of hemochromatosis genes in two mouse strains after phlebotomy and iron overload. Haematologica 90:1161-1167.
-
(2005)
Haematologica
, vol.90
, pp. 1161-1167
-
-
Bondi, A.1
-
4
-
-
40949120506
-
2- Oxoglutarate-dependent oxygenases control hepcidin gene expression
-
Braliou GG, et al. 2008. 2-Oxoglutarate-dependent oxygenases control hepcidin gene expression. J. Hepatol. 48:801-810.
-
(2008)
J. Hepatol
, vol.48
, pp. 801-810
-
-
Braliou, G.G.1
-
5
-
-
33644773569
-
Hepcidin is down-regulated in alcoholic liver injury: implications for the pathogenesis of alcoholic liver disease
-
Bridle K, et al. 2006. Hepcidin is down-regulated in alcoholic liver injury: implications for the pathogenesis of alcoholic liver disease. Alcohol. Clin. Exp. Res. 30:106-112.
-
(2006)
Alcohol. Clin. Exp. Res
, vol.30
, pp. 106-112
-
-
Bridle, K.1
-
6
-
-
39649097642
-
Evidence for differential effects of hepcidin in macrophages and intestinal epithelial cells
-
Chaston T, et al. 2008. Evidence for differential effects of hepcidin in macrophages and intestinal epithelial cells. Gut 57:374-382.
-
(2008)
Gut
, vol.57
, pp. 374-382
-
-
Chaston, T.1
-
7
-
-
79955132381
-
Hypoxia inhibits hepcidin expression in HuH7 hepatoma cells via decreased SMAD4 signaling
-
Chaston TB, et al. 2011. Hypoxia inhibits hepcidin expression in HuH7 hepatoma cells via decreased SMAD4 signaling. Am. J. Physiol. Cell Physiol. 300:C888-C895.
-
(2011)
Am. J. Physiol. Cell Physiol
, vol.300
-
-
Chaston, T.B.1
-
8
-
-
0037174609
-
C/EBPalpha regulates hepatic transcription of hepcidin, an antimicrobial peptide and regulator of iron metabolism. Cross-talk between C/EBP pathway and iron metabolism
-
Courselaud B, et al. 2002. C/EBPalpha regulates hepatic transcription of hepcidin, an antimicrobial peptide and regulator of iron metabolism. Cross-talk between C/EBP pathway and iron metabolism. J. Biol. Chem. 277:41163-41170.
-
(2002)
J. Biol. Chem
, vol.277
, pp. 41163-41170
-
-
Courselaud, B.1
-
9
-
-
4644301624
-
Delayed hepcidin response explains the lag period in iron absorption following a stimulus to increase erythropoiesis
-
Frazer DM, et al. 2004. Delayed hepcidin response explains the lag period in iron absorption following a stimulus to increase erythropoiesis. Gut 53:1509-1515.
-
(2004)
Gut
, vol.53
, pp. 1509-1515
-
-
Frazer, D.M.1
-
10
-
-
0034065378
-
Liver iron is predictive of death in alcoholic cirrhosis: a multivariate study of 229 consecutive patients with alcoholic and/or hepatitis C virus cirrhosis: a prospective follow up study
-
Ganne-Carrié N, et al. 2000. Liver iron is predictive of death in alcoholic cirrhosis: a multivariate study of 229 consecutive patients with alcoholic and/or hepatitis C virus cirrhosis: a prospective follow up study. Gut 46: 277-282.
-
(2000)
Gut
, vol.46
, pp. 277-282
-
-
Ganne-Carrié, N.1
-
11
-
-
84862820654
-
Alcohol activates TGF-beta but inhibits BMP receptor-mediated Smad signaling and Smad4 binding to hepcidin promoter in the liver
-
Gerjevic LN, Liu N, Lu S, Harrison-Findik DD. 2012. Alcohol activates TGF-beta but inhibits BMP receptor-mediated Smad signaling and Smad4 binding to hepcidin promoter in the liver. Int. J. Hepatol. 2012: 459278.
-
(2012)
Int. J. Hepatol
, vol.2012
, pp. 459278
-
-
Gerjevic, L.N.1
Liu, N.2
Lu, S.3
Harrison-Findik, D.D.4
-
12
-
-
81155149499
-
Chuvash polycythemia VHLR200W mutation is associated with down-regulation of hepcidin expression
-
Gordeuk VR, et al. 2011. Chuvash polycythemia VHLR200W mutation is associated with down-regulation of hepcidin expression. Blood 118: 5278-5282.
-
(2011)
Blood
, vol.118
, pp. 5278-5282
-
-
Gordeuk, V.R.1
-
13
-
-
24344452947
-
The VHL tumor suppressor in development and disease: functional studies in mice by conditional gene targeting
-
Haase VH. 2005. The VHL tumor suppressor in development and disease: functional studies in mice by conditional gene targeting. Semin. Cell Dev. Biol. 16:564-574.
-
(2005)
Semin. Cell Dev. Biol
, vol.16
, pp. 564-574
-
-
Haase, V.H.1
-
14
-
-
65649112386
-
Is the iron regulatory hormone hepcidin a risk factor for alcoholic liver disease? World J
-
Harrison-Findik DD. 2009. Is the iron regulatory hormone hepcidin a risk factor for alcoholic liver disease? World J. Gastroenterol. 15:1186-1193.
-
(2009)
Gastroenterol
, vol.15
, pp. 1186-1193
-
-
Harrison-Findik, D.D.1
-
15
-
-
34848838993
-
Iron-mediated regulation of liver hepcidin expression in rats and mice is abolished by alcohol
-
Harrison-Findik DD, et al. 2007. Iron-mediated regulation of liver hepcidin expression in rats and mice is abolished by alcohol. Hepatology 46:1979-1985.
-
(2007)
Hepatology
, vol.46
, pp. 1979-1985
-
-
Harrison-Findik, D.D.1
-
16
-
-
58249117786
-
Regulation of liver hepcidin expression by alcohol in vivo does not involve Kupffer cell activation or TNF-alpha signaling
-
Harrison-Findik DD, Klein E, Evans J, Gollan J. 2009. Regulation of liver hepcidin expression by alcohol in vivo does not involve Kupffer cell activation or TNF-alpha signaling. Am. J. Physiol. Gastrointest. Liver Physiol. 296:G112-G118.
-
(2009)
Am. J. Physiol. Gastrointest. Liver Physiol
, vol.296
-
-
Harrison-Findik, D.D.1
Klein, E.2
Evans, J.3
Gollan, J.4
-
17
-
-
33747359666
-
Alcohol metabolism-mediated oxidative stress down-regulates hepcidin transcription and leads to increased duodenal iron transporter expression
-
Harrison-Findik DD, et al. 2006. Alcohol metabolism-mediated oxidative stress down-regulates hepcidin transcription and leads to increased duodenal iron transporter expression. J. Biol. Chem. 281:22974-22982.
-
(2006)
J. Biol. Chem
, vol.281
, pp. 22974-22982
-
-
Harrison-Findik, D.D.1
-
18
-
-
84859712679
-
Downregulating hypoxia-inducible factor-2alpha improves the efficacy of doxorubicin in the treatment of hepatocellular carcinoma
-
He C, et al. 2012. Downregulating hypoxia-inducible factor-2alpha improves the efficacy of doxorubicin in the treatment of hepatocellular carcinoma. Cancer Sci. 103:528-534.
-
(2012)
Cancer Sci
, vol.103
, pp. 528-534
-
-
He, C.1
-
19
-
-
68149094347
-
Hepcidin regulation in wild-type and Hfe knockout mice in response to alcohol consumption: evidence for an alcohol-induced hypoxic response
-
Heritage ML, et al. 2009. Hepcidin regulation in wild-type and Hfe knockout mice in response to alcohol consumption: evidence for an alcohol-induced hypoxic response. Alcohol. Clin. Exp. Res. 33:1391-1400.
-
(2009)
Alcohol. Clin. Exp. Res
, vol.33
, pp. 1391-1400
-
-
Heritage, M.L.1
-
20
-
-
74049100236
-
Is iron overload in alcohol-related cirrhosis mediated by hepcidin?
-
Iqbal T, et al. 2009. Is iron overload in alcohol-related cirrhosis mediated by hepcidin? World J. Gastroenterol. 15:5864-5866.
-
(2009)
World J Gastroenterol
, vol.15
, pp. 5864-5866
-
-
Iqbal, T.1
-
21
-
-
40949136438
-
The VHL tumor suppressor and HIF: insights from genetic studies in mice
-
Kapitsinou PP, Haase VH. 2008. The VHL tumor suppressor and HIF: insights from genetic studies in mice. Cell Death Differ. 15:650-659.
-
(2008)
Cell Death Differ
, vol.15
, pp. 650-659
-
-
Kapitsinou, P.P.1
Haase, V.H.2
-
22
-
-
51649096725
-
Iron regulates phosphorylation of Smad1/5/8 and gene expression of Bmp6, Smad7, Id1, and Atoh8 in the mouse liver
-
Kautz L, et al. 2008. Iron regulates phosphorylation of Smad1/5/8 and gene expression of Bmp6, Smad7, Id1, and Atoh8 in the mouse liver. Blood 112:1503-1509.
-
(2008)
Blood
, vol.112
, pp. 1503-1509
-
-
Kautz, L.1
-
23
-
-
32044456491
-
Iron accumulation in alcoholic liver diseases
-
Kohgo Y, et al. 2005. Iron accumulation in alcoholic liver diseases. Alcohol. Clin. Exp. Res. 29:189S-193S.
-
(2005)
Alcohol. Clin. Exp. Res
, vol.29
-
-
Kohgo, Y.1
-
24
-
-
0034284595
-
LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity
-
Krause A, et al. 2000. LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity. FEBS Lett. 480:147-150.
-
(2000)
FEBS Lett
, vol.480
, pp. 147-150
-
-
Krause, A.1
-
25
-
-
61949188604
-
Role of iron deficiency and overload in the pathogenesis of diabetes and diabetic complications
-
Liu Q, et al. 2009. Role of iron deficiency and overload in the pathogenesis of diabetes and diabetic complications. Curr. Med. Chem. 16:113-129.
-
(2009)
Curr. Med. Chem
, vol.16
, pp. 113-129
-
-
Liu, Q.1
-
26
-
-
84862148400
-
Hepatic HIF-2 down-regulates hepcidin expression in mice through epo-mediated increase in erythropoiesis
-
Mastrogiannaki M, et al. 2012. Hepatic HIF-2 down-regulates hepcidin expression in mice through epo-mediated increase in erythropoiesis. Haematologica 97:827-834.
-
(2012)
Haematologica
, vol.97
, pp. 827-834
-
-
Mastrogiannaki, M.1
-
27
-
-
66749147761
-
Activated macrophages induce hepcidin expression in HuH7 hepatoma cells
-
Matak P, et al. 2009. Activated macrophages induce hepcidin expression in HuH7 hepatoma cells. Haematologica 94:773-780.
-
(2009)
Haematologica
, vol.94
, pp. 773-780
-
-
Matak, P.1
-
28
-
-
10844258104
-
Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization
-
Nemeth E, et al. 2004. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science 306:2090-2093.
-
(2004)
Science
, vol.306
, pp. 2090-2093
-
-
Nemeth, E.1
-
29
-
-
0035902605
-
Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice
-
Nicolas G, et al. 2001. Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice. Proc. Natl. Acad. Sci. U. S. A. 98:8780-8785.
-
(2001)
Proc. Natl. Acad. Sci. U. S. A.
, vol.98
, pp. 8780-8785
-
-
Nicolas, G.1
-
30
-
-
0036791486
-
The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation
-
Nicolas G, et al. 2002. The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation. J. Clin. Invest. 110:1037-1044.
-
(2002)
J. Clin. Invest
, vol.110
, pp. 1037-1044
-
-
Nicolas, G.1
-
31
-
-
33846293650
-
Hepcidin is down-regulated in alcohol loading
-
Ohtake T, et al. 2007. Hepcidin is down-regulated in alcohol loading. Alcohol. Clin. Exp. Res. 31:S2-S8.
-
(2007)
Alcohol. Clin. Exp. Res
, vol.31
-
-
Ohtake, T.1
-
32
-
-
0035093813
-
Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-alpha (C/EBPalpha), in acute myeloid leukemia
-
Pabst T, et al. 2001. Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-alpha (C/EBPalpha), in acute myeloid leukemia. Nat. Genet. 27:263-270.
-
(2001)
Nat. Genet.
, vol.27
, pp. 263-270
-
-
Pabst, T.1
-
33
-
-
0035896642
-
Hepcidin, a urinary antimicrobial peptide synthesized in the liver
-
Park CH, Valore EV, Waring AJ, Ganz T. 2001. Hepcidin, a urinary antimicrobial peptide synthesized in the liver. J. Biol. Chem. 276:7806-7810.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 7806-7810
-
-
Park, C.H.1
Valore, E.V.2
Waring, A.J.3
Ganz, T.4
-
34
-
-
83255187561
-
C/EBPalpha dysregulation in AML and ALL
-
Paz-Priel I, Friedman A. 2011. C/EBPalpha dysregulation in AML and ALL. Crit. Rev. Oncog. 16:93-102.
-
(2011)
Crit. Rev. Oncog
, vol.16
, pp. 93-102
-
-
Paz-Priel, I.1
Friedman, A.2
-
35
-
-
34447120059
-
Regulation of iron homeostasis by the hypoxia-inducible transcription factors (HIFs)
-
Peyssonnaux C, et al. 2007. Regulation of iron homeostasis by the hypoxia-inducible transcription factors (HIFs). J. Clin. Invest. 117:1926-1932.
-
(2007)
J. Clin. Invest
, vol.117
, pp. 1926-1932
-
-
Peyssonnaux, C.1
-
36
-
-
47049116150
-
Erythropoietin mediates hepcidin expression in hepatocytes through EPOR signaling and regulation of C/EBPalpha
-
Pinto JP, et al. 2008. Erythropoietin mediates hepcidin expression in hepatocytes through EPOR signaling and regulation of C/EBPalpha. Blood 111:5727-5733.
-
(2008)
Blood
, vol.111
, pp. 5727-5733
-
-
Pinto, J.P.1
-
37
-
-
79953108427
-
Modulation of hepcidin production during hypoxia-induced erythropoiesis in humans in vivo: data from the HIGHCARE project
-
Piperno A, et al. 2011. Modulation of hepcidin production during hypoxia-induced erythropoiesis in humans in vivo: data from the HIGHCARE project. Blood 117:2953-2959.
-
(2011)
Blood
, vol.117
, pp. 2953-2959
-
-
Piperno, A.1
-
38
-
-
79960745146
-
Hypoxia-inducible transcription factor 2alpha promotes steatohepatitis through augmenting lipid accumulation, inflammation, and fibrosis
-
Qu A, et al. 2011. Hypoxia-inducible transcription factor 2alpha promotes steatohepatitis through augmenting lipid accumulation, inflammation, and fibrosis. Hepatology 54:472-483.
-
(2011)
Hepatology
, vol.54
, pp. 472-483
-
-
Qu, A.1
-
39
-
-
77956998439
-
Transferrin receptor 2 is crucial for iron sensing in human hepatocytes
-
Rapisarda C, et al. 2010. Transferrin receptor 2 is crucial for iron sensing in human hepatocytes. Am. J. Physiol. Gastrointest. Liver Physiol. 299: G778-G783.
-
(2010)
Am. J. Physiol. Gastrointest. Liver Physiol
, vol.299
-
-
Rapisarda, C.1
-
40
-
-
30444445382
-
Mouse model for noninvasive imaging of HIF prolyl hydroxylase activity: assessment of an oral agent that stimulates erythropoietin production
-
Safran M, et al. 2006. Mouse model for noninvasive imaging of HIF prolyl hydroxylase activity: assessment of an oral agent that stimulates erythropoietin production. Proc. Natl. Acad. Sci. U. S. A. 103:105-110.
-
(2006)
Proc. Natl. Acad. Sci. U. S. A.
, vol.103
, pp. 105-110
-
-
Safran, M.1
-
41
-
-
4043062056
-
Efficient temporally controlled targeted somatic mutagenesis in hepatocytes of the mouse
-
Schuler M, Dierich A, Chambon P, Metzger D. 2004. Efficient temporally controlled targeted somatic mutagenesis in hepatocytes of the mouse. Genesis 39:167-172.
-
(2004)
Genesis
, vol.39
, pp. 167-172
-
-
Schuler, M.1
Dierich, A.2
Chambon, P.3
Metzger, D.4
-
43
-
-
0026468180
-
A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation
-
Semenza GL, Wang GL. 1992. A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. Mol. Cell. Biol. 12:5447-5454.
-
(1992)
Mol. Cell. Biol
, vol.12
, pp. 5447-5454
-
-
Semenza, G.L.1
Wang, G.L.2
-
44
-
-
2342625392
-
Analysis of adenovirus sequestration in the liver, transduction of hepatic cells, and innate toxicity after injection of fiber-modified vectors
-
Shayakhmetov DM, Li ZY, Ni S, Lieber A. 2004. Analysis of adenovirus sequestration in the liver, transduction of hepatic cells, and innate toxicity after injection of fiber-modified vectors. J. Virol. 78:5368-5381.
-
(2004)
J. Virol
, vol.78
, pp. 5368-5381
-
-
Shayakhmetov, D.M.1
Li, Z.Y.2
Ni, S.3
Lieber, A.4
-
45
-
-
56449096622
-
The serine protease matriptase-2 (TMPRSS6) inhibits hepcidin activation by cleaving membrane hemojuvelin
-
Silvestri L, et al. 2008. The serine protease matriptase-2 (TMPRSS6) inhibits hepcidin activation by cleaving membrane hemojuvelin. Cell Metab. 8:502-511.
-
(2008)
Cell Metab
, vol.8
, pp. 502-511
-
-
Silvestri, L.1
-
46
-
-
79958146087
-
Hypoxia-inducible factor-2alpha mediates the adaptive increase of intestinal ferroportin during iron deficiency in mice
-
Taylor M, et al. 2011. Hypoxia-inducible factor-2alpha mediates the adaptive increase of intestinal ferroportin during iron deficiency in mice. Gastroenterology 140:2044-2055.
-
(2011)
Gastroenterology
, vol.140
, pp. 2044-2055
-
-
Taylor, M.1
-
47
-
-
0033777202
-
Conditional disruption of the aryl hydrocarbon receptor nuclear translocator (Arnt) gene leads to loss of target gene induction by the aryl hydrocarbon receptor and hypoxia-inducible factor 1alpha
-
Tomita S, Sinal CJ, Yim SH, Gonzalez FJ. 2000. Conditional disruption of the aryl hydrocarbon receptor nuclear translocator (Arnt) gene leads to loss of target gene induction by the aryl hydrocarbon receptor and hypoxia-inducible factor 1alpha. Mol. Endocrinol. 14:1674-1681.
-
(2000)
Mol. Endocrinol
, vol.14
, pp. 1674-1681
-
-
Tomita, S.1
Sinal, C.J.2
Yim, S.H.3
Gonzalez, F.J.4
-
48
-
-
33745742487
-
Hepcidin mRNA levels in mouse liver respond to inhibition of erythropoiesis
-
Vokurka M, Krijt J, Sulc K, Necas E. 2006. Hepcidin mRNA levels in mouse liver respond to inhibition of erythropoiesis. Physiol. Res. 55:667-674.
-
(2006)
Physiol. Res
, vol.55
, pp. 667-674
-
-
Vokurka, M.1
Krijt, J.2
Sulc, K.3
Necas, E.4
-
49
-
-
70849095971
-
Evidence for a lack of a direct transcriptional suppression of the iron regulatory peptide hepcidin by hypoxia-inducible factors
-
doi:10.1371/journal.pone.0007875
-
Volke M, et al. 2009. Evidence for a lack of a direct transcriptional suppression of the iron regulatory peptide hepcidin by hypoxia-inducible factors. PLoS One 4:e7875. doi:10.1371/journal.pone.0007875.
-
(2009)
PLoS One
, vol.4
-
-
Volke, M.1
-
50
-
-
77954964456
-
Elimination of C/EBPalpha through the ubiquitinproteasome system promotes the development of liver cancer in mice
-
Wang GL, et al. 2010. Elimination of C/EBPalpha through the ubiquitinproteasome system promotes the development of liver cancer in mice. J. Clin. Invest. 120:2549-2562.
-
(2010)
J. Clin. Invest
, vol.120
, pp. 2549-2562
-
-
Wang, G.L.1
-
51
-
-
65349142586
-
Ablation of ARNT/HIF1beta in liver alters gluconeogenesis, lipogenic gene expression, and serum ketones
-
Wang XL, et al. 2009. Ablation of ARNT/HIF1beta in liver alters gluconeogenesis, lipogenic gene expression, and serum ketones. Cell Metab. 9:428-439.
-
(2009)
Cell Metab
, vol.9
, pp. 428-439
-
-
Wang, X.L.1
-
52
-
-
79953870540
-
Targeting HIF1alpha eliminates cancer stem cells in hematological malignancies
-
Wang Y, Liu Y, Malek SN, Zheng P. 2011. Targeting HIF1alpha eliminates cancer stem cells in hematological malignancies. Cell Stem Cell 8:399-411.
-
(2011)
Cell Stem Cell
, vol.8
, pp. 399-411
-
-
Wang, Y.1
Liu, Y.2
Malek, S.N.3
Zheng, P.4
-
53
-
-
67649968443
-
Oxidative stress and alcoholic liver disease
-
Wu D, Cederbaum AI. 2009. Oxidative stress and alcoholic liver disease. Semin. Liver Dis. 29:141-154.
-
(2009)
Semin. Liver Dis.
, vol.29
, pp. 141-154
-
-
Wu, D.1
Cederbaum, A.I.2
-
54
-
-
84860520642
-
HIF-2alpha activation promotes colorectal cancer progression by dysregulating iron homeostasis
-
Xue X, et al. 2012. HIF-2alpha activation promotes colorectal cancer progression by dysregulating iron homeostasis. Cancer Res. 72:2285-2293.
-
(2012)
Cancer Res
, vol.72
, pp. 2285-2293
-
-
Xue, X.1
|