Alcohol metabolism-mediated oxidative stress down-regulates hepcidin transcription and leads to increased duodenal iron transporter expression

Journal of Biological Chemistry

Volumn 281, Issue 32, 2006, Pages 22974-22982

  Harrison Findik, Duygu Dee ^a,f   Schafer, Denise ^a   Klein, Elizabeth ^a   Timchenko, Nikolai A ^b   Kulaksiz, Hasan ^c   Clemens, Dahn ^a,d   Fein, Evelyn ^c   Andriopoulos, Billy ^e   Pantopoulos, Kostas ^e   Gollan, John ^a  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF HEIDELBERG   (Germany)

^d VA NEBRASKA WESTERN IOWA HEALTH CARE SYSTEM   (United States)

^e MCGILL UNIVERSITY   (Canada)

^f UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOLS; DISEASE CONTROL; HISTOLOGY; IRON; METABOLISM; OXIDATION; PATIENT TREATMENT; RNA;

ETHANOL METABOLISM; HEPCIDIN TRANSCRIPTION; IRON TRANSPORTER EXPRESSION; OXIDATIVE STRESS;

DISEASES;

4 METHYLPYRAZOLE; ACETYLCYSTEINE; ALCOHOL; ALPHA TOCOPHEROL; CCAAT ENHANCER BINDING PROTEIN ALPHA; CCAAT ENHANCER BINDING PROTEIN BETA; CD71 ANTIGEN; FERRITIN; FERROPORTIN 1; HEPCIDIN; IRON REGULATORY PROTEIN 1; IRON REGULATORY PROTEIN 2; MESSENGER RNA; NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN 2; TRIACYLGLYCEROL;

ALCOHOL LIVER DISEASE; ALCOHOL METABOLISM; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DNA BINDING; DOWN REGULATION; DRUG INHIBITION; DUODENUM; FEMALE; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IRON METABOLISM; IRON OVERLOAD; LIVER FIBROSIS; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN SYNTHESIS;

ANIMALS; ANTIMICROBIAL CATIONIC PEPTIDES; ANTIOXIDANTS; BIOLOGICAL TRANSPORT; CCAAT-ENHANCER-BINDING PROTEIN-ALPHA; CCAAT-ENHANCER-BINDING PROTEIN-BETA; DUODENUM; ETHANOL; FEMALE; GENE EXPRESSION REGULATION; HUMANS; IRON; MALE; MICE; OXIDATIVE STRESS; PYRAZOLES; REACTIVE OXYGEN SPECIES;

EID: 33747359666     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M602098200     Document Type: Article

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