Liver iron is predictive of death in alcoholic cirrhosis: A multivariate study of 229 consecutive patients with alcoholic and/or hepatitis c virus cirrhosis: A prospective follow up study

Gut

Volumn 46, Issue 2, 2000, Pages 277-282

  Ganne Carrie N ^a   Christidis, C ^a   Chastang, C ^b   Ziol, M ^a   Chapel, F ^a   Imbert Bismut, F ^c   Trinchet, J C ^a   Guettier, C ^a   Beaugrand, M ^a  

^a HÔPITAL JEAN VERDIER   (France)

^b SAINT LOUIS HOSPITAL   (France)

^c PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

Author keywords

Alcohol; Cirrhosis; Hepatocellular carcinoma; Iron; Liver; Survival

Indexed keywords

IRON;

ADULT; ALCOHOL LIVER CIRRHOSIS; ARTICLE; CONTROLLED STUDY; FEMALE; HEPATITIS C; HUMAN; HUMAN TISSUE; LIVER BIOPSY; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; MAJOR CLINICAL STUDY; MALE; MORTALITY; MULTIVARIATE ANALYSIS; PRIORITY JOURNAL; SCORING SYSTEM; SURVIVAL;

CARCINOMA, HEPATOCELLULAR; DISEASE PROGRESSION; FEMALE; FOLLOW-UP STUDIES; HEPACIVIRUS; HEPATITIS C, CHRONIC; HUMANS; IRON; LIVER; LIVER CIRRHOSIS, ALCOHOLIC; LIVER NEOPLASMS; MALE; MIDDLE AGED; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; PROSPECTIVE STUDIES; SURVIVAL RATE;

EID: 0034065378     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.46.2.277     Document Type: Article

References (24)

1. 1 Ludwig J, Haschimoto E, Porayko M, et al. Hemosiderosis in cirrhosis: a study of 447 native livers. Gastroenterology 1997;112:882-8.
2. 2 Fargion S, Mandelli C, Piperno A, et al. Survival and prognostic in 212 Italian patients with genetic hemochromatosis. Hepatology 1992;15:655-9.
3. 3 Houglum K, Ramm G, Crawford D, et al. Excess iron induces hepatic oxidative stress and transforming growth factor β1 in genetic hemochromatosis. Hepatology 1997;26: 605-10.
4. 4 Britton R. Metal-induced hepatotoxicity. Semin Liver Dis 1996;16:3-12.
5. 5 Adams P, Agnew S. Alcoholism in hereditary hemochromatosis revisited: prevalence and clinical consequences among homozygous siblings. Hepatology 1996;23:724-7.
6. 6 Bonkovsky H, Banner B, Lambrecht R, et al. Iron in liver diseases other than hemochromatosis. Semin Liver Dis 1996;16:65-82.
7. 7 Chenoufi N, Loréal O, Drénou B, et al. Iron induces both DNA synthesis and repair in rat hepatocyte stimulated by EGF/pyruvate [abstract]. Hepatology 1995;22:199.
8. 8 Turlin B, Juguet F, Moirand R, et al. Increased liver iron stores in patients with hepatocellular carcinoma developed on a noncirrhotic liver. Hepatology 1995;22:446-50.
9. 9 Farinati F, Cardin R, De Maria N, et al. Iron storage, lipid peroxydation and glutathione turnover in chronic anti-HCV positive hepatitis. J Hepatol 1995;22:449-59.
10. 10 Deugnier Y, Turlin B, Powell L, et al. Differenciation between heterozygotes and homozygotes in genetic hemochromatosis by means of a histological hepatic iron index: a study of 192 cases. Hepatology 1993;17:30-4.
11. 11 Barry M, Sherlock S. Measurement of liver iron concentration in needle-biopsy specimens. Lancet 1971;i:100-3.
12. 12 Kaplan E L, Meier P. Nonparametric estimation from incomplete observations. J Am Stat Assoc 1958;53: 457-81.
13. 13 Peto R, Peto J. Asymptomatically efficient rank invariant test procedures (with discussion). J R Stat Soc [A] 1972;135: 185-9.
14. 14 Cox DR. Regression models and life tables (with discussion). J R Stat Soc [B] 1972;34:187-220.
15. 15 Deugnier Y, Turlin B, Le Quilleuc D, et al. A reappraisal of hepatic siderosis in patients with end-stage cirrhosis: practical implications for the diagnosis of hemochromatosis. Am J Surg Pathol 1997;21:669-75.
16. 16 Bronner M, Kowdley K, Carlson T, et al. Intra-organ variability of hepatic iron concentration with hepatitis C [abstract]. Hepatology 1995;22:677.
17. 17 Villeneuve J, Bilodeau M, Lepage R, et al. Variability in hepatic iron concentrations measurement from needle-biopsy specimens. J Hepatol 1996;25:172-7.
18. 18 Grove J, Daly A, Burt A, et al. Heterozygotes for HFE mutations have no increased risk of advanced alcoholic liver disease. Gut 1998;43:262-6.
19. 19 Hezode C, Cazeneuve C, Coué O, et al. Hemochromatosis Cys282Tyr mutation and liver iron overload in patients with chronic active hepatitis C. Hepatology 1998;27:306.
20. 20 Piperno A, Vergani A, Malosio I, et al. Hepatic iron overload in patients with chronic viral hepatitis : a role of HFE gene mutations. Hepatology 1998;28:1105-9.
21. 21 Halimi C, Deny P, Gotheil C, et al. Pathogenesis of liver cirrhosis in alcoholic patients: histological evidence for hepatitis C virus responsability. Liver 1991;11:329-33.
22. 22 Mackinnon M, Clayton C, Plummer J, et al. Iron overload facilitates hepatic fibrosis in the rat alcohol/low-dose carbon tetrachloride model. Hepatology 1995;21:1083-8.
23. 23 Tsukamoto H, Horne W, Kamimura S, et al. Experimental liver cirrhosis induced by alcohol and iron. J Clin Invest 1995;65:620-30.
24. 24 Ferenci P, Dragosics B, Dittrich H, et al. Randomized controlled trial of Silymarin treatment in patients with cirrhosis of the liver. J Hepatol 1989;9:105-1.