메뉴 건너뛰기




Volumn 94, Issue 6, 2009, Pages 773-780

Activated macrophages induce hepcidin expression in HuH7 hepatoma cells

Author keywords

Cytokines; Hepcidin; hepatocytes; Inflammation; Macrophages

Indexed keywords

BONE MORPHOGENETIC PROTEIN; CCAAT ENHANCER BINDING PROTEIN; HEPCIDIN; INTERLEUKIN 1 ANTIBODY; INTERLEUKIN 6 ANTIBODY; MESSENGER RNA; NOGGIN; SMAD4 PROTEIN; STAT3 PROTEIN;

EID: 66749147761     PISSN: 03906078     EISSN: 15928721     Source Type: Journal    
DOI: 10.3324/haematol.2008.003400     Document Type: Article
Times cited : (34)

References (36)
  • 1
  • 2
    • 33750133047 scopus 로고    scopus 로고
    • Regulation of iron metabolism by hepcidin
    • Nemeth E, Ganz T. Regulation of iron metabolism by hepcidin. Annu Rev Nutr 2006;26:323-342
    • (2006) Annu Rev Nutr , vol.26 , pp. 323-342
    • Nemeth, E.1    Ganz, T.2
  • 3
    • 0038662619 scopus 로고    scopus 로고
    • Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein
    • DOI 10.1182/blood-2002-10-3235
    • Nemeth E, Valore EV, Territo M, Schiller G, Lichtenstein A, Ganz T. Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein. Blood 2003;101:2461-2463 (Pubitemid 36857598)
    • (2003) Blood , vol.101 , Issue.7 , pp. 2461-2463
    • Nemeth, E.1    Valore, E.V.2    Territo, M.3    Schiller, G.4    Lichtenstein, A.5    Ganz, T.6
  • 4
    • 39649097642 scopus 로고    scopus 로고
    • Evidence for differential effects of hepcidin in macrophages and intestinal epithelial cells
    • Chaston T, Chung B, Mascarenhas M, Marks J, Patel B, Srai SK, et al. Evidence for differential effects of hepcidin in macrophages and intestinal epithelial cells. Gut 2008;57:374-382
    • (2008) Gut , vol.57 , pp. 374-382
    • Chaston, T.1    Chung, B.2    Mascarenhas, M.3    Marks, J.4    Patel, B.5    Srai, S.K.6
  • 5
    • 28444488323 scopus 로고    scopus 로고
    • Presence of the iron exporter ferroportin at the plasma membrane of macrophages is enhanced by iron loading and down-regulated by hepcidin
    • DOI 10.1182/blood-2005-06-2398
    • Delaby C, Pilard N, Goncalves AS, Beaumont C, Canonne-Hergaux F. Presence of the iron exporter ferroportin at the plasma membrane of macrophages is enhanced by iron loading and down-regulated by hepcidin. Blood 2005;106:3979-3984 (Pubitemid 41739041)
    • (2005) Blood , vol.106 , Issue.12 , pp. 3979-3984
    • Delaby, C.1    Pilard, N.2    Goncalves, A.S.3    Beaumont, C.4    Canonne-Hergaux, F.5
  • 7
    • 24744458603 scopus 로고    scopus 로고
    • Synthetic hepcidin causes rapid dose-dependent hypoferremia and is concentrated in ferroportin-containing organs
    • DOI 10.1182/blood-2005-04-1766
    • Rivera S, Nemeth E, Gabayan V, Lopez MA, Farshidi D, Ganz T. Synthetic hepcidin causes rapid dose-dependent hypoferremia and is concentrated in ferroportin-containing organs. Blood 2005;106:2196-2199 (Pubitemid 41291740)
    • (2005) Blood , vol.106 , Issue.6 , pp. 2196-2199
    • Rivera, S.1    Nemeth, E.2    Gabayan, V.3    Lopez, M.A.4    Farshidi, D.5    Ganz, T.6
  • 8
    • 41949133287 scopus 로고    scopus 로고
    • Iron regulation and erythropoiesis
    • Nemeth E. Iron regulation and erythropoiesis. Curr Opin Hematol 2008;15:169-175
    • (2008) Curr Opin Hematol , vol.15 , pp. 169-175
    • Nemeth, E.1
  • 9
    • 47049116150 scopus 로고    scopus 로고
    • Erythropoietin mediates hepcidin expression in hepatocytes through EPOR signaling and regulation of C/EBPα
    • Pinto JP, Ribeiro S, Pontes H, Thowfeequ S, Tosh D, Carvalho F, et al. Erythropoietin mediates hepcidin expression in hepatocytes through EPOR signaling and regulation of C/EBPα. Blood 2008;111:5727-5733
    • (2008) Blood , vol.111 , pp. 5727-5733
    • Pinto, J.P.1    Ribeiro, S.2    Pontes, H.3    Thowfeequ, S.4    Tosh, D.5    Carvalho, F.6
  • 10
    • 1642416424 scopus 로고    scopus 로고
    • Hepcidin, a candidate modifier of the hemochromatosis phenotype in mice
    • DOI 10.1182/blood-2003-09-3358
    • Nicolas G, Andrews NC, Kahn A, Vaulont S. Hepcidin, a candidate modifier of the hemochromatosis phenotype in mice. Blood 2004;103:2841-2843 (Pubitemid 38393048)
    • (2004) Blood , vol.103 , Issue.7 , pp. 2841-2843
    • Nicolas, G.1    Andrews, N.C.2    Kahn, A.3    Vaulont, S.4
  • 13
    • 41649120714 scopus 로고    scopus 로고
    • Hepcidin expression in mouse retina and its regulation via lipopolysaccharide/Toll-like receptor-4 pathway independent of Hfe
    • Gnana-Prakasam JP, Martin PM, Mysona BA, Roon P, Smith SB, Ganapathy V. Hepcidin expression in mouse retina and its regulation via lipopolysaccharide/ Toll-like receptor-4 pathway independent of Hfe. Biochem J 2008;411:79-88.
    • (2008) Biochem J , vol.411 , pp. 79-88
    • Gnana-Prakasam, J.P.1    Martin, P.M.2    Mysona, B.A.3    Roon, P.4    Smith, S.B.5    Ganapathy, V.6
  • 15
  • 16
    • 0842263988 scopus 로고    scopus 로고
    • Localization of iron metabolism-related mRNAs in rat liver indicate that HFE is expressed predominantly in hepatocytes
    • DOI 10.1182/blood-2003-07-2378
    • Zhang AS, Xiong S, Tsukamoto H, Enns CA. Localization of iron metabolism-related mRNAs in rat liver indicate that HFE is expressed predominantly in hepatocytes. Blood 2004;103:1509-1514 (Pubitemid 38168670)
    • (2004) Blood , vol.103 , Issue.4 , pp. 1509-1514
    • Zhang, A.-S.1    Xiong, S.2    Tsukamoto, H.3    Enns, C.A.4
  • 18
    • 33845985236 scopus 로고    scopus 로고
    • STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation
    • DOI 10.1182/blood-2006-07-033969
    • Verga Falzacappa MV, Vujic Spasic M, Kessler R, Stolte J, Hentze MW, Muckenthaler MU. STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation. Blood 2007;109:353-358 (Pubitemid 46053077)
    • (2007) Blood , vol.109 , Issue.1 , pp. 353-358
    • Verga Falzacappa, M.V.1    Spasic, M.V.2    Kessler, R.3    Stolte, J.4    Hentze, M.W.5    Muckenthaler, M.U.6
  • 19
    • 44449124500 scopus 로고    scopus 로고
    • Iron responses in hepatic, intestinal and macrophage/monocyte cell lines under different culture conditions
    • Jacolot S, Ferec C, Mura C. Iron responses in hepatic, intestinal and macrophage/monocyte cell lines under different culture conditions. Blood Cells Mol Dis 2008;41:100-108
    • (2008) Blood Cells Mol Dis , vol.41 , pp. 100-108
    • Jacolot, S.1    Ferec, C.2    Mura, C.3
  • 23
    • 33751175421 scopus 로고    scopus 로고
    • Interleukin-6 induces hepcidin expression through STAT3
    • DOI 10.1182/blood-2006-06-027631
    • Wrighting DM, Andrews NC. Interleukin-6 induces hepcidin expression through STAT3. Blood 2006;108:3204-3209 (Pubitemid 44776963)
    • (2006) Blood , vol.108 , Issue.9 , pp. 3204-3209
    • Wrighting, D.M.1    Andrews, N.C.2
  • 24
    • 43049132128 scopus 로고    scopus 로고
    • A bone morphogenetic protein (BMP)-responsive element in the hepcidin promoter controls HFE2-mediated hepatic hepcidin expression and its response to IL-6 in cultured cells
    • Verga Falzacappa MV, Casanovas G, Hentze MW, Muckenthaler MU. A bone morphogenetic protein (BMP)-responsive element in the hepcidin promoter controls HFE2-mediated hepatic hepcidin expression and its response to IL-6 in cultured cells. J Mol Med 2008;86:531-540
    • (2008) J Mol Med , vol.86 , pp. 531-540
    • Verga Falzacappa, M.V.1    Casanovas, G.2    Hentze, M.W.3    Muckenthaler, M.U.4
  • 25
    • 33845477874 scopus 로고    scopus 로고
    • Cis and trans regulation of hepcidin expression by upstream stimulatory factor
    • DOI 10.1182/blood-2005-07-027037
    • Bayele HK, McArdle H, Srai SK. Cis and trans regulation of hepcidin expression by upstream stimulatory factor. Blood 2006;108:4237-4245 (Pubitemid 44913299)
    • (2006) Blood , vol.108 , Issue.13 , pp. 4237-4245
    • Bayele, H.K.1    McArdle, H.2    Srai, S.K.S.3
  • 26
    • 33646152944 scopus 로고    scopus 로고
    • Hepcidin generated by hepatoma cells inhibits iron export from cocultured THP1 monocytes
    • Andriopoulos B, Pantopoulos K. Hepcidin generated by hepatoma cells inhibits iron export from cocultured THP1 monocytes. J Hepatol 2006;44:1125-1131
    • (2006) J Hepatol , vol.44 , pp. 1125-1131
    • Andriopoulos, B.1    Pantopoulos, K.2
  • 27
    • 33646370235 scopus 로고    scopus 로고
    • Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression
    • Babitt JL, Huang FW, Wrighting DM, Xia Y, Sidis Y, Samad TA, et al. Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression. Nat Genet 2006;38:531-539
    • (2006) Nat Genet , vol.38 , pp. 531-539
    • Babitt, J.L.1    Huang, F.W.2    Wrighting, D.M.3    Xia, Y.4    Sidis, Y.5    Samad, T.A.6
  • 28
    • 2342510407 scopus 로고    scopus 로고
    • IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin
    • DOI 10.1172/JCI200420945
    • Nemeth E, Rivera S, Gabayan V, Keller C, Taudorf S, Pedersen BK, et al. IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. J Clin Invest 2004;113:1271-1276 (Pubitemid 39069926)
    • (2004) Journal of Clinical Investigation , vol.113 , Issue.9 , pp. 1271-1276
    • Nemeth, E.1    Rivera, S.2    Gabayan, V.3    Keller, C.4    Taudorf, S.5    Pedersen, B.K.6    Ganz, T.7
  • 30
    • 33745898241 scopus 로고    scopus 로고
    • Bone morphogenetic proteins 2, 4, and 9 stimulate murine hepcidin 1 expression independently of Hfe, transferrin receptor 2 (Tfr2), and IL-6
    • Truksa J, Peng H, Lee P, Beutler E. Bone morphogenetic proteins 2, 4, and 9 stimulate murine hepcidin 1 expression independently of Hfe, transferrin receptor 2 (Tfr2), and IL-6. Proc Natl Acad Sci USA 2006;103:10289-10293
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 10289-10293
    • Truksa, J.1    Peng, H.2    Lee, P.3    Beutler, E.4
  • 31
    • 9744269529 scopus 로고    scopus 로고
    • A comparison of differences in the gene expression profiles of phorbol 12-myristate 13-acetate differentiated THP-1 cells and human monocyte-derived macrophage
    • Kohro T, Tanaka T, Murakami T, Wada Y, Aburatani H, Hamakubo T, et al. A comparison of differences in the gene expression profiles of phorbol 12-myristate 13-acetate differentiated THP-1 cells and human monocyte-derived macrophage. J Atheroscler Thromb 2004;11:88-97.
    • (2004) J Atheroscler Thromb , vol.11 , pp. 88-97
    • Kohro, T.1    Tanaka, T.2    Murakami, T.3    Wada, Y.4    Aburatani, H.5    Hamakubo, T.6
  • 32
    • 35848934560 scopus 로고    scopus 로고
    • Leptin increases the expression of the iron regulatory hormone hepcidin in HuH7 human hepatoma cells
    • Chung B, Matak P, McKie AT, Sharp P. Leptin increases the expression of the iron regulatory hormone hepcidin in HuH7 human hepatoma cells. J Nutr 2007;137:2366-2370 (Pubitemid 350058702)
    • (2007) Journal of Nutrition , vol.137 , Issue.11 , pp. 2366-2370
    • Chung, B.1    Matak, P.2    McKie, A.T.3    Sharp, P.4
  • 34
    • 0037465251 scopus 로고    scopus 로고
    • The interleukin-1 receptor/Toll-like receptor superfamily: Signal transduction during inflammation and host defense
    • Dunne A, O'Neill LA. The interleukin-1 receptor/Toll-like receptor superfamily: signal transduction during inflammation and host defense. Sci STKE 2003;2003:re3.
    • (2003) Sci STKE , vol.2003
    • Dunne, A.1    O'Neill, L.A.2
  • 35
    • 0036683653 scopus 로고    scopus 로고
    • CCAAT/enhancer-binding proteins: Structure, function and regulation
    • DOI 10.1042/BJ20020508
    • Ramji DP, Foka P. CCAAT/enhancer-binding proteins: structure, function and regulation. Biochem J 2002;365:561-575 (Pubitemid 34864439)
    • (2002) Biochemical Journal , vol.365 , Issue.3 , pp. 561-575
    • Ramji, D.P.1    Foka, P.2
  • 36
    • 40849135497 scopus 로고    scopus 로고
    • Interleukin-1β stimulates acute phase response and C-reactive protein synthesis by inducing an NFκB-and C/EBPβ-dependent autocrine interleukin-6 loop
    • Kramer F, Torzewski J, Kamenz J, Veit K, Hombach V, Dedio J, et al. Interleukin-1β stimulates acute phase response and C-reactive protein synthesis by inducing an NFκB-and C/EBPβ-dependent autocrine interleukin-6 loop. Mol Immunol 2008;45:2678-2689
    • (2008) Mol Immunol , vol.45 , pp. 2678-2689
    • Kramer, F.1    Torzewski, J.2    Kamenz, J.3    Veit, K.4    Hombach, V.5    Dedio, J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.